Segmentation of ultrasound images of thyroid nodule for assisting fine needle aspiration cytology

The incidence of thyroid nodule is very high and generally increases with the age. Thyroid nodule may presage the emergence of thyroid cancer. The thyroid nodule can be completely cured if detected early. Fine needle aspiration cytology is a recognized early diagnosis method of thyroid nodule. There are still some limitations in the fine needle aspiration cytology, and the ultrasound diagnosis of thyroid nodule has become the first choice for auxiliary examination of thyroid nodular disease. If we could combine medical imaging technology and fine needle aspiration cytology, the diagnostic rate of thyroid nodule would be improved significantly. The properties of ultrasound will degrade the image quality, which makes it difficult to recognize the edges for physicians. Image segmentation technique based on graph theory has become a research hotspot at present. Normalized cut (Ncut) is a representative one, which is suitable for segmentation of feature parts of medical image. However, how to solve the normalized cut has become a problem, which needs large memory capacity and heavy calculation of weight matrix. It always generates over segmentation or less segmentation which leads to inaccurate in the segmentation. The speckle noise in B ultrasound image of thyroid tumor makes the quality of the image deteriorate. In the light of this characteristic, we combine the anisotropic diffusion model with the normalized cut in this paper. After the enhancement of anisotropic diffusion model, it removes the noise in the B ultrasound image while preserves the important edges and local details. This reduces the amount of computation in constructing the weight matrix of the improved normalized cut and improves the accuracy of the final segmentation results. The feasibility of the method is proved by the experimental results.Comment: 15pages,13figure

Textural Difference Enhancement based on Image Component Analysis

In this thesis, we propose a novel image enhancement method to magnify the textural differences in the images with respect to human visual characteristics. The method is intended to be a preprocessing step to improve the performance of the texture-based image segmentation algorithms. We propose to calculate the six Tamura's texture features (coarseness, contrast, directionality, line-likeness, regularity and roughness) in novel measurements. Each feature follows its original understanding of the certain texture characteristic, but is measured by some local low-level features, e.g., direction of the local edges, dynamic range of the local pixel intensities, kurtosis and skewness of the local image histogram. A discriminant texture feature selection method based on principal component analysis (PCA) is then proposed to find the most representative characteristics in describing textual differences in the image. We decompose the image into pairwise components representing the texture characteristics strongly and weakly, respectively. A set of wavelet-based soft thresholding methods are proposed as the dictionaries of morphological component analysis (MCA) to sparsely highlight the characteristics strongly and weakly from the image. The wavelet-based thresholding methods are proposed in pair, therefore each of the resulted pairwise components can exhibit one certain characteristic either strongly or weakly. We propose various wavelet-based manipulation methods to enhance the components separately. For each component representing a certain texture characteristic, a non-linear function is proposed to manipulate the wavelet coefficients of the component so that the component is enhanced with the corresponding characteristic accentuated independently while having little effect on other characteristics. Furthermore, the above three methods are combined into a uniform framework of image enhancement. Firstly, the texture characteristics differentiating different textures in the image are found. Secondly, the image is decomposed into components exhibiting these texture characteristics respectively. Thirdly, each component is manipulated to accentuate the corresponding texture characteristics exhibited there. After re-combining these manipulated components, the image is enhanced with the textural differences magnified with respect to the selected texture characteristics. The proposed textural differences enhancement method is used prior to both grayscale and colour image segmentation algorithms. The convincing results of improving the performance of different segmentation algorithms prove the potential of the proposed textural difference enhancement method

Image Inpainting and Enhancement using Fractional Order Variational Model

The intention of image inpainting is to complete or fill the corrupted or missing zones of an image by considering the knowledge from the source region. A novel fractional order variational image inpainting model in reference to Caputo definition is introduced in this article. First, the fractional differential, and its numerical methods are represented according to Caputo definition. Then, a fractional differential mask is represented in 8-directions. The complex diffusivity function is also defined to preserve the edges. Finally, the missing regions are filled by using variational model with fractional differentials of 8-directions. The simulation results and analysis display that the new model not only inpaints the missing regions, but also heightens the contrast of the image. The inpainted images have better visual quality than other fractional differential filters

