Multivariate EEG feature analysis and its application on brain death determination and brain computer interface

埼玉工業大学201

Tensor Decompositions for Signal Processing Applications From Two-way to Multiway Component Analysis

The widespread use of multi-sensor technology and the emergence of big datasets has highlighted the limitations of standard flat-view matrix models and the necessity to move towards more versatile data analysis tools. We show that higher-order tensors (i.e., multiway arrays) enable such a fundamental paradigm shift towards models that are essentially polynomial and whose uniqueness, unlike the matrix methods, is guaranteed under verymild and natural conditions. Benefiting fromthe power ofmultilinear algebra as theirmathematical backbone, data analysis techniques using tensor decompositions are shown to have great flexibility in the choice of constraints that match data properties, and to find more general latent components in the data than matrix-based methods. A comprehensive introduction to tensor decompositions is provided from a signal processing perspective, starting from the algebraic foundations, via basic Canonical Polyadic and Tucker models, through to advanced cause-effect and multi-view data analysis schemes. We show that tensor decompositions enable natural generalizations of some commonly used signal processing paradigms, such as canonical correlation and subspace techniques, signal separation, linear regression, feature extraction and classification. We also cover computational aspects, and point out how ideas from compressed sensing and scientific computing may be used for addressing the otherwise unmanageable storage and manipulation problems associated with big datasets. The concepts are supported by illustrative real world case studies illuminating the benefits of the tensor framework, as efficient and promising tools for modern signal processing, data analysis and machine learning applications; these benefits also extend to vector/matrix data through tensorization. Keywords: ICA, NMF, CPD, Tucker decomposition, HOSVD, tensor networks, Tensor Train

Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography

Anterior temporal lobe resection is often complicated by superior quadrantic visual field deficits (VFDs). In some cases this can be severe enough to prohibit driving, even if a patient is free of seizures. These deficits are caused by damage to Meyer's loop of the optic radiation, which shows considerable heterogeneity in its anterior extent. This structure cannot be distinguished using clinical magnetic resonance imaging sequences. Diffusion tensor tractography is an advanced magnetic resonance imaging technique that enables the parcellation of white matter. Using seed voxels antero-lateral to the lateral geniculate nucleus, we applied this technique to 20 control subjects, and 21 postoperative patients. All patients had visual fields assessed with Goldmann perimetry at least three months after surgery. We measured the distance from the tip of Meyer's loop to the temporal pole and horn in all subjects. In addition, we measured the size of temporal lobe resection using postoperative T1-weighted images, and quantified VFDs. Nine patients suffered VFDs ranging from 22% to 87% of the contralateral superior quadrant. In patients, the range of distance from the tip of Meyer's loop to the temporal pole was 24–43 mm (mean 34 mm), and the range of distance from the tip of Meyer's loop to the temporal horn was –15 to +9 mm (mean 0 mm). In controls the range of distance from the tip of Meyer's loop to the temporal pole was 24–47 mm (mean 35 mm), and the range of distance from the tip of Meyer's loop to the temporal horn was –11 to +9 mm (mean 0 mm). Both quantitative and qualitative results were in accord with recent dissections of cadaveric brains, and analysis of postoperative VFDs and resection volumes. By applying a linear regression analysis we showed that both distance from the tip of Meyer's loop to the temporal pole and the size of resection were significant predictors of the postoperative VFDs. We conclude that there is considerable variation in the anterior extent of Meyer's loop. In view of this, diffusion tensor tractography of the optic radiation is a potentially useful method to assess an individual patient's risk of postoperative VFDs following anterior temporal lobe resection

Advanced tensor based signal processing techniques for wireless communication systems and biomedical signal processing

