Innovative machine vision technique for 2D/3Dcomplex and irregular surfaces modelling

Abstract—This study propose and demonstrates a novel technique incorporating multilayer perceptron (MLP) neural networks for feature extraction with Photometric stereo based image capture techniques for the analysis of complex and irregular 2D profiles and 3D surfaces. In order to develop the method and to ensure that it is capable of modelling non-axisymmetric and complex 2D/3D profiles, the network was initially trained and tested on 2D profiles, and subsequently using objects consisting of between 1 and 4 hemispherical 3D forms. To test the capability of the proposed model, random noise was added to 2D profiles.3D objects were coated with various degrees of coarsenesses(ranging from low-high). The gradient of each surface normalwas quantified in terms of the slant and tilt angles of the vector about the x and y axis respectively. The slant and tilt angles were obtained from the bump maps and these data were subsequently employed for training of a NN that had x and y as inputs and slant and tilt angles as outputs. The network employed had the following architecture: MLP and a Levenberg-Marquardt algorithm (LMA) for training the network for 12,000 epochs. At each point on the surface the network was consulted to predict slant and tilt and the actual slant and tilt was subtracted, giving a measure of surface irregularity. The network was able to model the underlying asymmetrical geometry with an accuracyregression analysis R-value of 0.93 for a single 3D hemispheres and 0.90 for four adjacent 3D non-axisymmetric hemispheres

In vivo measurement of skin microrelief using photometricstereo in the presence of interreflections

This paper proposes and describes an implementation of a novel photometric stereo based technique for in vivo assessment of three-dimensional (3D) skin topographyin the presence of interreflections. The proposed method illuminates skin with red, green, and blue colored lights and uses the resulting variation in surface gradients tomitigate the effects of interreflections. Experiments were carried out on Caucasian, Asian and African American subjects to demonstrate the accuracy of our methodand to validate the measurements produced by our system. Our method produced significant improvement in 3D surface reconstruction for all Caucasian, Asian and African American skin types. The results also illustrate the differences in recovered skin topography due to non-diffuse Bidirectional reflectance distribution function(BRDF) for each color illumination used, which also concur with the existing multispectral BRDF data available for skin

PROGRAM and PROCEEDINGS THE NEBRASKA ACADEMY OF SCIENCES: 139th Anniversary Year, One Hundred-Twenty-Ninth Annual Meeting, April 12, 2019, NEBRASKA WESLEYAN UNIVERSITY, LINCOLN, NEBRASKA