Textural Difference Enhancement based on Image Component Analysis

In this thesis, we propose a novel image enhancement method to magnify the textural differences in the images with respect to human visual characteristics. The method is intended to be a preprocessing step to improve the performance of the texture-based image segmentation algorithms. We propose to calculate the six Tamura's texture features (coarseness, contrast, directionality, line-likeness, regularity and roughness) in novel measurements. Each feature follows its original understanding of the certain texture characteristic, but is measured by some local low-level features, e.g., direction of the local edges, dynamic range of the local pixel intensities, kurtosis and skewness of the local image histogram. A discriminant texture feature selection method based on principal component analysis (PCA) is then proposed to find the most representative characteristics in describing textual differences in the image. We decompose the image into pairwise components representing the texture characteristics strongly and weakly, respectively. A set of wavelet-based soft thresholding methods are proposed as the dictionaries of morphological component analysis (MCA) to sparsely highlight the characteristics strongly and weakly from the image. The wavelet-based thresholding methods are proposed in pair, therefore each of the resulted pairwise components can exhibit one certain characteristic either strongly or weakly. We propose various wavelet-based manipulation methods to enhance the components separately. For each component representing a certain texture characteristic, a non-linear function is proposed to manipulate the wavelet coefficients of the component so that the component is enhanced with the corresponding characteristic accentuated independently while having little effect on other characteristics. Furthermore, the above three methods are combined into a uniform framework of image enhancement. Firstly, the texture characteristics differentiating different textures in the image are found. Secondly, the image is decomposed into components exhibiting these texture characteristics respectively. Thirdly, each component is manipulated to accentuate the corresponding texture characteristics exhibited there. After re-combining these manipulated components, the image is enhanced with the textural differences magnified with respect to the selected texture characteristics. The proposed textural differences enhancement method is used prior to both grayscale and colour image segmentation algorithms. The convincing results of improving the performance of different segmentation algorithms prove the potential of the proposed textural difference enhancement method

Contributions en optimisation topologique : extension de la méthode adjointe et applications au traitement d'images

De nos jours, l'optimisation topologique a été largement étudiée en optimisation de structure, problème majeur en conception de systèmes mécaniques pour l'industrie et dans les problèmes inverses avec la détection de défauts et d'inclusions. Ce travail se concentre sur les approches de dérivées topologiques et propose une généralisation plus flexible de cette méthode rendant possible l'investigation de nouvelles applications. Dans une première partie, nous étudions des problèmes classiques en traitement d'images (restauration, inpainting), et exposons une formulation commune à ces problèmes. Nous nous concentrons sur la diffusion anisotrope et considérons un nouveau problème : la super-résolution. Notre approche semble meilleure comparée aux autres méthodes. L'utilisation des dérivées topologiques souffre d'inconvénients : elle est limitée à des problèmes simples, nous ne savons pas comment remplir des trous ... Dans une seconde partie, une nouvelle méthode visant à surmonter ces difficultés est présentée. Cette approche, nommée voûte numérique, est une extension de la méthode adjointe. Ce nouvel outil nous permet de considérer de nouveaux champs d'application et de réaliser de nouvelles investigations théoriques dans le domaine des dérivées topologiques.Nowadays, topology optimization has been extensively studied in structural optimization which is a major interest in the design of mechanical systems in the industry and in inverse problems with the detection of defects or inclusions. This work focuses on the topological derivative approach and proposes a more flexible generalization of this method making it possible to address new applications. In a first part, we study classical image processing problems (restoration, inpainting), and give a common framework to theses problems. We focus on anisotropic diffusion and consider a new problem: super-resolution. Our approach seems to be powerful in comparison with other methods. Topological derivative method has some drawbacks: it is limited to simple problems, we do not know how to fill holes, ... In a second part, to overcome these difficulties, an extension of the adjoint method is presented. Named the numerical vault, it allows us to consider new fields of applications and to explore new theoretical investigations in the area of topological derivative