Many observed signals in signal processing applications including wireless communications, biomedical signal processing, image processing, and machine learning are multi-dimensional. Tensors preserve the multi-dimensional structure and provide a natural representation of these signals/data. Moreover, tensors provide often an improved identifiability. Therefore, we benefit from using tensor algebra in the above mentioned applications and many more. In this thesis, we present the benefits of utilizing tensor algebra in two signal processing areas. These include signal processing for MIMO (Multiple-Input Multiple-Output) wireless communication systems and biomedical signal processing. Moreover, we contribute to the theoretical aspects of tensor algebra by deriving new properties and ways of computing tensor decompositions. Often, we only have an element-wise or a slice-wise description of the signal model. This representation of the signal model does not reveal the explicit tensor structure. Therefore, the derivation of all tensor unfoldings is not always obvious. Consequently, exploiting the multi-dimensional structure of these models is not always straightforward. We propose an alternative representation of the element-wise multiplication or the slice-wise multiplication based on the generalized tensor contraction operator. Later in this thesis, we exploit this novel representation and the properties of the contraction operator such that we derive the final tensor models. There exist a number of different tensor decompositions that describe different signal models such as the HOSVD (Higher Order Singular Value Decomposition), the CP/PARAFAC (Canonical Polyadic / PARallel FACtors) decomposition, the BTD (Block Term Decomposition), the PARATUCK2 (PARAfac and TUCker2) decomposition, and the PARAFAC2 (PARAllel FACtors2) decomposition. Among these decompositions, the CP decomposition is most widely spread and used. Therefore, the development of algorithms for the efficient computation of the CP decomposition is important for many applications. The SECSI (Semi-Algebraic framework for approximate CP decomposition via SImultaneaous matrix diagonalization) framework is an efficient and robust tool for the calculation of the approximate low-rank CP decomposition via simultaneous matrix diagonalizations. In this thesis, we present five extensions of the SECSI framework that reduce the computational complexity of the original framework and/or introduce constraints to the factor matrices. Moreover, the PARAFAC2 decomposition and the PARATUCK2 decomposition are usually described using a slice-wise notation that can be expressed in terms of the generalized tensor contraction as proposed in this thesis. We exploit this novel representation to derive explicit tensor models for the PARAFAC2 decomposition and the PARATUCK2 decomposition. Furthermore, we use the PARAFAC2 model to derive an ALS (Alternating Least-Squares) algorithm for the computation of the PARAFAC2 decomposition. Moreover, we exploit the novel contraction properties for element wise and slice-wise multiplications to model MIMO multi-carrier wireless communication systems. We show that this very general model can be used to derive the tensor model of the received signal for MIMO-OFDM (Multiple-Input Multiple-Output - Orthogonal Frequency Division Multiplexing), Khatri-Rao coded MIMO-OFDM, and randomly coded MIMO-OFDM systems. We propose the transmission techniques Khatri-Rao coding and random coding in order to impose an additional tensor structure of the transmit signal tensor that otherwise does not have a particular structure. Moreover, we show that this model can be extended to other multi-carrier techniques such as GFDM (Generalized Frequency Division Multiplexing). Utilizing these models at the receiver side, we design several types for receivers for these systems that outperform the traditional matrix based solutions in terms of the symbol error rate. In the last part of this thesis, we show the benefits of using tensor algebra in biomedical signal processing by jointly decomposing EEG (ElectroEncephaloGraphy) and MEG (MagnetoEncephaloGraphy) signals. EEG and MEG signals are usually acquired simultaneously, and they capture aspects of the same brain activity. Therefore, EEG and MEG signals can be decomposed using coupled tensor decompositions such as the coupled CP decomposition. We exploit the proposed coupled SECSI framework (one of the proposed extensions of the SECSI framework) for the computation of the coupled CP decomposition to first validate and analyze the photic driving effect. Moreover, we validate the effects of scull defects on the measurement EEG and MEG signals by means of a joint EEG-MEG decomposition using the coupled SECSI framework. Both applications show that we benefit from coupled tensor decompositions and the coupled SECSI framework is a very practical tool for the analysis of biomedical data.Zahlreiche messbare Signale in verschiedenen Bereichen der digitalen Signalverarbeitung, z.B. in der drahtlosen Kommunikation, im Mobilfunk, biomedizinischen