Quantitative Screening of Cervical Cancers for Low-Resource Settings: Pilot Study of Smartphone-Based Endoscopic Visual Inspection After Acetic Acid Using Machine Learning Techniques

Background: Approximately 90% of global cervical cancer (CC) is mostly found in low- and middle-income countries. In most cases, CC can be detected early through routine screening programs, including a cytology-based test. However, it is logistically difficult to offer this program in low-resource settings due to limited resources and infrastructure, and few trained experts. A visual inspection following the application of acetic acid (VIA) has been widely promoted and is routinely recommended as a viable form of CC screening in resource-constrained countries. Digital images of the cervix have been acquired during VIA procedure with better quality assurance and visualization, leading to higher diagnostic accuracy and reduction of the variability of detection rate. However, a colposcope is bulky, expensive, electricity-dependent, and needs routine maintenance, and to confirm the grade of abnormality through its images, a specialist must be present. Recently, smartphone-based imaging systems have made a significant impact on the practice of medicine by offering a cost-effective, rapid, and noninvasive method of evaluation. Furthermore, computer-aided analyses, including image processing-based methods and machine learning techniques, have also shown great potential for a high impact on medicinal evaluations

Investigating the impact of image content on the energy efficiency of hardware-accelerated digital spatial filters

Battery-operated low-power portable computing devices are becoming an inseparable part of human daily life. One of the major goals is to achieve the longest battery life in such a device. Additionally, the need for performance in processing multimedia content is ever increasing. Processing image and video content consume more power than other applications. A widely used approach to improving energy efficiency is to implement the computationally intensive functions as digital hardware accelerators. Spatial filtering is one of the most commonly used methods of digital image processing. As per the Fourier theory, an image can be considered as a two-dimensional signal that is composed of spatially extended two-dimensional sinusoidal patterns called gratings. Spatial frequency theory states that sinusoidal gratings can be characterised by its spatial frequency, phase, amplitude, and orientation. This article presents results from our investigation into assessing the impact of these characteristics of a digital image on the energy efficiency of hardware-accelerated spatial filters employed to process the same image. Two greyscale images each of size 128 × 128 pixels comprising two-dimensional sinusoidal gratings at maximum spatial frequency of 64 cycles per image orientated at 0° and 90°, respectively, were processed in a hardware implemented Gaussian smoothing filter. The energy efficiency of the filter was compared with the baseline energy efficiency of processing a featureless plain black image. The results show that energy efficiency of the filter drops to 12.5% when the gratings are orientated at 0° whilst rises to 72.38% at 90°

On the Estimation of Nonrandom Signal Coefficients from Jittered Samples

This paper examines the problem of estimating the parameters of a bandlimited signal from samples corrupted by random jitter (timing noise) and additive iid Gaussian noise, where the signal lies in the span of a finite basis. For the presented classical estimation problem, the Cramer-Rao lower bound (CRB) is computed, and an Expectation-Maximization (EM) algorithm approximating the maximum likelihood (ML) estimator is developed. Simulations are performed to study the convergence properties of the EM algorithm and compare the performance both against the CRB and a basic linear estimator. These simulations demonstrate that by post-processing the jittered samples with the proposed EM algorithm, greater jitter can be tolerated, potentially reducing on-chip ADC power consumption substantially.Comment: 11 pages, 8 figure

STR: a student developed star tracker for the ESA-LED ESMO moon mission

In the frame of their engineering degree, ISAE’s students are developing a Star Tracker, with the aim of being the core attitude estimation equipment of the European Moon Student Orbiter. This development goes on since several years and is currently in phase B. We intend to start building an integrated breadboard for the end of the academic year. The STR is composed of several sub-systems: the optical and detection sub-system, the electronics, the mechanics and the software. The optical detection part is based on an in-house developed new generation of APS detectors. The optical train is made of several lenses enclosed in a titanium tube. The electronics includes a FPGA for the pre-processing of the image and a microcontroller in order to manage the high level functions of the instrument. The mechanical part includes the electronics box, as well as the sensor baffle. The design is optimized to minimize the thermo-elastic noise of the assembly. Embedded on ESMO platform, this Star Tracker will be able to compute the satellite‘s attitude, taking into account the specific requirements linked to a Moon mission (illumination, radiation requirements and baffle adaptation to lunar orbit). In order to validate the design, software end-to-end simulation will include a complete simulation of the STR in its lunar dynamic environment. Therefore, we are developing a simple orbital model for the mission (including potential dazzling by celestial bodies)

Master slave en-face OCT/SLO

Master Slave optical coherence tomography (MS-OCT) is an OCT method that does not require resampling of data and can be used to deliver en-face images from several depths simultaneously. As the MS-OCT method requires important computational resources, the number of multiple depth en-face images that can be produced in real-time is limited. Here, we demonstrate progress in taking advantage of the parallel processing feature of the MS-OCT technology. Harnessing the capabilities of graphics processing units (GPU)s, information from 384 depth positions is acquired in one raster with real time display of up to 40 en-face OCT images. These exhibit comparable resolution and sensitivity to the images produced using the conventional Fourier domain based method. The GPU facilitates versatile real time selection of parameters, such as the depth positions of the 40 images out of the set of 384 depth locations, as well as their axial resolution. In each updated displayed frame, in parallel with the 40 en-face OCT images, a scanning laser ophthalmoscopy (SLO) lookalike image is presented together with two B-scan OCT images oriented along rectangular directions. The thickness of the SLO lookalike image is dynamically determined by the choice of number of en-face OCT images displayed in the frame and the choice of differential axial distance between them

The Murchison Widefield Array: Design Overview

The Murchison Widefield Array (MWA) is a dipole-based aperture array synthesis telescope designed to operate in the 80-300 MHz frequency range. It is capable of a wide range of science investigations, but is initially focused on three key science projects. These are detection and characterization of 3-dimensional brightness temperature fluctuations in the 21cm line of neutral hydrogen during the Epoch of Reionization (EoR) at redshifts from 6 to 10, solar imaging and remote sensing of the inner heliosphere via propagation effects on signals from distant background sources,and high-sensitivity exploration of the variable radio sky. The array design features 8192 dual-polarization broad-band active dipoles, arranged into 512 tiles comprising 16 dipoles each. The tiles are quasi-randomly distributed over an aperture 1.5km in diameter, with a small number of outliers extending to 3km. All tile-tile baselines are correlated in custom FPGA-based hardware, yielding a Nyquist-sampled instantaneous monochromatic uv coverage and unprecedented point spread function (PSF) quality. The correlated data are calibrated in real time using novel position-dependent self-calibration algorithms. The array is located in the Murchison region of outback Western Australia. This region is characterized by extremely low population density and a superbly radio-quiet environment,allowing full exploitation of the instrumental capabilities.Comment: 9 pages, 5 figures, 1 table. Accepted for publication in Proceedings of the IEE