Quasi-static imaged-based immersed boundary-finite element model of human left ventricle in diastole

SUMMARY: Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient-specific models of the left ventricle using an immersed boundary (IB) method with a finite element (FE) structural mechanics model. We use a structure-based hyperelastic strain-energy function to describe the passive mechanics of the ventricular myocardium, a realistic anatomical geometry reconstructed from clinical magnetic resonance images of a healthy human heart, and a rule-based fiber architecture. Numerical predictions of this IB/FE model are compared with results obtained by a commercial FE solver. We demonstrate that the IB/FE model yields results that are in good agreement with those of the conventional FE model under diastolic loading conditions, and the predictions of the LV model using either numerical method are shown to be consistent with previous computational and experimental data. These results are among the first to analyze the stress and strain predictions of IB models of ventricular mechanics, and they serve both to verify the IB/FE simulation framework and to validate the IB/FE model. Moreover, this work represents an important step toward using such models for fully dynamic fluid–structure interaction simulations of the heart

Simulation of incompressible viscous flows around moving objects by a variant of immersed boundary-Lattice Boltzmann method

A variant of immersed boundary-lattice Boltzmann method (IB-LBM) is presented in this paper to simulate incompressible viscous flows around moving objects. As compared with the conventional IB-LBM where the force density is computed explicitly by Hook's law or the direct forcing method and the non-slip condition is only approximately satisfied, in the present work, the force density term is considered as the velocity correction which is determined by enforcing the non-slip condition at the boundary. The lift and drag forces on the moving object can be easily calculated via the velocity correction on the boundary points. The capability of the present method for moving objects is well demonstrated through its application to simulate flows around a moving circular cylinder, a rotationally oscillating cylinder, and an elliptic flapping wing. Furthermore, the simulation of flows around a flapping flexible airfoil is carried out to exhibit the ability of the present method for implementing the elastic boundary condition. It was found that under certain conditions, the flapping flexible airfoil can generate larger propulsive force than the flapping rigid airfoil

A Simulation Method to Resolve Hydrodynamic Interactions in Colloidal Dispersions

A new computational method is presented to resolve hydrodynamic interactions acting on solid particles immersed in incompressible host fluids. In this method, boundaries between solid particles and host fluids are replaced with a continuous interface by assuming a smoothed profile. This enabled us to calculate hydrodynamic interactions both efficiently and accurately, without neglecting many-body interactions. The validity of the method was tested by calculating the drag force acting on a single cylindrical rod moving in an incompressible Newtonian fluid. This method was then applied in order to simulate sedimentation process of colloidal dispersions.Comment: 7pages, 7 figure