PROGRAM AT-A-GLANCE FRIDAY, APRIL 12, 2019 7:30 a.m. REGISTRATION OPENS - Lobby of Lecture Wing, Olin Hall 8:00 Aeronautics and Space Science, Session A – Acklie 109 Aeronautics and Space Science, Session B – Acklie 111 Collegiate Academy; Biology, Session B - Olin B Biological and Medical Sciences, Session A - Olin 112 Biological and Medical Sciences, Session B - Smith Callen Conference Center Chemistry and Physics; Chemistry - Olin A 8:00 “Teaching and Learning the Dynamics of Cellular Respiration Using Interactive Computer Simulations” Workshop – Olin 110 9:30 “Life After College: Building Your Resume for the Future” Workshop – Acklie 218 8:25 Collegiate Academy; Chemistry and Physics, Session A – Acklie 007 8:36 Collegiate Academy; Biology, Session A - Olin 111 9:00 Chemistry and Physics; Physics – Acklie 320 9:10 Aeronautics and Space Science, Poster Session – Acklie 109 & 111 10:30 Aeronautics and Space Science, Poster Session – Acklie 109 & 111 11:00 MAIBEN MEMORIAL LECTURE: Dr David Swanson - OLIN B Scholarship and Friend of Science Award announcements 12:00 p.m. LUNCH – WESLEYAN CAFETERIA Round-Table Discussion – “Assessing the Academy: Current Issues and Avenues for Growth” led by Todd Young – Sunflower Room 12:50 Anthropology – Acklie 109 1:00 Applied Science and Technology - Olin 111 Biological and Medical Sciences, Session C - Olin 112 Biological and Medical Sciences, Session D - Smith Callen Conference Center Chemistry and Physics; Chemistry - Olin A Collegiate Academy; Biology, Session B - Olin B Earth Science – Acklie 007 Environmental Sciences – Acklie 111 Teaching of Science and Math – Acklie 218 1:20 Chemistry and Physics; Physics – Acklie 320 4:30 BUSINESS MEETING - OLIN B NEBRASKA ASSOCIATION OF TEACHERS OF SCIENCE (NATS) The 2019 Fall Conference of the Nebraska Association of Teachers of Science (NATS) will be held at the Younes Conference Center, Kearney, NE, September 19-21, 2019. President: Betsy Barent, Norris Public Schools, Firth, NE President-Elect: Anya Covarrubias, Grand Island Public Schools, Grand Island, NE AFFILIATED SOCIETIES OF THE NEBRASKA ACADEMY OF SCIENCES, INC. 1. American Association of Physics Teachers, Nebraska Section Web site: http://www.aapt.org/sections/officers.cfm?section=Nebraska 2. Friends of Loren Eiseley Web site: http://www.eiseley.org/ 3. Lincoln Gem & Mineral Club Web site: http://www.lincolngemmineralclub.org/ 4. Nebraska Chapter, National Council for Geographic Education 5. Nebraska Geological Society Web site: http://www.nebraskageologicalsociety.org Sponsors of a $50 award to the outstanding student paper presented at the Nebraska Academy of Sciences Annual Meeting, Earth Science /Nebraska Chapter, Nat\u27l Council Sections 6. Nebraska Graduate Women in Science 7. Nebraska Junior Academy of Sciences Web site: http://www.nebraskajunioracademyofsciences.org/ 8. Nebraska Ornithologists’ Union Web site: http://www.noubirds.org/ 9. Nebraska Psychological Association http://www.nebpsych.org/ 10. Nebraska-Southeast South Dakota Section Mathematical Association of America Web site: http://sections.maa.org/nesesd/ 11. Nebraska Space Grant Consortium Web site: http://www.ne.spacegrant.org

Building models from multiple point sets with kernel density estimation

One of the fundamental problems in computer vision is point set registration. Point set registration finds use in many important applications and in particular can be considered one of the crucial stages involved in the reconstruction of models of physical objects and environments from depth sensor data. The problem of globally aligning multiple point sets, representing spatial shape measurements from varying sensor viewpoints, into a common frame of reference is a complex task that is imperative due to the large number of critical functions that accurate and reliable model reconstructions contribute to. In this thesis we focus on improving the quality and feasibility of model and environment reconstruction through the enhancement of multi-view point set registration techniques. The thesis makes the following contributions: First, we demonstrate that employing kernel density estimation to reason about the unknown generating surfaces that range sensors measure allows us to express measurement variability, uncertainty and also to separate the problems of model design and viewpoint alignment optimisation. Our surface estimates define novel view alignment objective functions that inform the registration process. Our surfaces can be estimated from point clouds in a datadriven fashion. Through experiments on a variety of datasets we demonstrate that we have developed a novel and effective solution to the simultaneous multi-view registration problem. We then focus on constructing a distributed computation framework capable of solving generic high-throughput computational problems. We present a novel task-farming model that we call Semi-Synchronised Task Farming (SSTF), capable of modelling and subsequently solving computationally distributable problems that benefit from both independent and dependent distributed components and a level of communication between process elements. We demonstrate that this framework is a novel schema for parallel computer vision algorithms and evaluate the performance to establish computational gains over serial implementations. We couple this framework with an accurate computation-time prediction model to contribute a novel structure appropriate for addressing expensive real-world algorithms with substantial parallel performance and predictable time savings. Finally, we focus on a timely instance of the multi-view registration problem: modern range sensors provide large numbers of viewpoint samples that result in an abundance of depth data information. The ability to utilise this abundance of depth data in a feasible and principled fashion is of importance to many emerging application areas making use of spatial information. We develop novel methodology for the registration of depth measurements acquired from many viewpoints capturing physical object surfaces. By defining registration and alignment quality metrics based on our density estimation framework we construct an optimisation methodology that implicitly considers all viewpoints simultaneously. We use a non-parametric data-driven approach to consider varying object complexity and guide large view-set spatial transform optimisations. By aligning large numbers of partial, arbitrary-pose views we evaluate this strategy quantitatively on large view-set range sensor data where we find that we can improve registration accuracy over existing methods and contribute increased registration robustness to the magnitude of coarse seed alignment. This allows large-scale registration on problem instances exhibiting varying object complexity with the added advantage of massive parallel efficiency

