Yeast Protein Interactome Topology Provides Framework for Coordinated-Functionality

The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and `Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pair-wise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.Comment: Final, revised version. 13 pages. Please see Nucleic Acids open access article for higher resolution figure

Developing front-end Web 2.0 technologies to access services, content and things in the future Internet

The future Internet is expected to be composed of a mesh of interoperable web services accessible from all over the web. This approach has not yet caught on since global user?service interaction is still an open issue. This paper states one vision with regard to next-generation front-end Web 2.0 technology that will enable integrated access to services, contents and things in the future Internet. In this paper, we illustrate how front-ends that wrap traditional services and resources can be tailored to the needs of end users, converting end users into prosumers (creators and consumers of service-based applications). To do this, we propose an architecture that end users without programming skills can use to create front-ends, consult catalogues of resources tailored to their needs, easily integrate and coordinate front-ends and create composite applications to orchestrate services in their back-end. The paper includes a case study illustrating that current user-centred web development tools are at a very early stage of evolution. We provide statistical data on how the proposed architecture improves these tools. This paper is based on research conducted by the Service Front End (SFE) Open Alliance initiative

Web-course search engine : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Computer Science at Massey University

The World Wide Web is an amazing place that people's lives more and more rely on. Especially, for the young generation, they spend a significant amount of their play and study time using the Internet. Many tools have been developed to help the educational users in finding educational resources. These tools include various search engines. Web directories and educational domain gateways. Nevertheless, these systems have many weaknesses that made them unsuitable for the specific search needs of the learners. The research presented in this thesis describes the development of the Web-course search engine, which is a friendly, efficient and accurate helper for the learners to get what they want in the vast Internet ocean. The most attractive feature of this system is that the system uses one universal language, which lets the searchers and the resources "communicate" with each other. Then the learner searchers can find the Web-based educational resources that are most fit to their needs and course providers can provide all necessary information about their courseware. This universal language is one widely acceptable Metadata standard. Following the Metadata standard, the system collects exact information about educational resources, provides adequate search parameters for search and returns evaluative results. By using the Web-course search engine, the learners and the other educational users are able to find useful, valuable and related educational resources more effectively and efficiently. Some improvement suggestions of the search mechanism in the World Wide Web have been brought forward for the future research as a result of this project

SGXIO: Generic Trusted I/O Path for Intel SGX

Application security traditionally strongly relies upon security of the underlying operating system. However, operating systems often fall victim to software attacks, compromising security of applications as well. To overcome this dependency, Intel introduced SGX, which allows to protect application code against a subverted or malicious OS by running it in a hardware-protected enclave. However, SGX lacks support for generic trusted I/O paths to protect user input and output between enclaves and I/O devices. This work presents SGXIO, a generic trusted path architecture for SGX, allowing user applications to run securely on top of an untrusted OS, while at the same time supporting trusted paths to generic I/O devices. To achieve this, SGXIO combines the benefits of SGX's easy programming model with traditional hypervisor-based trusted path architectures. Moreover, SGXIO can tweak insecure debug enclaves to behave like secure production enclaves. SGXIO surpasses traditional use cases in cloud computing and makes SGX technology usable for protecting user-centric, local applications against kernel-level keyloggers and likewise. It is compatible to unmodified operating systems and works on a modern commodity notebook out of the box. Hence, SGXIO is particularly promising for the broad x86 community to which SGX is readily available.Comment: To appear in CODASPY'1

Student-Centered Learning: Functional Requirements for Integrated Systems to Optimize Learning

The realities of the 21st-century learner require that schools and educators fundamentally change their practice. "Educators must produce college- and career-ready graduates that reflect the future these students will face. And, they must facilitate learning through means that align with the defining attributes of this generation of learners."Today, we know more than ever about how students learn, acknowledging that the process isn't the same for every student and doesn't remain the same for each individual, depending upon maturation and the content being learned. We know that students want to progress at a pace that allows them to master new concepts and skills, to access a variety of resources, to receive timely feedback on their progress, to demonstrate their knowledge in multiple ways and to get direction, support and feedback from—as well as collaborate with—experts, teachers, tutors and other students.The result is a growing demand for student-centered, transformative digital learning using competency education as an underpinning.iNACOL released this paper to illustrate the technical requirements and functionalities that learning management systems need to shift toward student-centered instructional models. This comprehensive framework will help districts and schools determine what systems to use and integrate as they being their journey toward student-centered learning, as well as how systems integration aligns with their organizational vision, educational goals and strategic plans.Educators can use this report to optimize student learning and promote innovation in their own student-centered learning environments. The report will help school leaders understand the complex technologies needed to optimize personalized learning and how to use data and analytics to improve practices, and can assist technology leaders in re-engineering systems to support the key nuances of student-centered learning