A Survey of Processing Systems for Phylogenetics and Population Genetics

The COVID-19 pandemic brought Bioinformatics into the spotlight, revealing that several existing methods, algorithms, and tools were not well prepared to handle large amounts of genomic data efficiently. This led to prohibitively long execution times and the need to reduce the extent of analyses to obtain results in a reasonable amount of time. In this survey, we review available high-performance computing and hardware-accelerated systems based on FPGA and GPU technology. Optimized and hardware-accelerated systems can conduct more thorough analyses considerably faster than pure software implementations, allowing to reach important conclusions in a timely manner to drive scientific discoveries. We discuss the reasons that are currently hindering high-performance solutions from being widely deployed in real-world biological analyses and describe a research direction that can pave the way to enable this

FPGA acceleration of the phylogenetic likelihood function for Bayesian MCMC inference methods

Background Likelihood (ML)-based phylogenetic inference has become a popular method for estimating the evolutionary relationships among species based on genomic sequence data. This method is used in applications such as RAxML, GARLI, MrBayes, PAML, and PAUP. The Phylogenetic Likelihood Function (PLF) is an important kernel computation for this method. The PLF consists of a loop with no conditional behavior or dependencies between iterations. As such it contains a high potential for exploiting parallelism using micro-architectural techniques. In this paper, we describe a technique for mapping the PLF and supporting logic onto a Field Programmable Gate Array (FPGA)-based co-processor. By leveraging the FPGA\u27s on-chip DSP modules and the high-bandwidth local memory attached to the FPGA, the resultant co-processor can accelerate ML-based methods and outperform state-of-the-art multi-core processors. Results We use the MrBayes 3 tool as a framework for designing our co-processor. For large datasets, we estimate that our accelerated MrBayes, if run on a current-generation FPGA, achieves a 10× speedup relative to software running on a state-of-the-art server-class microprocessor. The FPGA-based implementation achieves its performance by deeply pipelining the likelihood computations, performing multiple floating-point operations in parallel, and through a natural log approximation that is chosen specifically to leverage a deeply pipelined custom architecture. Conclusions Heterogeneous computing, which combines general-purpose processors with special-purpose co-processors such as FPGAs and GPUs, is a promising approach for high-performance phylogeny inference as shown by the growing body of literature in this field. FPGAs in particular are well-suited for this task because of their low power consumption as compared to many-core processors and Graphics Processor Units (GPUs)

FPGA-based acceleration of the RMAP short read mapping tool

Bioinformatics is a quickly emerging field. Next generation sequencing technologies are producing data up to several gigabytes per day, making bioinformatics applications increasingly computationally intensive. In order to achieve greater speeds for processing this data, various techniques have been developed. These techniques involve parallelizing algorithms and/or spreading data across many computing nodes composed of devices such as Microprocessors, Graphics Processing Units (GPUs), and Field Programmable Gate Arrays (FPGAs). In this thesis, an FPGA is used to accelerate a bioinformatics application called RMAP, which is used for Short-Read Mapping. The most computationally intensive function in RMAP, the read mapping function, is implemented on the FPGA\u27s reconfigurable hardware fabric. This is a first step in a larger effort to develop a more optimal hardware/software co-design for RMAP. The Convey HC-1 Hybrid Computing System was used as the platform for development. The short-read mapping functionality of RMAP was implemented on one of the four Xilinx Virtex 5 FPGAs available in the HC-1 system. The RMAP 2.0 software was rewritten to separate the read mapping function to facilitate its porting over to hardware. The implemented design was evaluated by varying input parameters such as genome size and number of reads. In addition, the hardware design was analyzed to find potential bottlenecks. The implementation results showed a speedup of ~5x using datasets with varying number of reads and a fixed reference genome, and ~2x using datasets with varying genome size and a fixed number of reads, for the hardware-implemented short-read mapping function of RMAP

Accelerating Phylogenetics Using FPGAs in the Cloud

Phylogenetics study the evolutionary history of organisms using an iterative process of creating and evaluating phylogenetic trees. This process is very computationally intensive; constructing a large phylogenetic tree requires hundreds to thousands of CPU hours. In this article, we describe an FPGA-based system that can be deployed on AWS EC2 F1 cloud instances to accelerate phylogenetic analyses by boosting performance of the phylogenetic likelihood function, i.e., a widely employed tree-evaluation function that accounts for up to 95% of the overall analysis time. We exploit domain-specific knowledge to reduce the amount of transferred data that limits overall system performance. Our proof-of-concept implementation reveals that the effective accelerator throughput nearly quadruples with optimized data movement, reaching up to 75% of its theoretical peak and nearly 10× faster processing than a CPU using AVX2 extensions

