UNH Law Alumni Magazine, Winter 2006

https://scholars.unh.edu/alumni_mag/1015/thumbnail.jp

NASA Ocean Altimeter Pathfinder Project

The NOAA/NASA Pathfinder program was created by the Earth Observing System (EOS) Program Office to determine how existing satellite-based data sets can be processed and used to study global change. The data sets are designed to be long time-series data processed with stable calibration and community consensus algorithms to better assist the research community. The Ocean Altimeter Pathfinder Project involves the reprocessing of all altimeter observations with a consistent set of improved algorithms, based on the results from TOPEX/POSEIDON (T/P), into easy-to-use data sets for the oceanographic community for climate research. Details are currently presented in two technical reports: Report# 1: Data Processing Handbook Report #2: Data Set Validation This report describes the validation of the data sets against a global network of high quality tide gauge measurements and provides an estimate of the error budget. The first report describes the processing schemes used to produce the geodetic consistent data set comprised of SEASAT, GEOSAT, ERS-1, TOPEX/ POSEIDON, and ERS-2 satellite observations

Doctor of Philosophy

dissertationMany cellular membrane fission events are mediated by dynamin-related proteins (DRP), which self-assemble into spirals encircling the lipid tubes at their sites of action. DRPs are GTPases whose activities are dramatically stimulated upon assembly. Rapid GTP hydrolysis causes constriction of DRP spirals and leads to membrane fission. DRPmediated membrane fission is initiated by the recruitment of a certain DRP to the specific cellular membrane via adaptor proteins. The adaptors also co-assemble with DRPs to form active fission complexes. The molecular mechanism for this important recruitment step is poorly understood, as is the function of adaptor proteins during fission complex formation and membrane severing. In this thesis, we studied DRP membrane recruitment and adaptor functions using the yeast mitochondrial fission machinery including the DRP Dnm1, the adaptor Mdv1, and the membrane anchor Fis1. To initiate mitochondrial fission, Dnm1 is recruited to the mitochondria via a direct interaction with Mdv1, which binds Fis1 on the mitochondrial outer membrane. As described in Chapter 2, we identified a novel motif in the Dnml Insert B domain that is essential for the interaction of Dnml with Mdvl. Mutations in this conserved motif severely impaired Dnml-Mdvl interaction and mitochondrial fission. Suppressor mutations in the Mdvl P-propeller domain rescued defects caused by the Insert B mutations. The positions of these suppressor mutations define potential binding sites for Insert B on the Mdvl P-propeller. In Chapter 3, we demonstrated that Mdvl plays dual functions, as an adaptor and in scaffolding, during fission complex formation. Mdvl dimerizes via a 92A coiled-coil, which determines the optimal architecture of fission complexes. Together, these studies provide mechanistic insights regarding DRP membrane recruitment and the functions of adaptors in DRP-mediated membrane fission. Although the sequence of Insert B and the adaptors are varied among DRPs, we believe that they are functionally conserved and may have co-evolved to meet the requirements of specific fission events in different tissues and cell types

Strategic Issues, Problems and Challenges in Inductive Theorem Proving

Abstract(Automated) Inductive Theorem Proving (ITP) is a challenging field in automated reasoning and theorem proving. Typically, (Automated) Theorem Proving (TP) refers to methods, techniques and tools for automatically proving general (most often first-order) theorems. Nowadays, the field of TP has reached a certain degree of maturity and powerful TP systems are widely available and used. The situation with ITP is strikingly different, in the sense that proving inductive theorems in an essentially automatic way still is a very challenging task, even for the most advanced existing ITP systems. Both in general TP and in ITP, strategies for guiding the proof search process are of fundamental importance, in automated as well as in interactive or mixed settings. In the paper we will analyze and discuss the most important strategic and proof search issues in ITP, compare ITP with TP, and argue why ITP is in a sense much more challenging. More generally, we will systematically isolate, investigate and classify the main problems and challenges in ITP w.r.t. automation, on different levels and from different points of views. Finally, based on this analysis we will present some theses about the state of the art in the field, possible criteria for what could be considered as substantial progress, and promising lines of research for the future, towards (more) automated ITP

