Shannon’s Energy Based Algorithm in ECG Signal Processing

Physikalisch-Technische Bundesanstalt (PTB) database is electrocardiograms (ECGs) set from healthy volunteers and patients with different heart diseases. PTB is provided for research and teaching purposes by National Metrology Institute of Germany. The analysis method of complex QRS in ECG signals for diagnosis of heart disease is extremely important. In this article, a method on Shannon energy (SE) in order to detect QRS complex in 12 leads of ECG signal is provided. At first, this algorithm computes the Shannon energy (SE) and then makes an envelope of Shannon energy (SE) by using the defined threshold. Then, the signal peaks are determined. The efficiency of the algorithm is tested on 70 cases. Of all 12 standard leads, ECG signals include 840 leads of the PTB Diagnostic ECG Database (PTBDB). The algorithm shows that the Shannon energy (SE) sensitivity is equal to 99.924%, the detection error rate (DER) is equal to 0.155%, Positive Predictivity (+P) is equal to 99.922%, and Classification Accuracy (Acc) is equal to 99.846%

Automatic analysis and classification of cardiac acoustic signals for long term monitoring

Objective: Cardiovascular diseases are the leading cause of death worldwide resulting in over 17.9 million deaths each year. Most of these diseases are preventable and treatable, but their progression and outcomes are significantly more positive with early-stage diagnosis and proper disease management. Among the approaches available to assist with the task of early-stage diagnosis and management of cardiac conditions, automatic analysis of auscultatory recordings is one of the most promising ones, since it could be particularly suitable for ambulatory/wearable monitoring. Thus, proper investigation of abnormalities present in cardiac acoustic signals can provide vital clinical information to assist long term monitoring. Cardiac acoustic signals, however, are very susceptible to noise and artifacts, and their characteristics vary largely with the recording conditions which makes the analysis challenging. Additionally, there are challenges in the steps used for automatic analysis and classification of cardiac acoustic signals. Broadly, these steps are the segmentation, feature extraction and subsequent classification of recorded signals using selected features. This thesis presents approaches using novel features with the aim to assist the automatic early-stage detection of cardiovascular diseases with improved performance, using cardiac acoustic signals collected in real-world conditions. Methods: Cardiac auscultatory recordings were studied to identify potential features to help in the classification of recordings from subjects with and without cardiac diseases. The diseases considered in this study for the identification of the symptoms and characteristics are the valvular heart diseases due to stenosis and regurgitation, atrial fibrillation, and splitting of fundamental heart sounds leading to additional lub/dub sounds in the systole or diastole interval of a cardiac cycle. The localisation of cardiac sounds of interest was performed using an adaptive wavelet-based filtering in combination with the Shannon energy envelope and prior information of fundamental heart sounds. This is a prerequisite step for the feature extraction and subsequent classification of recordings, leading to a more precise diagnosis. Localised segments of S1 and S2 sounds, and artifacts, were used to extract a set of perceptual and statistical features using wavelet transform, homomorphic filtering, Hilbert transform and mel-scale filtering, which were then fed to train an ensemble classifier to interpret S1 and S2 sounds. Once sound peaks of interest were identified, features extracted from these peaks, together with the features used for the identification of S1 and S2 sounds, were used to develop an algorithm to classify recorded signals. Overall, 99 features were extracted and statistically analysed using neighborhood component analysis (NCA) to identify the features which showed the greatest ability in classifying recordings. Selected features were then fed to train an ensemble classifier to classify abnormal recordings, and hyperparameters were optimized to evaluate the performance of the trained classifier. Thus, a machine learning-based approach for the automatic identification and classification of S1 and S2, and normal and abnormal recordings, in real-world noisy recordings using a novel feature set is presented. The validity of the proposed algorithm was tested using acoustic signals recorded in real-world, non-controlled environments at four auscultation sites (aortic valve, tricuspid valve, mitral valve, and pulmonary valve), from the subjects with and without cardiac diseases; together with recordings from the three large public databases. The performance metrics of the methodology in relation to classification accuracy (CA), sensitivity (SE), precision (P+), and F1 score, were evaluated. Results: This thesis proposes four different algorithms to automatically classify fundamental heart sounds – S1 and S2; normal fundamental sounds and abnormal additional lub/dub sounds recordings; normal and abnormal recordings; and recordings with heart valve disorders, namely the mitral stenosis (MS), mitral regurgitation (MR), mitral valve prolapse (MVP), aortic stenosis (AS) and murmurs, using cardiac acoustic signals. The results obtained from these algorithms were as follows: • The algorithm to classify S1 and S2 sounds achieved an average SE of 91.59% and 89.78%, and F1 score of 90.65% and 89.42%, in classifying S1 and S2, respectively. 87 features were extracted and statistically studied to identify the top 14 features which showed the best capabilities in classifying S1 and S2, and artifacts. The analysis showed that the most relevant features were those extracted using Maximum Overlap Discrete Wavelet Transform (MODWT) and Hilbert transform. • The algorithm to classify normal fundamental heart sounds and abnormal additional lub/dub sounds in the systole or diastole intervals of a cardiac cycle, achieved an average SE of 89.15%, P+ of 89.71%, F1 of 89.41%, and CA of 95.11% using the test dataset from the PASCAL database. The top 10 features that achieved the highest weights in classifying these recordings were also identified. • Normal and abnormal classification of recordings using the proposed algorithm achieved a mean CA of 94.172%, and SE of 92.38%, in classifying recordings from the different databases. Among the top 10 acoustic features identified, the deterministic energy of the sound peaks of interest and the instantaneous frequency extracted using the Hilbert Huang-transform, achieved the highest weights. • The machine learning-based approach proposed to classify recordings of heart valve disorders (AS, MS, MR, and MVP) achieved an average CA of 98.26% and SE of 95.83%. 99 acoustic features were extracted and their abilities to differentiate these abnormalities were examined using weights obtained from the neighborhood component analysis (NCA). The top 10 features which showed the greatest abilities in classifying these abnormalities using recordings from the different databases were also identified. The achieved results demonstrate the ability of the algorithms to automatically identify and classify cardiac sounds. This work provides the basis for measurements of many useful clinical attributes of cardiac acoustic signals and can potentially help in monitoring the overall cardiac health for longer duration. The work presented in this thesis is the first-of-its-kind to validate the results using both, normal and pathological cardiac acoustic signals, recorded for a long continuous duration of 5 minutes at four different auscultation sites in non-controlled real-world conditions.Open Acces

