38 research outputs found

    Chapter 34 - Biocompatibility of nanocellulose: Emerging biomedical applications

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    Nanocellulose already proved to be a highly relevant material for biomedical applications, ensued by its outstanding mechanical properties and, more importantly, its biocompatibility. Nevertheless, despite their previous intensive research, a notable number of emerging applications are still being developed. Interestingly, this drive is not solely based on the nanocellulose features, but also heavily dependent on sustainability. The three core nanocelluloses encompass cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC). All these different types of nanocellulose display highly interesting biomedical properties per se, after modification and when used in composite formulations. Novel applications that use nanocellulose includewell-known areas, namely, wound dressings, implants, indwelling medical devices, scaffolds, and novel printed scaffolds. Their cytotoxicity and biocompatibility using recent methodologies are thoroughly analyzed to reinforce their near future applicability. By analyzing the pristine core nanocellulose, none display cytotoxicity. However, CNF has the highest potential to fail long-term biocompatibility since it tends to trigger inflammation. On the other hand, neverdried BNC displays a remarkable biocompatibility. Despite this, all nanocelluloses clearly represent a flag bearer of future superior biomaterials, being elite materials in the urgent replacement of our petrochemical dependence

    EVOLUTION OF THE SUBCONTINENTAL LITHOSPHERE DURING MESOZOIC TETHYAN RIFTING: CONSTRAINTS FROM THE EXTERNAL LIGURIAN MANTLE SECTION (NORTHERN APENNINE, ITALY)

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    Our study is focussed on mantle bodies from the External Ligurian ophiolites, within the Monte Gavi and Monte Sant'Agostino areas. Here, two distinct pyroxenite-bearing mantle sections were recognized, mainly based on their plagioclase-facies evolution. The Monte Gavi mantle section is nearly undeformed and records reactive melt infiltration under plagioclase-facies conditions. This process involved both peridotites (clinopyroxene-poor lherzolites) and enclosed spinel pyroxenite layers, and occurred at 0.7–0.8 GPa. In the Monte Gavi peridotites and pyroxenites, the spinel-facies clinopyroxene was replaced by Ca-rich plagioclase and new orthopyroxene, typically associated with secondary clinopyroxene. The reactive melt migration caused increase of TiO2 contents in relict clinopyroxene and spinel, with the latter also recording a Cr2O3 increase. In the Monte Gavi peridotites and pyroxenites, geothermometers based on slowly diffusing elements (REE and Y) record high temperature conditions (1200-1250 °C) related to the melt infiltration event, followed by subsolidus cooling until ca. 900°C. The Monte Sant'Agostino mantle section is characterized by widespread ductile shearing with no evidence of melt infiltration. The deformation recorded by the Monte Sant'Agostino peridotites (clinopyroxene-rich lherzolites) occurred at 750–800 °C and 0.3–0.6 GPa, leading to protomylonitic to ultramylonitic textures with extreme grain size reduction (10–50 μm). Compared to the peridotites, the enclosed pyroxenite layers gave higher temperature-pressure estimates for the plagioclase-facies re-equilibration (870–930 °C and 0.8–0.9 GPa). We propose that the earlier plagioclase crystallization in the pyroxenites enhanced strain localization and formation of mylonite shear zones in the entire mantle section. We subdivide the subcontinental mantle section from the External Ligurian ophiolites into three distinct domains, developed in response to the rifting evolution that ultimately formed a Middle Jurassic ocean-continent transition: (1) a spinel tectonite domain, characterized by subsolidus static formation of plagioclase, i.e. the Suvero mantle section (Hidas et al., 2020), (2) a plagioclase mylonite domain experiencing melt-absent deformation and (3) a nearly undeformed domain that underwent reactive melt infiltration under plagioclase-facies conditions, exemplified by the the Monte Sant'Agostino and the Monte Gavi mantle sections, respectively. We relate mantle domains (1) and (2) to a rifting-driven uplift in the late Triassic accommodated by large-scale shear zones consisting of anhydrous plagioclase mylonites. Hidas K., Borghini G., Tommasi A., Zanetti A. & Rampone E. 2021. Interplay between melt infiltration and deformation in the deep lithospheric mantle (External Liguride ophiolite, North Italy). Lithos 380-381, 105855

    Impact of Etna’s volcanic emission on major ions and trace elements composition of the atmospheric deposition

