Classification methodology of CVD with localized feature analysis using Phase Space Reconstruction targeting personalized remote health monitoring

2016 Computing in Cardiology Conference (CinC), 11-14 September 2016, Vancouver, BC, CanadaThis is the final version of the article. Available from the publisher via the DOI in this recordThis paper introduces the classification methodology of Cardiovascular Disease (CVD) with localized feature analysis using Phase Space Reconstruction (PSR) technique targeting personalized health care. The proposed classification methodology uses a few localized features (QRS interval and PR interval) of individual Electrocardiogram (ECG) beats from the Feature Extraction (FE) block and detects the desynchronization in the given intervals after applying the PSR technique. Considering the QRS interval, if any notch is present in the QRS complex, then the corresponding contour will appear and the variation in the box count indicating a notch in the QRS complex. Likewise, the contour and the disparity of box count due to the variation in the PR interval localized wave have been noticed using the proposed PSR technique. ECG database from the Physionet (MIT-BIH and PTBDB) has been used to verify the proposed analysis on localized features using proposed PSR and has enabled us to classify the various abnormalities like fragmented QRS complexes, myocardial infarction, ventricular arrhythmia and atrial fibrillation. The design have been successfully tested for diagnosing various disorders with 98% accuracy on all the specified abnormal databases.This work is partly supported by the Department of Electronics and Information and Technology (DeitY), India under the “Internet of Things (IoT) for Smarter Healthcare” under Grant No: 13(7)/2012-CC&BT, dated 25 Feb 2013. Naresh V is funded by Ministry of Human Resource Development (MHRD) PhD studentship through IIT Hyderabad

Non-Invasive Data Acquisition and IoT Solution for Human Vital Signs Monitoring: Applications, Limitations and Future Prospects

The rapid development of technology has brought about a revolution in healthcare stimulating a wide range of smart and autonomous applications in homes, clinics, surgeries and hospitals. Smart healthcare opens the opportunity for a qualitative advance in the relations between healthcare providers and end-users for the provision of healthcare such as enabling doctors to diagnose remotely while optimizing the accuracy of the diagnosis and maximizing the benefits of treatment by enabling close patient monitoring. This paper presents a comprehensive review of non-invasive vital data acquisition and the Internet of Things in healthcare informatics and thus reports the challenges in healthcare informatics and suggests future work that would lead to solutions to address the open challenges in IoT and non-invasive vital data acquisition. In particular, the conducted review has revealed that there has been a daunting challenge in the development of multi-frequency vital IoT systems, and addressing this issue will help enable the vital IoT node to be reachable by the broker in multiple area ranges. Furthermore, the utilization of multi-camera systems has proven its high potential to increase the accuracy of vital data acquisition, but the implementation of such systems has not been fully developed with unfilled gaps to be bridged. Moreover, the application of deep learning to the real-time analysis of vital data on the node/edge side will enable optimal, instant offline decision making. Finally, the synergistic integration of reliable power management and energy harvesting systems into non-invasive data acquisition has been omitted so far, and the successful implementation of such systems will lead to a smart, robust, sustainable and self-powered healthcare system

A Novel Low Complexity On body CVD Classifier ASIC Design Methodology

Due to increasing rate of cardiac disorders in developed and developing countries Continuous on body monitoring of ECG signal using the concept of IoT and Body Sensor Network has become the necessity. In this work we are proposing a novel low complex, low power algorithm and architecturefor E.C.G. classification which can be incorporated in present era of IOT and Body Sensor Network. Rather than going for Artificial Intelligence based pattern matching and complex DSP algorithm we have used the simplicity of Hurst exponent and Haar wavelet for filtering out anomalous E.C.G. signals and normal ones

From Wearable Sensors to Smart Implants – Towards Pervasive and Personalised Healthcare

<p>Objective: This article discusses the evolution of pervasive healthcare from its inception for activity recognition using wearable sensors to the future of sensing implant deployment and data processing. Methods: We provide an overview of some of the past milestones and recent developments, categorised into different generations of pervasive sensing applications for health monitoring. This is followed by a review on recent technological advances that have allowed unobtrusive continuous sensing combined with diverse technologies to reshape the clinical workflow for both acute and chronic disease management. We discuss the opportunities of pervasive health monitoring through data linkages with other health informatics systems including the mining of health records, clinical trial databases, multi-omics data integration and social media. Conclusion: Technical advances have supported the evolution of the pervasive health paradigm towards preventative, predictive, personalised and participatory medicine. Significance: The sensing technologies discussed in this paper and their future evolution will play a key role in realising the goal of sustainable healthcare systems.</p> <p> </p

Revolutionizing Healthcare through Health Monitoring Applications with Wearable Biomedical Devices

