In-vitro Cytotoxicity and In-silico Insights of the Multi-target Anticancer Candidates from Haplophyllum tuberculatum

This study aimed to investigate the anticancer activity of Haplophyllum tuberculatum(Forsk.) aerial parts ethanol extract and fractions and reveal the potential anticancer targets, binding modes, pharmacokinetics, and toxicity properties of its phytoconstituents. MTT assay was used to investigate the anticancer activity. TargetNet, ChemProt version 2.0, and CLC-Pred web servers were used for virtual screening, and Cresset Flare software was used for molecular docking with the 26 predicted targets. Moreover, pkCSM, swiss ADME, and eMolTox web servers were used to predict pharmacokinetics and safety. Ethanolic extracts of H. tuberculatum on HepG2 and HeLa cell lines showed promising activities with IC50 values 54.12 and 48.1 µg/mL, respectively. Further, ethyl acetate fraction showed the highest cytotoxicity on HepG2 and HeLa cell lines with IC50 values 41.7 and 52.31 µg/mL. Of 70 compounds screened virtually, polygamain, justicidin A, justicidin B, haplotubine, kusunokinin, and flindersine were predicted as safe anticancer drugs candidates. They showed the highest binding scores with targets involved in cell growth, proliferation, survival, migration, tumor suppression, induction of apoptosis, metastasis, and drug resistance. Our findings revealed the potency of H. tuberculatum as a source of anticancer candidates that further studies should support

William H.N. Hull Fonds, 1955-1995, n.d. (non-inclusive)

William Henry Nelles Hull was born in Grimsby, Ontario in 1929. He received an Honours Bachelor of Arts in Business Administration from the University of Western Ontario in 1951; a Master’s Degree in Economics and Political Science from the University of Western Ontario in 1955 and a Ph.D. in Political Science from Duke University, Durham, North Carolina in 1959. Dr. Hull was a lecturer in Political Science at the University of Western Ontario from 1958-1959. He worked as an Associate Professor of Political Science at the University of Manitoba from 1959-1964 while he was also an Assistant to the Dean of Arts and Science at the same university. In 1964-1965, he took on the roles of Visiting Assistant Professor in Political Science and Executive Director of the Commonwealth Studies Center at Duke University. He became an Associate Professor of Politics and Chairman of the Department of Politics at Brock University in 1965-1967. From 1967-1968 he was a Professor of Politics and Chairman of the Department of Politics at Brock. He also acted as the Chairman of the Department of Economics at Brock from 1966-1968. His roles in 1968- 1970 included Professor of Politics and Chairman of the Department of Politics at Brock. He remained a Professor of Politics at Brock, and from 1970 onward and took on the added duty of being the Co-coordinator of Communications in 1983- 1986. Dr. Hull retired from Brock University in 1995. He received numerous honours and awards including: a Fellowship from the Commonwealth Studies Center at Duke University; a grant from the Institute of Public Administration of Canada to W.U.S. (World University Service) International Assembly, Lund, Sweden; a grant from the Department of External Affairs to accept invitations to lecture in Australia; the Queen’s Silver Jubilee Medal; a Social Science and Humanities Research Council Research Grant and a Brock Advancement Fund grant. Dr. Hull has lectured at numerous universities and he is a prolific writer. The Police and the Mass Media, Background Study prepared for the Royal Commission investigating Niagara Regional Police, 1989 is featured in this fonds.The textual materials of the William H.N. Hull fonds include correspondence, clerical records, and writings by Dr. Hul

Las desigualdades territoriales en el Estado español. 1955-1995

En este trabajo se trata de presentar la dinámica territorial del crecimiento desde una óptica diferente a la que utiliza la teoría convencional, centrando la atención en la localización de actividades y en el rango y la naturaleza de las funciones que desempeñan los diferentes territorios en la división regional del trabajo. Ello nos permitiría llegar a algunas consideraciones sobre la dirección y el camino por el que han transitado las diferentes regiones españolas en esta etapa de cuatro décadas que se extiende desde mediados de los cincuenta hasta mitad de los años noventaIn this paper we try to show the spatial dynamic of growth from a point of view which is quite different to that used by conventional theory (neoclassical theory) of economic growth. Our interest is the spatial location of the economic activities and the range and nature of the roles attributed to the different territories in the regional division of the work. By this way, it will be possible to get some inside about the path followed by Spanish regions along for the last four decades, those form the middle fifties to the middle ninetie

