Design of a Power Management Circuit for an Opto-Electro Stimulator

This paper presents the design of an integrated power management circuit for use in an implantable opto-electro stimulator. It features an active rectifier with pulse width modulation (PWM) regulation to generate a 3.3 V regulated output, and a 3-stage high voltage charge pump (CP) that generates a 12 V output from a 3.3 V input with a 20 MHz, two-phase non-overlapping clock generator. The circuits were designed in a 0.18-µm CMOS technology requiring a chip area of 0.048 mm 2 . Simulation results show that the regulating rectifier has a voltage conversion efficiency of 94.3% and 92.8% with an ac input magnitude of 3.5 V and 3.6 V, respectively. The peak power transfer efficiency of the regulated 3.3V output voltage is 70.7% with a maximum output power of 30.3 mW. The CP with an overall on-chip capacitance is 60 pF

High Efficiency Power Management Unit for Implantable Optical-Electrical Stimulators

Battery-less active implantable devices are of interest because they offer longer life span and eliminate costly battery replacement surgical interventions. This is possible as a result of advances in inductive power transfer and development of power management circuits to maximize the overall power transfer and provide various voltage levels for multi-functional implantable devices. Rehabilitation therapy using optical stimulation of genetically modified peripheral neurons requires high current loads. Standard rectification topologies are inefficient and have associated voltage drops unsuited for miniaturized implants. This paper presents an integrated power management unit (PMU) for an optical-electrical stimulator to be used in the treatment of motor neurone disease. It includes a power-efficient regulating rectifier with a novel body biased high-speed comparator providing 3.3 V for the operation of the stimulator, a 3-stage latch-up charge pump with 12 V output for the input stage of the optical-electrical stimulator, and 1.8 V for digital control logic. The chip was fabricated in a 0.18 μm CMOS process. Measured results show that for a regulated output of 3.3 V delivering 30.3 mW power, the peak power conversion efficiency is 84.2% at 6.78 MHz inductive link tunable frequency reducing to 70.3% at 13.56 MHz. The charge pump with on chip capacitors has 90.9% measured voltage conversion efficiency

Wireless Power Transfer System for Battery-Less Body Implantable Devices

Department of Electrical EngineeringAs the life expectancy is increased and the welfare is promoted, researches on the body implantable medical devices (BIMD) are actively being carried out, and products providing more various functions are being released. On the other hand, due to these various functions, the power consumption of the BIMD is also increased, so that the primary battery alone cannot provide sufficient power for the devices. The limited capacity and life time of batteries force patients to make an additional payment and suffering for the power supply of the BIMD. Wireless power transfer technology is the technology which has been making remarkable progress mainly in wireless charging for personal portable devices and electric vehicles. Convergence of wireless power transfer technology (WPT) and rechargeable battery can extend the life time of the BIMD and reduce the suffering and the cost for battery replacements. Furthermore, WPT enables the devices which do not need to operate consistently such as body implantable sensor devices to be used without batteries. In this dissertation, techniques to support WPT for BIMD are introduced and proposed. First, basic researches on magnetic coupled WPT are presented. The basics which are important factors to analyze power transmission are introduced. In addition, circuits that make up the WPT system are described. There are three common technical challenges in WPT. Those are efficiency degradation on coil geometry, voltage gain variation with coil geometry, and power losses in WPT. The common challenges are discussed in chapter II. Moreover, additional challenges which are arisen in WPT for BIMD and approaches to resolve the challenges are addressed in chapter II. Then, efficiency improvement techniques and control techniques in WPT are presented in chapter III. The presented techniques to improve efficiency are applied in coil parts and circuit parts. In coil parts, efficiency enhancement technique by geometric variation is proposed. In circuit parts, instantaneous power consuming technique for step-down converter is suggested. Li-ion battery charger is also discussed in chapter III. Additionally, the wireless controlled constant current / constant voltage charging mode and the proposed step charging method are described. After that, WPT system for BIMD is discussed one by one with the proposed techniques for each part in chapter IV. A load transformation is suggested to improve efficiency in weak coupling, and suppress voltage gain variation under coil displacement. Power conversion efficiency improvement techniques for rectifier and converter are also proposed. By using the proposed technique for the converter, we can remove the bootstrap capacitors, and reduce the overall size of power circuits. In conclusion, techniques in coil parts and circuit parts to handle challenges in WPT for BIMD are fully investigated in this thesis in addition to the efficiency improvement and control techniques in common WPT. All the techniques are verified through simulations or experiments. The approaches realized in the thesis can be applied to other applications employing the WPT.clos