Aspects of age, growth, demographics and thermal biology of two lamniform shark species

Age and growth rates for salmon sharks (Lamna ditropis) in the eastern North Pacific (ENP) were estimated from seasonally formed bands in the vertebrae, and compared to previously published life history parameters for this species from the western North Pacific (WNP). Results of this study show that salmon sharks in the ENP achieve their maximum length at a faster rate, reach sexual maturity at an earlier age and achieve a greater weight-at-length than those in the WNP. Additionally, this dissertation shows that adult salmon sharks maintain a specific body temperature independent of changes in ambient temperature through a combination of physical and physiological means, and essentially function as homeotherms. Due to uncertainty in previous life history parameter estimates for sand tiger sharks (Carcharias taurus) in the western North Atlantic, age and growth rates were re-estimated using a larger sample size and captive individuals injected with oxytetracycline (OTC), a fluorescent skeletal marker. The results support a hypothesis that this species forms one pair of growth bands annually in the vertebral centra, whereas previous growth rate estimates were based on the formation of two bands per year. as such, the growth rate of this species is considerably slower than previously predicted and the population more susceptible to fishing mortality. Demographic analyses were conducted for salmon sharks in the ENP and WNP, and for sand tiger sharks (based on new life history parameter estimates) with uncertainty in vital rates incorporated via Monte Carlo simulations. Density-dependent compensation was included in models where fishing mortality was imposed by increasing sub-adult survivorship from output values generated by a previously published Intrinsic Rebound Potential model. The results indicate that both species are extremely vulnerable to fishing mortality and that no fishery should be implemented for sand tiger sharks or salmon sharks in the WNP. Salmon sharks in the ENP were the only population examined that indicated the potential to tolerate any fishing mortality. A comparison of growth completion rates and other life history parameters of ectothermic and endothermic sharks did not indicate that endothermic sharks achieve their maximum length at a faster rate than ectothermic sharks

Relating state-based and process-based concurrency through linear logic (full-version)

AbstractThis paper has the purpose of reviewing some of the established relationships between logic and concurrency, and of exploring new ones.Concurrent and distributed systems are notoriously hard to get right. Therefore, following an approach that has proved highly beneficial for sequential programs, much effort has been invested in tracing the foundations of concurrency in logic. The starting points of such investigations have been various idealized languages of concurrent and distributed programming, in particular the well established state-transformation model inspired by Petri nets and multiset rewriting, and the prolific process-based models such as the π-calculus and other process algebras. In nearly all cases, the target of these investigations has been linear logic, a formal language that supports a view of formulas as consumable resources. In the first part of this paper, we review some of these interpretations of concurrent languages into linear logic and observe that, possibly modulo duality, they invariably target a small semantic fragment of linear logic that we call LVobs.In the second part of the paper, we propose a new approach to understanding concurrent and distributed programming as a manifestation of logic, which yields a language that merges those two main paradigms of concurrency. Specifically, we present a new semantics for multiset rewriting founded on an alternative view of linear logic and specifically LVobs. The resulting interpretation is extended with a majority of linear connectives into the language of ω-multisets. This interpretation drops the distinction between multiset elements and rewrite rules, and considerably enriches the expressive power of standard multiset rewriting with embedded rules, choice, replication, and more. Derivations are now primarily viewed as open objects, and are closed only to examine intermediate rewriting states. The resulting language can also be interpreted as a process algebra. For example, a simple translation maps process constructors of the asynchronous π-calculus to rewrite operators. The language of ω-multisets forms the basis for the security protocol specification language MSR 3. With relations to both multiset rewriting and process algebra, it supports specifications that are process-based, state-based, or of a mixed nature, with the potential of combining verification techniques from both worlds. Additionally, its logical underpinning makes it an ideal common ground for systematically comparing protocol specification languages