The Internet of Things (IoT) has revolutionized the connectivity and communication of tangible objects, and it serves as a versatile and cost-effective solution in the healthcare sector, particularly in regions with limited healthcare infrastructure. This research explores the application of sensors such as LM35, AD8232, and MAX30100 for the detection of vital health indicators, including body temperature, pulse rate, electrocardiogram (ECG), and oxygen saturation levels, with data transmission through IoT cloud, offering real-time parameter access via an Android application for non-invasive remote patient monitoring. The study aims to expand healthcare services to various settings, such as hospitals, commercial areas, educational institutions, workplaces, and residential neighborhoods. After the COVID-19 pandemic, IoT-enabled continuous monitoring of critical health metrics such as temperature and pulse rate has become increasingly crucial for early illness detection and efficient communication with healthcare providers. Our low-cost wearable device, which includes ECG monitoring, aims to bridge the accessibility gap for people with limited financial resources, with the primary goal of providing efficient healthcare solutions to underserved rural areas while also contributing valuable data to future medical research. Our proposed system is a low-cost, high-efficiency solution that outperforms existing systems in healthcare data collection and patient monitoring. It improves access to vital health data and shows economic benefits, indicating a significant advancement in healthcare technology

Developments in Transduction, Connectivity and AI/Machine Learning for Point-of-Care Testing

We review some emerging trends in transduction, connectivity and data analytics for Point-of-Care Testing (POCT) of infectious and non-communicable diseases. The patient need for POCT is described along with developments in portable diagnostics, specifically in respect of Lab-on-chip and microfluidic systems. We describe some novel electrochemical and photonic systems and the use of mobile phones in terms of hardware components and device connectivity for POCT. Developments in data analytics that are applicable for POCT are described with an overview of data structures and recent AI/Machine learning trends. The most important methodologies of machine learning, including deep learning methods, are summarised. The potential value of trends within POCT systems for clinical diagnostics within Lower Middle Income Countries (LMICs) and the Least Developed Countries (LDCs) are highlighted

Point-of-care diagnostics for niche applications

Point-of-care or point-of-use diagnostics are analytical devices that provide clinically relevant information without the need for a core clinical laboratory. In this review we define point-of-care diagnostics as portable versions of assays performed in a traditional clinical chemistry laboratory. This review discusses five areas relevant to human and animal health where increased attention could produce significant impact: veterinary medicine, space travel, sports medicine, emergency medicine, and operating room efficiency. For each of these areas, clinical need, available commercial products, and ongoing research into new devices are highlighted

Multidimensional embedded MEMS motion detectors for wearable mechanocardiography and 4D medical imaging

Background: Cardiovascular diseases are the number one cause of death. Of these deaths, almost 80% are due to coronary artery disease (CAD) and cerebrovascular disease. Multidimensional microelectromechanical systems (MEMS) sensors allow measuring the mechanical movement of the heart muscle offering an entirely new and innovative solution to evaluate cardiac rhythm and function. Recent advances in miniaturized motion sensors present an exciting opportunity to study novel device-driven and functional motion detection systems in the areas of both cardiac monitoring and biomedical imaging, for example, in computed tomography (CT) and positron emission tomography (PET). Methods: This Ph.D. work describes a new cardiac motion detection paradigm and measurement technology based on multimodal measuring tools — by tracking the heart’s kinetic activity using micro-sized MEMS sensors — and novel computational approaches — by deploying signal processing and machine learning techniques—for detecting cardiac pathological disorders. In particular, this study focuses on the capability of joint gyrocardiography (GCG) and seismocardiography (SCG) techniques that constitute the mechanocardiography (MCG) concept representing the mechanical characteristics of the cardiac precordial surface vibrations. Results: Experimental analyses showed that integrating multisource sensory data resulted in precise estimation of heart rate with an accuracy of 99% (healthy, n=29), detection of heart arrhythmia (n=435) with an accuracy of 95-97%, ischemic disease indication with approximately 75% accuracy (n=22), as well as significantly improved quality of four-dimensional (4D) cardiac PET images by eliminating motion related inaccuracies using MEMS dual gating approach. Tissue Doppler imaging (TDI) analysis of GCG (healthy, n=9) showed promising results for measuring the cardiac timing intervals and myocardial deformation changes. Conclusion: The findings of this study demonstrate clinical potential of MEMS motion sensors in cardiology that may facilitate in time diagnosis of cardiac abnormalities. Multidimensional MCG can effectively contribute to detecting atrial fibrillation (AFib), myocardial infarction (MI), and CAD. Additionally, MEMS motion sensing improves the reliability and quality of cardiac PET imaging.Moniulotteisten sulautettujen MEMS-liiketunnistimien käyttö sydänkardiografiassa sekä lääketieteellisessä 4D-kuvantamisessa Tausta: Sydän- ja verisuonitaudit ovat yleisin kuolinsyy. Näistä kuolemantapauksista lähes 80% johtuu sepelvaltimotaudista (CAD) ja aivoverenkierron häiriöistä. Moniulotteiset mikroelektromekaaniset järjestelmät (MEMS) mahdollistavat sydänlihaksen mekaanisen liikkeen mittaamisen, mikä puolestaan tarjoaa täysin uudenlaisen ja innovatiivisen ratkaisun sydämen rytmin ja toiminnan arvioimiseksi. Viimeaikaiset teknologiset edistysaskeleet mahdollistavat uusien pienikokoisten liiketunnistusjärjestelmien käyttämisen sydämen toiminnan tutkimuksessa sekä lääketieteellisen kuvantamisen, kuten esimerkiksi tietokonetomografian (CT) ja positroniemissiotomografian (PET), tarkkuuden parantamisessa. Menetelmät: Tämä väitöskirjatyö esittelee uuden sydämen kineettisen toiminnan mittaustekniikan, joka pohjautuu MEMS-anturien käyttöön. Uudet laskennalliset lähestymistavat, jotka perustuvat signaalinkäsittelyyn ja koneoppimiseen, mahdollistavat sydämen patologisten häiriöiden havaitsemisen MEMS-antureista saatavista signaaleista. Tässä tutkimuksessa keskitytään erityisesti mekanokardiografiaan (MCG), joihin kuuluvat gyrokardiografia (GCG) ja seismokardiografia (SCG). Näiden tekniikoiden avulla voidaan mitata kardiorespiratorisen järjestelmän mekaanisia ominaisuuksia. Tulokset: Kokeelliset analyysit osoittivat, että integroimalla usean sensorin dataa voidaan mitata syketiheyttä 99% (terveillä n=29) tarkkuudella, havaita sydämen rytmihäiriöt (n=435) 95-97%, tarkkuudella, sekä havaita iskeeminen sairaus noin 75% tarkkuudella (n=22). Lisäksi MEMS-kaksoistahdistuksen avulla voidaan parantaa sydämen 4D PET-kuvan laatua, kun liikeepätarkkuudet voidaan eliminoida paremmin. Doppler-kuvantamisessa (TDI, Tissue Doppler Imaging) GCG-analyysi (terveillä, n=9) osoitti lupaavia tuloksia sydänsykkeen ajoituksen ja intervallien sekä sydänlihasmuutosten mittaamisessa. Päätelmä: Tämän tutkimuksen tulokset osoittavat, että kardiologisilla MEMS-liikeantureilla on kliinistä potentiaalia sydämen toiminnallisten poikkeavuuksien diagnostisoinnissa. Moniuloitteinen MCG voi edistää eteisvärinän (AFib), sydäninfarktin (MI) ja CAD:n havaitsemista. Lisäksi MEMS-liiketunnistus parantaa sydämen PET-kuvantamisen luotettavuutta ja laatua

