Functionalized Single-walled Nanotubes And Methods Thereof

Described are single-walled metal oxide nanotubes having a plurality of organic functional units or moieties bonded generally in a covalent manner to the inner wall of the single-walled nanotubes. Functionalization of the single-walled metal oxide nanotubes is performed in a single-step during synthesis of the nanotubes. The organic functional units are found dispersed throughout the length of the inner wall and not sterically hindered or contained at only the mouth or ends of the single-walled metal oxide nanotubes.Georgia Tech Research Corporatio

Performance Evaluation of Network Anomaly Detection Systems

Nowadays, there is a huge and growing concern about security in information and communication technology (ICT) among the scientific community because any attack or anomaly in the network can greatly affect many domains such as national security, private data storage, social welfare, economic issues, and so on. Therefore, the anomaly detection domain is a broad research area, and many different techniques and approaches for this purpose have emerged through the years. Attacks, problems, and internal failures when not detected early may badly harm an entire Network system. Thus, this thesis presents an autonomous profile-based anomaly detection system based on the statistical method Principal Component Analysis (PCADS-AD). This approach creates a network profile called Digital Signature of Network Segment using Flow Analysis (DSNSF) that denotes the predicted normal behavior of a network traffic activity through historical data analysis. That digital signature is used as a threshold for volume anomaly detection to detect disparities in the normal traffic trend. The proposed system uses seven traffic flow attributes: Bits, Packets and Number of Flows to detect problems, and Source and Destination IP addresses and Ports, to provides the network administrator necessary information to solve them. Via evaluation techniques, addition of a different anomaly detection approach, and comparisons to other methods performed in this thesis using real network traffic data, results showed good traffic prediction by the DSNSF and encouraging false alarm generation and detection accuracy on the detection schema. The observed results seek to contribute to the advance of the state of the art in methods and strategies for anomaly detection that aim to surpass some challenges that emerge from the constant growth in complexity, speed and size of today’s large scale networks, also providing high-value results for a better detection in real time.Atualmente, existe uma enorme e crescente preocupação com segurança em tecnologia da informação e comunicação (TIC) entre a comunidade científica. Isto porque qualquer ataque ou anomalia na rede pode afetar a qualidade, interoperabilidade, disponibilidade, e integridade em muitos domínios, como segurança nacional, armazenamento de dados privados, bem-estar social, questões econômicas, e assim por diante. Portanto, a deteção de anomalias é uma ampla área de pesquisa, e muitas técnicas e abordagens diferentes para esse propósito surgiram ao longo dos anos. Ataques, problemas e falhas internas quando não detetados precocemente podem prejudicar gravemente todo um sistema de rede. Assim, esta Tese apresenta um sistema autônomo de deteção de anomalias baseado em perfil utilizando o método estatístico Análise de Componentes Principais (PCADS-AD). Essa abordagem cria um perfil de rede chamado Assinatura Digital do Segmento de Rede usando Análise de Fluxos (DSNSF) que denota o comportamento normal previsto de uma atividade de tráfego de rede por meio da análise de dados históricos. Essa assinatura digital é utilizada como um limiar para deteção de anomalia de volume e identificar disparidades na tendência de tráfego normal. O sistema proposto utiliza sete atributos de fluxo de tráfego: bits, pacotes e número de fluxos para detetar problemas, além de endereços IP e portas de origem e destino para fornecer ao administrador de rede as informações necessárias para resolvê-los. Por meio da utilização de métricas de avaliação, do acrescimento de uma abordagem de deteção distinta da proposta principal e comparações com outros métodos realizados nesta tese usando dados reais de tráfego de rede, os resultados mostraram boas previsões de tráfego pelo DSNSF e resultados encorajadores quanto a geração de alarmes falsos e precisão de deteção. Com os resultados observados nesta tese, este trabalho de doutoramento busca contribuir para o avanço do estado da arte em métodos e estratégias de deteção de anomalias, visando superar alguns desafios que emergem do constante crescimento em complexidade, velocidade e tamanho das redes de grande porte da atualidade, proporcionando também alta performance. Ainda, a baixa complexidade e agilidade do sistema proposto contribuem para que possa ser aplicado a deteção em tempo real

Ant-based sorting and ACO-based clustering approaches: A review

Data clustering is used in a number of fields including statistics, bioinformatics, machine learning exploratory data analysis, image segmentation, security, medical image analysis, web handling and mathematical programming.Its role is to group data into clusters with high similarity within clusters and with high dissimilarity between clusters.This paper reviews the problems that affect clustering performance for deterministic clustering and stochastic clustering approaches.In deterministic clustering, the problems are caused by sensitivity to the number of provided clusters.In stochastic clustering, problems are caused either by the absence of an optimal number of clusters or by the projection of data.The review is focused on ant-based sorting and ACO-based clustering which have problems of slow convergence, un-robust results and local optima solution.The results from this review can be used as a guide for researchers working in the area of data clustering as it shows the strengths and weaknesses of using both clustering approaches

