Sch 29482, laboratory evaluation of a new penem antibiotic

The antibacterial activity of a new penem antibiotic, Sch 29482 (SCH), was examined in comparison with appropriate cephalosporins and penicillins. The drug inhibited penicillinase-positive and negative staphylococci equally well, being 2-5 times more active than cephalothin or cefamandole and 10-20 times more active than methicillin. Staphylococci resistant to methicillin were susceptible to SCH in agar dilution tests. Staphylococci tolerant to methicillin were also tolerant to SCH. Streptococci and pneumococci were highly susceptible to the drug. The agent was of only moderate activity against enterococci, especially Streptococcus faecium strains. MICs of ampicillin and penicillin G against enterococci were 4-8 times lower than those of SCH. SCH was bactericidal. Neither the choice of the method used for susceptibility testing, nor the size of the inoculum nor various test media influenced the in-vitro activity of this drug against a representative collection of Gram-negative and Gram-positive bacteri

Fault-free validation of a fault-tolerant multiprocessor: Baseline experiments and workoad implementation

In the future, aircraft employing active control technology must use highly reliable multiprocessors in order to achieve flight safety. Such computers must be experimentally validated before they are deployed. This project outlines a methodology for doing fault-free validation of reliable multiprocessors. The methodology begins with baseline experiments, which test single phenomenon. As experiments progress, tools for performance testing are developed. This report presents the results of interrupt baseline experiments performed on the Fault-Tolerant Multiprocessor (FTMP) at NASA-Langley's AIRLAB. Interrupt-causing excepting conditions were tested, and several were found to have unimplemented interrupt handling software while one had an unimplemented interrupt vector. A synthetic workload model for realtime multiprocessors is then developed as an application level performance analysis tool. Details of the workload implementation and calibration are presented. Both the experimental methodology and the synthetic workload model are general enough to be applicable to reliable multi-processors besides FTMP

Sensor-fault tolerance using robust MPC with set-based state estimation and active fault isolation

In this paper, a sensor fault-tolerant control (FTC) scheme using robust model predictive control (MPC) and set theoretic fault detection and isolation (FDI) is proposed. The MPC controller is used to both robustly control the plant and actively guarantee fault isolation (FI). In this scheme, fault detection (FD) is passive by interval observers, while fault isolation (FI) is active by MPC. The advantage of the proposed approach consists in using MPC to actively decouple the effect of sensor faults on the outputs such that one output component only corresponds to one sensor fault in terms of FI, which can utilize the feature of sensor faults for FI. A numerical example is used to illustrate the effectiveness of the proposed scheme.Postprint (author’s final draft

Radiation Risks and Mitigation in Electronic Systems

Electrical and electronic systems can be disturbed by radiation-induced effects. In some cases, radiation-induced effects are of a low probability and can be ignored; however, radiation effects must be considered when designing systems that have a high mean time to failure requirement, an impact on protection, and/or higher exposure to radiation. High-energy physics power systems suffer from a combination of these effects: a high mean time to failure is required, failure can impact on protection, and the proximity of systems to accelerators increases the likelihood of radiation-induced events. This paper presents the principal radiation-induced effects, and radiation environments typical to high-energy physics. It outlines a procedure for designing and validating radiation-tolerant systems using commercial off-the-shelf components. The paper ends with a worked example of radiation-tolerant power converter controls that are being developed for the Large Hadron Collider and High Luminosity-Large Hadron Collider at CERN.Comment: 19 pages, contribution to the 2014 CAS - CERN Accelerator School: Power Converters, Baden, Switzerland, 7-14 May 201

Shared memory for a fault-tolerant computer

A system is described for sharing a memory in a fault-tolerant computer. The memory is under the direct control and monitoring of error detecting and error diagnostic units in the fault-tolerant computer. This computer verifies that data to and from the memory is legally encoded and verifies that words read from the memory at a desired address are, in fact, actually delivered from that desired address. The means are provided for a second processor, which is independent of the direct control and monitoring of the error checking and diagnostic units of the fault-tolerant computer, and to share the memory of the fault-tolerant computer. Circuitry is included to verify that: (1) the processor has properly accessed a desired memory location in the memory; (2) a data word read-out from the memory is properly coded; and (3) no inactive memory was erroneously outputting data onto the shared memory bus

Robust MPC for actuator-fault tolerance using set-based passive fault detection and active fault isolation

In this paper, an actuator fault-tolerant control (FTC) scheme is proposed, which is based on tube-based model predictive control (MPC) and set-theoretic fault detection and isolation (FDI). As a robust MPC technique, tube-based MPC, can effectively deal with system constraints and uncertainties with relatively low computational complexity. Set-based FDI can robustly detect and isolate actuator faults. Here, fault detection (FD) is passive by invariant sets, while fault isolation (FI) is active by tubes. Using the constraint-handling ability of MPC controllers, an active FI approach is implemented. A numerical example illustrates the effectiveness of the proposed approach.Postprint (author’s final draft

Implementing fault tolerant applications using reflective object-oriented programming

Abstract: Shows how reflection and object-oriented programming can be used to ease the implementation of classical fault tolerance mechanisms in distributed applications. When the underlying runtime system does not provide fault tolerance transparently, classical approaches to implementing fault tolerance mechanisms often imply mixing functional programming with non-functional programming (e.g. error processing mechanisms). The use of reflection improves the transparency of fault tolerance mechanisms to the programmer and more generally provides a clearer separation between functional and non-functional programming. The implementations of some classical replication techniques using a reflective approach are presented in detail and illustrated by several examples, which have been prototyped on a network of Unix workstations. Lessons learnt from our experiments are drawn and future work is discussed