A sample of low energy bursts from FRB 121102

We present 41 bursts from the first repeating fast radio burst discovered (FRB 121102). A deep search has allowed us to probe unprecedentedly low burst energies during two consecutive observations (separated by one day) using the Arecibo telescope at 1.4 GHz. The bursts are generally detected in less than a third of the 580-MHz observing bandwidth, demonstrating that narrow-band FRB signals may be more common than previously thought. We show that the bursts are likely faint versions of previously reported multi-component bursts. There is a striking lack of bursts detected below 1.35 GHz and simultaneous VLA observations at 3 GHz did not detect any of the 41 bursts, but did detect one that was not seen with Arecibo, suggesting preferred radio emission frequencies that vary with epoch. A power law approximation of the cumulative distribution of burst energies yields an index $-1.8\pm0.3$ that is much steeper than the previously reported value of $\sim-0.7$. The discrepancy may be evidence for a more complex energy distribution. We place constraints on the possibility that the associated persistent radio source is generated by the emission of many faint bursts ($\sim700$ ms$^{-1}$). We do not see a connection between burst fluence and wait time. The distribution of wait times follows a log-normal distribution centered around $\sim200$ s; however, some bursts have wait times below 1 s and as short as 26 ms, which is consistent with previous reports of a bimodal distribution. We caution against exclusively integrating over the full observing band during FRB searches, because this can lower signal-to-noise.Comment: Accepted version. 16 pages, 7 figures, 1 tabl

A Comparison of Wavelet and Simplicity-Based Heart Sound and Murmur Segmentation Methods

Stethoscopes are the most commonly used medical devices for diagnosing heart conditions because they are inexpensive, noninvasive, and light enough to be carried around by a clinician. Auscultation with a stethoscope requires considerable skill and experience, but the introduction of digital stethoscopes allows for the automation of this task. Auscultation waveform segmentation, which is the process of determining the boundaries of heart sound and murmur segments, is the primary challenge in automating the diagnosis of various heart conditions. The purpose of this thesis is to improve the accuracy and efficiency of established techniques for detecting, segmenting, and classifying heart sounds and murmurs in digitized phonocardiogram audio files. Two separate segmentation techniques based on the discrete wavelet transform (DWT) and the simplicity transform are integrated into a MATLAB software system that is capable of automatically detecting and classifying sound segments. The performance of the two segmentation methods for recognizing normal heart sounds and several different heart murmurs is compared by quantifying the results with clinical and technical metrics. The two clinical metrics are the false negative detection rate (FNDR) and the false positive detection rate (FPDR), which count heart cycles rather than sound segments. The wavelet and simplicity methods have a 4% and 9% respective FNDR, so it is unlikely that either method would not detect a heart condition. However, the 22% and 0% respective FPDR signifies that the wavelet method is likely to detect false heart conditions, while the simplicity method is not. The two technical metrics are the true murmur detection rate (TMDR) and the false murmur detection rate (FMDR), which count sound segments rather than heart cycles. Both methods are equally likely to detect true murmurs given their 83% TMDR. However, the 13% and 0% respective FMDR implies that the wavelet method is susceptible to detecting false murmurs, while the simplicity method is not. Simplicity-based segmentation, therefore, demonstrates superior performance to wavelet-based segmentation, as both are equally likely to detect true murmurs, but only the simplicity method has no chance of detecting false murmurs

