17,082 research outputs found

    An iterative warping and clustering algorithm to estimate multiple wave-shape functions from a nonstationary oscillatory signal

    Full text link
    Nonsinusoidal oscillatory signals are everywhere. In practice, the nonsinusoidal oscillatory pattern, modeled as a 1-periodic wave-shape function (WSF), might vary from cycle to cycle. When there are finite different WSFs, s1,…,sKs_1,\ldots,s_K, so that the WSF jumps from one to another suddenly, the different WSFs and jumps encode useful information. We present an iterative warping and clustering algorithm to estimate s1,…,sKs_1,\ldots,s_K from a nonstationary oscillatory signal with time-varying amplitude and frequency, and hence the change points of the WSFs. The algorithm is a novel combination of time-frequency analysis, singular value decomposition entropy and vector spectral clustering. We demonstrate the efficiency of the proposed algorithm with simulated and real signals, including the voice signal, arterial blood pressure, electrocardiogram and accelerometer signal. Moreover, we provide a mathematical justification of the algorithm under the assumption that the amplitude and frequency of the signal are slowly time-varying and there are finite change points that model sudden changes from one wave-shape function to another one.Comment: 39 pages, 11 figure

    Bayesian networks for disease diagnosis: What are they, who has used them and how?

    Full text link
    A Bayesian network (BN) is a probabilistic graph based on Bayes' theorem, used to show dependencies or cause-and-effect relationships between variables. They are widely applied in diagnostic processes since they allow the incorporation of medical knowledge to the model while expressing uncertainty in terms of probability. This systematic review presents the state of the art in the applications of BNs in medicine in general and in the diagnosis and prognosis of diseases in particular. Indexed articles from the last 40 years were included. The studies generally used the typical measures of diagnostic and prognostic accuracy: sensitivity, specificity, accuracy, precision, and the area under the ROC curve. Overall, we found that disease diagnosis and prognosis based on BNs can be successfully used to model complex medical problems that require reasoning under conditions of uncertainty.Comment: 22 pages, 5 figures, 1 table, Student PhD first pape

    Imagination as Thought in Aristotle\u27s De Anima

    Get PDF
    Aristotle appears to indicate in various passages in the De Anima that imagination is a kind of thought, and my thesis attempts to make some sense out of this claim. I examine three possible interpretations of the claim that imagination is a kind of thought and eliminate two of them. The first states that Aristotle only calls imagination a kind of thought in a superficial “in name only” sense. The second, more radical interpretation, identifies images as the most basic kind of thoughts. My final chapter defends a more moderate position—inspired by Avempace and the early Averroes—which steers between the superficial and radical interpretations, by construing the formal content of images as a sort of quasi-corporeal substrate for the generation of learned thoughts

    The Genetics of Pain: An exploration of gene-by-environment interactions and their effects on pain

    Get PDF
    The findings presented in this dissertation are part of the bigger SYMBIOME project which aims to use the biopsychosocial model of pain to develop a prognostic clinical phenotype for people that experience musculoskeletal (MSK) trauma. Chapter 2 presents an exploratory analysis to assess the relationships between genetic polymorphisms and pain severity and interference. Early childhood trauma was also explored as a moderator between genetic polymorphisms and pain outcomes. For pain severity, major allele carriers (A/A and G/A) of FKBP5 rs9394314 reported significantly higher scores than minor allele carriers (G/G). Further, major allele carriers who had at least one adverse childhood experience (ACE) reported significantly higher scores than minor allele carriers with at least one ACE. For pain interference, minor allele carriers (G/G) of CNR2 rs2501431 scored significantly higher than major allele carriers (A/A and G/A). Chapter 3 presents a cluster analysis that combines genotypes of FKBP5 rs9394314 and CNR2 rs2501431 to explore meaningful relationships with pain and trauma-related distress. ACE was also explored as a moderator of these relationships. Three clusters were identified where the second cluster characterized by major allele carriers of rs9394314 and minor allele carriers of rs2501431 reported significantly higher pain-related functional interference scores. Participants in the second cluster with at least one ACE reported higher pain interference and traumatic distress scores compared to the third cluster, while participants in the first cluster with at least one ACE reported higher pain severity compared to the first cluster. Chapter 4 presents genomic structural equation models (SEM) that explore the relationships of genotypes with trauma-related distress using the traumatic injuries distress scale (TIDS), ACE, and recovery outcomes. The results demonstrate a relationship between TIDS and recovery outcomes, and an indirect relationship between FKBP5 rs9394314 and recovery outcomes exist which is mediated by TIDS. Major allele carriers of FKBP5 rs9394314 reported higher TIDS scores, which was also demonstrated for participants that had at least one ACE. Major allele carriers that scored higher on the TIDS were predicted to be in the none-recovered category. These results support the notion that gene-x-environment interactions may play an important role in pain and recovery

