Investigating the Use of Geometric Semantic Operators in Vectorial Genetic Programming

Azzali, I., Vanneschi, L., & Giacobini, M. (2020). Investigating the Use of Geometric Semantic Operators in Vectorial Genetic Programming. In T. Hu, N. Lourenço, E. Medvet, & F. Divina (Eds.), Genetic Programming - 23rd European Conference, EuroGP 2020, Held as Part of EvoStar 2020, Proceedings (pp. 52-67). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 12101 LNCS). Springer. https://doi.org/10.1007/978-3-030-44094-7_4 ------- This work was partially supported by FCT, Portugal through funding of LASIGE Research Unit (UID/CEC/00408/2019), and projects PREDICT (PTDC/CCI-IF/29877/2017), BINDER (PTDC/CCI-INF/29168/2017), GADgET (DSAIPA/DS/0022/2018) and AICE (DSAIPA/DS/0113/2019).Vectorial Genetic Programming (VE_GP) is a new GP approach for panel data forecasting. Besides permitting the use of vectors as terminal symbols to represent time series and including aggregation functions to extract time series features, it introduces the possibility of evolving the window of aggregation. The local aggregation of data allows the identification of meaningful patterns overcoming the drawback of considering always the previous history of a series of data. In this work, we investigate the use of geometric semantic operators (GSOs) in VE_GP, comparing its performance with traditional GP with GSOs. Experiments are conducted on two real panel data forecasting problems, one allowing the aggregation on moving windows, one not. Results show that classical VE_GP is the best approach in both cases in terms of predictive accuracy, suggesting that GSOs are not able to evolve efficiently individuals when time series are involved. We discuss the possible reasons of this behaviour, to understand how we could design valuable GSOs for time series in the future.authorsversionpublishe

Supporting medical decisions for treating rare diseases through genetic programming

Bakurov, I., Castelli, M., Vanneschi, L., & Freitas, M. J. (2019). Supporting medical decisions for treating rare diseases through genetic programming. In P. Kaufmann, & P. A. Castillo (Eds.), Applications of Evolutionary Computation: 22nd International Conference, EvoApplications 2019, Held as Part of EvoStar 2019, Proceedings (pp. 187-203). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11454 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-030-16692-2_13. ISBN: 978-3-030-16691-5; Online ISBN: 978-3-030-16692-2Casa dos Marcos is the largest specialized medical and residential center for rare diseases in the Iberian Peninsula. The large number of patients and the uniqueness of their diseases demand a considerable amount of diverse and highly personalized therapies, that are nowadays largely managed manually. This paper aims at catering for the emergent need of efficient and effective artificial intelligence systems for the support of the everyday activities of centers like Casa dos Marcos. We present six predictive data models developed with a genetic programming based system which, integrated into a web-application, enabled data-driven support for the therapists in Casa dos Marcos. The presented results clearly indicate the usefulness of the system in assisting complex therapeutic procedures for children suffering from rare diseases.authorsversionpublishe

A flexible and efficient multi-purpose optimization library in python

Bakurov, I., Buzzelli, M., Castelli, M., Vanneschi, L., & Schettini, R. (2021). General purpose optimization library (Gpol): A flexible and efficient multi-purpose optimization library in python. Applied Sciences (Switzerland), 11(11), 1-34. [4774]. https://doi.org/10.3390/app11114774Several interesting libraries for optimization have been proposed. Some focus on individual optimization algorithms, or limited sets of them, and others focus on limited sets of problems. Frequently, the implementation of one of them does not precisely follow the formal definition, and they are difficult to personalize and compare. This makes it difficult to perform comparative studies and propose novel approaches. In this paper, we propose to solve these issues with the General Purpose Optimization Library (GPOL): a flexible and efficient multipurpose optimization library that covers a wide range of stochastic iterative search algorithms, through which flexible and modular implementation can allow for solving many different problem types from the fields of continuous and combinatorial optimization and supervised machine learning problem solving. Moreover, the library supports full-batch and mini-batch learning and allows carrying out computations on a CPU or GPU. The package is distributed under an MIT license. Source code, installation instructions, demos and tutorials are publicly available in our code hosting platform (the reference is provided in the Introduction).publishersversionpublishe

