Algorithms to Explore the Structure and Evolution of Biological Networks

High-throughput experimental protocols have revealed thousands of relationships amongst genes and proteins under various conditions. These putative associations are being aggressively mined to decipher the structural and functional architecture of the cell. One useful tool for exploring this data has been computational network analysis. In this thesis, we propose a collection of novel algorithms to explore the structure and evolution of large, noisy, and sparsely annotated biological networks. We first introduce two information-theoretic algorithms to extract interesting patterns and modules embedded in large graphs. The first, graph summarization, uses the minimum description length principle to find compressible parts of the graph. The second, VI-Cut, uses the variation of information to non-parametrically find groups of topologically cohesive and similarly annotated nodes in the network. We show that both algorithms find structure in biological data that is consistent with known biological processes, protein complexes, genetic diseases, and operational taxonomic units. We also propose several algorithms to systematically generate an ensemble of near-optimal network clusterings and show how these multiple views can be used together to identify clustering dynamics that any single solution approach would miss. To facilitate the study of ancient networks, we introduce a framework called ``network archaeology'') for reconstructing the node-by-node and edge-by-edge arrival history of a network. Starting with a present-day network, we apply a probabilistic growth model backwards in time to find high-likelihood previous states of the graph. This allows us to explore how interactions and modules may have evolved over time. In experiments with real-world social and biological networks, we find that our algorithms can recover significant features of ancestral networks that have long since disappeared. Our work is motivated by the need to understand large and complex biological systems that are being revealed to us by imperfect data. As data continues to pour in, we believe that computational network analysis will continue to be an essential tool towards this end

The contour tree image encoding technique and file format

The process of contourization is presented which converts a raster image into a discrete set of plateaux or contours. These contours can be grouped into a hierarchical structure, defining total spatial inclusion, called a contour tree. A contour coder has been developed which fully describes these contours in a compact and efficient manner and is the basis for an image compression method. Simplification of the contour tree has been undertaken by merging contour tree nodes thus lowering the contour tree's entropy. This can be exploited by the contour coder to increase the image compression ratio. By applying general and simple rules derived from physiological experiments on the human vision system, lossy image compression can be achieved which minimises noticeable artifacts in the simplified image. The contour merging technique offers a complementary lossy compression system to the QDCT (Quantised Discrete Cosine Transform). The artifacts introduced by the two methods are very different; QDCT produces a general blurring and adds extra highlights in the form of overshoots, whereas contour merging sharpens edges, reduces highlights and introduces a degree of false contouring. A format based on the contourization technique which caters for most image types is defined, called the contour tree image format. Image operations directly on this compressed format have been studied which for certain manipulations can offer significant operational speed increases over using a standard raster image format. A couple of examples of operations specific to the contour tree format are presented showing some of the features of the new format.Science and Engineering Research Counci

Visual region understanding: unsupervised extraction and abstraction

The ability to gain a conceptual understanding of the world in uncontrolled environments is the ultimate goal of vision-based computer systems. Technological societies today are heavily reliant on surveillance and security infrastructure, robotics, medical image analysis, visual data categorisation and search, and smart device user interaction, to name a few. Out of all the complex problems tackled by computer vision today in context of these technologies, that which lies closest to the original goals of the field is the subarea of unsupervised scene analysis or scene modelling. However, its common use of low level features does not provide a good balance between generality and discriminative ability, both a result and a symptom of the sensory and semantic gaps existing between low level computer representations and high level human descriptions. In this research we explore a general framework that addresses the fundamental problem of universal unsupervised extraction of semantically meaningful visual regions and their behaviours. For this purpose we address issues related to (i) spatial and spatiotemporal segmentation for region extraction, (ii) region shape modelling, and (iii) the online categorisation of visual object classes and the spatiotemporal analysis of their behaviours. Under this framework we propose (a) a unified region merging method and spatiotemporal region reduction, (b) shape representation by the optimisation and novel simplication of contour-based growing neural gases, and (c) a foundation for the analysis of visual object motion properties using a shape and appearance based nearest-centroid classification algorithm and trajectory plots for the obtained region classes. 1 Specifically, we formulate a region merging spatial segmentation mechanism that combines and adapts features shown previously to be individually useful, namely parallel region growing, the best merge criterion, a time adaptive threshold, and region reduction techniques. For spatiotemporal region refinement we consider both scalar intensity differences and vector optical flow. To model the shapes of the visual regions thus obtained, we adapt the growing neural gas for rapid region contour representation and propose a contour simplication technique. A fast unsupervised nearest-centroid online learning technique next groups observed region instances into classes, for which we are then able to analyse spatial presence and spatiotemporal trajectories. The analysis results show semantic correlations to real world object behaviour. Performance evaluation of all steps across standard metrics and datasets validate their performance

Transform Based And Search Aware Text Compression Schemes And Compressed Domain Text Retrieval

