Non-Invasive Picosecond Pulse System for Electrostimulation

Picosecond pulsed electric fields have been shown to have stimulatory effects, such as calcium influx, activation of action potential, and membrane depolarization, on biological cells. Because the pulse duration is so short, it has been hypothesized that the pulses permeate a cell and can directly affect intracellular cell structures by bypassing the shielding of the membrane. This provides an opportunity for studying new biophysics. Furthermore, radiating picosecond pulses can be efficiently done by a compact antenna because the antenna size is comparable to the pulse width. However, all of the previous bioelectric studies regarding picosecond pulses have been conducted in vitro, using electrodes. There is not yet a device which can non-invasively deliver picosecond-pulsed electric fields to neurological tissue for therapeutic applications. It is unclear whether a radiated electric field at a given penetration depth can reach the threshold to cause biological effects. In this dissertation, a picosecond- pulsed electric field system designed for the electrosimulation of neural cells is presented. This begins with the design of an ultra-wideband biconical dielectric rod antenna. It consists of a dielectrically loaded V-conical launcher which feeds a cylindrical waveguide. The waveguide then transitions into a taper, which acts like a lens to focus the energy in the tissue target. To describe the antenna delivery of picosecond pulses to tissues, the initial performance was simulated using a 3-layer tissue model and then a human head model. The final model was shown to effectively deliver pulses of 11.5 V/m to the brain for a 1 V input. The spot size of the stimulation is on the order of 1 cm. The electric field was able to penetrate to a depth of 2 cm, which is equal to the pulse width of a 200 ps pulse. The antenna was constructed and characterized in free space in time domain and in frequency domain. The experimental results have a good agreement with the simulation. The ultimate biological application relies on adequate electric field. To reach a threshold electric field for effective stimulation, the antenna should be driven by a high voltage, picosecond-pulsed power supply, which, in our case, consists of a nanosecond charging transformer, a parallel-plate transmission line, and a picosecond discharging switch. This transformer was used to charge a parallel-plate transmission line, with the antenna as the load. To generate pulses with a rise time of hundreds of picoseconds, an oil switch with a millimeter gap was used. For the charging, a dual resonance pulse transformer was designed and constructed. The novel aspect of this transformer is has a fast charge time. It was shown to be capable of producing over 100 kV voltages in less than 100 ns. After the closing of the peaking switch and the picosecond rise time generation, the antenna was able to create an electric field of 600 V/cm in the air at a distance of 3 cm. This field was comparable to the simulation. Higher voltage operation was met with dielectric breakdown across the insulation layer that separates the high voltage side and the ground side. Before the designed antenna is used in vivo, it is critical to determine the biological effect of picosecond pulses. This is especially important if we focus on stimulatory effects, which require that the electric field intensity be close to the range that the antenna system can deliver. Toward that end, neural stem cells were chosen to study for the proliferation, metabolism, and gene expression. Instead of using the antenna, the electrodes were used to deliver the pulses to the cells. In order to treat enough cells for downstream analyses, the electrodes were mounted on a 3-D printer head, which could be moved freely and could be controlled accurately by programming. The results show that pulses on the order of 20 kV/cm affect the proliferation, metabolism, and gene expression of both neural and mesenchymal stem cells, without reducing viability. In general, we came to the conclusion that picosecond pulses can be a useful stimulus for a variety of applications, but the possibility of using antennas to directly stimulate tissue functions relies on the development of a pulsed power system, high voltage insulation, and antenna material

Design and application of a contact barcode reader, for use on low-visibility printed conductive patterns

This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.This thesis presents the design and development of a hand-held electronic reader, designed to decode conductive patterns printed on a paper substrate. Data read from the patterns, by the reader, is used to trigger events in the digital domain. The reader and associated conductive patterns are devices for linking paper documents with the digital world. The patterns are formed by masking conductive-coated paper with a non-conductive, printed lacquer. The reader is a low cost and ergonomic device, capable of transmitting the embedded data from the conductive paper to the computer. The first reader designed and developed was tethered to a computer by data cable, using the USB communication protocol. The second design was developed further, with transmission of data achieved by replacing the cable with short-range Bluetooth wireless technology. Both devices were designed and developed using embedded systems and low cost electronic components. Additional work was undertaken to optimise the device's mechanical structure, ergonomics and integration of hardware. Alongside the development of the reader, test and development work was carried out to optimise the printed media, in materials and design. User trials demonstrated that the complete printed and reading system was functional, with varied rates of success among participants. Further work is required to improve the conductivity of the coated paper, and the accuracy of the decoding algorithm.This work resulted from a research project funded by EU FP6