    Interval Type-2 Beta Fuzzy Near Sets Approach to Content-Based Image Retrieval

    Get PDF
    In computer-based search systems, similarity plays a key role in replicating the human search process. Indeed, the human search process underlies many natural abilities such as image recovery, language comprehension, decision making, or pattern recognition. The search for images consists of establishing a correspondence between the available image and that sought by the user, by measuring the similarity between the images. Image search by content is generaly based on the similarity of the visual characteristics of the images. The distance function used to evaluate the similarity between images depends notonly on the criteria of the search but also on the representation of the characteristics of the image. This is the main idea of a content-based image retrieval (CBIR) system. In this article, first, we constructed type-2 beta fuzzy membership of descriptor vectors to help manage inaccuracy and uncertainty of characteristics extracted the feature of images. Subsequently, the retrieved images are ranked according to the novel similarity measure, noted type-2 fuzzy nearness measure (IT2FNM). By analogy to Type-2 Fuzzy Logic and motivated by near sets theory, we advanced a new fuzzy similarity measure (FSM) noted interval type-2 fuzzy nearness measure (IT-2 FNM). Then, we proposed three new IT-2 FSMs and we have provided mathematical justification to demonstrate that the proposed FSMs satisfy proximity properties (i.e. reflexivity, transitivity, symmetry, and overlapping). Experimental results generated using three image databases showing consistent and significant results

    TOWARDS AN UNDERSTANDING OF EFFORTFUL FUNDRAISING EXPERIENCES: USING INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS IN FUNDRAISING RESEARCH

    Get PDF
    Physical-activity oriented community fundraising has experienced an exponential growth in popularity over the past 15 years. The aim of this study was to explore the value of effortful fundraising experiences, from the point of view of participants, and explore the impact that these experiences have on people’s lives. This study used an IPA approach to interview 23 individuals, recognising the role of participants as proxy (nonprofessional) fundraisers for charitable organisations, and the unique organisation donor dynamic that this creates. It also bought together relevant psychological theory related to physical activity fundraising experiences (through a narrative literature review) and used primary interview data to substantiate these. Effortful fundraising experiences are examined in detail to understand their significance to participants, and how such experiences influence their connection with a charity or cause. This was done with an idiographic focus at first, before examining convergences and divergences across the sample. This study found that effortful fundraising experiences can have a profound positive impact upon community fundraisers in both the short and the long term. Additionally, it found that these experiences can be opportunities for charitable organisations to create lasting meaningful relationships with participants, and foster mutually beneficial lifetime relationships with them. Further research is needed to test specific psychological theory in this context, including self-esteem theory, self determination theory, and the martyrdom effect (among others)

    Effectiveness of Lateral Auditory Collision Warnings: Should Warnings Be Toward Danger or Toward Safety?

    Get PDF
    Objective. The present study investigated the design of spatially oriented auditory collision warning signals to facilitate drivers’ responses to potential collisions. Background. Prior studies on collision warnings have mostly focused on manual driving. It is necessary to examine the design of collision warnings for safe take-over actions in semi-autonomous driving. Method. In a video-based semi-autonomous driving scenario, participants responded to pedestrians walking across the road, with a warning tone presented in either the avoidance direction or the collision direction. The time interval between the warning tone and the potential collision was also manipulated. In Experiment 1, pedestrians always started walking from one side of the road to the other side. In Experiment 2, pedestrians appeared in the middle of the road and walked toward either side of the road. Results. In Experiment 1, drivers reacted to the pedestrian faster with collision-direction warnings than with avoidance-direction warnings. In Experiment 2, the difference between the two warning directions became non-significant. In both experiments, shorter time intervals to potential collisions resulted in faster reactions but did not influence the effect of warning direction. Conclusion. The collision-direction warnings were advantageous over the avoidance-direction warnings only when they occurred at the same lateral location as the pedestrian, indicating that this advantage was due to the capture of attention by the auditory warning signals. Application. The present results indicate that drivers would benefit most when warnings occur at the side of potential collision objects rather than the direction of a desirable action during semi-autonomous driving

    Healthcare Innovation Absenteeism: The Rise of Physician Entrepreneurs & Medical Startups

    Get PDF
    For years, warning signs have illuminated imminent days of reckoning for stalled healthcare innovation across the dynamic American healthcare landscape. An evolving epic battle for healthcare innovation delivery has silently raged and set arena stages throughout the healthcare industry. Urgent innovative healthcare delivery is needed to ameliorate longstanding points of failures in providing healthcare delivery to society. Historically, the science of medicine has fostered cultural practices of innovation absenteeism and resistance to change. Mired by archaic processes, legacy systems, and fractionally useful equipment, our current healthcare ecosystems are unsustainable. Recently, some unhindered frontline physicians opted to take on a portion of critical healthcare challenges and followed their ideas to leverage clinical expertise and drive the agenda for changing healthcare innovation delivery. Our qualitative multi-case study design centered around empirical evidence that answered the research question: How do physician entrepreneurs navigate decision-making strategies for medical startups from ideation, innovation, to commercialization of new medical products and services? We examined 21 cases of physician founded medical startups to understand particularizations around physician entrepreneurship. Findings suggest three contributions towards knowledge accumulation about physician entrepreneurs and medical startups: exclusive decision-making processes, industry-specific insights, and illuminations of physician voices that might not otherwise be heard
    • …
    corecore