INTRODUCING AN OPTIMAL QCA CROSSBAR SWITCH FOR BASELINE NETWORK

Crossbar switch is the basic component in multi-stage interconnection networks. Therefore, this study was conducted to investigate performance of a crossbar switch with two multiplexers. The presented crossbar switch was simulated using quantum-dot cellular automata (QCA) technology and QCA Designer software, and was studied and optimized in terms of cell number, occupied area, number of clocks, and energy consumption. Using the provided crossbar switch, the baseline network was designed to be optimal in terms of cell number and occupied area. Also, the number of input states was investigated and simulated to verify accuracy of the baseline network. The proposed crossbar switch uses 62 QCA cells and the occupied area by the switch is equal to 0.06µm2 and its latency equals 4 clock zones, which is more efficient than the other designs. In this paper, using the presented crossbar switch, the baseline network was designed with 1713 cells, and occupied area of 2.89µm2

Exploration and Design of Power-Efficient Networked Many-Core Systems

Multiprocessing is a promising solution to meet the requirements of near future applications. To get full benefit from parallel processing, a manycore system needs efficient, on-chip communication architecture. Networkon- Chip (NoC) is a general purpose communication concept that offers highthroughput, reduced power consumption, and keeps complexity in check by a regular composition of basic building blocks. This thesis presents power efficient communication approaches for networked many-core systems. We address a range of issues being important for designing power-efficient manycore systems at two different levels: the network-level and the router-level. From the network-level point of view, exploiting state-of-the-art concepts such as Globally Asynchronous Locally Synchronous (GALS), Voltage/ Frequency Island (VFI), and 3D Networks-on-Chip approaches may be a solution to the excessive power consumption demanded by today’s and future many-core systems. To this end, a low-cost 3D NoC architecture, based on high-speed GALS-based vertical channels, is proposed to mitigate high peak temperatures, power densities, and area footprints of vertical interconnects in 3D ICs. To further exploit the beneficial feature of a negligible inter-layer distance of 3D ICs, we propose a novel hybridization scheme for inter-layer communication. In addition, an efficient adaptive routing algorithm is presented which enables congestion-aware and reliable communication for the hybridized NoC architecture. An integrated monitoring and management platform on top of this architecture is also developed in order to implement more scalable power optimization techniques. From the router-level perspective, four design styles for implementing power-efficient reconfigurable interfaces in VFI-based NoC systems are proposed. To enhance the utilization of virtual channel buffers and to manage their power consumption, a partial virtual channel sharing method for NoC routers is devised and implemented. Extensive experiments with synthetic and real benchmarks show significant power savings and mitigated hotspots with similar performance compared to latest NoC architectures. The thesis concludes that careful codesigned elements from different network levels enable considerable power savings for many-core systems.Siirretty Doriast

Micro/nanofluidic and lab-on-a-chip devices for biomedical applications

Micro/Nanofluidic and lab-on-a-chip devices have been increasingly used in biomedical research [1]. Because of their adaptability, feasibility, and cost-efficiency, these devices can revolutionize the future of preclinical technologies. Furthermore, they allow insights into the performance and toxic effects of responsive drug delivery nanocarriers to be obtained, which consequently allow the shortcomings of two/three-dimensional static cultures and animal testing to be overcome and help to reduce drug development costs and time [2–4]. With the constant advancements in biomedical technology, the development of enhanced microfluidic devices has accelerated, and numerous models have been reported. Given the multidisciplinary of this Special Issue (SI), papers on different subjects were published making a total of 14 contributions, 10 original research papers, and 4 review papers. The review paper of Ko et al. [1] provides a comprehensive overview of the significant advancements in engineered organ-on-a-chip research in a general way while in the review presented by Kanabekova and colleagues [2], a thorough analysis of microphysiological platforms used for modeling liver diseases can be found. To get a summary of the numerical models of microfluidic organ-on-a-chip devices developed in recent years, the review presented by Carvalho et al. [5] can be read. On the other hand, Maia et al. [6] report a systematic review of the diagnosis methods developed for COVID-19, providing an overview of the advancements made since the start of the pandemic. In the following, a brief summary of the research papers published in this SI will be presented, with organs-on-a-chip, microfluidic devices for detection, and device optimization having been identified as the main topics.info:eu-repo/semantics/publishedVersio