Viking '75 spacecraft design and test summary. Volume 1: Lander design

The Viking Mars program is summarized. The design of the Viking lander spacecraft is described

Impulse ageing of polymeric materials

Impulse over-voltage is a common phenomenon in electric power systems. A switching impulse is created by a switching surge or local fault while a lightning impulse is due to direct lightning strike to high voltage plant such as an overhead line. Both impulse events create travelling waves in the system, damaging insulation components and equipment. This work is concerned with the hypothesis that lightning impulses can lead to accelerated ageing of extruded polymeric cables. The results show that there may well be a reduction in electric field strength of the insulation of a power cable that experiences a lot of impressed lightning impulse over-voltages. Pre-designed shaped polyethylene material sample discs have been manufactured using a mould tool. The samples then have been electrically aged using an impulse generator. A real-time software based monitoring tool has been designed to control the impulse wave-shape and process the measurement data. Sets of identical lightning impulses were applied to samples and this was then followed by ramped AC breakdown tests. The obtained results were analyzed using the Weibull distribution to identify any differences in lifetime between aged and un-aged samples. This thesis also provides insight into the dominant ageing processes through the analysis of dielectric spectroscopy and space charge measurement data. In order to quantify the effects of dielectric ageing due to impressed lighting impulse over voltages, experiments have also been undertaken using samples that have been aged under UV light and thermally. Analysis of obtained results reveals that mechanisms of these two ageing processes are significantly different from the mechanisms due to lightning impulse agein

Engineering study for a mass memory system for advanced spacecrafts Final report, 1 Dec. 1969 - 1 Jul. 1970

Mass memory system for advanced spacecraf

Artificial Intelligence-based Cybersecurity for Connected and Automated Vehicles

The damaging effects of cyberattacks to an industry like the Cooperative Connected and Automated Mobility (CCAM) can be tremendous. From the least important to the worst ones, one can mention for example the damage in the reputation of vehicle manufacturers, the increased denial of customers to adopt CCAM, the loss of working hours (having direct impact on the European GDP), material damages, increased environmental pollution due e.g., to traffic jams or malicious modifications in sensors’ firmware, and ultimately, the great danger for human lives, either they are drivers, passengers or pedestrians. Connected vehicles will soon become a reality on our roads, bringing along new services and capabilities, but also technical challenges and security threats. To overcome these risks, the CARAMEL project has developed several anti-hacking solutions for the new generation of vehicles. CARAMEL (Artificial Intelligence-based Cybersecurity for Connected and Automated Vehicles), a research project co-funded by the European Union under the Horizon 2020 framework programme, is a project consortium with 15 organizations from 8 European countries together with 3 Korean partners. The project applies a proactive approach based on Artificial Intelligence and Machine Learning techniques to detect and prevent potential cybersecurity threats to autonomous and connected vehicles. This approach has been addressed based on four fundamental pillars, namely: Autonomous Mobility, Connected Mobility, Electromobility, and Remote Control Vehicle. This book presents theory and results from each of these technical directions

The effects of crosslinking byproducts on the electrical properties of low density polyethylene