Principled Design and Implementation of Steerable Detectors

We provide a complete pipeline for the detection of patterns of interest in an image. In our approach, the patterns are assumed to be adequately modeled by a known template, and are located at unknown position and orientation. We propose a continuous-domain additive image model, where the analyzed image is the sum of the template and an isotropic background signal with self-similar isotropic power-spectrum. The method is able to learn an optimal steerable filter fulfilling the SNR criterion based on one single template and background pair, that therefore strongly responds to the template, while optimally decoupling from the background model. The proposed filter then allows for a fast detection process, with the unknown orientation estimation through the use of steerability properties. In practice, the implementation requires to discretize the continuous-domain formulation on polar grids, which is performed using radial B-splines. We demonstrate the practical usefulness of our method on a variety of template approximation and pattern detection experiments

Texture descriptor combining fractal dimension and artificial crawlers

Texture is an important visual attribute used to describe images. There are many methods available for texture analysis. However, they do not capture the details richness of the image surface. In this paper, we propose a new method to describe textures using the artificial crawler model. This model assumes that each agent can interact with the environment and each other. Since this swarm system alone does not achieve a good discrimination, we developed a new method to increase the discriminatory power of artificial crawlers, together with the fractal dimension theory. Here, we estimated the fractal dimension by the Bouligand-Minkowski method due to its precision in quantifying structural properties of images. We validate our method on two texture datasets and the experimental results reveal that our method leads to highly discriminative textural features. The results indicate that our method can be used in different texture applications.Comment: 12 pages 9 figures. Paper in press: Physica A: Statistical Mechanics and its Application

Advanced Algorithms for 3D Medical Image Data Fusion in Specific Medical Problems

Fúze obrazu je dnes jednou z nejběžnějších avšak stále velmi diskutovanou oblastí v lékařském zobrazování a hraje důležitou roli ve všech oblastech lékařské péče jako je diagnóza, léčba a chirurgie. V této dizertační práci jsou představeny tři projekty, které jsou velmi úzce spojeny s oblastí fúze medicínských dat. První projekt pojednává o 3D CT subtrakční angiografii dolních končetin. V práci je využito kombinace kontrastních a nekontrastních dat pro získání kompletního cévního stromu. Druhý projekt se zabývá fúzí DTI a T1 váhovaných MRI dat mozku. Cílem tohoto projektu je zkombinovat stukturální a funkční informace, které umožňují zlepšit znalosti konektivity v mozkové tkáni. Třetí projekt se zabývá metastázemi v CT časových datech páteře. Tento projekt je zaměřen na studium vývoje metastáz uvnitř obratlů ve fúzované časové řadě snímků. Tato dizertační práce představuje novou metodologii pro klasifikaci těchto metastáz. Všechny projekty zmíněné v této dizertační práci byly řešeny v rámci pracovní skupiny zabývající se analýzou lékařských dat, kterou vedl pan Prof. Jiří Jan. Tato dizertační práce obsahuje registrační část prvního a klasifikační část třetího projektu. Druhý projekt je představen kompletně. Další část prvního a třetího projektu, obsahující specifické předzpracování dat, jsou obsaženy v disertační práci mého kolegy Ing. Romana Petera.Image fusion is one of today´s most common and still challenging tasks in medical imaging and it plays crucial role in all areas of medical care such as diagnosis, treatment and surgery. Three projects crucially dependent on image fusion are introduced in this thesis. The first project deals with the 3D CT subtraction angiography of lower limbs. It combines pre-contrast and contrast enhanced data to extract the blood vessel tree. The second project fuses the DTI and T1-weighted MRI brain data. The aim of this project is to combine the brain structural and functional information that purvey improved knowledge about intrinsic brain connectivity. The third project deals with the time series of CT spine data where the metastases occur. In this project the progression of metastases within the vertebrae is studied based on fusion of the successive elements of the image series. This thesis introduces new methodology of classifying metastatic tissue. All the projects mentioned in this thesis have been solved by the medical image analysis group led by Prof. Jiří Jan. This dissertation concerns primarily the registration part of the first project and the classification part of the third project. The second project is described completely. The other parts of the first and third project, including the specific preprocessing of the data, are introduced in detail in the dissertation thesis of my colleague Roman Peter, M.Sc.