Bayesian Spatial Binary Regression for Label Fusion in Structural Neuroimaging

Many analyses of neuroimaging data involve studying one or more regions of interest (ROIs) in a brain image. In order to do so, each ROI must first be identified. Since every brain is unique, the location, size, and shape of each ROI varies across subjects. Thus, each ROI in a brain image must either be manually identified or (semi-) automatically delineated, a task referred to as segmentation. Automatic segmentation often involves mapping a previously manually segmented image to a new brain image and propagating the labels to obtain an estimate of where each ROI is located in the new image. A more recent approach to this problem is to propagate labels from multiple manually segmented atlases and combine the results using a process known as label fusion. To date, most label fusion algorithms either employ voting procedures or impose prior structure and subsequently find the maximum a posteriori estimator (i.e., the posterior mode) through optimization. We propose using a fully Bayesian spatial regression model for label fusion that facilitates direct incorporation of covariate information while making accessible the entire posterior distribution. We discuss the implementation of our model via Markov chain Monte Carlo and illustrate the procedure through both simulation and application to segmentation of the hippocampus, an anatomical structure known to be associated with Alzheimer's disease.Comment: 24 pages, 10 figure

Saliency-guided integration of multiple scans

we present a novel method..

Morphable Face Models - An Open Framework

In this paper, we present a novel open-source pipeline for face registration based on Gaussian processes as well as an application to face image analysis. Non-rigid registration of faces is significant for many applications in computer vision, such as the construction of 3D Morphable face models (3DMMs). Gaussian Process Morphable Models (GPMMs) unify a variety of non-rigid deformation models with B-splines and PCA models as examples. GPMM separate problem specific requirements from the registration algorithm by incorporating domain-specific adaptions as a prior model. The novelties of this paper are the following: (i) We present a strategy and modeling technique for face registration that considers symmetry, multi-scale and spatially-varying details. The registration is applied to neutral faces and facial expressions. (ii) We release an open-source software framework for registration and model-building, demonstrated on the publicly available BU3D-FE database. The released pipeline also contains an implementation of an Analysis-by-Synthesis model adaption of 2D face images, tested on the Multi-PIE and LFW database. This enables the community to reproduce, evaluate and compare the individual steps of registration to model-building and 3D/2D model fitting. (iii) Along with the framework release, we publish a new version of the Basel Face Model (BFM-2017) with an improved age distribution and an additional facial expression model

An evaluation method for multiview surface reconstruction algorithms

We propose a new method...

Curvelet Approach for SAR Image Denoising, Structure Enhancement, and Change Detection

In this paper we present an alternative method for SAR image denoising, structure enhancement, and change detection based on the curvelet transform. Curvelets can be denoted as a two dimensional further development of the well-known wavelets. The original image is decomposed into linear ridge-like structures, that appear in different scales (longer or shorter structures), directions (orientation of the structure) and locations. The influence of these single components on the original image is weighted by the corresponding coefficients. By means of these coefficients one has direct access to the linear structures present in the image. To suppress noise in a given SAR image weak structures indicated by low coefficients can be suppressed by setting the corresponding coefficients to zero. To enhance structures only coefficients in the scale of interest are preserved and all others are set to zero. Two same-sized images assumed even a change detection can be done in the curvelet coefficient domain. The curvelet coefficients of both images are differentiated and manipulated in order to enhance strong and to suppress small scale (pixel-wise) changes. After the inverse curvelet transform the resulting image contains only those structures, that have been chosen via the coefficient manipulation. Our approach is applied to TerraSAR-X High Resolution Spotlight images of the city of Munich. The curvelet transform turns out to be a powerful tool for image enhancement in fine-structured areas, whereas it fails in originally homogeneous areas like grassland. In the change detection context this method is very sensitive towards changes in structures instead of single pixel or large area changes. Therefore, for purely urban structures or construction sites this method provides excellent and robust results. While this approach runs without any interaction of an operator, the interpretation of the detected changes requires still much knowledge about the underlying objects

Automatic Differentiation of Algorithms for Machine Learning

Automatic differentiation---the mechanical transformation of numeric computer programs to calculate derivatives efficiently and accurately---dates to the origin of the computer age. Reverse mode automatic differentiation both antedates and generalizes the method of backwards propagation of errors used in machine learning. Despite this, practitioners in a variety of fields, including machine learning, have been little influenced by automatic differentiation, and make scant use of available tools. Here we review the technique of automatic differentiation, describe its two main modes, and explain how it can benefit machine learning practitioners. To reach the widest possible audience our treatment assumes only elementary differential calculus, and does not assume any knowledge of linear algebra.Comment: 7 pages, 1 figur