Crosslinked polyethylene (XLPE) is widely used for high voltage insulation in power transmission systems. However, it has been found that, after crosslinking with Dicumyl Peroxide (DCP), the crosslinking byproducts such as acetophenone, ?-methylstyrene and cumyl alcohol have a significant influence on electrical properties of XLPE power cables. This thesis distinguished the individual contribution of the crosslinking byproducts on space charge formation, dielectric properties, dc conductivity as well as the ac breakdown strength. Percentage weight increases as well as the Fourier Transform Infrared (FTIR) spectrum were used to monitor the chemical level in the soaked samples. Despite high concentration of byproducts in the LDPE film compared to practical, the measurement results have successfully reveal the contribution of each byproduct on the electrical properties. It should be noted that some consideration should be taken when taking the quantitative value from the result obtained. Space charge accumulation was measured using the pulsed electroacoustic (PEA) technique. Homocharges are observed in acetophenone and ?-methylstyrene soaked LDPE. Meanwhile heterocharge formed in cumyl alcohol soaked LDPE. From the charge decay profile in dc condition, these chemicals are observed to assist the transportation of the charges in the sample bulk due to shallow traps from the byproducts. These shallow traps assist the trapping process into deep traps when ac field is applied to the byproduct soaked LDPE. As a result, more charges trapped in deep traps were found in soaked LDPE compared to clean LDPE. In addition, from the space charge measurement in ac condition, it is proved that the amount of charge trapped in deep traps also depends on the population of shallow traps in the polymer which is contradicted to the literature where the byproducts are normally associated to the deep traps. Permittivity values of acetophenone, ?-methylstyrene soaked LDPE and cumyl alcohol are slightly higher than permittivity value of the clean untreated LDPE. Cumyl alcohol soaked LDPE has higher dielectric loss at lower frequency due to Maxwell-Wagner-Sillars polarisation as well as space charge polarisation effect. In contrast, acetophenone does not change the dielectric loss value and ?-methylstyrene gives very little effect. These byproducts have very high dc conductivity values. It is also proposed that the chemicals provide shallow traps that aid the charge movement and this is consistent with the mobility values that calculated from the conduction current result. The ac breakdown results however show no significant difference from the breakdown strength of clean LDPE. Based on ac space charge results and ac breakdown test results, it is concluded that the byproducts have little effects in ac conditio

Microelectromechanical Systems and Devices

The advances of microelectromechanical systems (MEMS) and devices have been instrumental in the demonstration of new devices and applications, and even in the creation of new fields of research and development: bioMEMS, actuators, microfluidic devices, RF and optical MEMS. Experience indicates a need for MEMS book covering these materials as well as the most important process steps in bulk micro-machining and modeling. We are very pleased to present this book that contains 18 chapters, written by the experts in the field of MEMS. These chapters are groups into four broad sections of BioMEMS Devices, MEMS characterization and micromachining, RF and Optical MEMS, and MEMS based Actuators. The book starts with the emerging field of bioMEMS, including MEMS coil for retinal prostheses, DNA extraction by micro/bio-fluidics devices and acoustic biosensors. MEMS characterization, micromachining, macromodels, RF and Optical MEMS switches are discussed in next sections. The book concludes with the emphasis on MEMS based actuators

Resilient and Real-time Control for the Optimum Management of Hybrid Energy Storage Systems with Distributed Dynamic Demands

A continuous increase in demands from the utility grid and traction applications have steered public attention toward the integration of energy storage (ES) and hybrid ES (HESS) solutions. Modern technologies are no longer limited to batteries, but can include supercapacitors (SC) and flywheel electromechanical ES well. However, insufficient control and algorithms to monitor these devices can result in a wide range of operational issues. A modern day control platform must have a deep understanding of the source. In this dissertation, specialized modular Energy Storage Management Controllers (ESMC) were developed to interface with a variety of ES devices. The EMSC provides the capability to individually monitor and control a wide range of different ES, enabling the extraction of an ES module within a series array to charge or conduct maintenance, while remaining storage can still function to serve a demand. Enhancements and testing of the ESMC are explored in not only interfacing of multiple ES and HESS, but also as a platform to improve management algorithms. There is an imperative need to provide a bridge between the depth of the electrochemical physics of the battery and the power engineering sector, a feat which was accomplished over the course of this work. First, the ESMC was tested on a lead acid battery array to verify its capabilities. Next, physics-based models of lead acid and lithium ion batteries lead to the improvement of both online battery management and established multiple metrics to assess their lifetime, or state of health. Three unique HESS were then tested and evaluated for different applications and purposes. First, a hybrid battery and SC HESS was designed and tested for shipboard power systems. Next, a lithium ion battery and SC HESS was utilized for an electric vehicle application, with the goal to reduce cycling on the battery. Finally, a lead acid battery and flywheel ES HESS was analyzed for how the inclusion of a battery can provide a dramatic improvement in the power quality versus flywheel ES alone