Inductively Coupled CMOS Power Receiver For Embedded Microsensors

Inductively coupled power transfer can extend the lifetime of embedded microsensors that save costs, energy, and lives. To expand the microsensors' functionality, the transferred power needs to be maximized. Plus, the power receiver needs to handle wide coupling variations in real applications. Therefore, the objective of this research is to design a power receiver that outputs the highest power for the widest coupling range. This research proposes a switched resonant half-bridge power stage that adjusts both energy transfer frequency and duration so the output power is maximally high. A maximum power point (MPP) theory is also developed to predict the optimal settings of the power stage with 98.6% accuracy. Finally, this research addresses the system integration challenges such as synchronization and over-voltage protection. The fabricated self-synchronized prototype outputs up to 89% of the available power across 0.067%~7.9% coupling range. The output power (in percentage of available power) and coupling range are 1.3× and 13× higher than the comparable state of the arts.Ph.D

Ultrasonically powered compact implantable dust for optogenetics

This paper presents an ultrasonically powered microsystem for deep tissue optogenetic stimulation. All the phases in developing the prototype starting from modelling the piezoelectric crystal used for energy harvesting, design, simulation and measurement of the chip, and finally testing the whole system in a mimicking setup are explained. The developed system is composed of a piezoelectric harvesting cube, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (LED), and envisioned to be used for freely moving animal studies. The proposed rectifier chip with a silicon area of 300 μm × 300 μm is implemented in standard TSMC 0.18 μm CMOS technology, for interfacing the piezoelectric cube and the microLED. Experimental results show that the proposed microsystem produces an available electrical power of 2.2 mW while loaded by a microLED, out of an acoustic intensity of 7.2 mW/mm 2 using a (1 mm) 3 crystal as the receiver. The whole system including the tested rectifier chip, a piezoelectric cube with the dimensions of (500 μm) 3 , and a μLED of 300 μm × 130 μm have been integrated on a 3 mm × 1.5 mm glass substrate, encapsulated inside a bio-compatible PDMS layer and tested successfully for final prototyping. The total volume of the fully-packaged device is estimated around 2.85 mm 3

A Novel Power-Efficient Wireless Multi-channel Recording System for the Telemonitoring of Electroencephalography (EEG)

This research introduces the development of a novel EEG recording system that is modular, batteryless, and wireless (untethered) with the supporting theoretical foundation in wireless communications and related design elements and circuitry. Its modular construct overcomes the EEG scaling problem and makes it easier for reconfiguring the hardware design in terms of the number and placement of electrodes and type of standard EEG system contemplated for use. In this development, portability, lightweight, and applicability to other clinical applications that rely on EEG data are sought. Due to printer tolerance, the 3D printed cap consists of 61 electrode placements. This recording capacity can however extend from 21 (as in the international 10-20 systems) up to 61 EEG channels at sample rates ranging from 250 to 1000 Hz and the transfer of the raw EEG signal using a standard allocated frequency as a data carrier. The main objectives of this dissertation are to (1) eliminate the need for heavy mounted batteries, (2) overcome the requirement for bulky power systems, and (3) avoid the use of data cables to untether the EEG system from the subject for a more practical and less restrictive setting. Unpredictability and temporal variations of the EEG input make developing a battery-free and cable-free EEG reading device challenging. Professional high-quality and high-resolution analog front ends are required to capture non-stationary EEG signals at microvolt levels. The primary components of the proposed setup are the wireless power transmission unit, which consists of a power amplifier, highly efficient resonant-inductive link, rectification, regulation, and power management units, as well as the analog front end, which consists of an analog to digital converter, pre-amplification unit, filtering unit, host microprocessor, and the wireless communication unit. These must all be compatible with the rest of the system and must use the least amount of power possible while minimizing the presence of noise and the attenuation of the recorded signal A highly efficient resonant-inductive coupling link is developed to decrease power transmission dissipation. Magnetized materials were utilized to steer electromagnetic flux and decrease route and medium loss while transmitting the required energy with low dissipation. Signal pre-amplification is handled by the front-end active electrodes. Standard bio-amplifier design approaches are combined to accomplish this purpose, and a thorough investigation of the optimum ADC, microcontroller, and transceiver units has been carried out. We can minimize overall system weight and power consumption by employing battery-less and cable-free EEG readout system designs, consequently giving patients more comfort and freedom of movement. Similarly, the solutions are designed to match the performance of medical-grade equipment. The captured electrical impulses using the proposed setup can be stored for various uses, including classification, prediction, 3D source localization, and for monitoring and diagnosing different brain disorders. All the proposed designs and supporting mathematical derivations were validated through empirical and software-simulated experiments. Many of the proposed designs, including the 3D head cap, the wireless power transmission unit, and the pre-amplification unit, are already fabricated, and the schematic circuits and simulation results were based on Spice, Altium, and high-frequency structure simulator (HFSS) software. The fully integrated head cap to be fabricated would require embedding the active electrodes into the 3D headset and applying current technological advances to miniaturize some of the design elements developed in this dissertation

