DNA Confinement drives uncoating of the HIV Virus

We present a model for the uncoating of the HIV virus driven by forces exerted on the protein shell of HIV generated by DNA confinement

The Use of Layered Freeform Fabrication Technologies to Produce Tissue Engineering Scaffolds for Skull Patches

Congenital skull defects in infants are difficult to correct using metal plates due to the growth of the skull. Tissue engineering of bone patches could be the answer to help such patients. Custom scaffolds have been designed based on Computed Tomography (CT) images of the patient’s skull. An in-house developed single screw extruder, casting and a commercial laser cutter has been evaluated in the fabrication of pure polycaprolactone (PCL) scaffolds as well as PCL mixed with hydroxyapatite (HA) scaffolds. Evaluation criteria for each process included the ability to maintain an optimal pore size for cells to proliferate, inclusion of micro surface properties for cell adhesion, incorporation of hydroxyapatite, and ability to maintain desired shape. The mechanical properties of the fabricated scaffolds will be presented in this paper as well as initial cell seeding results with human adipose-derived adult stem (hADAS) cells.Mechanical Engineerin

A multi-level interface model for damaged masonry

The aim of the present work is to propose a new micro-mechanical model in the context of the deductive approach used to derive interface models. This model, based on a previous study introduced previously by A. Rekik and F. Lebon, is used to reproduce the damage in masonry by combining structural analysis and homogenization methods. The focal point of this method is to assume the existence of a third material, called interphase, which is a mixture of the two principal constituents of masonry, brick and mortar, and that is the interface between them. This new element presents a low thickness, a low stiffness and a given damage ratio. The mechanical problem of masonry, initially a 3D problem, is solved numerically as a 2D problem using finite element methods. The properties of the interface brick-mortar material are obtained using three essentials steps. First of all, an exact homogenisation of a laminates is used to define a first homogeneous equivalent medium named HEM-1. After, the assumption of damaged material is taken into account by using the general framework given by M. Kachanov to evaluate the global behaviour of the damaged HEM-1 defining thus a second equivalent homogeneous medium noted HEM-2. The last step consists in using an asymptotic analysis technique which is performed to model HEM-2 as an interface or a joint. The properties of this joint are deduced from those of the HEM-2 material as proposed in former papers. Particularly, through the second homogenization are taken into account the variability of microcracks oriented family and simultaneously the opening-closure effects (unilateral behaviour). Numerically this interface is modelled with connector finite elements. Numerical results are compared to experimental ones available in the literature

Grappling with Issues of Learning Science from Everyday Experiences: An Illustrative Case Study

There are different perceptions among researchers with regard to the infusion of everyday experience in the teaching of science: 1) it hinders the learning of science concepts; or, 2) it increases the participation and motivation of students in science learning. This article attempts to contemplate those different perspectives of everyday knowledge in science classrooms by using everyday contexts to teach grade 3 science in Singapore. In this study, two groups of grade 3 students were presented with a scenario that required them to apply the concept of properties of materials to design a shoe. Subsequently, the transcripts of classroom discussions and interactions were analyzed using the framework of sociocultural learning and an interpretative analytic lens. Our analysis suggests that providing an authentic everyday context is insufficient to move young learners of science from their everyday knowledge to scientific knowledge. Further, group interactions among young learners of science to solve an everyday issue need to be scaffolded to ensure meaningful, focused, and sustained learning. Implications for research in science learning among younger students are discussed

Earthen construction: structural vulnerabilities and retrofit solutions for seismic actions

Earthen structures present very appealing characteristics regarding a more sustainable practice with the preservation of our natural resources. However, when subjected to earthquake ground motions, this type of construction may present a deficient performance, which may cause significant human losses and important structural damage. The seismic response of earthen structures is typically characterized by fragile failures. There are several examples of recent earthquakes that affected earthen buildings in a severe way, evidencing the vulnerability of this type of construction, like the El Salvador earthquake, in 2001, the Bam, Iran earthquake, in 2003, the Pisco, Peru earthquake, in 2007 and the Maule, Chile earthquake, in 2010. The construction of earth structures on earthquake-prone areas must be carefully studied and should include seismic reinforcement solutions in order to improve their seismic performance. In this paper, the performance of earthen structures in recent earthquakes will be examined, analyzing failure modes inherent to these particular construction materials and associated construction techniques. Also, seismic reinforcement approaches and techniques will be presented in a comprehensive manner. Examples of tests conducted for the assessment of retrofitting solutions efficiency will be presented, and the results obtained will be discussed

