Assessment of Canine Pancreas-Specific Lipase and Outcomes in Dogs with Hemodialysis-Dependent Acute Kidney Injury.

BackgroundRenal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome.Hypothesis/objectivesTo investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements.AnimalsFifty-three client-owned dogs presented to teaching hospitals between November 2008 and September 2016 that underwent IHD.MethodsRetrospective medical record review from dogs that received IHD for management of AKI and also had a Spec cPL measurement. Association between survival, dialysis-dependency, and Spec cPL measurements was assessed.ResultsForty of 53 (76%) dogs were alive at 30-days and 33/53(62%) had a Spec cPL result ≥400 μg/L. Spec cPL was not significantly different either between surviving (635.5 μg/L, range 29-1,001) and nonsurviving dogs (860 μg/L, range 56-1,001; P = 0.75) or between dialysis-dependent (1,001 μg/L, range 177-1,001) and nondialysis-dependent dogs (520 μg/L, range 29-1,001; P = 0.08). Spec cPL ≥400 μg/L was not significantly associated either with survival (P = 0.74) or dialysis-dependency (P = 0.33).Conclusions and clinical importanceResults revealed a high prevalence of Spec cPL ≥400 μg/L in dogs with AKI treated with IHD. No significant associations between Spec cPL and survival or dialysis-dependency in dogs with AKI at 30 days were identified in the current study, however, the latter could be due to lack of power in this study

Evaluation of Canine Pancreas-Specific Lipase Activity, Lipase Activity, and Trypsin-Like Immunoreactivity in an Experimental Model of Acute Kidney Injury in Dogs.

BackgroundDiagnosis of pancreatitis in dogs is complicated by extrapancreatic disorders that can alter the results of laboratory tests. Extrapancreatic disorders can also affect the diagnosis of exocrine pancreatic insufficiency (EPI). The effects of acute kidney injury (AKI) on pancreas-specific lipase activity (Spec cPL(®) Test), serum lipase activity and trypsin-like immunoreactivity (TLI) in dogs have not been evaluated.Hypothesis/objectivesSerum Spec cPL, lipase activity, and TLI concentrations will increase secondary to decreased kidney function.AnimalsFive purpose-bred dogs.MethodsExperimental prospective study. Gentamicin was used to induce AKI in 5 purpose-bred dogs. Serum samples were collected for measurement of creatinine, Spec cPL, lipase activity and TLI over 60 days, during both induction of, and recovery from, AKI.ResultsAll dogs developed and recovered from AKI. Six of 52 (12%) serum Spec cPL concentrations were increased (2 in the equivocal zone and 4 consistent with pancreatitis) in 2 of 5 (40%) dogs. Two of 51 (4%) serum lipase activity values were increased in 2 of 5 dogs. Serum TLI was increased above the reference range in 17 of 50 (34%) samples in 3 of 5 dogs. For all biomarkers, there was no consistent correlation with increases in serum creatinine concentration.Conclusions and clinical importanceDecreased renal excretion during experimental AKI did not cause consistent and correlated increases in serum Spec cPL, lipase activity, or TLI in this cohort of dogs

A test of the CPL parameterization for rapid dark energy equation of state transitions

We test the robustness and flexibility of the Chevallier-Polarski-Linder (CPL) parameterization of the Dark Energy equation of state $w(z)=w_0+w_a \frac{z}{1+z}$ in recovering a four-parameter step-like fiducial model. We constrain the parameter space region of the underlying fiducial model where the CPL parameterization offers a reliable reconstruction. It turns out that non negligible biases leak into the results for recent ($z<2.5$) rapid transitions, but that CPL yields a good reconstruction in all other cases. The presented analysis is performed with supernova Ia data as forecasted for a space mission like SNAP/JDEM, combined with future expectations for the CMB shift parameter $R$ and the BAO parameter $A$.Comment: 8 pages, 6 ps figure

Constructive Provability Logic

We present constructive provability logic, an intuitionstic modal logic that validates the L\"ob rule of G\"odel and L\"ob's provability logic by permitting logical reflection over provability. Two distinct variants of this logic, CPL and CPL*, are presented in natural deduction and sequent calculus forms which are then shown to be equivalent. In addition, we discuss the use of constructive provability logic to justify stratified negation in logic programming within an intuitionstic and structural proof theory.Comment: Extended version of IMLA 2011 submission of the same titl

Development and integration of the capillary pumped loop GAS and Hitchhiker flight experiments

