Generalized bisimulation metrics

International audienceThe pseudometric based on the Kantorovich lifting is one of the most popular notion of distance between probabilistic processes proposed in the literature. However, its application in verification is limited to linear properties. We propose a generalization which allows to deal with a wider class of properties, such as those used in security and privacy. More precisely, we propose a family of pseudometrics, parametrized on a notion of distance which depends on the property we want to verify. Furthermore, we show that the members of this family still characterize bisimilarity in terms of their kernel, and provide a bound on the corresponding distance between trace distributions. Finally, we study the instance corresponding to differential privacy, and we show that it has a dual form, easier to compute. We also prove that the typical process-algebra constructs are non-expansive, thus paving the way to a modular approach to verification

Towards Trace Metrics via Functor Lifting

We investigate the possibility of deriving metric trace semantics in a coalgebraic framework. First, we generalize a technique for systematically lifting functors from the category Set of sets to the category PMet of pseudometric spaces, showing under which conditions also natural transformations, monads and distributive laws can be lifted. By exploiting some recent work on an abstract determinization, these results enable the derivation of trace metrics starting from coalgebras in Set. More precisely, for a coalgebra on Set we determinize it, thus obtaining a coalgebra in the Eilenberg-Moore category of a monad. When the monad can be lifted to PMet, we can equip the final coalgebra with a behavioral distance. The trace distance between two states of the original coalgebra is the distance between their images in the determinized coalgebra through the unit of the monad. We show how our framework applies to nondeterministic automata and probabilistic automata

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors

Probabilistic Semantics: Metric and Logical Character¨ations for Nondeterministic Probabilistic Processes

In this thesis we focus on processes with nondeterminism and probability in the PTS model, and we propose novel techniques to study their semantics, in terms of both classic behavioral relations and the more recent behavioral metrics. Firstly, we propose a method for decomposing modal formulae in a probabilistic extension of the Hennessy-Milner logic. This decomposition method allows us to derive the compositional properties of probabilistic (bi)simulations. Then, we propose original notions of metrics measuring the disparities in the behavior of processes with respect to (decorated) trace and testing semantics. To capture the differences in the expressive power of the metrics we order them by the relation `makes processes further than'. Thus, we obtain the first spectrum of behavioral metrics on the PTS model. From this spectrum we derive an analogous one for the kernels of the metrics, ordered by the relation `makes strictly less identification than'. Finally, we introduce a novel technique for the logical characterization of both behavioral metrics and their kernels, based on the notions of mimicking formula and distance on formulae. This kind of characterization allows us to obtain the first example of a spectrum of distances on processes obtained directly from logics. Moreover, we show that the kernels of the metrics can be characterized by simply comparing the mimicking formulae of processes

Data integration and analysis for circadian medicine

Data integration, data sharing, and standardized analyses are important enablers for data-driven medical research. Circadian medicine is an emerging field with a particularly high need for coordinated and systematic collaboration between researchers from different disciplines. Datasets in circadian medicine are multimodal, ranging from molecular circadian profiles and clinical parameters to physiological measurements and data obtained from (wearable) sensors or reported by patients. Uniquely, data spanning both the time dimension and the spatial dimension (across tissues) are needed to obtain a holistic view of the circadian system. The study of human rhythms in the context of circadian medicine has to confront the heterogeneity of clock properties within and across subjects and our inability to repeatedly obtain relevant biosamples from one subject. This requires informatics solutions for integrating and visualizing relevant data types at various temporal resolutions ranging from milliseconds and seconds to minutes and several hours. Associated challenges range from a lack of standards that can be used to represent all required data in a common interoperable form, to challenges related to data storage, to the need to perform transformations for integrated visualizations, and to privacy issues. The downstream analysis of circadian rhythms requires specialized approaches for the identification, characterization, and discrimination of rhythms. We conclude that circadian medicine research provides an ideal environment for developing innovative methods to address challenges related to the collection, integration, visualization, and analysis of multimodal multidimensional biomedical data.Peer Reviewe

