A Novel Approach to Detecting Epistasis using Random Sampling Regularisation

Epistasis is a progressive approach that complements the ‘common disease, common variant’ hypothesis that highlights the potential for connected networks of genetic variants collaborating to produce a phenotypic expression. Epistasis is commonly performed as a pairwise or limitless-arity capacity that considers variant networks as either variant vs variant or as high order interactions. This type of analysis extends the number of tests that were previously performed in a standard approach such as Genome-Wide Association Study (GWAS), in which False Discovery Rate (FDR) is already an issue, therefore by multiplying the number of tests up to a factorial rate also increases the issue of FDR. Further to this, epistasis introduces its own limitations of computational complexity and intensity that are generated based on the analysis performed; to consider the most intense approach, a multivariate analysis introduces a time complexity of O(n!). Proposed in this paper is a novel methodology for the detection of epistasis using interpretable methods and best practice to outline interactions through filtering processes. Using a process of Random Sampling Regularisation which randomly splits and produces sample sets to conduct a voting system to regularise the significance and reliability of biological markers, SNPs. Preliminary results are promising, outlining a concise detection of interactions. Results for the detection of epistasis, in the classification of breast cancer patients, indicated eight outlined risk candidate interactions from five variants and a singular candidate variant with high protective association

Zero-Gravity Atmospheric Cloud Physics Experiment Laboratory-engineering concepts/design tradeoffs. Volume 2: Detailed approaches

For abstract, see N75-10953

Beside our selves : panic as unbecoming

Beside Our Selves: Panic as Unbecoming is a creative PhD in an experimental container. Part autotheory, part experimental poetics and part literary performance, it explores the phenomenology of panic and the ontology of the panicked subject and their entangled relationship to the social, the political, the speculative and the material. I explore how subjectivity is constituted by panic within a practice situated at the intersections of pathology, philosophy, and politics⎯and also in excess of these categories. Through this intersectional lens I develop a complex politics of panic arising from a phenomenologically layered understanding of what happens to bodies and subjectivities in the event of a panic attack. “Beside Our Selves” makes these relations explicit through a creative experimental practice that is driven by situated knowledges gleaned from my personal experience with panic and its affective siblings across a lifetime. I employ Arts Based Methodology, mobilised via the practises of autotheory, experimental poetics and performance, to generate affective atmospheres and reveal the entangled nature of the body in and of the world, as well as what it is that panic can reveal about the existential condition. Using the autotheoretical work of sociologist Jackie Orr and employing Merleau-Ponty’s concept of the “flesh of the world”, I chart the complex ways in which panic can be both annihilating and transformational. The work of Karen Barad and Magdalena Gorska shine a light on these intra-active relations. As part of the original scholarship of this thesis I utilise the concepts of “ictic vocalities” and the “shimmer body”, to explore whether we can turn states of panic into sites of productive agency. “Beside Our Selves” is comprised of a dynamic and deconstructed website which can be navigated in a non-linear manner and is a container for texts, objects and ephemera which flesh out and augment the exegesis. The exegetical work and the website exist in a feedback loop, always mutually referential. This form mirrors the non-linearity and dissolving boundaries at the heart of the world of the panicked subject

Counter Unmanned Aircraft Systems Technologies and Operations

As the quarter-century mark in the 21st Century nears, new aviation-related equipment has come to the forefront, both to help us and to haunt us. (Coutu, 2020) This is particularly the case with unmanned aerial vehicles (UAVs). These vehicles have grown in popularity and accessible to everyone. Of different shapes and sizes, they are widely available for purchase at relatively low prices. They have moved from the backyard recreation status to important tools for the military, intelligence agencies, and corporate organizations. New practical applications such as military equipment and weaponry are announced on a regular basis – globally. (Coutu, 2020) Every country seems to be announcing steps forward in this bludgeoning field. In our successful 2nd edition of Unmanned Aircraft Systems in the Cyber Domain: Protecting USA’s Advanced Air Assets (Nichols, et al., 2019), the authors addressed three factors influencing UAS phenomena. First, unmanned aircraft technology has seen an economic explosion in production, sales, testing, specialized designs, and friendly / hostile usages of deployed UAS / UAVs / Drones. There is a huge global growing market and entrepreneurs know it. Second, hostile use of UAS is on the forefront of DoD defense and offensive planners. They are especially concerned with SWARM behavior. Movies like “Angel has Fallen,” where drones in a SWARM use facial recognition technology to kill USSS agents protecting POTUS, have built the lore of UAS and brought the problem forefront to DHS. Third, UAS technology was exploding. UAS and Counter- UAS developments in navigation, weapons, surveillance, data transfer, fuel cells, stealth, weight distribution, tactics, GPS / GNSS elements, SCADA protections, privacy invasions, terrorist uses, specialized software, and security protocols has exploded. (Nichols, et al., 2019) Our team has followed / tracked joint ventures between military and corporate entities and specialized labs to build UAS countermeasures. As authors, we felt compelled to address at least the edge of some of the new C-UAS developments. It was clear that we would be lucky if we could cover a few of – the more interesting and priority technology updates – all in the UNCLASSIFIED and OPEN sphere. Counter Unmanned Aircraft Systems: Technologies and Operations is the companion textbook to our 2nd edition. The civilian market is interesting and entrepreneurial, but the military and intelligence markets are of concern because the US does NOT lead the pack in C-UAS technologies. China does. China continues to execute its UAS proliferation along the New Silk Road Sea / Land routes (NSRL). It has maintained a 7% growth in military spending each year to support its buildup. (Nichols, et al., 2019) [Chapter 21]. They continue to innovate and have recently improved a solution for UAS flight endurance issues with the development of advanced hydrogen fuel cell. (Nichols, et al., 2019) Reed and Trubetskoy presented a terrifying map of countries in the Middle East with armed drones and their manufacturing origin. Guess who? China. (A.B. Tabriski & Justin, 2018, December) Our C-UAS textbook has as its primary mission to educate and train resources who will enter the UAS / C-UAS field and trust it will act as a call to arms for military and DHS planners.https://newprairiepress.org/ebooks/1031/thumbnail.jp