Development and Fabrication of Novel Woven Meshes as Bone Graft Substitutes for Critical Sized Defects

With more than $2.5 billion spent per year, and over 2.2 million procedures conducted annually worldwide, bone grafting continues to be a large part of the treatment strategy for large non-healing bone defects (critical-sized defects). However, complication rates (\u3e20%), donor shortage, and donor site morbidity have led to the promotion of bone tissue engineering as an important option in these cases. This work explored the use of a novel bio-loom to make woven polymeric meshes as viable bone tissue engineering scaffolds. Melt-spun poly-l-lactide and poly-l-lactide-co-ε-caprolactone fibers were used to produce mesh with varying porosity, pore size, and cellular affinity. Fluid flow properties and cellular behaviors were characterized in a series of in vitro tests. Mesh with variable properties were effectively created and the modulation of mesh specifications resulted in significant differences in cell metabolic activity and deoxyribonucleic acid concentrations. Changes in mesh parameters also significantly effected mesh permeability. Additionally, an interactive camp was designed to investigate ways to encourage underrepresented minority middle school students to pursue Science, Technology, Engineering, and Mathematics (STEM) careers was conducted. Results showed that parental encouragement, the external STEM environment, and extracurricular STEM exposure were closely related to a student\u27s likelihood to express interest in a STEM career. Student interest in STEM careers significantly increased after participation in an interactive camp based on mesh-based modules. Further work explored the effect of early research experiences on the development of research identity for underrepresented minority science and engineering undergraduates. Results showed that students participating in this program significantly increased their research identity through increased self-recognition and competence in research activities

Indirect microfabrication of biomimetic materials for locomotor tissues regeneration

Tissue Engineering is a new field of the scientific research with a final aim to develop techniques for regeneration, repair, maintenance and growth of tissues or organs to overcome the limitations intrinsic to current therapeutic strategies. A fundamental element of this approach is the scaffold. The scaffold is a 2D and 3D structure, made with natural or synthetic material, that emulates the extracellular matrix, that is it offers mechanical, topological, biochemical and chemical stimuli to promote cellular organization, growth and differentiation to create a tissue with adequate functional and morphological characteristic. Scaffolds are therefore characterized by peculiar features (e.g. porosity, mechanical properties) determined by the material and by the manufacture process. Nowadays, the additive Rapid Prototyping (RP) techniques are the best approach to realize complex structures, because overcome all the problem of conventional (subtractive) techniques. Despite the high potential, RP techniques are not always compatible with all materials. In particular, hydrogels, an elective class of biomaterial for scaffolds realization because the lot of features in common with the extracellular matrix, results very difficult to be processed. To overcome these limitations and take advantage of all benefits of rapid prototyping, indirect rapid prototyping (iRP) was developed, that is the realization of scaffold or other structures starting from sacrificial molds realized by RP. The iRP offers the benefits to fabricate composite scaffold realized with different materials, with less waste and high fidelity in the realization of the designed structure. One of the critical aspect of this class of realization process is the extraction of the final object from the mold. A possible solution, proposed in this research, is to realize the mold with low melting point materials, dissolving the mold at the end of the process without damaging the scaffold. Moving in this direction, the attention of this research is focused on two classes of materials, low melting point waxes and agarose. Two alternative RP techniques have been evaluated: new modules of the PAM^2, a continuous flow system, and a inkjet-based device have been designed and realized to test the feasibility of this approach. In addiction, an alternative approach to fabricate agarose microstructure, by exploiting the different agarose gelling ability in DMSO and water, has been proposed. In a future perspective, casting of the desired material, which may include also cells, should be performed directly in the surgery room using an anatomical shaped mold designed on the patient needs. Following this approach, two plugins for bioimages de-noising and segmentation, based on the ITK library, have been implemented for the OsiriX software. To further test the versatility of the two microfabrication devices, other applications have been explored, such as the realization of microfluidic circuits using PAM^2 or printing carbon nanotubes suspension for polymeric actuators