Diagnosing epilepsy using entropy measures and embedding parameters of EEG signals

Epilepsy is a neurological disorder that affects normal neural activity. These electrical activities can be recorded as signals containing information about the brain known as Electroencephalography (EEG) signals. Analysis of the EEG signals by individuals for epilepsy diagnosis is subjective and time-consuming. So, an automatic classification system with high detection accuracy is required to overcome possible errors. In this study, the discrete wavelet transform has been applied to EEG signals. Then, entropy measures and embedding parameters have been extracted. These features have been investigated individually to find the most discriminating ones. The significance level of each feature was evaluated by statistical analysis. Consequently, LDA and SVM algorithms have been employed to categorize the EEG signals. The results have indicated that the features of Embedding parameters, PermutationEntropy, FuzzyEntropy, SampleEntropy, NormEntropy, SureEntropy, LogEntropy, and ThresholdEntropy have the potential to discriminate epileptic patients from healthy subjects significantly. Also, SVM classifier has achieved the highest classification accuracy. In this study, we could find effective embedding-based and entropy-based features as appropriate single measures for identifying abnormal activities that can efficiently discriminate the EEG signals of epileptics from healthy individuals. According to the results, they can be used for automatic classification of epileptic EEG signals that are difficult to examine visually

Epileptic Seizure Detection And Prediction From Electroencephalogram Using Neuro-Fuzzy Algorithms

This dissertation presents innovative approaches based on fuzzy logic in epileptic seizure detection and prediction from Electroencephalogram (EEG). The fuzzy rule-based algorithms were developed with the aim to improve quality of life of epilepsy patients by utilizing intelligent methods. An adaptive fuzzy logic system was developed to detect seizure onset in a patient specific way. Fuzzy if-then rules were developed to mimic the human reasoning and taking advantage of the combination in spatial-temporal domain. Fuzzy c-means clustering technique was utilized for optimizing the membership functions for varying patterns in the feature domain. In addition, application of the adaptive neuro-fuzzy inference system (ANFIS) is presented for efficient classification of several commonly arising artifacts from EEG. Finally, we present a neuro-fuzzy approach of seizure prediction by applying the ANFIS. Patient specific ANFIS classifier was constructed to forecast a seizure followed by postprocessing methods. Three nonlinear seizure predictive features were used to characterize changes prior to seizure. The nonlinear features used in this study were similarity index, phase synchronization, and nonlinear interdependence. The ANFIS classifier was constructed based on these features as inputs. Fuzzy if-then rules were generated by the ANFIS classifier using the complex relationship of feature space provided during training. In this dissertation, the application of the neuro-fuzzy algorithms in epilepsy diagnosis and treatment was demonstrated by applying the methods on different datasets. Several performance measures such as detection delay, sensitivity and specificity were calculated and compared with results reported in literature. The proposed algorithms have potentials to be used in diagnostics and therapeutic applications as they can be implemented in an implantable medical device to detect a seizure, forecast a seizure, and initiate neurostimulation therapy for the purpose of seizure prevention or abortion

Classification of Epileptic and Non-Epileptic Electroencephalogram (EEG) Signals Using Fractal Analysis and Support Vector Regression

Seizures are a common symptom of this neurological condition, which is caused by the discharge of brain nerve cells at an excessively fast rate. Chaos, nonlinearity, and other nonlinearities are common features of scalp and intracranial Electroencephalogram (EEG) data recorded in clinics. EEG signals that aren't immediately evident are challenging to categories because of their complexity. The Gradient Boost Decision Tree (GBDT) classifier was used to classify the majority of the EEG signal segments automatically. According to this study, the Hurst exponent, in combination with AFA, is an efficient way to identify epileptic signals. As with any fractal analysis approach, there are problems and factors to keep in mind, such as identifying whether or not linear scaling areas are present. These signals were classified as either epileptic or non-epileptic by using a combination of GBDT and a Support Vector Regression (SVR). The combined method's identification accuracy was 98.23%. This study sheds light on the effectiveness of AFA feature extraction and GBDT classifiers in EEG classification. The findings can be utilized to develop theoretical guidance for the clinical identification and prediction of epileptic EEG signals. Doi: 10.28991/ESJ-2022-06-01-011 Full Text: PD

Seizure detection from Electroencephalogram signals via Wavelets and Graph Theory metrics

