Freeze-drying modeling and monitoring using a new neuro-evolutive technique

This paper is focused on the design of a black-box model for the process of freeze-drying of pharmaceuticals. A new methodology based on a self-adaptive differential evolution scheme is combined with a back-propagation algorithm, as local search method, for the simultaneous structural and parametric optimization of the model represented by a neural network. Using the model of the freeze-drying process, both the temperature and the residual ice content in the product vs. time can be determine off-line, given the values of the operating conditions (the temperature of the heating shelf and the pressure in the drying chamber). This makes possible to understand if the maximum temperature allowed by the product is trespassed and when the sublimation drying is complete, thus providing a valuable tool for recipe design and optimization. Besides, the black box model can be applied to monitor the freeze-drying process: in this case, the measurement of product temperature is used as input variable of the neural network in order to provide in-line estimation of the state of the product (temperature and residual amount of ice). Various examples are presented and discussed, thus pointing out the strength of the too

Transfer learning for batch process optimal control using LV-PTM and adaptive control strategy

In this study, we investigate a data-driven optimal control for a new batch process. Existing data-driven optimal control methods often ignore an important problem, namely, because of the short operation time of the new batch process, the modeling data in the initial stage can be insufficient. To address this issue, we introduce the idea of transfer learning, i.e., a latent variable process transfer model (LV-PTM) is adopted to transfer sufficient data and process information from similar processes to a new one to assist its modeling and quality optimization control. However, due to fluctuations in raw materials, equipment, etc., differences between similar batch processes are always inevitable, which lead to the serious and complicated mismatch of the necessary condition of optimality (NCO) between the new batch process and the LV-PTM-based optimization problem. In this work, we propose an LV-PTM-based batch-to-batch adaptive optimal control strategy, which consists of three stages, to ensure the best optimization performance during the whole operation lifetime of the new batch process. This adaptive control strategy includes model updating, data removal, and modifier-adaptation methodology using final quality measurements in response. Finally, the feasibility of the proposed method is demonstrated by simulations

Iterative Machine Learning for Precision Trajectory Tracking with Series Elastic Actuators

When robots operate in unknown environments small errors in postions can lead to large variations in the contact forces, especially with typical high-impedance designs. This can potentially damage the surroundings and/or the robot. Series elastic actuators (SEAs) are a popular way to reduce the output impedance of a robotic arm to improve control authority over the force exerted on the environment. However this increased control over forces with lower impedance comes at the cost of lower positioning precision and bandwidth. This article examines the use of an iteratively-learned feedforward command to improve position tracking when using SEAs. Over each iteration, the output responses of the system to the quantized inputs are used to estimate a linearized local system models. These estimated models are obtained using a complex-valued Gaussian Process Regression (cGPR) technique and then, used to generate a new feedforward input command based on the previous iteration's error. This article illustrates this iterative machine learning (IML) technique for a two degree of freedom (2-DOF) robotic arm, and demonstrates successful convergence of the IML approach to reduce the tracking error.Comment: 9 pages, 16 figure. Submitted to AMC Worksho

Shaping of molecular weight distribution by iterative learning probability density function control strategies

A mathematical model is developed for the molecular weight distribution (MWD) of free-radical styrene polymerization in a simulated semi-batch reactor system. The generation function technique and moment method are employed to establish the MWD model in the form of Schultz-Zimmdistribution. Both static and dynamic models are described in detail. In order to achieve the closed-loop MWD shaping by output probability density function (PDF) control, the dynamic MWD model is further developed by a linear B-spline approximation. Based on the general form of the B-spline MWD model, iterative learning PDF control strategies have been investigated in order to improve the MWD control performance. Discussions on the simulation studies show the advantages and limitations of the methodology

Predictive functional control for the temperature control of a chemical batch reactor

A predictive functional control (PFC) technique is applied to the temperature control of a pilot-plant batch reactor equipped with a mono-fluid heating/cooling system. A cascade control structure has been implemented according to the process sub-units reactor and heating/cooling system. Hereby differences in the sub-units dynamics are taken into consideration. PFC technique is described and its main differences with a standard model predictive control (MPC) technique are discussed. To evaluate its robustness, PFC has been applied to the temperature control of an exothermic chemical reaction. Experimental results show that PFC enables a precise tracking of the set-point temperature and that the PFC performances are mainly determined by its internal dynamic process model. Finally, results show the performance of the cascade control structure to handle different dynamics of the heating/cooling system