Characterization of normal facial features and their association with genes

ABSTRACT Background: Craniofacial morphology has been reported to be highly heritable, but little is known about which genetic variants influence normal facial variation in the general population. Aim: To identify facial variation and explore phenotype-genotype associations in a 15-year-old population (2514 females and 2233 males). Subjects and Methods: The subjects involved in this study were recruited from the Avon Longitudinal Study of Parents and Children (ALSPAC). Three-dimensional (3D) facial images were obtained for each subject using two high-resolution Konica Minolta laser scanners. Twenty-one reproducible facial soft tissue landmarks and one constructed mid-endocanthion point (men) were identified and their coordinates were recorded. The 3D facial images were registered using Procrustes analysis (with and without scaling). Principal Component Analysis (PCA) was then employed to identify independent groups ‘principal components, PCs’ of correlated landmark coordinates that represent key facial features contributing to normal facial variation. A novel surface-based method of facial averaging was employed to visualize facial variation. Facial parameters (distances, angles, and ratios) were also generated using facial landmarks. Sex prediction based on facial parameters was explored using discriminant function analysis. A discovery-phase genome-wide association analysis (GWAS) was carried out for 2,185 ALSPAC subjects and replication was undertaken in a further 1,622 ALSPAC individuals. Results: 14 (unscaled) and 17 (scaled) PCs were identified explaining 82% of the total variance in facial form and shape. 250 facial parameters were derived (90 distances, 118 angles, 42 ratios). 24 facial parameters were found to provide sex prediction efficiency of over 70%, 23 of these parameters are distances that describe variation in face height, nose width, and prominence of various facial structures. 54 distances associated with previous reported high heritability and the 14 (unscaled) PCs were included in the discovery-phase GWAS. Four genetic associations with the distances were identified in the discovery analysis, and one of these, the association between the common ‘intronic’ SNP (rs7559271) in PAX3 gene on chromosome (2) and the nasion to mid-endocanthion 3D distance (n-men) was replicated strongly (p = 4 x 10-7). PAX3 gene encodes a transcription factor that plays crucial role in fetal development including craniofacial bones. PAX3 contains two DNA-binding domains, a paired-box domain and a homeodomain. The protein made from PAX3 gene directs the activity of other genes that signal neural crest cells to form specialized tissues such as craniofacial bones. PAX3 different mutations may lead to non-functional PAX3 polypeptides and destroy the ability of the PAX3 proteins to bind to DNA and regulate the activity of other genes to form bones and other specific tissues. Conclusions: The variation in facial form and shape can be accurately quantified and visualized as a multidimensional statistical continuum with respect to the principal components. The derived PCs may be useful to identify and classify faces according to a scale of normality. A strong genetic association was identified between the common SNP (rs7559271) in PAX3 gene on chromosome (2) and the nasion to mid-endocanthion 3D distance (n-men). Variation in this distance leads to nasal bridge prominence

Immune-Mediated Drug Induced Liver Injury: A Multidisciplinary Approach

This thesis presents an approach to expose relationships between immune mediated drug induced liver injury (IMDILI) and the three-dimensional structural features of toxic drug molecules and their metabolites. The series of analyses test the hypothesis that drugs which produce similar patterns of toxicity interact with targets within common toxicological pathways and that activation of the underlying mechanisms depends on structural similarity among toxic molecules. Spontaneous adverse drug reaction (ADR) reports were used to identify cases of IMDILI. Network map tools were used to compare the known and predicted protein interactions with each of the probe drugs to explore the interactions that are common between the drugs. The IMDILI probe set was then used to develop a pharmacophore model which became the starting point for identifying potential toxicity targets for IMDILI. Pharmacophore screening results demonstrated similarities between the probe IMDILI set of drugs and Toll-Like Receptor 7 (TLR7) agonists, suggesting TLR7 as a potential toxicity target. This thesis highlights the potential for multidisciplinary approaches in the study of complex diseases. Such approaches are particularly helpful for rare diseases where little knowledge is available, and may provide key insights into mechanisms of toxicity that cannot be gleaned from a single disciplinary study