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    Mt. Etna, on the eastern coast of Sicily (Italy), is one of the most active volcanoes on the planet and it is widely recognized as a big source of volcanic gases (e.g., CO2 and SO2), halogens, and a lot of trace elements, to the atmosphere in the Mediterranean region. Especially during eruptive periods, Etna’s emissions can be dispersed over long distances and cover wide areas. A group of trace elements has been recently brought to attention for their possible environmental and human health impacts, the Technology-critical elements. The current knowledge about their geochemical cycles is still scarce, nevertheless, recent studies (Brugnone et al., 2020) evidenced a contribution from the volcanic activity for some of them (Te, Tl, and REE). In 2021, in the framework of the research project “Pianeta Dinamico”, by INGV, a network of 10 bulk collectors was implemented to collect, monthly, atmospheric deposition samples. Four of these collectors are located on the flanks of Mt. Etna, other two are in the urban area of Catania and three are in the industrial area of Priolo, all most of the time downwind of the main craters. The last one, close to Cesarò (Nebrodi Regional Park), represents the regional background. The research aims to produce a database on major ions and trace element compositions of the bulk deposition and here we report the values of the main physical-chemical parameters and the deposition fluxes of major ions and trace elements from the first year of research. The pH ranged from 3.1 to 7.7, with a mean value of 5.6, in samples from the Etna area, while it ranged between 5.2 and 7.6, with a mean value of 6.4, in samples from the other study areas. The EC showed values ranging from 5 to 1032 μS cm-1, with a mean value of 65 μS cm-1. The most abundant ions were Cl- and SO42- for anions, Na+ and Ca+ for cations, whose mean deposition fluxes, considering all sampling sites, were 16.6, 6.8, 8.4, and 6.0 mg m-2 d, respectively. The highest deposition fluxes of volcanic refractory elements, such as Al, Fe, and Ti, were measured in the Etna’s sites, with mean values of 948, 464, and 34.3 μg m-2 d-1, respectively, higher than those detected in the other sampling sites, further away from the volcanic source (26.2, 12.4, 0.5 μg m-2 d-1, respectively). The same trend was also observed for volatile elements of prevailing volcanic origin, such as Tl (0.49 μg m-2 d-1), Te (0.07 μg m-2 d-1), As (0.95 μg m-2 d-1), Se (1.92 μg m-2 d-1), and Cd (0.39 μg m-2 d-1). Our preliminary results show that, close to a volcanic area, volcanic emissions must be considered among the major contributors of ions and trace elements to the atmosphere. Their deposition may significantly impact the pedosphere, hydrosphere, and biosphere and directly or indirectly human health

    Impact of geogenic degassing on C-isotopic composition of dissolved carbon in karst systems of Greece

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    The Earth C-cycle is complex, where endogenic and exogenic sources are interconnected, operating in a multiple spatial and temporal scale (Lee et al., 2019). Non-volcanic CO2 degassing from active tectonic structures is one of the less defined components of this cycle (Frondini et al., 2019). Carbon mass-balance (Chiodini et al., 2000) is a useful tool to quantify the geogenic carbon output from regional karst hydrosystems. This approach has been demonstrated for central Italy and may be valid also for Greece, due to the similar geodynamic settings. Deep degassing in Greece has been ascertained mainly at hydrothermal and volcanic areas, but the impact of geogenic CO2 released by active tectonic areas has not yet been quantified. The main aim of this research is to investigate the possible deep degassing through the big karst aquifers of Greece. Since 2016, 156 karst springs were sampled along most of the Greek territory. To discriminate the sources of carbon, the analysis of the isotopic composition of carbon was carried out. δ13CTDIC values vary from -16.61 to -0.91‰ and can be subdivided into two groups characterized by (a) low δ13CTDIC, and (b) intermediate to high δ13CTDIC with a threshold value of -6.55‰. The composition of the first group can be related to the mixing of organic-derived CO2 and the dissolution of marine carbonates. Springs of the second group, mostly located close to Quaternary volcanic areas, are linked to possible carbon input from deep sources

    Brain and Human Body Modeling

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    This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner. Describes construction and application of computational human models including anatomically detailed and subject specific models; Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations; Includes a survey of modern applications for which computational human models are critical; Describes cellular-level interactions between the human body and electromagnetic fields

    XI CIDU. La transformaciĂłn digital de la universidad Congreso Iberoamericano de Docencia Universitaria