Probabilistic Semantics: Metric and Logical Character\ua8ations for Nondeterministic Probabilistic Processes

In this thesis we focus on processes with nondeterminism and probability in the PTS model, and we propose novel techniques to study their semantics, in terms of both classic behavioral relations and the more recent behavioral metrics. Firstly, we propose a method for decomposing modal formulae in a probabilistic extension of the Hennessy-Milner logic. This decomposition method allows us to derive the compositional properties of probabilistic (bi)simulations. Then, we propose original notions of metrics measuring the disparities in the behavior of processes with respect to (decorated) trace and testing semantics. To capture the differences in the expressive power of the metrics we order them by the relation `makes processes further than'. Thus, we obtain the first spectrum of behavioral metrics on the PTS model. From this spectrum we derive an analogous one for the kernels of the metrics, ordered by the relation `makes strictly less identification than'. Finally, we introduce a novel technique for the logical characterization of both behavioral metrics and their kernels, based on the notions of mimicking formula and distance on formulae. This kind of characterization allows us to obtain the first example of a spectrum of distances on processes obtained directly from logics. Moreover, we show that the kernels of the metrics can be characterized by simply comparing the mimicking formulae of processes

Privacy-aware Security Applications in the Era of Internet of Things

In this dissertation, we introduce several novel privacy-aware security applications. We split these contributions into three main categories: First, to strengthen the current authentication mechanisms, we designed two novel privacy-aware alternative complementary authentication mechanisms, Continuous Authentication (CA) and Multi-factor Authentication (MFA). Our first system is Wearable-assisted Continuous Authentication (WACA), where we used the sensor data collected from a wrist-worn device to authenticate users continuously. Then, we improved WACA by integrating a noise-tolerant template matching technique called NTT-Sec to make it privacy-aware as the collected data can be sensitive. We also designed a novel, lightweight, Privacy-aware Continuous Authentication (PACA) protocol. PACA is easily applicable to other biometric authentication mechanisms when feature vectors are represented as fixed-length real-valued vectors. In addition to CA, we also introduced a privacy-aware multi-factor authentication method, called PINTA. In PINTA, we used fuzzy hashing and homomorphic encryption mechanisms to protect the users\u27 sensitive profiles while providing privacy-preserving authentication. For the second privacy-aware contribution, we designed a multi-stage privacy attack to smart home users using the wireless network traffic generated during the communication of the devices. The attack works even on the encrypted data as it is only using the metadata of the network traffic. Moreover, we also designed a novel solution based on the generation of spoofed traffic. Finally, we introduced two privacy-aware secure data exchange mechanisms, which allow sharing the data between multiple parties (e.g., companies, hospitals) while preserving the privacy of the individual in the dataset. These mechanisms were realized with the combination of Secure Multiparty Computation (SMC) and Differential Privacy (DP) techniques. In addition, we designed a policy language, called Curie Policy Language (CPL), to handle the conflicting relationships among parties. The novel methods, attacks, and countermeasures in this dissertation were verified with theoretical analysis and extensive experiments with real devices and users. We believe that the research in this dissertation has far-reaching implications on privacy-aware alternative complementary authentication methods, smart home user privacy research, as well as the privacy-aware and secure data exchange methods

Critical Thinking Via Storytelling: Theory and Social Media Experiment

In a stylized voting model, we establish that increasing the share of critical thinkers -- individuals who are aware of the ambivalent nature of a certain issue -- in the population increases the efficiency of surveys (elections) but might increase surveys' bias. In an incentivized online social media experiment on a representative US population (N = 706), we show that different digital storytelling formats -- different designs to present the same set of facts -- affect the intensity at which individuals become critical thinkers. Intermediate-length designs (Facebook posts) are most effective at triggering individuals into critical thinking. Individuals with a high need for cognition mostly drive the differential effects of the treatments