Catalytic Asymmetric Synthesis of Optically Active Allenes from Terminal Alkynes
Abstract
CuBr and ZnI<sub>2</sub> have been developed as catalysts or subcatalysts for the efficient asymmetric synthesis of axially chiral allenols with up to 97% ee from readily available propargylic alcohols, aliphatic or aromatic aldehyde, pyrrolidine, and commerically available ligands. The alcohol unit in the terminal alkynes plays a very important role for ensuring high enantioselectivity via coordination- Text
- Journal contribution
- Biophysics
- Biochemistry
- Medicine
- Microbiology
- Molecular Biology
- Biotechnology
- Sociology
- Developmental Biology
- Chemical Sciences not elsewhere classified
- enantioselectivity
- propargylic alcohols
- ee
- Allene
- subcatalyst
- aliphatic
- terminal alkynes
- coordination
- Optically
- pyrrolidine
- role
- aldehyde
- synthesis
- Catalytic Asymmetric Synthesis
- commerically
- alcohol unit
- catalyst
- ligand
- ZnI 2
- Terminal AlkynesCuBr
- chiral allenols
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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