Medical semiconductor sensors: a market perspective on state-of-the-art solutions and trends

The aim of this Master Thesis is to analyse the worldwide state-of-the art market solutions and trends in semiconductor sensors within medical applications; specially magnetic and pressure sensors, with the intention of developing a potential entry plan of Infineon Technologies AG into this market. For that purpose, a fit between a top-down and bottom-up qualitative and quantitative estimation of the medical semiconductor sensor’s market size has been made; with application units, sensor volumes and sensor revenues, with a horizontal scope of five years. Once understood the existing market, some insight into the competitive landscape is provided, where the key suppliers are analysed in terms of product portfolio and revenue share estimates, on an application basis. And also, a spotlight on innovation and trends at three levels – healthcare, medical devices and medical semiconductor sensors – is presented, to forecast a possible evolution of the fore-mentioned market. The research that has been conducted is based on three main sources of information; internal contacts (i.e. within Infineon), external contacts (most of them through internal references) and internet research. Access to market research company’s reports and interviews has been particularly helpful, to complement extensive internet research. Outcomes of this study indicate that the global medical semiconductor magnetic sensor market reveals low revenue potential; as most of the applications are yet innovation fields. Reed switch replacement in battery-powered medical devices can be an opportunity for magnetic switches. However, this project suggests that there is a key investment opportunity: magnetic beads for viral detection with spintronics sensors. The global medical semiconductor pressure sensor market seems a fairly mature market; the gross part of the revenue comes from blood pressure measurement. Blood pressure measurement might be an opportunity for existing automotive semiconductor pressure sensor products. Furthermore, this report suggests that the future of blood pressure measurement might tend towards implantable pressure sensors, with a non-significantly different technological basis. To conclude, this report unveils certain business opportunities for Infineon’s semiconductor magnetic and pressure sensor products; and puts special focus on the development of derivative products to pioneer the commercialization of innovative medical applications, with a forecasted huge revenue potential

From Concept to Market: Surgical Robot Development

Surgical robotics and supporting technologies have really become a prime example of modern applied information technology infiltrating our everyday lives. The development of these systems spans across four decades, and only the last few years brought the market value and saw the rising customer base imagined already by the early developers. This chapter guides through the historical development of the most important systems, and provide references and lessons learnt for current engineers facing similar challenges. A special emphasis is put on system validation, assessment and clearance, as the most commonly cited barrier hindering the wider deployment of a system