In recent times, we have witnessed an unprecedented growth of textual information via the Internet, digital libraries and archival text in many applications. While a good fraction of this information is of transient interest, useful information of archival value will continue to accumulate. We need ways to manage, organize and transport this data from one point to the other on data communications links with limited bandwidth. We must also have means to speedily find the information we need from this huge mass of data. Sometimes, a single site may also contain large collections of data such as a library database, thereby requiring an efficient search mechanism even to search within the local data. To facilitate the information retrieval, an emerging ad hoc standard for uncompressed text is XML which preprocesses the text by putting additional user defined metadata such as DTD or hyperlinks to enable searching with better efficiency and effectiveness. This increases the file size considerably, underscoring the importance of applying text compression. On account of efficiency (in terms of both space and time), there is a need to keep the data in compressed form for as much as possible. Text compression is concerned with techniques for representing the digital text data in alternate representations that takes less space. Not only does it help conserve the storage space for archival and online data, it also helps system performance by requiring less number of secondary storage (disk or CD Rom) accesses and improves the network transmission bandwidth utilization by reducing the transmission time. Unlike static images or video, there is no international standard for text compression, although compressed formats like .zip, .gz, .Z files are increasingly being used. In general, data compression methods are classified as lossless or lossy. Lossless compression allows the original data to be recovered exactly. Although used primarily for text data, lossless compression algorithms are useful in special classes of images such as medical imaging, finger print data, astronomical images and data bases containing mostly vital numerical data, tables and text information. Many lossy algorithms use lossless methods at the final stage of the encoding stage underscoring the importance of lossless methods for both lossy and lossless compression applications. In order to be able to effectively utilize the full potential of compression techniques for the future retrieval systems, we need efficient information retrieval in the compressed domain. This means that techniques must be developed to search the compressed text without decompression or only with partial decompression independent of whether the search is done on the text or on some inversion table corresponding to a set of key words for the text. In this dissertation, we make the following contributions: (1) Star family compression algorithms: We have proposed an approach to develop a reversible transformation that can be applied to a source text that improves existing algorithm\u27s ability to compress. We use a static dictionary to convert the English words into predefined symbol sequences. These transformed sequences create additional context information that is superior to the original text. Thus we achieve some compression at the preprocessing stage. We have a series of transforms which improve the performance. Star transform requires a static dictionary for a certain size. To avoid the considerable complexity of conversion, we employ the ternary tree data structure that efficiently converts the words in the text to the words in the star dictionary in linear time. (2) Exact and approximate pattern matching in Burrows-Wheeler transformed (BWT) files: We proposed a method to extract the useful context information in linear time from the BWT transformed text. The auxiliary arrays obtained from BWT inverse transform brings logarithm search time. Meanwhile, approximate pattern matching can be performed based on the results of exact pattern matching to extract the possible candidate for the approximate pattern matching. Then fast verifying algorithm can be applied to those candidates which could be just small parts of the original text. We present algorithms for both k-mismatch and k-approximate pattern matching in BWT compressed text. A typical compression system based on BWT has Move-to-Front and Huffman coding stages after the transformation. We propose a novel approach to replace the Move-to-Front stage in order to extend compressed domain search capability all the way to the entropy coding stage. A modification to the Move-to-Front makes it possible to randomly access any part of the compressed text without referring to the part before the access point. (3) Modified LZW algorithm that allows random access and partial decoding for the compressed text retrieval: Although many compression algorithms provide good compression ratio and/or time complexity, LZW is the first one studied for the compressed pattern matching because of its simplicity and efficiency. Modifications on LZW algorithm provide the extra advantage for fast random access and partial decoding ability that is especially useful for text retrieval systems. Based on this algorithm, we can provide a dynamic hierarchical semantic structure for the text, so that the text search can be performed on the expected level of granularity. For example, user can choose to retrieve a single line, a paragraph, or a file, etc. that contains the keywords. More importantly, we will show that parallel encoding and decoding algorithm is trivial with the modified LZW. Both encoding and decoding can be performed with multiple processors easily and encoding and decoding process are independent with respect to the number of processors

Efficient Algorithms for Large-Scale Image Analysis

This work develops highly efficient algorithms for analyzing large images. Applications include object-based change detection and screening. The algorithms are 10-100 times as fast as existing software, sometimes even outperforming FGPA/GPU hardware, because they are designed to suit the computer architecture. This thesis describes the implementation details and the underlying algorithm engineering methodology, so that both may also be applied to other applications

The discretized polyhedra simplification (DPS): a framework for polyhedra simplification based on decomposition schemes

This work discusses simplification algorithms for the generation of a multiresolution family of solid representations from an initial polyhedral solid. We introduce the Discretized Polyhedra Simplification (DPS), a framework for polyhedra simplification using space decomposition models. The DPS is based on a new error measurement and provides a sound scheme for error-bounded, geometry and topology simplification while preserving the validity of the model. A method following this framework, Direct DPS, is presented and discussed. Direct DPS uses an octree for topology simplification and error control, and generates valid solid representations. Our method is also able to generate approximations which do not interpenetrate the original model, either being completely contained in the input solid or bounding it. Unlike most of the current methods, our algorithm can deal and also produces faces with arbitrary complexity. An extension of the Direct method for appearance preservation, called Hybrid DPS, is also discussed