Anwendungen, der Bild- oder akustischen Signalverarbeitung und dem maschinellen Lernen sind mehrdimensional. Tensoren erhalten die mehrdimensionale Struktur und stellen eine natürliche Darstellung dieser Signale/Daten dar. Darüber hinaus bieten Tensoren oft eine verbesserte Trennbarkeit von enthaltenen Signalkomponenten. Daher profitieren wir von der Verwendung der Tensor-Algebra in den oben genannten Anwendungen und vielen mehr. In dieser Arbeit stellen wir die Vorteile der Nutzung der Tensor-Algebra in zwei Bereichen der Signalverarbeitung vor: drahtlose MIMO (Multiple-Input Multiple-Output) Kommunikationssysteme und biomedizinische Signalverarbeitung. Darüber hinaus tragen wir zu theoretischen Aspekten der Tensor-Algebra bei, indem wir neue Eigenschaften und Berechnungsmethoden für die Tensor-Zerlegung ableiten. Oftmals verfügen wir lediglich über eine elementweise oder ebenenweise Beschreibung des Signalmodells, welche nicht die explizite Tensorstruktur zeigt. Daher ist die Ableitung aller Tensor-Unfoldings nicht offensichtlich, wodurch die multidimensionale Struktur dieser Modelle nicht trivial nutzbar ist. Wir schlagen eine alternative Darstellung der elementweisen Multiplikation oder der ebenenweisen Multiplikation auf der Grundlage des generalisierten Tensor-Kontraktionsoperators vor. Weiterhin nutzen wir diese neuartige Darstellung und deren Eigenschaften zur Ableitung der letztendlichen Tensor-Modelle. Es existieren eine Vielzahl von Tensor-Zerlegungen, die verschiedene Signalmodelle beschreiben, wie die HOSVD (Higher Order Singular Value Decomposition), CP/PARAFAC (Canonical Polyadic/ PARallel FACtors) Zerlegung, die BTD (Block Term Decomposition), die PARATUCK2-(PARAfac und TUCker2) und die PARAFAC2-Zerlegung (PARAllel FACtors2). Dabei ist die CP-Zerlegung am weitesten verbreitet und wird findet in zahlreichen Gebieten Anwendung. Daher ist die Entwicklung von Algorithmen zur effizienten Berechnung der CP-Zerlegung von besonderer Bedeutung. Das SECSI (Semi-Algebraic Framework for approximate CP decomposition via Simultaneaous matrix diagonalization) Framework ist ein effizientes und robustes Werkzeug zur Berechnung der approximierten Low-Rank CP-Zerlegung durch simultane Matrixdiagonalisierung. In dieser Arbeit stellen wir fünf Erweiterungen des SECSI-Frameworks vor, welche die Rechenkomplexität des ursprünglichen Frameworks reduzieren bzw. Einschränkungen für die Faktormatrizen einführen. Darüber hinaus werden die PARAFAC2- und die PARATUCK2-Zerlegung in der Regel mit einer ebenenweisen Notation beschrieben, die sich in Form der allgemeinen Tensor-Kontraktion, wie sie in dieser Arbeit vorgeschlagen wird, ausdrücken lässt. Wir nutzen diese neuartige Darstellung, um explizite Tensormodelle für diese beiden Zerlegungen abzuleiten. Darüber hinaus verwenden wir das PARAFAC2-Modell, um einen ALS-Algorithmus (Alternating Least-Squares) für die Berechnung der PARAFAC2-Zerlegungen abzuleiten. Weiterhin nutzen wir die neuartigen Kontraktionseigenschaften für elementweise und ebenenweise Multiplikationen, um MIMO Multi-Carrier-Mobilfunksysteme zu modellieren. Wir zeigen, dass dieses sehr allgemeine Modell verwendet werden kann, um das Tensor-Modell des empfangenen Signals für MIMO-OFDM- (Multiple- Input Multiple-Output - Orthogonal Frequency Division Multiplexing), Khatri-Rao codierte MIMO-OFDM- und zufällig codierte MIMO-OFDM-Systeme abzuleiten. Wir schlagen die Übertragungstechniken der Khatri-Rao-Kodierung und zufällige Kodierung vor, um eine zusätzliche Tensor-Struktur des Sendesignal-Tensors einzuführen, welcher gewöhnlich keine bestimmte Struktur aufweist. Darüber hinaus zeigen wir, dass dieses Modell auf andere Multi-Carrier-Techniken wie GFDM (Generalized Frequency Division Multiplexing) erweitert werden kann. Unter Verwendung dieser Modelle auf der Empfängerseite entwerfen wir verschiedene Typen von Empfängern für diese Systeme, die die traditionellen matrixbasierten Lösungen in Bezug auf die Symbolfehlerrate übertreffen. Im letzten Teil dieser Arbeit zeigen wir die Vorteile der Verwendung von Tensor-Algebra in der biomedizinischen Signalverarbeitung durch die gemeinsame Zerlegung von EEG-(ElectroEncephaloGraphy) und MEG- (MagnetoEncephaloGraphy) Signalen. Diese werden in der Regel gleichzeitig erfasst, wobei sie gemeinsame Aspekte derselben Gehirnaktivität beschreiben. Daher können EEG- und MEG-Signale mit gekoppelten Tensor-Zerlegungen wie der gekoppelten CP Zerlegung analysiert werden. Wir nutzen das vorgeschlagene gekoppelte SECSI-Framework (eine der vorgeschlagenen Erweiterungen des SECSI-Frameworks) für die Berechnung der gekoppelten CP Zerlegung, um zunächst den photic driving effect zu validieren und zu analysieren. Darüber hinaus validieren wir die Auswirkungen von Schädeldefekten auf die Messsignale von EEG und MEG durch eine gemeinsame EEG-MEG-Zerlegung mit dem gekoppelten SECSI-Framework. Beide Anwendungen zeigen, dass wir von gekoppelten Tensor-Zerlegungen profitieren, wobei die Methoden des gekoppelten SECSI-Frameworks erfolgreich zur Analyse biomedizinischer Daten genutzt werden können

