Calibration: Respice, Adspice, Prospice

“Those who claim for themselves to judge the truth are bound to possess a criterion of truth.” JEL Code: C18, C53, D89calibration, prediction

Impact of Fuel Price Increases on Texas Crops

Replaced with revised version of paper 02/02/06.crop model, simulation, input-output model, Resource /Energy Economics and Policy, C53, Q10,

Trends and cycles in the euro area: how much heterogeneity and should we worry about it?

Not so much and we should not, at least not yet. JEL Classification: E32, C33, C53, F2, F43euro area, European Integration, Income Insurance, International Business Cycles, Risk Sharing

Characterising the anticancer effects of a small molecule with potential to inhibit nuclear import via karyopherin beta1

The Karyopherin superfamily is a group of soluble transport proteins which are involved in nuclear-cytoplasmic trafficking. Studies have shown the involvement of Karyopherin proteins in nuclear pore assembly, nuclear membrane assembly and DNA replication. Since all these cell regulatory functions are critical for normal cell function, dysregulation of Karyopherin proteins may have an impact on cancer cell survival. Previous research in our laboratory and in that of others has shown that Karyopherin Beta 1 (KPNB1) is elevated in and necessary for the survival of cervical cancer cells as inhibiting its expression with siRNAs interfered with the proliferation of cancer cells. KPNB1 has thus been proposed as an anticancer target. In addition to inhibition by siRNA, an in silico screen for small molecules with potential to bind KPNB1 identified a number of compounds that are currently under investigation for their cancer cell killing effects. In this study, we investigated the ability of a novel small molecule 1-benzyl-4[(4-methoxy-1-naphyl) methylamino]-N-methyl pyrrolidine-2-carboxamide (Compound 53) to kill cancer cells and inhibit the activity of KPNB1 cargo proteins. In addition, the in vitro pharmacokinetic properties and in vivo toxicology of Compound 53 (C53) were investigated. Cervical (HeLa and CaSki) and oesophageal (WHCO6 and Kyse30) cancer cell lines were found to be more sensitive to C53 treatment compared to non-cancer cells (FG₀), with EC₅₀ values of ~20 μM for the cancer cell lines and ~30-40 μM for the non-cancer cells. C53 treatment significantly inhibited proliferation in cancer cell lines. The reduction in proliferation in cancer cells was associated with a block in the G1 phase of the cell cycle and a change in the expression of cell cycle related proteins such as CyclinD1 and CDK4. C53 treatment resulted in cell death via apoptosis as observed using Annexin V staining and PARP cleavage. To assess whether C53 interferes with KPNB1 associated nuclear import, we investigated the effect of C53 on the activity of KPNB1 cargo proteins, NFAT and NF-ĸB as well as investigate its effect on KPNB1 localisation. The results show that C53 has no effect on the localisation of KPNB1 but it does however block the nuclear activity of the KPNB1 cargoes, NFAT and NF-ĸB. In order to predict the behaviour of C53 in a living system, in vitro ADME pharmacokinetic studies showed that C53 has moderate solubility, permeability and protein binding however, rapid clearance was shown by liver microsome assay. In vivo repeated dose toxicology studies showed that C53 is tolerable in nude mice. Taken together, the data presented in this study shows that a novel small molecule, C53 has a negative effect on the proliferation of cancer cells, inhibits the nuclear import of KPNB1 cargoes, displays tolerable in vitro ADME pharmacokinetic properties and showed no toxic side effects in vivo. These results suggest that C53 targets KPNB1 and shows potential as an anticancer molecule

Inflation Forecasts, monetary policy and unemployment dynamics: evidence from the US and the euro area

This paper explores the role that inflation forecasts play in the uncertainty surrounding the estimated effects of alternative monetary rules on unemployment dynamics in the euro area and the US. We use the inflation forecasts of 8 competing models in a standard Bayesian VAR to analyse the size and the timing of these effects, as well as to quantify the uncertainty relative to the different inflation models under two rules. The results suggest that model uncertainty can be a serious issue and strengthen the case for a policy strategy that takes into account several sources of information. We find that combining inflation forecasts from many models not only yields more accurate forecasts than those of any specific model, but also reduces the uncertainty associated with the real effects of policy decisions. These results are in line with the model-combination approach that central banks already follow when conceiving their strategy. JEL Classification: C53, E24, E37E24, E37, Inflation forecasts, JEL Classification: C53, Model uncertainty, Unemployment

Tetra­butyl­ammonium tris­(methyl­sulfanylmeth­yl)phenyl­borate

In the title molecular salt, C16H36N+·C12H20BS3-, three of the four n-butyl chains show a trans conformation, whereas the fourth has the C—C—C—C torsion angle in a gauche conformation [-77.8 (5)°]. In the crystal, mol­ecules are packed in layers parallel to the (101) plane

Benthic macrofauna and sediment reworking quantification in contrasted environments in the Thau Lagoon

As part of the Microbent-PNEC Program: ‘‘Biogeochemical processes at the wateresediment interface in eutrophicated environment’’, the aim of this work was to specifically investigate and quantify the relationships between macrobenthos and sediment reworking in the Thau Lagoon in order to provide information on the potential contaminant distribution and movements at the wateresediment interface. In order to achieve this, three cores were sampled at two stations (in the central part of the Thau Lagoon and near the shellfish farming zone) in the Thau Lagoon, in December 2001, April 2002, August 2002, January 2003 and May 2003. On the basis of quantification of macrobenthos and sediment reworking, evidence is provided of: (1) similar sediment mixing intensities for different species composition at the two stations; (2) the major role of functional bioturbation groups (e.g., biodiffusors and gallery-diffusors) modulated by seasonal variability on sediment mixing; (3) an increase of intensity in summer suggesting potentially different patterns of redistribution, bioaccumulation and chemical fate (e.g., speciation) of deposited contaminants

C53

C53 merupakan hasil pengecekan similaritas paper berjudul “Penentuan Kuat Kutub Magnet Batang dengan Metode Simpangan Kumparan Solenoida Berarus Listrik

[my]-Bis(diphenylphosphanyl)borato-[kappa]2P:P'-bis[dicarbonyl([eta]5-cyclopentadienyl)iron(II)] tetrachloridoferrate(III) chloroform solvate

The title compound, [Fe2(C5H5)2(C24H22BP2)(CO)4][FeCl4]·CHCl3, is an oxidation product of CpFe(CO)2PPh2BH3. One pair of phenyl rings attached to the two different P atoms are almost parallel, as are the other pair [dihedral angles = 8.7 (5) and 8.9 (5)°]. The planes of the two cyclopentadienyl rings are inclined by 26.8 (7)° with respect to each other. The carbonyl groups at each Fe atom are almost perpendicular [C-Fe-C = 92.6 (6) and 94.3 (5)°]. Key indicators: single-crystal X-ray study; T = 173 K; mean σ(C–C) = 0.019 Å; R factor = 0.112; wR factor = 0.177; data-to-parameter ratio = 16.8