It's About How and Where We Build: Connecting Energy and Smart Growth

In recent years, energy issues have become a growing concern for Americans. Largely missing from present energy discussions, however, is the role that land-use practices have on energy consumption and the use of alternative energy resources. By efficiently locating development, we can reduce the amount of energy needed for transportation and for other infrastructure as compared with spread-out, suburban development. Moreover, by including greater use of energy efficient design, these "smart growth" land-use practices could become even smarter -- and better achieve their goals of environmental protection, economic prosperity, and community livability. The smart growth land-use and energy efficiency movements are intrinsically linked, yet these two fields have mostly operated in separate worlds. Greater coordination between these two professions is warranted, yet substantial barriers exist. A recent survey reveals that planners' technical knowledge of energy issues is limited, as is their inclusion of energy factors in comprehensive planning, zoning, and development review. Heightened concern about foreign oil dependence, climate change, and the other ill effects of fossil fuel usage makes the energy-land-use collaboration especially important. Recently, there have been some hopeful signs of collaboration between energy professionals and community developers

Catch and release’ cascades: a resin-mediated three-component cascade approach to small molecules

The application of a ‘catch and release’ approach to palladium-catalysed multi-component cascade reactions leads to diverse libraries of pharmacologically interesting small molecules in high yield and with excellent purity

Ecofriendly Synthesis in Aqueous Medium: An Expeditious Approach to New N,N-Diethyl Amide Bearing Benzenemethanesulfonamides

An highly expeditious synthetic approach for the synthesis of benzenemethanesulfonamides (1a-k) and their new corresponding N,N-diethyl substituted amido moieties (2a-k) has been achieved in aqueous medium at room tem-perature. The reaction condition was thoroughly optimized thereby allowing significant rate enhancement and resulting into excellent yields. The chemical structures of the successful candidates were confirmed using elemental analytical and spectroscopic data such as IR, 1H NMR, 13C NMR and some selected mass spectral dat

New Majoritarian Constitutionalism

Ever since Alexander Bickel coined the phrase “countermajoritarian difficulty,” commentators have frequently described the Supreme Court as either a “majoritarian” or “counter-majoritarian” institution. In this heuristic dichotomy, the Justices either base constitutional law on their own independent and subjective interpretations or they rely on extrinsic indicators to determine constitutional meaning. In practice, however, this dichotomy is neither clearly evident, nor clearly applied, and a third approach—“New Majoritarian” Constitutionalism—has emerged. Under new majoritarian constitutionalism, the Court considers (1) the actual decisions of courts and juries; (2) legislative trends; (3) executive branch practices; and (4) geographic disparities within various jurisdictions. This model of majoritarianism accepts the traditional idea that constitutional decisions must be grounded in conventional lawmaking sources and that interpretations of vague constitutional language should accord with broadly held, majoritarian positions. This approach, however, creatively uses traditional indicators to a far greater extent than others. This Article provides a new typology of majoritarian constitutional theories that reorients our understanding of the role of objective indicators of meaning, with major implications for scholarship and doctrine. In addition to its descriptive power, new majoritarianism has important normative implications—promoting institutional process values such as stability and transparency, while reinforcing the centrality of coordinate branch dialogue in evolving constitutional meaning

The Temporal and Spatial Distribution of Catlinite and Redstone Pipes on Caddo Sites

Catlinite and redstone pipes are widely distributed on post-A.D 1450 native American sites across eastern North America, including the Caddo area of the far Southeast. As Rodning indicates, however, catlinite pipes are much more widespread from the late seventeenth century to the early eighteenth century, where the smoking of catlinite pipes is associated with calumet ceremonialism, and the spread of calumet ceremonialism associated with the “spread of European colonists and colonialism.” In this article, I discuss the temporal and spatial distribution of catlinite and redstone pipes on Caddo sites across the northern and southern Caddo areas. These pipes occur in both pre- and post-European contexts in Caddo sites, and take several forms (disk and elbow pipes), but their widest distribution is on sites that date from ca. A.D. 1690-1780 on Caddo sites in East Texas. Catlinite and redstone pipes are made from argillite found in sources in the Great Plains and the upper Midwest, most notably at Pipestone National Monument in southwestern Minnesota. According to Rodning, the French “colonists are known to have imported argillite and perhaps catlinite from the Midwest or Plains… for the purpose of making calumet pipes to give as gifts to native American groups with whom the French sought alliances.

