Improvement of 5G performance through network densification in millimetre wave band

Recently, there has been a substantial growth in mobile data traffic due to the widespread of data hungry devices such as mobiles and laptops. The anticipated high traffic demands and low latency requirements stemmed from the Internet of Things (IoT) and Machine Type Communications (MTC) can only be met with radical changes to the network paradigm such as harnessing the millimetre wave (mmWave) band in Ultra-Dense Network (UDN). This thesis presents many challenges, problems and questions that arise in research and design stage of 5G network. The main challenges of 5G in mmWave can be characterised with the following attributes: i- huge traffic demands, with very high data rate requirements, ii- high interference in UDN, iii increased handover in UDN, higher dependency on Line of Sight (LOS) coverage and high shadow fading, and iv-massive MTC traffic due to billions of connected devices. In this work, software simulation tools have been used to evaluate the proposed solutions. Therefore, we have introduced 5G network based on network densification. Network densification includes densification over frequency through mmWave, and densification over space through higher number of antennas, Higher Order Sectorisation (HOS), and denser deployment of small-cells. Our results show that the densification theme has significantly improved network capacity and user Quality of Experience (QoE). UDN network can efficiently raise the user experience to the level that 5G vision promised. However, one of the drawback of using UDN and HOS is the significant increase in Inter-Cell Interference (ICI). Therefore, ICI has been addressed in this work to increase the gain of densification. ICI can degrade the performance of wireless network, particularly in UDN due to the increased interference from surrounding cells. We have used Fractional Frequency Reuse (FFR) as ICI Coordination (ICIC) for UDN network and HOS environment. The work shows that FFR has improved the network performance in terms of cell-edge data throughput and average cell throughput, and maintain the peak data throughput at a certain threshold. Additionally, HOS has shown even greater gain over default sectored sites when the interference is carefully coordinated. To generalise the principle of densification, we have introduced Distributed Base Station (DBS) as the envisioned network architecture for 5G in mmWave. Remotely distributed antennas in DBS architecture have been harnessed in order to compensate for the high path loss that characterise mmWave propagation. The proposed architecture has significantly improved the user data throughput, decreased the unnecessary handovers as a result of dense network, increased the LOS coverage probability, and reduced the impact of shadow fading. Additionally, this research discusses the regulatory requirements at mmWave band for the Maximum Permissible Exposure (MPE). Finally, scheduling massive MTC traffic in 5G has been considered. MTC is expected to contribute to the majority of IoT traffic. In this context, an algorithm has been developed to schedule this type of traffic. The results demonstrate the gain of using distributed antennas on MTC traffic in terms of spectral efficiency, data throughput, and fairness. The results show considerable improvement in the performance metrics. The combination of these contributions has provided remarkable increase in data throughput to achieve the 5G vision of “massive” capacity and to support human and machine traffic

Physical principles for scalable neural recoding

Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, motivating an analysis of the fundamental physical constraints on the problem. We outline the physical principles governing brain activity mapping using optical, electrical, magnetic resonance, and molecular modalities of neural recording. Focusing on the mouse brain, we analyze the scalability of each method, concentrating on the limitations imposed by spatiotemporal resolution, energy dissipation, and volume displacement. Based on this analysis, all existing approaches require orders of magnitude improvement in key parameters. Electrical recording is limited by the low multiplexing capacity of electrodes and their lack of intrinsic spatial resolution, optical methods are constrained by the scattering of visible light in brain tissue, magnetic resonance is hindered by the diffusion and relaxation timescales of water protons, and the implementation of molecular recording is complicated by the stochastic kinetics of enzymes. Understanding the physical limits of brain activity mapping may provide insight into opportunities for novel solutions. For example, unconventional methods for delivering electrodes may enable unprecedented numbers of recording sites, embedded optical devices could allow optical detectors to be placed within a few scattering lengths of the measured neurons, and new classes of molecularly engineered sensors might obviate cumbersome hardware architectures. We also study the physics of powering and communicating with microscale devices embedded in brain tissue and find that, while radio-frequency electromagnetic data transmission suffers from a severe power–bandwidth tradeoff, communication via infrared light or ultrasound may allow high data rates due to the possibility of spatial multiplexing. The use of embedded local recording and wireless data transmission would only be viable, however, given major improvements to the power efficiency of microelectronic devices

