Multiresolution Recurrent Neural Networks: An Application to Dialogue Response Generation

We introduce the multiresolution recurrent neural network, which extends the sequence-to-sequence framework to model natural language generation as two parallel discrete stochastic processes: a sequence of high-level coarse tokens, and a sequence of natural language tokens. There are many ways to estimate or learn the high-level coarse tokens, but we argue that a simple extraction procedure is sufficient to capture a wealth of high-level discourse semantics. Such procedure allows training the multiresolution recurrent neural network by maximizing the exact joint log-likelihood over both sequences. In contrast to the standard log- likelihood objective w.r.t. natural language tokens (word perplexity), optimizing the joint log-likelihood biases the model towards modeling high-level abstractions. We apply the proposed model to the task of dialogue response generation in two challenging domains: the Ubuntu technical support domain, and Twitter conversations. On Ubuntu, the model outperforms competing approaches by a substantial margin, achieving state-of-the-art results according to both automatic evaluation metrics and a human evaluation study. On Twitter, the model appears to generate more relevant and on-topic responses according to automatic evaluation metrics. Finally, our experiments demonstrate that the proposed model is more adept at overcoming the sparsity of natural language and is better able to capture long-term structure.Comment: 21 pages, 2 figures, 10 table

Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes.

Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to be defined. We demonstrate here that selective loss of IL10 receptor α in adipocytes recapitulates the beneficial effects of global IL10 deletion, and that local crosstalk between IL10-producing immune cells and adipocytes is a determinant of thermogenesis and systemic energy balance. Single Nuclei Adipocyte RNA-sequencing (SNAP-seq) of subcutaneous adipose tissue defined a metabolically-active mature adipocyte subtype characterized by robust expression of genes involved in thermogenesis whose transcriptome was selectively responsive to IL10Rα deletion. Furthermore, single-cell transcriptomic analysis of adipose stromal populations identified lymphocytes as a key source of IL10 production in response to thermogenic stimuli. These findings implicate adaptive immune cell-adipocyte communication in the maintenance of adipose subtype identity and function

Automated Firearms Identification System (AFIDS), phase 1

Items critical to the future development of an automated firearms identification system (AFIDS) have been examined, with the following specific results: (1) Types of objective data, that can be utilized to help establish a more factual basis for determining identity and nonidentity between pairs of fired bullets, have been identified. (2) A simulation study has indicated that randomly produced lines, similar in nature to the individual striations on a fired bullet, can be modeled and that random sequences, when compared to each other, have predictable relationships. (3) A schematic diagram of the general concept for AFIDS has been developed and individual elements of this system have been briefly tested for feasibility. Future implementation of such a proposed system will depend on such factors as speed, utility, projected total cost and user requirements for growth. The success of the proposed system, when operational, would depend heavily on existing firearms examiners

The applicability of a use value-based file retention method

The determination of the relative value of files is important for an organization while determining a retrieval service level for its files and a corresponding file retention policy. This paper discusses via a literature review methods for developing file retention policies based on the use values of files. On basis of these results we propose an enhanced version of one of them. In a case study, we demonstrate how one can develop a customized file retention policy by testing causal relations between file parameters and the use value of files. This case shows that, contrary to suggestions of previous research, the file type has no significant relation with the value of a file and thus should be excluded from a retention policy in this case. The case study also shows a strong relation between the position of a file user and the value of this file. Furthermore, we have improved the Information Value Questionnaire (IVQ) for subjective valuation of files. However, the resulting method needs software to be efficient in its application. Therefore, we developed a prototype for the automatic execution of a file retention policy. We conclude with a discussio

The multi-faceted use of the OAI-PMH in the LANL Repository

This paper focuses on the multifaceted use of the OAI-PMH in a repository architecture designed to store digital assets at the Research Library of the Los Alamos National Laboratory (LANL), and to make the stored assets available in a uniform way to various downstream applications. In the architecture, the MPEG-21 Digital Item Declaration Language is used as the XML-based format to represent complex digital objects. Upon ingestion, these objects are stored in a multitude of autonomous OAI-PMH repositories. An OAI-PMH compliant Repository Index keeps track of the creation and location of all those repositories, whereas an Identifier Resolver keeps track of the location of individual objects. An OAI-PMH Federator is introduced as a single-point-of-access to downstream harvesters. It hides the complexity of the environment to those harvesters, and allows them to obtain transformations of stored objects. While the proposed architecture is described in the context of the LANL library, the paper will also touch on its more general applicability

A methodology for the capture and analysis of hybrid data: a case study of program debugging

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BlogForever D3.2: Interoperability Prospects

This report evaluates the interoperability prospects of the BlogForever platform. Therefore, existing interoperability models are reviewed, a Delphi study to identify crucial aspects for the interoperability of web archives and digital libraries is conducted, technical interoperability standards and protocols are reviewed regarding their relevance for BlogForever, a simple approach to consider interoperability in specific usage scenarios is proposed, and a tangible approach to develop a succession plan that would allow a reliable transfer of content from the current digital archive to other digital repositories is presented