Energy management techniques for ultra-small bio-medical implants

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 167-174).Trends in the medical industry have created a growing demand for implantable medical devices. In particular, the need to provide medical professionals a means to continuously monitor bio-markers over long time scales with increased precision is paramount to efficient healthcare. To make medical implants more attractive, there is a need to reduce their size and power consumption. Small medical implants would allow for less invasive procedures and greater comfort for patients. The two primary limitations to the size of small medical implants are the batteries that provide energy to circuit and sensor components, and the antennas that enable wireless communication to terminals outside of the body. In this work we present energy management and low-power techniques to help solve the engineering challenges posed by using ultracapacitors for energy storage. A major problem with using any capacitor as an energy source is the fact that its voltage drops rapidly with decreasing charge. This leaves the circuit to cope with a large supply variation and can lead to energy being left on the capacitor when its voltage gets too low to supply a sufficient supply voltage for operation. Rather than use a single ultracapacitor, we demonstrate higher energy utilization by splitting a single capacitor into an array of capacitors that are progressively reconfigured as energy is drawn out. An energy management IC fabricated in 180-nm CMOS implements a stacking procedure that allows for more than 98% of the initial energy stored in the ultracapacitors to be removed before the output voltage drops unsuitably low for circuit operation. The second part of this work develops techniques for wide-input-range energy management. The first chip implementing stacking suffered an efficiency penalty by using a switchedcapacitor voltage regulator with only a single conversion ratio. In a second implementation, we introduce a better solution that preserves efficiency performance by using a multiple conversion ratio switched-capacitor voltage regulator. At any given input voltage from an ultracapcitor array, the switched-capacitor voltage regulator is configured to maximize efficiency. Fabricated in a 180-nm CMOS process, the chip achieves a peak efficiency of 90% and the efficiency does not fall below 70% for input voltages between 1.25 and 3 V.by William R. Sanchez.Ph.D

GaN-Based High Efficiency Transmitter for Multiple-Receiver Wireless Power Transfer

Wireless power transfer (WPT) has attracted great attention from industry and academia due to high charging flexibility. However, the efficiency of WPT is lower and the cost is higher than the wired power transfer approaches. Efforts including converter optimization, power delivery architecture improvement, and coils have been made to increase system efficiency.In this thesis, new power delivery architectures in the WPT of consumer electronics have been proposed to improve the overall system efficiency and increase the power density.First, a two-stage transmitter architecture is designed for a 100 W WPT system. After comparing with other topologies, the front-end ac-dc power factor correction (PFC) rectifier employs a totem-pole rectifier. A full bridge 6.78 MHz resonant inverter is designed for the subsequent stage. An impedance matching network provides constant transmitter coil current. The experimental results verify the high efficiency, high PF, and low total harmonic distortion (THD).Then, a single-stage transmitter is derived based on the verified two-stage structure. By integration of the PFC rectifier and full bridge inverter, two GaN FETs are saved and high efficiency is maintained. The integrated DCM operated PFC rectifier provides high PF and low THD. By adopting a control scheme, the transmitter coil current and power are regulated. A simple auxiliary circuit is employed to improve the light load efficiency. The experimental results verify the achievement of high efficiency.A closed-loop control scheme is implemented in the single-stage transmitter to supply multiple receivers simultaneously. With a controlled constant transmitter current, the system provides a smooth transition during dynamically load change. ZVS detection circuit is proposed to protect the transmitter from continuous hard switching operation. The control scheme is verified in the experiments.The multiple-reciever WPT system with the single-stage transmitter is investigated. The system operating range is discussed. The method of tracking optimum system efficiency is studied. The system control scheme and control procedure, targeting at providing a wide system operating range, robust operation and capability of tracking the optimized system efficiency, are proposed. Experiment results demonstrate the WPT system operation

Biomedical Engineering

Biomedical engineering is currently relatively wide scientific area which has been constantly bringing innovations with an objective to support and improve all areas of medicine such as therapy, diagnostics and rehabilitation. It holds a strong position also in natural and biological sciences. In the terms of application, biomedical engineering is present at almost all technical universities where some of them are targeted for the research and development in this area. The presented book brings chosen outputs and results of research and development tasks, often supported by important world or European framework programs or grant agencies. The knowledge and findings from the area of biomaterials, bioelectronics, bioinformatics, biomedical devices and tools or computer support in the processes of diagnostics and therapy are defined in a way that they bring both basic information to a reader and also specific outputs with a possible further use in research and development