Optoelectronics – Devices and Applications

Optoelectronics - Devices and Applications is the second part of an edited anthology on the multifaced areas of optoelectronics by a selected group of authors including promising novices to experts in the field. Photonics and optoelectronics are making an impact multiple times as the semiconductor revolution made on the quality of our life. In telecommunication, entertainment devices, computational techniques, clean energy harvesting, medical instrumentation, materials and device characterization and scores of other areas of R&D the science of optics and electronics get coupled by fine technology advances to make incredibly large strides. The technology of light has advanced to a stage where disciplines sans boundaries are finding it indispensable. New design concepts are fast emerging and being tested and applications developed in an unimaginable pace and speed. The wide spectrum of topics related to optoelectronics and photonics presented here is sure to make this collection of essays extremely useful to students and other stake holders in the field such as researchers and device designers

Aerospace medicine and biology: A continuing bibliography with indexes (supplement 368)

This bibliography lists 305 reports, articles, and other documents introduced into the NASA Scientific and Technical Information System during Sep. 1992. The subject coverage concentrates on the biological, physiological, psychological, and environmental effects to which humans are subjected during and following simulated or actual flight in the Earth's atmosphere or in interplanetary space. References describing similar effects on biological organisms of lower order are also included. Such related topics as sanitary problems, pharmacology, toxicology, safety and survival, life support systems, exobiology, and personnel factors receive appropriate attention. Applied research receives the most emphasis, but references to fundamental studies and theoretical principles related to experimental development also qualify for inclusion

29th Annual Computational Neuroscience Meeting: CNS*2020

Meeting abstracts This publication was funded by OCNS. The Supplement Editors declare that they have no competing interests. Virtual | 18-22 July 202

Learning more with less data using domain-guided machine learning: the case for health data analytics

The United States is facing a shortage of neurologists with severe consequences: a) average wait-times to see neurologists are increasing, b) patients with chronic neurological disorders are unable to receive diagnosis and care in a timely fashion, and c) there is an increase in neurologist burnout leading to physical and emotional exhaustion. Present-day neurological care relies heavily on time-consuming visual review of patient data (e.g., neuroimaging and electroencephalography (EEG)), by expert neurologists who are already in short supply. As such, the healthcare system needs creative solutions that can increase the availability of neurologists to patient care. To meet this need, this dissertation develops a machine-learning (ML)-based decision support framework for expert neurologists that focuses the experts’ attention to actionable information extracted from heterogeneous patient data and reduces the need for expert visual review. Specifically, this dissertation introduces a novel ML framework known as domain-guided machine learning (DGML) and demonstrates its usefulness by improving the clinical treatments of two major neurological diseases, epilepsy and Alzheimer’s disease. In this dissertation, the applications of this framework are illustrated through several studies conducted in collaboration with the Mayo Clinic, Rochester, Minnesota. Chapters 3, 4, and 5 describe the application of DGML to model the transient abnormal discharges in the brain activity of epilepsy patients. These studies utilized the intracranial EEG data collected from epilepsy patients to delineate seizure generating brain regions without observing actual seizures; whereas, Chapters 6, 7, 8, and 9 describe the application of DGML to model the subtle but permanent changes in brain function and anatomy, and thereby enable the early detection of chronic epilepsy and Alzheimer’s disease. These studies utilized the scalp EEG data of epilepsy patients and two population-level multimodal imaging datasets collected from elderly individuals

Designing Scalable Biological Interfaces

This thesis presents the analysis and design of biological interfacing technologies in light of a need for radical improvements in scalability. It focuses primarily on structural and functional neural data acquisition, but also extends to other problems including genomic editing and nanoscale spatial control. Its main contributions include analysis of the physical limits of large-scale neural recording, experimental development of a screening platform for ion-dependent molecular recording devices, characterization of the design space for molecularly-annotated neural connectomics, and new designs for high-speed genome engineering and bio-nano-fabrication. Articulating governing principles and roadmaps for these domains has contributed to the initiation of multi-institutional projects that are strategically targeted towards scalability