Gambaran Kadar C-reactive Protein (CRP) Serum Pada Perokok Aktif Usia >40 Tahun

: Cigarette are the most cause of death around the world. Smoking cigarrete is harmful to the organs because it contains many toxic chemical that can stimulate inflammatory process. Smoking cigarrete is a risk factors for heart disease and chronic pulmonary disease (COPD). C-reactive protein (CRP) are a non spesific inflammatory marker that can elevated in both local and systemic disease. Beside biomarker, CRP also use as prognostic marker for inflammation. The purpose of this study was to identify the level of serum CRP of smokers aged >40 years old. Twenty eight smokers were eligible to this criteria and participated in this study. Cross-sectional design with a descriptive method was employed in this study. Sampels were analysed in laboratory for serum CRP levels. The results showed that 23 subjects (82%) had normal (negatif) serum CRP level and five subjects (18%) had positive serum CRP level. It can be concluded that serum CRP level of >40 years old smokers in Kolombo village, west Bitung two were mostly in normal level

C-Reactive Protein Predicts Hematoma Growth in Intracerebral Hemorrhage

Background and Purpose—Early hematoma growth (EHG) occurs in about one third of patients with spontaneous intracerebral hemorrhage. The main aim of this study was to investigate the potential of plasma C-reactive protein (CRP) for predicting EHG after acute spontaneous intracerebral hemorrhage. Methods—Plasma CRP was measured within 6 hours of onset (median, 120 minutes) in 399 patients with primary or vitamin K antagonist–associated spontaneous intracerebral hemorrhage and without recent infection. Computed tomography brain scans were performed at baseline and repeated within 24 hours (median, 22 hours). The primary outcome was EHG, defined as absolute growth >12.5 cm3 or relative growth >33%. Secondary outcomes included early neurological worsening (ENW) using the Glasgow Coma Scale and 30-day mortality. Multivariable regression analyses were used to evaluate associations of CRP concentration and outcomes. Kaplan–Meier analysis was used for survival. Results—EHG occurred in 25.8%, ENW in 19.3%, and mortality was 31.8% at 30 days. Thirty-day mortality was significantly higher in patients with ENW (hazard ratio, 3.21; 95% confidence interval, 2.00–5.17; P10 mg/L independently predicted EHG (odds ratio, 4.71; 95% confidence interval, 2.75–8.06; P<0.0001) and ENW (odds ratio, 2.70; 95% confidence interval, 1.50–4.84; P=0.0009). Conclusions—CRP>10 mg/L is independently predictive of EHG and ENW, both of which are associated with increased mortality. Inflammation may be important in contributing to EHG and warrants further investigation

Systemic inflammation predicts all-cause mortality: a Glasgow Inflammation Outcome Study

Introduction: Markers of the systemic inflammatory response, including C-reactive protein and albumin (combined to form the modified Glasgow Prognostic Score), as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of survival in patients with cancer. The aim of the present study was to examine the prognostic relationship between these markers of the systemic inflammatory response and all-cause, cancer, cardiovascular and cerebrovascular mortality in a large incidentally sampled cohort.&lt;p&gt;&lt;/p&gt; Methods: Patients (n = 160 481) who had an incidental blood sample taken between 2000 and 2008 were studied for the prognostic value of C-reactive protein (&gt;10mg/l, albumin (&#62;35mg/l), neutrophil (&#62;7.5×109/l) lymphocyte and platelet counts. Also, patients (n = 52 091) sampled following the introduction of high sensitivity C-reactive protein (&#62;3mg/l) measurements were studied. A combination of these markers, to make cumulative inflammation-based scores, were investigated.&lt;p&gt;&lt;/p&gt; Results: In all patients (n = 160 481) C-reactive protein (&#62;10mg/l) (HR 2.71, p&#60;0.001), albumin (&#62;35mg/l) (HR 3.68, p&#60;0.001) and neutrophil counts (HR 2.18, p&#60;0.001) were independently predictive of all-cause mortality. These associations were also observed in cancer, cardiovascular and cerebrovascular mortality before and after the introduction of high sensitivity C-reactive protein measurements (&#62;3mg/l) (n = 52 091). A combination of high sensitivity C-reactive protein (&#62;3mg/l), albumin and neutrophil count predicted all-cause (HR 7.37, p&#60;0.001, AUC 0.723), cancer (HR 9.32, p&#60;0.001, AUC 0.731), cardiovascular (HR 4.03, p&#60;0.001, AUC 0.650) and cerebrovascular (HR 3.10, p&#60;0.001, AUC 0.623) mortality. Conclusion The results of the present study showed that an inflammation-based prognostic score, combining high sensitivity C-reactive protein, albumin and neutrophil count is prognostic of all-cause mortality

Evaluation Of Serum High-sensitivity C-reactive Protein Levels During Various Periods Of Pregnancy In Woman, Infected With Parvovirus - B19 Infection

The aim of the research was analyze of C-reactive protein levels in serum blood samples during various periods of pregnancy in women, infected with parvovirus B19 and in case of presence of clinical complications.129 pregnant women, infected with parvovirus B19 infection and 16 women with physiological pregnancy during first, second and third trimesters of pregnancy were examined. Depending on the presence or absence of clinical complications each group of pregnant women (I, II, III) was divided into two subgroups. The concentration of C-reactive protein in blood serum was determined by the method of immunoassay analysis using diagnostic sets of reagents (ELISA kits, USA). Statistical processing of data was carried out using the package of applied programs Microsoft Office Excel 2010 and StatSoft Statistica 6.1.The mean age of pregnant woman in our study was 26±6 years. In the Iand II groups of infected B19 parvovirus pregnant women were identified a significant increasing of C-reactive protein levels compared to controls by 62.5 % and 50.0 % (p&lt;0.05). The largest increasing of C-reactive protein level relative to control values was observed in women with clinical complications in different pregnancy periods (p&lt;0.05).An increase levels of the marker of systemic inflammation the C-reactive protein in the blood testifies to its active participation in the launch of a complex mechanism for the development of labor activity and the occurrence of fetal disorders, which was confirmed in groups of pregnant women with clinical complications in different periods of pregnancy

