Pathophysiology, histopathology and therapeutic of SARS-CoV-2

The rapid transmission of SARS-CoV-2 through the world has induced the scientist to understand the histopathology of the virus and then to find an effective drug. However, many of the point associated with the virus pathogenicity still unknown and need more studies. In this chapter the pathophysiology, histopathology and therapeutic of SARS-CoV-2 has been reviewed. It was appeared that pathogenicity of SARS-CoV-2 is belonging to the viral with genome structure which acting by blocking the host innate immune response. Both chloroquine and hydroxyl-chloroquine have similar structure and mechanism action and they are among the most effective antiviral for treating the patents with the SARS-CoV-2. Chloroquine works by inhibition the intracellular organism by increasing the pH

The public health risk posed by Listeria monocytogenes in frozen fruit and vegetables including herbs, blanched during processing

A multi-country outbreak ofListeria monocytogenesST6 linked to blanched frozen vegetables (bfV)took place in the EU (2015–2018). Evidence of food-borne outbreaks shows thatL. monocytogenesisthe most relevant pathogen associated with bfV. The probability of illness per serving of uncooked bfV,for the elderly (65–74 years old) population, is up to 3,600 times greater than cooked bfV and verylikely lower than any of the evaluated ready-to-eat food categories. The main factors affectingcontamination and growth ofL. monocytogenesin bfV during processing are the hygiene of the rawmaterials and process water; the hygienic conditions of the food processing environment (FPE); andthe time/Temperature (t/T) combinations used for storage and processing (e.g. blanching, cooling).Relevant factors after processing are the intrinsic characteristics of the bfV, the t/T combinations usedfor thawing and storage and subsequent cooking conditions, unless eaten uncooked. Analysis of thepossible control options suggests that application of a complete HACCP plan is either not possible orwould not further enhance food safety. Instead, specific prerequisite programmes (PRP) andoperational PRP activities should be applied such as cleaning and disinfection of the FPE, water control,t/T control and product information and consumer awareness. The occurrence of low levels ofL. monocytogenesat the end of the production process (e.g.<10 CFU/g) would be compatible with thelimit of 100 CFU/g at the moment of consumption if any labelling recommendations are strictly followed(i.e. 24 h at 5°C). Under reasonably foreseeable conditions of use (i.e. 48 h at 12°C),L. monocytogeneslevels need to be considerably lower (not detected in 25 g). Routine monitoring programmes forL. monocytogenesshould be designed following a risk-based approach and regularly revised based ontrend analysis, being FPE monitoring a key activity in the frozen vegetable industry

Cost minimization for unstable concurrent products in multi-stage production line using queueing analysis

This research and resulting contribution are results of Assumption University of Thailand. The university partially supports financially the publication.Purpose: The paper copes with the queueing theory for evaluating a muti-stage production line process with concurrent goods. The intention of this article is to evaluate the efficiency of products assembly in the production line. Design/Methodology/Approach: To elevate the efficiency of the assembly line it is required to control the performance of individual stations. The arrival process of concurrent products is piled up before flowing to each station. All experiments are based on queueing network analysis. Findings: The performance analysis for unstable concurrent sub-items in the production line is discussed. The proposed analysis is based on the improvement of the total sub-production time by lessening the queue time in each station. Practical implications: The collected data are number of workers, incoming and outgoing sub-products, throughput rate, and individual station processing time. The front loading place unpacks product items into concurrent sub-items by an operator and automatically sorts them by RFID tag or bar code identifiers. Experiments of the work based on simulation are compared and validated with results from real approximation. Originality/Value: It is an alternative improvement to increase the efficiency of the operation in each station with minimum costs.peer-reviewe