New Majoritarian Constitutionalism

Ever since Alexander Bickel coined the phrase “countermajoritarian difficulty,” commentators have frequently described the Supreme Court as either a “majoritarian” or “counter-majoritarian” institution. In this heuristic dichotomy, the Justices either base constitutional law on their own independent and subjective interpretations or they rely on extrinsic indicators to determine constitutional meaning. In practice, however, this dichotomy is neither clearly evident, nor clearly applied, and a third approach—“New Majoritarian” Constitutionalism—has emerged. Under new majoritarian constitutionalism, the Court considers (1) the actual decisions of courts and juries; (2) legislative trends; (3) executive branch practices; and (4) geographic disparities within various jurisdictions. This model of majoritarianism accepts the traditional idea that constitutional decisions must be grounded in conventional lawmaking sources and that interpretations of vague constitutional language should accord with broadly held, majoritarian positions. This approach, however, creatively uses traditional indicators to a far greater extent than others. This Article provides a new typology of majoritarian constitutional theories that reorients our understanding of the role of objective indicators of meaning, with major implications for scholarship and doctrine. In addition to its descriptive power, new majoritarianism has important normative implications—promoting institutional process values such as stability and transparency, while reinforcing the centrality of coordinate branch dialogue in evolving constitutional meaning

The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene

We report the nucleotide sequence of a gene encoding the constant region of a human immnnoglobulin γ1 heavy chain (Cγ1). A comparison of this sequence with those of the Cγ2 and Cγ4 genes reveals that these three human Cγ genes share considerable homology in both coding and noncoding regions. The nucleotide sequence differences indicate that these genes diverged from one another approximately 6–8 million years ago. An examination of hinge exons shows that these coding regions have evolved more rapidly than any other areas of the Cγ genes in terms of both base substitution and deletion–insertion events. Coding sequence diversity also is observed in areas of CH domains which border the hinge

Exosomes: A Novel Zika Virus Vaccine Candidate

With the recent emergence of Zika virus (ZIKV) diseases, increasing global concern has driven the demand for a vaccine. One promising vaccine platform has presented itself in the form of exosomes: a subgroup of extracellular vesicles released by many human cell types that facilitate intercellular communication. The objective of this study is to engineer exosomes that incorporate ZIKV structural proteins into its phospholipid bilayer. Previous studies indicate that CD9 and CD63 proteins are highly enriched in exosomal membranes. From this, it was hypothesized that attaching ZIKV genes to CD9 or CD63 to produce a gene fusion may enable exosomes to act as antigen-presenting vesicles. These engineered exosomes may potentially stimulate T-cells to mount a strong immune response. The cDNA of the CD9, CD63, and the highly immunogenic ZIKV genes (envelope, precursor membrane, and NS1) were generated using RT-PCR. These products were used as a template for regular PCR, and cloned into pcDNA3.1/V5 vector. The chimeric gene fusion was assembled using the Gibson assembly kit, and transfected into human embryonic kidney epithelial (HEK293T) cells for expression. The exosomes were purified from the supernatant and subjected to immunoblotting and immunofluorescence assays to confirm the presence of ZIKV proteins. The results of this study are pending at the time of this abstract submission. A future study will be conducted using an in vitro activation assay to determine if the engineered exosomes induce T-cell activation. The potential candidates will be used in an animal study for immunity against ZIKV infection