Metabolite changes in blood predict the onset of tuberculosis

Immunogenetics and cellular immunology of bacterial infectious disease

Gait recognition based on shape and motion analysis of silhouette contours

This paper presents a three-phase gait recognition method that analyses the spatio-temporal shape and dynamic motion (STS-DM) characteristics of a human subject’s silhouettes to identify the subject in the presence of most of the challenging factors that affect existing gait recognition systems. In phase 1, phase-weighted magnitude spectra of the Fourier descriptor of the silhouette contours at ten phases of a gait period are used to analyse the spatio-temporal changes of the subject’s shape. A component-based Fourier descriptor based on anatomical studies of human body is used to achieve robustness against shape variations caused by all common types of small carrying conditions with folded hands, at the subject’s back and in upright position. In phase 2, a full-body shape and motion analysis is performed by fitting ellipses to contour segments of ten phases of a gait period and using a histogram matching with Bhattacharyya distance of parameters of the ellipses as dissimilarity scores. In phase 3, dynamic time warping is used to analyse the angular rotation pattern of the subject’s leading knee with a consideration of arm-swing over a gait period to achieve identification that is invariant to walking speed, limited clothing variations, hair style changes and shadows under feet. The match scores generated in the three phases are fused using weight-based score-level fusion for robust identification in the presence of missing and distorted frames, and occlusion in the scene. Experimental analyses on various publicly available data sets show that STS-DM outperforms several state-of-the-art gait recognition methods

Regulation-Structured Dynamic Metabolic Model Provides a Potential Mechanism for Delayed Enzyme Response in Denitrification Process

In a recent study of denitrification dynamics in hyporheic zone sediments, we observed a significant time lag (up to several days) in enzymatic response to the changes in substrate concentration. To explore an underlying mechanism and understand the interactive dynamics between enzymes and nutrients, we developed a trait-based model that associates a community’s traits with functional enzymes, instead of typically used species guilds (or functional guilds). This enzyme-based formulation allows to collectively describe biogeochemical functions of microbial communities without directly parameterizing the dynamics of species guilds, therefore being scalable to complex communities. As a key component of modeling, we accounted for microbial regulation occurring through transcriptional and translational processes, the dynamics of which was parameterized based on the temporal profiles of enzyme concentrations measured using a new signature peptide-based method. The simulation results using the resulting model showed several days of a time lag in enzymatic responses as observed in experiments. Further, the model showed that the delayed enzymatic reactions could be primarily controlled by transcriptional responses and that the dynamics of transcripts and enzymes are closely correlated. The developed model can serve as a useful tool for predicting biogeochemical processes in natural environments, either independently or through integration with hydrologic flow simulators

Modeling the pulse signal by wave-shape function and analyzing by synchrosqueezing transform

We apply the recently developed adaptive non-harmonic model based on the wave-shape function, as well as the time-frequency analysis tool called synchrosqueezing transform (SST) to model and analyze oscillatory physiological signals. To demonstrate how the model and algorithm work, we apply them to study the pulse wave signal. By extracting features called the spectral pulse signature, {and} based on functional regression, we characterize the hemodynamics from the radial pulse wave signals recorded by the sphygmomanometer. Analysis results suggest the potential of the proposed signal processing approach to extract health-related hemodynamics features