Multi-response Modelling of the Maillard reaction in a model cheese

International audienceProcessed cheese derives from a secondary milk processing step that involves mixing and heating dairy (cheese, butter and milk powders) and non-dairy products (emulsifiers). This processing yields a homogeneous product, usually spreadable, with a shelf-life often longer than 6 months. During cheese processing and storage, lipid oxidation, caramelization and Maillard reactions occur and produce odour-active compounds. In this study, a methodological approach was used in order to (i) identify odorants responsible for flavor attributes or compouds involved in the reaction chain, (ii) monitor the evolution of these markers during the heat treatment applied to the matrix, (iii) establish an observable reaction scheme and (iv) model and predict the evolution of these compounds during thermal operations. In this aim, a model cheese and a cooking cell were elaborated. Various couplings of gas chromatography with olfactometry were used to identify odorous compounds. Two-dimensional comprehensive chromatography allowed a semi-quantitation of trace and ultra-trace compounds, while precursors were quantitated by high performance liquid chromatography. An observable reaction scheme of the Maillard reaction was extracted from these data and makes the multi-response modeling step possible despite a partial quantitation of the volatile compounds. Finally, we obtained a formal model combining 19 components (including four odorants) connected by 14 stoechiometric balanced reactions. This model makes it possible to predict the evolution of these components depending on the initial content of lactose, galactose and according to the heat treatment applied to the cheese matrix. This work was carried out with the financial support of the ANR-Agence Nationale de la Recherche-The French National Research Agency under the Programme National de Recherche en Alimentation et nutrition humaine , project ANR-06-PNRA-023REACTIAL "Prediction and control of the appearance or disappearance of reactional markers during food process and conservation "

A Decentralized Processing Schema for Efficient and Robust Real-time Multi-GNSS Satellite Clock Estimation

Real-time multi-GNSS precise point positioning (PPP) requires the support of high-rate satellite clock corrections. Due to the large number of ambiguity parameters, it is difficult to update clocks at high frequency in real-time for a large reference network. With the increasing number of satellites of multi-GNSS constellations and the number of stations, real-time high-rate clock estimation becomes a big challenge. In this contribution, we propose a decentralized clock estimation (DECE) strategy, in which both undifferenced (UD) and epoch-differenced (ED) mode are implemented but run separately in different computers, and their output clocks are combined in another process to generate a unique product. While redundant UD and/or ED processing lines can be run in offsite computers to improve the robustness, processing lines for different networks can also be included to improve the clock quality. The new strategy is realized based on the Position and Navigation Data Analyst (PANDA) software package and is experimentally validated with about 110 real-time stations for clock estimation by comparison of the estimated clocks and the PPP performance applying estimated clocks. The results of the real-time PPP experiment using 12 global stations show that with the greatly improved computational efficiency, 3.14 cm in horizontal and 5.51 cm in vertical can be achieved using the estimated DECE clock

A modular hybrid simulation framework for complex manufacturing system design

For complex manufacturing systems, the current hybrid Agent-Based Modelling and Discrete Event Simulation (ABM–DES) frameworks are limited to component and system levels of representation and present a degree of static complexity to study optimal resource planning. To address these limitations, a modular hybrid simulation framework for complex manufacturing system design is presented. A manufacturing system with highly regulated and manual handling processes, composed of multiple repeating modules, is considered. In this framework, the concept of modular hybrid ABM–DES technique is introduced to demonstrate a novel simulation method using a dynamic system of parallel multi-agent discrete events. In this context, to create a modular model, the stochastic finite dynamical system is extended to allow the description of discrete event states inside the agent for manufacturing repeating modules (meso level). Moreover, dynamic complexity regarding uncertain processing time and resources is considered. This framework guides the user step-by-step through the system design and modular hybrid model. A real case study in the cell and gene therapy industry is conducted to test the validity of the framework. The simulation results are compared against the data from the studied case; excellent agreement with 1.038% error margin is found in terms of the company performance. The optimal resource planning and the uncertainty of the processing time for manufacturing phases (exo level), in the presence of dynamic complexity is calculated

The Potential of an Enhanced Cooperation Measure in the EAFRD (2014-2020): the case of Ireland

This report was funded by the Department of Agriculture, Food and the Marine (DAFM) through the National Rural Network (February-May, 2012).The current Proposal for a Regulation of the European Parliament and of the Council on support for Rural Development by the European Agricultural Fund for Rural Development (EAFRD) includes Article (36) Cooperation that is potentially instrumental for realising the objectives of FOOD HARVEST 20204. The purpose of this report is to assess the scope and potential of Article 36 in the context of Irish agriculture and its findings have four key aspects. First, the main areas of confluence between Article 36 and primary policy objectives as set out in Food Harvest 2020 are identified. Second, a range of cooperation categories and types relevant to Article 36, many of which are operational in Ireland, are profiled. Third, drawing from case-studies of these co-operation types5, the operational characteristics of each type are presented, focusing on compatibility with Article 36. Possible supports that would encourage and assist the formation and operation of the cooperation types on a broad scale into the future, and also any possible constraints that would prevent success, are indicated. Fourth, a brief discussion of some key implementation considerations arising from the analysis overall is presented.Department of Agriculture, Food and the Marin