Ensemble learning with GSGP

Dissertation presented as the partial requirement for obtaining a Master's degree in Data Science and Advanced AnalyticsThe purpose of this thesis is to conduct comparative research between Genetic Programming (GP) and Geometric Semantic Genetic Programming (GSGP), with different initialization (RHH and EDDA) and selection (Tournament and Epsilon-Lexicase) strategies, in the context of a model-ensemble in order to solve regression optimization problems. A model-ensemble is a combination of base learners used in different ways to solve a problem. The most common ensemble is the mean, where the base learners are combined in a linear fashion, all having the same weights. However, more sophisticated ensembles can be inferred, providing higher generalization ability. GSGP is a variant of GP using different genetic operators. No previous research has been conducted to see if GSGP can perform better than GP in model-ensemble learning. The evolutionary process of GP and GSGP should allow us to learn about the strength of each of those base models to provide a more accurate and robust solution. The base-models used for this analysis were Linear Regression, Random Forest, Support Vector Machine and Multi-Layer Perceptron. This analysis has been conducted using 7 different optimization problems and 4 real-world datasets. The results obtained with GSGP are statistically significantly better than GP for most cases.O objetivo desta tese é realizar pesquisas comparativas entre Programação Genética (GP) e Programação Genética Semântica Geométrica (GSGP), com diferentes estratégias de inicialização (RHH e EDDA) e seleção (Tournament e Epsilon-Lexicase), no contexto de um conjunto de modelos, a fim de resolver problemas de otimização de regressão. Um conjunto de modelos é uma combinação de alunos de base usados de diferentes maneiras para resolver um problema. O conjunto mais comum é a média, na qual os alunos da base são combinados de maneira linear, todos com os mesmos pesos. No entanto, conjuntos mais sofisticados podem ser inferidos, proporcionando maior capacidade de generalização. O GSGP é uma variante do GP usando diferentes operadores genéticos. Nenhuma pesquisa anterior foi realizada para verificar se o GSGP pode ter um desempenho melhor que o GP no aprendizado de modelos. O processo evolutivo do GP e GSGP deve permitir-nos aprender sobre a força de cada um desses modelos de base para fornecer uma solução mais precisa e robusta. Os modelos de base utilizados para esta análise foram: Regressão Linear, Floresta Aleatória, Máquina de Vetor de Suporte e Perceptron de Camadas Múltiplas. Essa análise foi realizada usando 7 problemas de otimização diferentes e 4 conjuntos de dados do mundo real. Os resultados obtidos com o GSGP são estatisticamente significativamente melhores que o GP na maioria dos casos

Credit scoring using genetic programming

Internship Report presented as the partial requirement for obtaining a Master's degree in Data Science and Advanced AnalyticsGrowing numbers in e-commerce orders lead to an increase in risk management to prevent default in payment. Default in payment is the failure of a customer to settle a bill within 90 days upon receipt. Frequently, credit scoring is employed to identify customers’ default probability. Credit scoring has been widely studied and many different methods in different fields of research have been proposed. The primary aim of this work is to develop a credit scoring model as a replacement for the pre risk check of the e-commerce risk management system risk solution services (rss). The pre risk check uses data of the order process and includes exclusion rules and a generic credit scoring model. The new model is supposed to work as a replacement for the whole pre risk check and has to be able to work in solitary and in unison with the rss main risk check. An application of Genetic Programming to credit scoring is presented. The model is developed on a real world data set provided by Arvato Financial Solutions. The data set contains order requests processed by rss. Results show that Genetic Programming outperforms the generic credit scoring model of the pre risk check in both classification accuracy and profit. Compared with Logistic Regression, Support Vector Machines and Boosted Trees, Genetic Programming achieved a similar classificatory accuracy. Furthermore, the Genetic Programming model can be used in combination with the rss main risk check in order to create a model with higher discriminatory power than its individual models

Pharmacovigilance Decision Support : The value of Disproportionality Analysis Signal Detection Methods, the development and testing of Covariability Techniques, and the importance of Ontology

The cost of adverse drug reactions to society in the form of deaths, chronic illness, foetal malformation, and many other effects is quite significant. For example, in the United States of America, adverse reactions to prescribed drugs is around the fourth leading cause of death. The reporting of adverse drug reactions is spontaneous and voluntary in Australia. Many methods that have been used for the analysis of adverse drug reaction data, mostly using a statistical approach as a basis for clinical analysis in drug safety surveillance decision support. This thesis examines new approaches that may be used in the analysis of drug safety data. These methods differ significantly from the statistical methods in that they utilize co variability methods of association to define drug-reaction relationships. Co variability algorithms were developed in collaboration with Musa Mammadov to discover drugs associated with adverse reactions and possible drug-drug interactions. This method uses the system organ class (SOC) classification in the Australian Adverse Drug Reaction Advisory Committee (ADRAC) data to stratify reactions. The text categorization algorithm BoosTexter was found to work with the same drug safety data and its performance and modus operandi was compared to our algorithms. These alternative methods were compared to a standard disproportionality analysis methods for signal detection in drug safety data including the Bayesean mulit-item gamma Poisson shrinker (MGPS), which was found to have a problem with similar reaction terms in a report and innocent by-stander drugs. A classification of drug terms was made using the anatomical-therapeutic-chemical classification (ATC) codes. This reduced the number of drug variables from 5081 drug terms to 14 main drug classes. The ATC classification is structured into a hierarchy of five levels. Exploitation of the ATC hierarchy allows the drug safety data to be stratified in such a way as to make them accessible to powerful existing tools. A data mining method that uses association rules, which groups them on the basis of content, was used as a basis for applying the ATC and SOC ontologies to ADRAC data. This allows different views of these associations (even very rare ones). A signal detection method was developed using these association rules, which also incorporates critical reaction terms.Doctor of Philosoph

Applications and Experiences of Quality Control

The rich palette of topics set out in this book provides a sufficiently broad overview of the developments in the field of quality control. By providing detailed information on various aspects of quality control, this book can serve as a basis for starting interdisciplinary cooperation, which has increasingly become an integral part of scientific and applied research