Medical image retrieval for augmenting diagnostic radiology

Even though the use of medical imaging to diagnose patients is ubiquitous in clinical settings, their interpretations are still challenging for radiologists. Many factors make this interpretation task difficult, one of which is that medical images sometimes present subtle clues yet are crucial for diagnosis. Even worse, on the other hand, similar clues could indicate multiple diseases, making it challenging to figure out the definitive diagnoses. To help radiologists quickly and accurately interpret medical images, there is a need for a tool that can augment their diagnostic procedures and increase efficiency in their daily workflow. A general-purpose medical image retrieval system can be such a tool as it allows them to search and retrieve similar cases that are already diagnosed to make comparative analyses that would complement their diagnostic decisions. In this thesis, we contribute to developing such a system by proposing approaches to be integrated as modules of a single system, enabling it to handle various information needs of radiologists and thus augment their diagnostic processes during the interpretation of medical images. We have mainly studied the following retrieval approaches to handle radiologists’different information needs; i) Retrieval Based on Contents, ii) Retrieval Based on Contents, Patients’ Demographics, and Disease Predictions, and iii) Retrieval Based on Contents and Radiologists’ Text Descriptions. For the first study, we aimed to find an effective feature representation method to distinguish medical images considering their semantics and modalities. To do that, we have experimented different representation techniques based on handcrafted methods (mainly texture features) and deep learning (deep features). Based on the experimental results, we propose an effective feature representation approach and deep learning architectures for learning and extracting medical image contents. For the second study, we present a multi-faceted method that complements image contents with patients’ demographics and deep learning-based disease predictions, making it able to identify similar cases accurately considering the clinical context the radiologists seek. For the last study, we propose a guided search method that integrates an image with a radiologist’s text description to guide the retrieval process. This method guarantees that the retrieved images are suitable for the comparative analysis to confirm or rule out initial diagnoses (the differential diagnosis procedure). Furthermore, our method is based on a deep metric learning technique and is better than traditional content-based approaches that rely on only image features and, thus, sometimes retrieve insignificant random images

Transferred semantic scores for scalable retrieval of histopathological breast cancer images

Content-based medical image retrieval (CBMIR) is an active field of research and a complementary decision support tool for the diagnosis of breast cancer. Current CBMIR systems employ hand-engineered image descriptors which are not effective enough at retrieval phase. Besides this drawback, the so-called semantic gap in the CBMIR is not still addressed leaving the room for further improvements. To fill in the two mentioned existing gaps, we proposed a new retrieval method which exploiteda deep pre-trained convolutional neural network model to extract class-specific and patient-specific tumorous descriptor tofirstly train a binary breast cancer classifier and then a multi-patient classifier aiming for reducing dimensions of the raw deeply transferred features and obtaining semantic scores which significantly enhanced the performance in terms of mean average precision. We evaluated the method on scalable BreakHis dataset of histopathological breast cancer images. After conductingfive sets of experiments, results demonstrated the superior effectiveness of the proposed semantic-driven retrieval methods by means of increased mean average precision and decreased dimensionality and retrieval time. In overall, an improvement of 29.03% was obtained by the proposed class-driven semantic retrieval method

A graph-based approach for the retrieval of multi-modality medical images

Medical imaging has revolutionised modern medicine and is now an integral aspect of diagnosis and patient monitoring. The development of new imaging devices for a wide variety of clinical cases has spurred an increase in the data volume acquired in hospitals. These large data collections offer opportunities for search-based applications in evidence-based diagnosis, education, and biomedical research. However, conventional search methods that operate upon manual annotations are not feasible for this data volume. Content-based image retrieval (CBIR) is an image search technique that uses automatically derived visual features as search criteria and has demonstrable clinical benefits. However, very few studies have investigated the CBIR of multi-modality medical images, which are making a monumental impact in healthcare, e.g., combined positron emission tomography and computed tomography (PET-CT) for cancer diagnosis. In this thesis, we propose a new graph-based method for the CBIR of multi-modality medical images. We derive a graph representation that emphasises the spatial relationships between modalities by structurally constraining the graph based on image features, e.g., spatial proximity of tumours and organs. We also introduce a graph similarity calculation algorithm that prioritises the relationships between tumours and related organs. To enable effective human interpretation of retrieved multi-modality images, we also present a user interface that displays graph abstractions alongside complex multi-modality images. Our results demonstrated that our method achieved a high precision when retrieving images on the basis of tumour location within organs. The evaluation of our proposed UI design by user surveys revealed that it improved the ability of users to interpret and understand the similarity between retrieved PET-CT images. The work in this thesis advances the state-of-the-art by enabling a novel approach for the retrieval of multi-modality medical images