Dynamically reconfigurable bio-inspired hardware

During the last several years, reconfigurable computing devices have experienced an impressive development in their resource availability, speed, and configurability. Currently, commercial FPGAs offer the possibility of self-reconfiguring by partially modifying their configuration bitstream, providing high architectural flexibility, while guaranteeing high performance. These configurability features have received special interest from computer architects: one can find several reconfigurable coprocessor architectures for cryptographic algorithms, image processing, automotive applications, and different general purpose functions. On the other hand we have bio-inspired hardware, a large research field taking inspiration from living beings in order to design hardware systems, which includes diverse topics: evolvable hardware, neural hardware, cellular automata, and fuzzy hardware, among others. Living beings are well known for their high adaptability to environmental changes, featuring very flexible adaptations at several levels. Bio-inspired hardware systems require such flexibility to be provided by the hardware platform on which the system is implemented. In general, bio-inspired hardware has been implemented on both custom and commercial hardware platforms. These custom platforms are specifically designed for supporting bio-inspired hardware systems, typically featuring special cellular architectures and enhanced reconfigurability capabilities; an example is their partial and dynamic reconfigurability. These aspects are very well appreciated for providing the performance and the high architectural flexibility required by bio-inspired systems. However, the availability and the very high costs of such custom devices make them only accessible to a very few research groups. Even though some commercial FPGAs provide enhanced reconfigurability features such as partial and dynamic reconfiguration, their utilization is still in its early stages and they are not well supported by FPGA vendors, thus making their use difficult to include in existing bio-inspired systems. In this thesis, I present a set of architectures, techniques, and methodologies for benefiting from the configurability advantages of current commercial FPGAs in the design of bio-inspired hardware systems. Among the presented architectures there are neural networks, spiking neuron models, fuzzy systems, cellular automata and random boolean networks. For these architectures, I propose several adaptation techniques for parametric and topological adaptation, such as hebbian learning, evolutionary and co-evolutionary algorithms, and particle swarm optimization. Finally, as case study I consider the implementation of bio-inspired hardware systems in two platforms: YaMoR (Yet another Modular Robot) and ROPES (Reconfigurable Object for Pervasive Systems); the development of both platforms having been co-supervised in the framework of this thesis

Embedded electronic systems driven by run-time reconfigurable hardware

Abstract This doctoral thesis addresses the design of embedded electronic systems based on run-time reconfigurable hardware technology –available through SRAM-based FPGA/SoC devices– aimed at contributing to enhance the life quality of the human beings. This work does research on the conception of the system architecture and the reconfiguration engine that provides to the FPGA the capability of dynamic partial reconfiguration in order to synthesize, by means of hardware/software co-design, a given application partitioned in processing tasks which are multiplexed in time and space, optimizing thus its physical implementation –silicon area, processing time, complexity, flexibility, functional density, cost and power consumption– in comparison with other alternatives based on static hardware (MCU, DSP, GPU, ASSP, ASIC, etc.). The design flow of such technology is evaluated through the prototyping of several engineering applications (control systems, mathematical coprocessors, complex image processors, etc.), showing a high enough level of maturity for its exploitation in the industry.Resumen Esta tesis doctoral abarca el diseño de sistemas electrónicos embebidos basados en tecnología hardware dinámicamente reconfigurable –disponible a través de dispositivos lógicos programables SRAM FPGA/SoC– que contribuyan a la mejora de la calidad de vida de la sociedad. Se investiga la arquitectura del sistema y del motor de reconfiguración que proporcione a la FPGA la capacidad de reconfiguración dinámica parcial de sus recursos programables, con objeto de sintetizar, mediante codiseño hardware/software, una determinada aplicación particionada en tareas multiplexadas en tiempo y en espacio, optimizando así su implementación física –área de silicio, tiempo de procesado, complejidad, flexibilidad, densidad funcional, coste y potencia disipada– comparada con otras alternativas basadas en hardware estático (MCU, DSP, GPU, ASSP, ASIC, etc.). Se evalúa el flujo de diseño de dicha tecnología a través del prototipado de varias aplicaciones de ingeniería (sistemas de control, coprocesadores aritméticos, procesadores de imagen, etc.), evidenciando un nivel de madurez viable ya para su explotación en la industria.Resum Aquesta tesi doctoral està orientada al disseny de sistemes electrònics empotrats basats en tecnologia hardware dinàmicament reconfigurable –disponible mitjançant dispositius lògics programables SRAM FPGA/SoC– que contribueixin a la millora de la qualitat de vida de la societat. S’investiga l’arquitectura del sistema i del motor de reconfiguració que proporcioni a la FPGA la capacitat de reconfiguració dinàmica parcial dels seus recursos programables, amb l’objectiu de sintetitzar, mitjançant codisseny hardware/software, una determinada aplicació particionada en tasques multiplexades en temps i en espai, optimizant així la seva implementació física –àrea de silici, temps de processat, complexitat, flexibilitat, densitat funcional, cost i potència dissipada– comparada amb altres alternatives basades en hardware estàtic (MCU, DSP, GPU, ASSP, ASIC, etc.). S’evalúa el fluxe de disseny d’aquesta tecnologia a través del prototipat de varies aplicacions d’enginyeria (sistemes de control, coprocessadors aritmètics, processadors d’imatge, etc.), demostrant un nivell de maduresa viable ja per a la seva explotació a la indústria

On microelectronic self-learning cognitive chip systems

After a brief review of machine learning techniques and applications, this Ph.D. thesis examines several approaches for implementing machine learning architectures and algorithms into hardware within our laboratory. From this interdisciplinary background support, we have motivations for novel approaches that we intend to follow as an objective of innovative hardware implementations of dynamically self-reconfigurable logic for enhanced self-adaptive, self-(re)organizing and eventually self-assembling machine learning systems, while developing this new particular area of research. And after reviewing some relevant background of robotic control methods followed by most recent advanced cognitive controllers, this Ph.D. thesis suggests that amongst many well-known ways of designing operational technologies, the design methodologies of those leading-edge high-tech devices such as cognitive chips that may well lead to intelligent machines exhibiting conscious phenomena should crucially be restricted to extremely well defined constraints. Roboticists also need those as specifications to help decide upfront on otherwise infinitely free hardware/software design details. In addition and most importantly, we propose these specifications as methodological guidelines tightly related to ethics and the nowadays well-identified workings of the human body and of its psyche