Evaluating the Relative Impact of Fiscal Incentives and Trade Policies on the Returns to Manufacturing in Taiwan 1955-1995

In this paper, an integrated cash flow model is developed to examine the relative impact of tax incentives, financial subsidies, and macroeconomic variables on the profitability of industrial investments. It allows for various variables to interact with each other. An application of the model is carried out for Taiwan, which implemented a variety of fiscal incentives over the past forty years. The principal policy conclusion is that trade and macroeconomic policies are much more important than income tax incentives or subsidized finance policies in determining the success of industrialization process. The effects of any of the fiscal incentives are found generally much smaller than those of the trade policies or the fundamental trends in macroeconomic variables such as the movement of the real exchange rate and the real wage rate.tax incentives, export promotion, industrialization, real exchange rate, trade policy, Taiwan

Estimating sea surface temperature measurement methods using characteristic differences in the diurnal cycle

Lack of reliable observational metadata represents a key barrier to understanding sea surface temperature (SST) measurement biases, a large contributor to uncertainty in the global surface record. We present a method to identify SST measurement practice by comparing the observed SST diurnal cycle from individual ships with a reference from drifting buoys under similar conditions of wind and solar radiation. Compared to existing estimates, we found a larger number of engine room-intake (ERI) reports post War World II and in the period 1960 – 1980. Differences in the inferred mixture of observations lead to a systematic warmer shift of the bias adjusted SST anomalies from 1980 compared to previous estimates, while reducing the ensemble spread. Changes in mean field differences between bucket and ERI SST anomalies in the Northern Hemisphere over the period 1955 – 1995 could be as large as 0.5 °C and are not well reproduced by current bias adjustment models

Dinámica de las regiones en España (1955-1995)

RESUMEN: El objeto de este trabajo es el estudio de la dinámica distributiva del VAB per cápita de las regiones españolas entre 1955 y 1995. De acuerdo con el modelo neoclásico, las economías convergen entre sí en un proceso de crecimiento caracterizado por una suave aproximación al estado estacionario. Sin embargo, en esta colaboración rechazamos la hipótesis de un modelo común. Las economías regionales siguen modelos diferentes cuando se agrupan de acuerdo con su renta per cápita inicial y su estructura productiva. La metodología aplicada se orienta en dos direcciones: las regresiones cruzadas con datos de panel y el análisis de la distribución a largo plazo, por medio de cadenas homogéneas de Markov. Nuestros resultados confirman que existen diferencias significativas en los estados estacionarios.ABSTRACT: According to the neoclassical model, economies converge in a growth process characterised by a smooth path towards a steady-state. However our results confirm that there are significant differences among the steady- states of Spanish regions over the period 1955-95. In this paper, we reject the common linear model hypothesis in favour of a multiple regime alternative, in which different economies obey different models when grouped according to their initial income per head and industrial mix. The methodology focuses on both the cross-sectional panel data regressions and modelling the growth process as a time homogeneous Markov chain

Appendix B: Roster of Deans and Faculty

This listing of ILR Deans and faculty has been compiled from a combination of human resource records kept at the school since 1946, ILR deans’ reports, and other university sources

MS-040: Woman’s League of Gettysburg College

This collection reflects and records almost a century of Gettysburg College history, and the first women\u27s--only organization officially affiliated with and recognized by the college. It is also a prime example of the kinds of activities and movements that were occurring during the Progressive Era in Pennsylvania and the United States. The collection consists of board minutes, minutes from numerous leagues, loose correspondence, convention programs, banquet programs, registrar\u27s reports, treasurer\u27s reports, treasurer\u27s ledger books, handbooks, scrapbooks, photographs, and Golden Books , volumes of calligraphy pages honoring League donors, service men and women, grandchildren and the like. The processing of this collection was supported by a grant from the Pennsylvania Historical and Museum Commission. This collection provides a variety of interesting materials that give insight to both the Woman’s League and the history of Gettysburg College. The majority of the material represents the records of the General League. However, there are additional records and memorabilia from the Sub-Leagues as well. Information is organized, foremost with the records of the General League, and then for the Sub-leagues according to the year of their inception. Names of Sub-leagues were only included if there was information received from that particular Sub-league in one of the relevant categories. It follows then, that not all of the Sub-leagues included on this Finding Aid have information for each Series. In such instances, researchers should refer to General League: Series: Official Records, where records were kept on each individual Sub-league for the number of years that the Sub-league was active. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special_collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1038/thumbnail.jp