An Enhanced Image retrieval Technique based on Edge-Orientation Technique

With the tremendous development in Networking and Multimedia technologies, Image Retrieval plays significant roleand is used for browsing, searching and retrieving images from a large database of digital images. Image Retrieval techniques utilize annotation methods of adding metadata such as captioning, keywords or descriptions to the images. The manual image annotation is much time consuming laborious and expensive.As the data bases size increases, annotation becomes a tedious task. Thus automatic image annotationhas drawn the attention of the researchers in recent years.. The increase in social web application and the semantic web drawn attention of researchers in  the development of several web-based image retrieval tools. This paper presents an easy, efficient image retrieval approach using a new image feature descriptor called Micro-Structure Descriptor (MSD). The microstructures are defined based on an edge orientation similarly while the MSD is built based on the underlying colors in micro-structures with similar edge orientation.In this method of Image retrieval the MSD extracts features by simulating human’s early visual processing by effectively integrating color, texture, color lay out information and shape. The proposed MSD algorithm has high indexing performance and low dimensionalityas it has only 72 dimensions for full color images.The technique is examined on Corel datasets with natural images; the results demonstrate that this image retrieval method is much more efficient and effective than reprehensive feature descriptors, such as Gabor features and Multi Texton Histograms

Bridging the semantic gap in content-based image retrieval.

To manage large image databases, Content-Based Image Retrieval (CBIR) emerged as a new research subject. CBIR involves the development of automated methods to use visual features in searching and retrieving. Unfortunately, the performance of most CBIR systems is inherently constrained by the low-level visual features because they cannot adequately express the user\u27s high-level concepts. This is known as the semantic gap problem. This dissertation introduces a new approach to CBIR that attempts to bridge the semantic gap. Our approach includes four components. The first one learns a multi-modal thesaurus that associates low-level visual profiles with high-level keywords. This is accomplished through image segmentation, feature extraction, and clustering of image regions. The second component uses the thesaurus to annotate images in an unsupervised way. This is accomplished through fuzzy membership functions to label new regions based on their proximity to the profiles in the thesaurus. The third component consists of an efficient and effective method for fusing the retrieval results from the multi-modal features. Our method is based on learning and adapting fuzzy membership functions to the distribution of the features\u27 distances and assigning a degree of worthiness to each feature. The fourth component provides the user with the option to perform hybrid querying and query expansion. This allows the enrichment of a visual query with textual data extracted from the automatically labeled images in the database. The four components are integrated into a complete CBIR system that can run in three different and complementary modes. The first mode allows the user to query using an example image. The second mode allows the user to specify positive and/or negative sample regions that should or should not be included in the retrieved images. The third mode uses a Graphical Text Interface to allow the user to browse the database interactively using a combination of low-level features and high-level concepts. The proposed system and ail of its components and modes are implemented and validated using a large data collection for accuracy, performance, and improvement over traditional CBIR techniques

Learning Binary Code Representations for Effective and Efficient Image Retrieval

The size of online image datasets is constantly increasing. Considering an image dataset with millions of images, image retrieval becomes a seemingly intractable problem for exhaustive similarity search algorithms. Hashing methods, which encodes high-dimensional descriptors into compact binary strings, have become very popular because of their high efficiency in search and storage capacity. In the first part, we propose a multimodal retrieval method based on latent feature models. The procedure consists of a nonparametric Bayesian framework for learning underlying semantically meaningful abstract features in a multimodal dataset, a probabilistic retrieval model that allows cross-modal queries and an extension model for relevance feedback. In the second part, we focus on supervised hashing with kernels. We describe a flexible hashing procedure that treats binary codes and pairwise semantic similarity as latent and observed variables, respectively, in a probabilistic model based on Gaussian processes for binary classification. We present a scalable inference algorithm with the sparse pseudo-input Gaussian process (SPGP) model and distributed computing. In the last part, we define an incremental hashing strategy for dynamic databases where new images are added to the databases frequently. The method is based on a two-stage classification framework using binary and multi-class SVMs. The proposed method also enforces balance in binary codes by an imbalance penalty to obtain higher quality binary codes. We learn hash functions by an efficient algorithm where the NP-hard problem of finding optimal binary codes is solved via cyclic coordinate descent and SVMs are trained in a parallelized incremental manner. For modifications like adding images from an unseen class, we propose an incremental procedure for effective and efficient updates to the previous hash functions. Experiments on three large-scale image datasets demonstrate that the incremental strategy is capable of efficiently updating hash functions to the same retrieval performance as hashing from scratch