Benthic invertebrates that form habitat on deep banks off southern California, with special reference to deep sea coral

There is increasing interest in the potential impacts that fishing activities have on megafaunal benthic invertebrates occurring in continental shelf and slope ecosystems. We examined how the structure, size, and high-density aggregations of invertebrates provided structural relief for fishes in continental shelf and slope ecosystems off southern California. We made 112 dives in a submersible at 32−320 m water depth, surveying a variety of habitats from high-relief rock to flat sand and mud. Using quantitative video transect methods, we made 12,360 observations of 15 structure-form-ing invertebrate taxa and 521,898 individuals. We estimated size and incidence of epizoic animals on 9105 sponges, black corals, and gorgonians. Size variation among structure-form-ing invertebrates was significant and 90% of the individuals were <0.5 m high. Less than 1% of the observations of organisms actually sheltering in or located on invertebrates involved fishes. From the analysis of spatial associations between fishes and large invertebrates, six of 108 fish species were found more often adjacent to invertebrate colonies than the number of fish predicted by the fish-density data from transects. This finding indicates that there may be spatial associations that do not necessarily include physical contact with the sponges and corals. However, the median distances between these six fish species and the invertebrates were not particularly small (1.0−5.5 m). Thus, it is likely that these fishes and invertebrates are present together in the same habitats but that there is not necessarily a functional relationship between these groups of organisms. Regardless of their associations with fishes, these invertebrates provide structure and diversity for continental shelf ecosystems off southern California and certainly deserve the attention of scientists undertaking future conservation efforts

Studies on the lichen genus Sticta (Schreber) Ach. : 5., Australian species

Twenty five species of Sticta occur in Australia. These are: Sticta baileyi, S. brevipes, S. camarae, S. caperata, S. cyphellulata, S. diversa, S. duplolimbata, S. filix, S. flavocyphellata, S. fuliginosa, S. howei, S. hypopsiloides, S. latifrons, S. limbata, S. marginifera, S. myrioclada, S. pedunculata, S. rutilans, S. sayeri, S. stipitata, S. sublimbata, S. subtomentella, S. variabilis and S. weigelii. A key and descriptions of each taxon are given together with details of biogeography, distribution, ecology and nomenclature. Sticta baileyi, S. flavocyphellata and S. howei are newly described, and Sticta myrioloba (Müll.Arg.) D.J.Galloway comb. & stat. nov., is proposed

Building resilient communities

This paper will explore the concept of resilience from its roots in ecology to the application of this ecological concept of resilience to social and community resilience in the context of climate change. In this context, resilience is seen as a property of complex adaptive communities rather than of individuals. This paper will explore how this ecological concept of resilience has been taken up both by climate adaptation research and by the Transition Town movement. This ecological concept of resilience is at odds with the individualism of both psychological and economic approaches to resilience in relation to climate change

Archives Conservation Discussion Group 2011: Digitization and Its Effect on Conservation Treatment Decisions: How Has Wide-Spread Digitizing of Collections Changed Our Approach to Treatment?

In line with this year’s AIC theme: ETHOS, LOGOS, PATHOS: ethical principles and critical thinking in conservation, The Archives Conservation Discussion Group 2011 examined the impact of providing digital collections in museums and libraries, and their conservation implications. Presentations and a subsequent discussion covered topics such as: How conservators are balancing ethical concerns, especially as dictated by the AIC Code of Ethics, with increased demand from digital projects. How conservators are keeping pace with large-scale or fast-paced digitizing projects, while maintaining standards. And the impact of limiting access to original materials by providing digital surrogates and its effect on treatment decisions