Decomposing the role of alpha oscillations during brain maturation

Childhood and adolescence are critical stages of the human lifespan, in which fundamental neural reorganizational processes take place. A substantial body of literature investigated accompanying neurophysiological changes, focusing on the most dominant feature of the human EEG signal: the alpha oscillation. Recent developments in EEG signal-processing show that conventional measures of alpha power are confounded by various factors and need to be decomposed into periodic and aperiodic components, which represent distinct underlying brain mechanisms. It is therefore unclear how each part of the signal changes during brain maturation. Using multivariate Bayesian generalized linear models, we examined aperiodic and periodic parameters of alpha activity in the largest openly available pediatric dataset (N=2529, age 5-22 years) and replicated these findings in a preregistered analysis of an independent validation sample (N=369, age 6-22 years). First, the welldocumented age-related decrease in total alpha power was replicated. However, when controlling for the aperiodic signal component, our findings provided strong evidence for an age-related increase in the aperiodic-adjusted alpha power. As reported in previous studies, also relative alpha power revealed a maturational increase, yet indicating an underestimation of the underlying relationship between periodic alpha power and brain maturation. The aperiodic intercept and slope decreased with increasing age and were highly correlated with total alpha power. Consequently, earlier interpretations on age-related changes of total alpha power need to be reconsidered, as elimination of active synapses rather links to decreases in the aperiodic intercept. Instead, analyses of diffusion tensor imaging data indicate that the maturational increase in aperiodic-adjusted alpha power is related to increased thalamocortical connectivity. Functionally, our results suggest that increased thalamic control of cortical alpha power is linked to improved attentional performance during brain maturation

Machine Learning Methods with Noisy, Incomplete or Small Datasets

In many machine learning applications, available datasets are sometimes incomplete, noisy or affected by artifacts. In supervised scenarios, it could happen that label information has low quality, which might include unbalanced training sets, noisy labels and other problems. Moreover, in practice, it is very common that available data samples are not enough to derive useful supervised or unsupervised classifiers. All these issues are commonly referred to as the low-quality data problem. This book collects novel contributions on machine learning methods for low-quality datasets, to contribute to the dissemination of new ideas to solve this challenging problem, and to provide clear examples of application in real scenarios