The Capillary Pumped Loop (CPL) is a thermal control system with high density heat acquisition and transport capability. A small spaceflight version of the CPL was built and flown as a GAS experiment on STS 51-D in April 1985 and STS 51-G in June 1985, and as a Hitchhiker-G experiment on STS 61-C in January 1986. The purpose of the experiments was to demonstrate the capability of a capillary pumped system under microgravity conditions for use in the thermal control of large scientific instruments, advanced orbiting spacecraft, and space station components. The development, integration, and test activities of the CPL are described

Investigation of thermal-fluid mechanical characteristics of the capillary pump and the pumped two-phase loop

This first semi-annual report summarized progress made on NASA Goddard Space Flight Center (GSFC) Grant NAG 5-834 during the period September 1, 1986 to February 28, 1987. The goal of the project is to gain a better understanding of the transient behavior of the Capillary Pump Loop (CPL) developed and tested by the GSFC. The investigation is directed toward development of analytical models to represent the transient thermal-fluid mechanic processes occurring in different parts of the CPL engineering model. Evaluation of the available test data has been the starting point for the investigation. Based on results of this evaluation, supplementary tests will be conducted by using a CPL test system already operational in the Heat Transfer laboratory of the university. Of particular interest is the oscillatory behavior of the CPL engineering model exhibited during some of the earlier test runs conducted at NASA-GSFC and Johnson Space Center (JSC)

Laser-induced splittings in the nuclear magnetic resonance spectra of the rare gases

Circularly polarized laser field causes a shift in the nuclear magnetic resonance (NMR) spectra of all substances. The shift is proportional to the intensity of the laser beam and yields oppositely signed values for left- and right-circularly polarized light, CPL -/+, respectively. Rapid switching -- in the NMR time scale -- between CPL+ and CPL- gives rise to a splitting of the NMR resonance lines. We present uncorrelated and correlated quadratic response calculations of the splitting per unit of beam intensity in the NMR spectra of $^{21}$Ne, $^{83}$Kr, and $^{129}$Xe. We study both the regions far away from and near to optical resonance and predict off-resonance shifts of the order 0.01, 0.1, and $1\times 10^{-6}$ Hz for $^{21}$Ne, $^{83}$Kr, and $^{129}$Xe, respectively, for a beam intensity of 10 W/cm$^2$. Enhancement by several orders of magnitude is predicted as the beam frequency approaches resonance. Only then can the effect on guest $^{129}$Xe atoms be potentially useful as a probe of the properties of the host material.Comment: 5 pages, 1 figur

UA1C12 Co. A 27th Tank Battalion, 20th Armored Division Broadside

Broadside of thanks from Company A of the 27th Tank Battalion of the 20th Armored Division. The inscription is: To those of you who made our lives happier. We thank you from the bottom of our hearts. The broadside was signed by the members of the battalion and it includes a photograph of a tank. Notations and signatures: Cpl. Bob Red Irwin Pvt. Jack Snafu Arkush Co. Capt. T. Piuhl T/5 Francis W. Cassidy Pvt. Ray F. Kitchen (K.) T/5 Slugger Derkman Cpl. Sloan Mullens (?) T/5 Ed Larger Sgt. George E. Blosus Cpl. Bruce Keating Pfc. Melvin Sveltenfucs Irish St. M. Heane Johnny Cpl. James H. Holmes Cpl. Chuck Buttell Rudolph O. Houston Old Sgt. Harry Kelby (Canteen Commandos) Keith Walker Peter Colosi Cpl. Merle V. Stul Bill Arensen Sgt. Robert Spencer Cpl. Dean Fountain Cpl. W. Stewart Pv.t Matt F. Adam P.V.T. Robert N. Cooksey Tough Boy, Ky Cpl. Keith Walker Harold Andy Anderson Pvt. Toby Korolkoff PFC. Larry Hison Pvt. Harry N. Miller Sgt. Samuel Chevuria Stock, Larry St. R.D. McMillan Mac Sgt. Harold J. Schreiner Toothless Carl Giordano Unk T/5 Frank S. Lisowski Polack Cpl. William Liptak Sgt. Johnnie Malish, Pennsylvania Cpl. Vincent E. Scutaro Sgt. S. Grabowski PFC Raymond Hoffman Pvt. Donald M. Nolan Spooks Emil Napolitane B\u27pt. Conn Cpl. Herb Peterson Cpl. John Gill Pvt. E.W. Sadorsky Cpl. Joe Brockin (?), Corn Cpl. Harold W. Heil, Queens, NY Pfc. Morton Katz Len Kowalski, C\u27dale, Pa. Cpl. Melvin J. Brown houer Pvt. Richard H. Finck Pvt. R.E. Brown Pfc. Victor F. Diaz Cpl. John Gil