Computational structure‐based drug design: Predicting target flexibility

The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in early phases of drug discovery. Medium and small companies with strong focus on computational chemistry are being created, some of them having introduced important leads in drug design pipelines. An important source for this success is the extraordinary development of faster and more efficient techniques for describing flexibility in three‐dimensional structural molecular modeling. At different levels, from docking techniques to atomistic molecular dynamics, conformational sampling between receptor and drug results in improved predictions, such as screening enrichment, discovery of transient cavities, etc. In this review article we perform an extensive analysis of these modeling techniques, dividing them into high and low throughput, and emphasizing in their application to drug design studies. We finalize the review with a section describing our Monte Carlo method, PELE, recently highlighted as an outstanding advance in an international blind competition and industrial benchmarks.We acknowledge the BSC-CRG-IRB Joint Research Program in Computational Biology. This work was supported by a grant from the Spanish Government CTQ2016-79138-R.J.I. acknowledges support from SVP-2014-068797, awarded by the Spanish Government.Peer ReviewedPostprint (author's final draft

Metaheuristic Design Patterns: New Perspectives for Larger-Scale Search Architectures

Design patterns capture the essentials of recurring best practice in an abstract form. Their merits are well established in domains as diverse as architecture and software development. They offer significant benefits, not least a common conceptual vocabulary for designers, enabling greater communication of high-level concerns and increased software reuse. Inspired by the success of software design patterns, this chapter seeks to promote the merits of a pattern-based method to the development of metaheuristic search software components. To achieve this, a catalog of patterns is presented, organized into the families of structural, behavioral, methodological and component-based patterns. As an alternative to the increasing specialization associated with individual metaheuristic search components, the authors encourage computer scientists to embrace the ‘cross cutting' benefits of a pattern-based perspective to optimization algorithms. Some ways in which the patterns might form the basis of further larger-scale metaheuristic component design automation are also discussed

Human treelike tubular structure segmentation: A comprehensive review and future perspectives

Various structures in human physiology follow a treelike morphology, which often expresses complexity at very fine scales. Examples of such structures are intrathoracic airways, retinal blood vessels, and hepatic blood vessels. Large collections of 2D and 3D images have been made available by medical imaging modalities such as magnetic resonance imaging (MRI), computed tomography (CT), Optical coherence tomography (OCT) and ultrasound in which the spatial arrangement can be observed. Segmentation of these structures in medical imaging is of great importance since the analysis of the structure provides insights into disease diagnosis, treatment planning, and prognosis. Manually labelling extensive data by radiologists is often time-consuming and error-prone. As a result, automated or semi-automated computational models have become a popular research field of medical imaging in the past two decades, and many have been developed to date. In this survey, we aim to provide a comprehensive review of currently publicly available datasets, segmentation algorithms, and evaluation metrics. In addition, current challenges and future research directions are discussed

A Hybrid Mining Approach to Facilitate Health Insurance Decision: Case Study of Non-Traditional Data Mining Applications in Taiwan NHI Databases

This study examines time-sensitive applications of data mining methods to facilitate claims review processing and provide policy information for insurance decision-making vis-à-vis the Taiwan National Health Insurance databases. In order to obtain the best payment management, a hybrid mining approach, which has been grounded on the extant knowledge of data mining projects and health insurance domain knowledge, is proposed. Through the integration of data warehousing, online analytical processing, data mining techniques and traditional data analysis in the healthcare field, an easy-to-use decision support platform, which will facilitate the health insurance decision-making process, is built. Drawing from lessons learned in case study, results showed that not only is hybrid mining approach a reliable, powerful, and user-friendly platform for diversified payment decision support, but that it also has great relevance for the practice and acceptance of evidence-based medicine. Researchers should develop hybrid mining approach combined with their own application systems in the future

PSO-Based Optimal Coverage Path Planning for Surface Defect Inspection of 3C Components with a Robotic Line Scanner

The automatic inspection of surface defects is an important task for quality control in the computers, communications, and consumer electronics (3C) industry. Conventional devices for defect inspection (viz. line-scan sensors) have a limited field of view, thus, a robot-aided defect inspection system needs to scan the object from multiple viewpoints. Optimally selecting the robot's viewpoints and planning a path is regarded as coverage path planning (CPP), a problem that enables inspecting the object's complete surface while reducing the scanning time and avoiding misdetection of defects. However, the development of CPP strategies for robotic line scanners has not been sufficiently studied by researchers. To fill this gap in the literature, in this paper, we present a new approach for robotic line scanners to detect surface defects of 3C free-form objects automatically. Our proposed solution consists of generating a local path by a new hybrid region segmentation method and an adaptive planning algorithm to ensure the coverage of the complete object surface. An optimization method for the global path sequence is developed to maximize the scanning efficiency. To verify our proposed methodology, we conduct detailed simulation-based and experimental studies on various free-form workpieces, and compare its performance with a state-of-the-art solution. The reported results demonstrate the feasibility and effectiveness of our approach

Progressive-Regressive Strategy for Biometrical Authentication

This chapter thoroughly investigates the use of the progressive–regressive strategy for biometrical authentication through the use of human gait and face images. A considerable amount of features were extracted and relevant parameters computed for such an investigation and a vast number of datasets developed. The datasets consist of features and computed parameters extracted from human gait and face images from various subjects of different ages. Soft-computing techniques, discrete wavelet transform (DWT), principal component analysis and the forward–backward dynamic programming method were applied for the best-fit selection of parameters and the complete matching process. The paretic and non-paretic characteristics were classified through Naïve Bayes’ classification theorem. Both classification and recognition were carried out in parallel with test and trained datasets and the whole process of investigation was successfully carried out through an algorithm developed in this chapter. The success rate of biometrical authentication is 89%