Automatic Heart Sounds Segmentation based on the Correlation Coefficients Matrix for Similar Cardiac Cycles Identification

This paper proposes a novel automatic heart sounds segmentation method for deployment in heart valve defect diagnosis. The method is based on the correlation coefficients matrix, calculated between all the heart cycles for similarity identification. Firstly, fundamental heart sounds (S1 and S2) in the presence of extra gallop sounds such as S3 and/or S4 and murmurs are localized with more accuracy. Secondly, two similarity-based filtering approaches (using time and time-frequency domains, respectively) for correlated heart cycles identification are proposed and evaluated in the context of professional clinical auscultated heart sounds of adult patients. Results show the superiority of the novel time-frequency method proposed here particularly in the presence of extra gallop sounds

An approach for automatic identification of fundamental and additional sounds from cardiac sounds recordings.

This paper presents an approach for automatic segmentation of cardiac events from non-invasive sounds recordings, without the need of having an auxiliary signal reference. In addition, methods are proposed to subsequently differentiate cardiac events which correspond to normal cardiac cycles, from those which are due to abnormal activity of the heart. The detection of abnormal sounds is based on a model built with parameters which are obtained following feature extraction from those segments that were previously identified as normal fundamental heart sounds. The proposed algorithm achieved a sensitivity of 91.79% and 89.23% for the identification of normal fundamental, S1 and S2 sounds, and a true positive (TP) rate of 81.48% for abnormal additional sounds. These results were obtained using the PASCAL Classifying Heart Sounds challenge (CHSC) database

A speech envelope landmark for syllable encoding in human superior temporal gyrus.

The most salient acoustic features in speech are the modulations in its intensity, captured by the amplitude envelope. Perceptually, the envelope is necessary for speech comprehension. Yet, the neural computations that represent the envelope and their linguistic implications are heavily debated. We used high-density intracranial recordings, while participants listened to speech, to determine how the envelope is represented in human speech cortical areas on the superior temporal gyrus (STG). We found that a well-defined zone in middle STG detects acoustic onset edges (local maxima in the envelope rate of change). Acoustic analyses demonstrated that timing of acoustic onset edges cues syllabic nucleus onsets, while their slope cues syllabic stress. Synthesized amplitude-modulated tone stimuli showed that steeper slopes elicited greater responses, confirming cortical encoding of amplitude change, not absolute amplitude. Overall, STG encoding of the timing and magnitude of acoustic onset edges underlies the perception of speech temporal structure

An algorithm for heart rate extraction from acoustic recordings at the neck

Heart rate is an important physiological parameter to assess the cardiac condition of an individual and is traditionally determined by attaching multiple electrodes on the chest of a subject to record the electrical activity of the heart. The installation and handling complexities of such systems does not prove feasible for a user to undergo a long-term monitoring in the home settings. A small-sized, battery-operated wearable monitoring device is placed on the suprasternal notch at neck to record acoustic signals containing information about breathing and cardiac sounds. The heart sounds obtained are heavily corrupted by the respiratory cycles and other external artifacts. This paper presents a novel algorithm for reliably extracting the heart rate from such acoustic recordings, keeping in mind the constraints posed by the wearable technology. The methodology constructs the Hilbert energy envelope of the signal by calculating its instantaneous characteristics to segment and classify a cardiac cycle into S1 and S2 sounds using their timing characteristics. The algorithm is tested on a dataset consisting of 13 subjects with an approximate data length of 75 hours and achieves an accuracy of 94.34%, an RMS error of 3.96 bpm and a correlation coefficient of 0.93 with reference to a commercial device in use

The quest for the solar g modes

Solar gravity modes (or g modes) -- oscillations of the solar interior for which buoyancy acts as the restoring force -- have the potential to provide unprecedented inference on the structure and dynamics of the solar core, inference that is not possible with the well observed acoustic modes (or p modes). The high amplitude of the g-mode eigenfunctions in the core and the evanesence of the modes in the convection zone make the modes particularly sensitive to the physical and dynamical conditions in the core. Owing to the existence of the convection zone, the g modes have very low amplitudes at photospheric levels, which makes the modes extremely hard to detect. In this paper, we review the current state of play regarding attempts to detect g modes. We review the theory of g modes, including theoretical estimation of the g-mode frequencies, amplitudes and damping rates. Then we go on to discuss the techniques that have been used to try to detect g modes. We review results in the literature, and finish by looking to the future, and the potential advances that can be made -- from both data and data-analysis perspectives -- to give unambiguous detections of individual g modes. The review ends by concluding that, at the time of writing, there is indeed a consensus amongst the authors that there is currently no undisputed detection of solar g modes.Comment: 71 pages, 18 figures, accepted by Astronomy and Astrophysics Revie