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    Nesta comunicação apresenta-se uma experiência de gamificação realizada numa turma online, numa Universidade Virtual. Foram utilizados como elementos de jogo pontos, badges, leadboard, avatares e desafios. Do ponto de vista do desenho da unidade curricular, foi proposto um desafio global, sob a forma de roleplaying, que percorreu todo o semestre. Para este desafio global contribuíram três outros desafios, nos quais os estudantes deveriam dinamizar discussões, sendo atribuídos pontos e badges em função da sua prestação. No que se refere à metodologia, tratou-se de uma investigação exploratória, com carácter qualitativo. Como técnicas de recolha de dados, privilegiou-se a observação, realizada durante toda a unidade curricular, complementada por um questionário aos estudantes no final do semestre. Constatou-se que a estratégia adotada incentivou a participação ativa dos estudantes, tendo estes gostado da experiência. Verificaram-se, contudo, algumas limitações, pelo facto de os estudantes desta amostra serem adultos trabalhadores a frequentar uma licenciatura online, com outros compromissos profissionais e familiares. Com efeito, verificou-se que vários deles mencionaram ter dificuldade na gestão do tempo, limitando a possibilidade de adesão a um percurso exigente em termos de participação ativa.In this paper, we present a gamification experiment that took place in an online class at a virtual university. The game elements were points, badges, leaderboard, avatars and challenges. Taking into account the curricular unit design, a global challenge was proposed, in the form of roleplaying, and took place along the whole semester. Three other challenges contributed to this global challenge: the students had to dynamize debates, and received points and badges, according to their performance. In terms of methodology, it consisted in an exploratory research of a qualitative character. Observation, complemented by a questionnaire made available to the students at the end of the semester, were the chosen techniques for data collection. It was observed that the adopted strategy motivated the students’ active participation, who really enjoyed the experience. However, some limitations were also observed, once these students, attending an online First Cycle Degree, are adults who have professional and family responsibilities and commitments. Actually, several of them mentioned that the difficulty in organizing their time did limit the possibility of participating in the challenge, which was indeed demanding in terms of active participation.info:eu-repo/semantics/publishedVersio

    Efficient Decision Support Systems

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    This series is directed to diverse managerial professionals who are leading the transformation of individual domains by using expert information and domain knowledge to drive decision support systems (DSSs). The series offers a broad range of subjects addressed in specific areas such as health care, business management, banking, agriculture, environmental improvement, natural resource and spatial management, aviation administration, and hybrid applications of information technology aimed to interdisciplinary issues. This book series is composed of three volumes: Volume 1 consists of general concepts and methodology of DSSs; Volume 2 consists of applications of DSSs in the biomedical domain; Volume 3 consists of hybrid applications of DSSs in multidisciplinary domains. The book is shaped upon decision support strategies in the new infrastructure that assists the readers in full use of the creative technology to manipulate input data and to transform information into useful decisions for decision makers

    Modeling and Analyzing Cyber-Physical Systems Using Hybrid Predicate Transition Nets

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    Cyber-Physical Systems (CPSs) are software controlled physical devices that are being used everywhere from utility features in household devices to safety-critical features in cars, trains, aircraft, robots, smart healthcare devices. CPSs have complex hybrid behaviors combining discrete states and continuous states capturing physical laws. Developing reliable CPSs are extremely difficult. Formal modeling methods are especially useful for abstracting and understanding complex systems and detecting and preventing early system design problems. To ensure the dependability of formal models, various analysis techniques, including simulation and reachability analysis, have been proposed in recent decades. This thesis aims to provide a unified formal modeling and analysis methodology for studying CPSs. Firstly, this thesis contributes to the modeling and analysis of discrete, continuous, and hybrid systems. This work enhances modeling of discrete systems using predicate transition nets (PrTNs) by fully realizing the underlying specification through incorporating the first-order logic with set theory, improving the type system, and providing incremental model composition. This work enhances the technique of analyzing discrete systems using PrTN by improving the simulation algorithm and its efficient implementation. This work also improves the analysis of discrete systems using SPIN by providing a more accurate and complete translation method. Secondly, this work contributes to the modeling and analysis of hybrid systems by proposing an extension of PrTNs, hybrid predicate transition nets (HPrTNs). The proposed method incorporates a novel concept of token evolution, which nicely addresses the continuous state evolution and the conflicts present in other related works. This work presents a powerful simulation capability that can handle linear, non-linear dynamics, transcendental functions through differential equations. This work also provides a complementary technique for reachability analysis through the translation of HPrTN models for analysis using SpaceEx
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