HS-C reactive protein and red blood cell distribution width as effective markers for hypertension

Background: Hypertension or elevated blood pressure is one of the leading causes of morbidity and mortality. HsCRP, which is a known marker for CVD, is also one of the predictive markers of inflammation processes which result in hypertension. Increased RDW is also believed to be associated with CVD morbidity and mortality in patients with previous myocardial infarction, brain vascular disease, strokes, septicemia, chronic obstructive pulmonary disease and hepatitis B. Methods: 200 patients 100 male and 100 females and 50 each of controls were selected for the study. Complete demographic details were collected from all the patients including the age, sex, height, weight, BMI, smoking/nonsmoking status, alcoholism etc. After a thorough clinical examination, venous blood was collected from all the patients after an overnight fast for lipid profile, hs-CRP and complete blood count. Results: The patients in both males and females had a higher BMI than that of the controls. Hs-CRP levels in males was 1.64 mg/L and in females it was 1.47 mg/L. Significant difference was seen in the RDW values also in the patients. Conclusions: Hs-CRP levels and RDW levels are both equally effective as a predictive marker for hypertension.Background: Hypertension or elevated blood pressure is one of the leading causes of morbidity and mortality. HsCRP, which is a known marker for CVD, is also one of the predictive markers of inflammation processes which result in hypertension. Increased RDW is also believed to be associated with CVD morbidity and mortality in patients with previous myocardial infarction, brain vascular disease, strokes, septicemia, chronic obstructive pulmonary disease and hepatitis B. Methods: 200 patients 100 male and 100 females and 50 each of controls were selected for the study. Complete demographic details were collected from all the patients including the age, sex, height, weight, BMI, smoking/nonsmoking status, alcoholism etc. After a thorough clinical examination, venous blood was collected from all the patients after an overnight fast for lipid profile, hs-CRP and complete blood count. Results: The patients in both males and females had a higher BMI than that of the controls. Hs-CRP levels in males was 1.64 mg/L and in females it was 1.47 mg/L. Significant difference was seen in the RDW values also in the patients. Conclusions: Hs-CRP levels and RDW levels are both equally effective as a predictive marker for hypertension

The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis

Background: Robenacoxib is a novel and highly selective inhibitor of COX-2 in dogs and cats and because of its acidic nature is regarded as being tissue-selective. Thirty four dogs with stifle osteoarthritis secondary to failure of the cranial cruciate ligament were recruited into this study. Lameness, radiographic features, synovial cytology and C-reactive protein concentrations in serum and synovial fluid were assessed before and 28 days after commencing a course of Robenacoxib at a dose of 1 mg/kg SID.&lt;p&gt;&lt;/p&gt; Results: There was a significant reduction in the lameness score (P &#60;0.01) and an increase in the radiographic score (P &#60; 0.05) between pre- and post-treatment assessments. There was no difference between pre- (median 1.49 mg/l; Q1-Q3 0.56-4.24 mg/L) and post – (1.10 mg/L; 0.31-1.78 mg/L) treatment serum C-reactive protein levels although synovial fluid levels were significantly reduced (pre- : 0.44 mg/L; 0.23-1.62 mg/L; post- : 0.17 mg/L; 0.05-0.49 mg/L) (P &#60; 0.05). There was no correlation between C-reactive protein concentrations in serum and matched synovial fluid samples.&lt;p&gt;&lt;/p&gt; Conclusions: Robenacoxib proved effective in reducing lameness in dogs with failure of the cranial cruciate ligament and osteoarthritis of the stifle joint. The drug also reduced levels of C-reactive protein in the synovial fluid taken from the affected stifle joint. Robenacoxib appears to reduce articular inflammation as assessed by C-reactive protein which supports the concept that Robenacoxib is a tissue-selective non-steroidal anti-inflammatory drug.&lt;p&gt;&lt;/p&gt

Area-Level Socioeconomic Status, Adiposity, Physical Activity, and Inflammation in Young Adults, 2013

INTRODUCTION: We assessed the independent effects of socioeconomic status, sex, adiposity, and physical activity on C-reactive protein in young adults. METHODS: During the fall semester of their first year, college students (n = 177; mean age, 18.1 y; 66.7% female; 65.5% white) were assessed for adiposity via dual x-ray absorptiometry, physical activity via accelerometer, and serum C-reactive protein. Area-level socioeconomic status was based on self-reported home zip code. Hierarchical linear modeling was used to assess the relationship of sex, adiposity, and physical activity on the dependent variable of C-reactive protein, with participants nested within geographic regions of similar socioeconomic characteristics. RESULTS: C-reactive protein was positively associated with adiposity and inversely associated with socioeconomic status (both P < .05). Area-level socioeconomic status explained 28.2% of the variance in C-reactive protein. Adiposity was significantly associated with C-reactive protein in the full model (P = .006); physical activity was not associated with C-reactive protein (P = .48), and area-level socioeconomic status approached significance (P = .05) within the age range of our analysis after accounting for the variance explained by adiposity. CONCLUSION: The significant positive association between adiposity and C-reactive protein suggests that young adults with higher adiposity have higher C-reactive protein levels after accounting for area-level socioeconomic status, sex, and physical activity