Epilepsy is one of the most prevalent neurological conditions, where an epileptic seizure is a transient occurrence due to abnormal, excessive and synchronous activity in the brain. Electroencephalogram signals emanating from the brain may be captured, analysed and then play a significant role in detection and prediction of epileptic seizures. In this work we enhance upon a previous approach that relied on the differing properties of the wavelet transform. Here we apply the Maximum Overlap Discrete Wavelet Transform to both reduce signal \textit{noise} and use signal variance exhibited at differing inherent frequency levels to develop various metrics of connection between the electrodes placed upon the scalp. %The properties of both the noise reduced signal and the interconnected electrodes differ significantly during the different brain states. Using short duration epochs, to approximate close to real time monitoring, together with simple statistical parameters derived from the reconstructed noise reduced signals we initiate seizure detection. To further improve performance we utilise graph theoretic indicators from derived electrode connectivity. From there we build the attribute space. We utilise open-source software and publicly available data to highlight the superior Recall/Sensitivity performance of our approach, when compared to existing published methods

Wavelet Based Feature Extraction for The Indonesian CV Syllables Sound

This paper proposes the combined methods of Wavelet Transform (WT) and Euclidean Distance (ED) to estimate the expected value of the possibly feature vector of Indonesian syllables. This research aims to find the best properties in effectiveness and efficiency on performing feature extraction of each syllable sound to be applied in the speech recognition systems. This proposed approach which is the state-of-the-art of the previous study consist of three main phase. In the first phase, the speech signal is segmented and normalized. In the second phase, the signal is transformed into frequency domain by using the WT. In the third phase, to estimate the expected feature vector, the ED algorithm is used. Th e result shows the list of features of each syllables can be used for the next research, and some recommendations on the most effective and efficient WT to be used in performing syllable sound recognition

Analysis of observed chaotic data

Thesis (Master)--Izmir Institute of Technology, Electronics and Communication Engineering, Izmir, 2004Includes bibliographical references (leaves: 86)Text in English; Abstract: Turkish and Englishxii, 89 leavesIn this thesis, analysis of observed chaotic data has been investigated. The purpose of analyzing time series is to make a classification between the signals observed from dynamical systems. The classifiers are the invariants related to the dynamics. The correlation dimension has been used as classifier which has been obtained after phase space reconstruction. Therefore, necessary methods to find the phase space parameters which are time delay and the embedding dimension have been offered. Since observed time series practically are contaminated by noise, the invariants of dynamical system can not be reached without noise reduction. The noise reduction has been performed by the new proposed singular value decomposition based rank estimation method.Another classification has been realized by analyzing time-frequency characteristics of the signals. The time-frequency distribution has been investigated by wavelet transform since it supplies flexible time-frequency window. Classification in wavelet domain has been performed by wavelet entropy which is expressed by the sum of relative wavelet energies specified in certain frequency bands. Another wavelet based classification has been done by using the wavelet ridges where the energy is relatively maximum in time-frequency domain. These new proposed analysis methods have been applied to electrical signals taken from healthy human brains and the results have been compared with other studies

Automatic Localization of Epileptic Spikes in EEGs of Children with Infantile Spasms

Infantile Spasms (ISS) characterized by electroencephalogram (EEG) recordings exhibiting hypsarrythmia (HYPS) are a severe form of epilepsy. Many clinicians have been trying to improve ISS outcomes; however, quantification of discharges from hypsarrythmic EEG readings remains challenging. This thesis describes the development of a novel method that assists clinicians to successfully localize the epileptic discharges associated with ISS in HYPS. The approach includes: construct the time-frequency domain (TFD) of the EEG recording using matching pursuit TFD (MP-TFD), decompose the TFD matrix into two submatrices using nonnegative matrix factorizations (NMF), and employ the decomposed vectors to locate the spikes. The proposed method was employed to an EEG dataset of five ISS individuals, and identification of spikes was compared with those which were identified by the epileptologists and those obtained using clinical software (Persyst). Performance evaluations showed results based on classification techniques: thresholdings, and support vector machine (SVM). Using the thresholdings, average true positive (TP) and false negative (FN) percentages of 86% and 14% were achieved, which represented a significant improvement over the use of Persyst, which only achieved average TP and FN percentages of 4% and 96%, respectively. Using SVM, the percentage of area under curve (AUC) of receiver operating characteristic (ROC) was significantly improved up to 98.56%. In summary, the proposed novel algorithm based on MP-TFD and NMF was able to successfully detect the epileptic discharges from the dataset. The development of the proposed automated method can potentially assist clinicians to successfully localize the epileptic discharges associated with ISS in HYPS. The quantitative assessment of spike detection, as well as other features of HYPS, is expected to allow a more accurate assessment of the relevance of EEG to clinical outcomes, which is significant in therapy management of ISS