Image Compression Techniques: A Survey in Lossless and Lossy algorithms

The bandwidth of the communication networks has been increased continuously as results of technological advances. However, the introduction of new services and the expansion of the existing ones have resulted in even higher demand for the bandwidth. This explains the many efforts currently being invested in the area of data compression. The primary goal of these works is to develop techniques of coding information sources such as speech, image and video to reduce the number of bits required to represent a source without significantly degrading its quality. With the large increase in the generation of digital image data, there has been a correspondingly large increase in research activity in the field of image compression. The goal is to represent an image in the fewest number of bits without losing the essential information content within. Images carry three main type of information: redundant, irrelevant, and useful. Redundant information is the deterministic part of the information, which can be reproduced without loss from other information contained in the image. Irrelevant information is the part of information that has enormous details, which are beyond the limit of perceptual significance (i.e., psychovisual redundancy). Useful information, on the other hand, is the part of information, which is neither redundant nor irrelevant. Human usually observes decompressed images. Therefore, their fidelities are subject to the capabilities and limitations of the Human Visual System. This paper provides a survey on various image compression techniques, their limitations, compression rates and highlights current research in medical image compression

ISHPC 2021 proceedings – online pre-conference 2020

For decades there has been intense research and development on sorption heat pumping and cooling processes; still, looking at the sales numbers, it is mainly a niche technology. The current transition to an energy system based on renewables changes the boundary conditions. Sorption heat pumps will have an indispensable place in this context, especially for its potential to make use of waste heat. We want to look at the future of sorption heat pumping devices including the newest research developments, as well as reports about pilots and mature technology

Space station systems: A bibliography with indexes (supplement 3)

This bibliography lists 780 reports, articles and other documents introduced into the NASA scientific and technical information system between January 1, 1986 and June 30, 1986. Its purpose is to provide helpful information to the researcher, manager, and designer in technology development and mission design according to system, interactive analysis and design, structural and thermal analysis and design, structural concepts and control systems, electronics, advanced materials, assembly concepts, propulsion, and solar power satellite system. The coverage includes documents that define major systems and subsystems, servicing and support requirements, procedures and operations, and missions for the current and future space station

Technology 2000, volume 1

The purpose of the conference was to increase awareness of existing NASA developed technologies that are available for immediate use in the development of new products and processes, and to lay the groundwork for the effective utilization of emerging technologies. There were sessions on the following: Computer technology and software engineering; Human factors engineering and life sciences; Information and data management; Material sciences; Manufacturing and fabrication technology; Power, energy, and control systems; Robotics; Sensors and measurement technology; Artificial intelligence; Environmental technology; Optics and communications; and Superconductivity

Open Source Law, Policy and Practice

This book examines various policies, including the legal and commercial aspects of the Open Source phenomenon. Here, ‘Open Source’ is adopted as convenient shorthand for a collection of diverse users and communities, whose differences can be as great as their similarities. The common thread is their reliance on, and use of, law and legal mechanisms to govern the source code they write, use, and distribute. The central fact of open source is that maintaining control over source code relies on the existence and efficacy of intellectual property (‘IP’) laws, particularly copyright law. Copyright law is the primary statutory tool that achieves the end of openness, although implemented through private law arrangements at varying points within the software supply chain. This dependent relationship is itself a cause of concern for some philosophically in favour of ‘open’, with some predicting (or hoping) that the free software movement will bring about the end of copyright as a means for protecting software