Infrastructure for Retinal Image Analysis

This paper introduces a retinal image analysis infrastructure for the automatic assessment of biomarkers related to early signs of diabetes, hypertension and other systemic diseases. The developed application provides several tools, namely normalization, vessel enhancement and segmentation, optic disc and fovea detection, junction detection, bifurcation/crossing discrimination, artery/vein classification and red lesion detection. The pipeline of these methods allows the assessment of important biomarkers characterizing dynamic properties of retinal vessels, such as tortuosity, width, fractal dimension and bifurcation geometry features

Retinal Image Analysis: A Review

Images of the eye ground or retina not only provide an insight to important parts of the visual system but also reflect the general state of health of the entire human body. Automated retina image analysis is becoming an important screening tool for early detection of certain risks and diseases like diabetic retinopathy, hypertensive retinopathy, age related macular degeneration, glaucoma etc. This can in turn be used to reduce human errors or to provide services to remote areas. In this review paper, we discuss some of the current techniques used to automatically detect the important clinical features of retinal image, such as the blood vessels, optic disc and macula. The quantitative analysis and measurements of these features can be used to better understand the relationship between various diseases and the retinal features

Curvelet Transform based Retinal Image Analysis

Edge detection is an important assignment in image processing, as it is used as a primary tool for pattern  recognition, image segmentation and scene analysis.  An edge detector is a high-pass filter that can be applied for extracting the edge points within an image. Edge detection in the spatial domain is  accomplished through convolution with a set of directional derivative masks in this domain. On the other hand, working in the  frequency domain has many advantages, starting from introducing an alternative description to the  spatial representation and providing more efficient and faster computational schemes with less sensitivity  to noise through high filtering, de-noising and compression algorithms. Fourier transforms, wavelet and  curvelet transform are among the most widely used frequency-domain edge detection from satellite  images. However, the Fourier transform is global and poorly adapted to local singularities. Some of  these draw backs are solved by the wavelet transforms especially for singularities detection and  computation. In this paper, the relatively new multi-resolution technique, curvelet transform, is assessed  and introduced to overcome the wavelet transform limitation in directionality and scaling.  In this research paper, the assessment of second generation curvelet transforms as an edge detection tool  will be introduced and compared with first generation cuevelet transform.DOI:http://dx.doi.org/10.11591/ijece.v3i3.245

Retinal Image Analysis Oriented to the Clinical Task

Ophthalmology can profit greatly from the analysis of digital images because they can aid in establishing an early diagnosis even before the first symptoms appear. This dissertation contributes to the digital analysis of such images and the problems that arise along the imaging pipeline of fundus photography, a field that is commonly referred to as retinal image analysis. We have dealt with and proposed solutions to problems that arise in retinal image acquisition and longitudinal monitoring of retinal disease evolution. Specifically, non- uniform illumination compensation[1], poor image quality [2], automated focusing [3], image segmentation [4], change detection [5], space-invariant (SI) [5] and space-variant (SV) [6] blind deconvolution (BD). Digital retinal image analysis can be effective and cost-efficient for disease management, computer-aided-diagnosis, screening and telemedicine and applicable to a variety of disorders such as glaucoma, macular degeneration, and retinopathy [7, 8]

Context encoder transfer learning approaches for retinal image analysis

Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG.[Abstract]: During the last years, deep learning techniques have emerged as powerful alternatives to solve biomedical image analysis problems. However, the training of deep neural networks usually needs great amounts of labeled data to be done effectively. This is even more critical in the case of biomedical imaging due to the added difficulty of obtaining data labeled by experienced clinicians. To mitigate the impact of data scarcity, one of the most commonly used strategies is transfer learning. Nevertheless, the success of this approach depends on the effectiveness of the available pre-training techniques for learning from little or no labeled data. In this work, we explore the application of the Context Encoder paradigm for transfer learning in the domain of retinal image analysis. To this aim, we propose several approaches that allow to work with full resolution images and improve the recognition of the retinal structures. In order to validate the proposals, the Context Encoder pre-trained models are fine-tuned to perform two relevant tasks in the domain: vessels segmentation and fovea localization. The experiments performed on different public datasets demonstrate that the proposed Context Encoder approaches allow mitigating the impact of data scarcity, being superior to previous alternatives in this domain.Xunta de Galicia; ED481A 2021/196Xunta de Galicia; ED481B-2022-025Xunta de Galicia; ED431C 2020/24Xunta de Galicia; IN845D 2020/38Xunta de Galicia; ED431G 2019/01This research was funded by Instituto de Salud Carlos III, Gov- ernment of Spain, DTS18/00136 research project; Ministerio de Cien- cia e Innovación y Universidades, Government of Spain, RTI2018- 095894-B-I00 research project; Ministerio de Ciencia e Innovación, Government of Spain through the research project with reference PID2019-108435RB-I00; Consellería de Cultura, Educación e Univer- sidade, Xunta de Galicia, Spain through the predoctoral grant contract ref. ED481A 2021/196 and postdoctoral grant contract ref. ED481B- 2022-025; and Grupos de Referencia Competitiva, grant ref. ED431C 2020/24; Axencia Galega de Innovación (GAIN), Spain, Xunta de Galicia, grant ref. IN845D 2020/38; CITIC, Centro de Investigación de Galicia, Spain ref. ED431G 2019/01, receives financial support from Consellería de Educación, Universidade e Formación Profesional, Xunta de Galicia, Spain, through the ERDF (80%) and Secretaría Xeral de Universidades (20%). Funding for open access charge: Universidade da Coruña/CISUG

Measurement of retinal vessel widths from fundus images based on 2-D modeling

Changes in retinal vessel diameter are an important sign of diseases such as hypertension, arteriosclerosis and diabetes mellitus. Obtaining precise measurements of vascular widths is a critical and demanding process in automated retinal image analysis as the typical vessel is only a few pixels wide. This paper presents an algorithm to measure the vessel diameter to subpixel accuracy. The diameter measurement is based on a two-dimensional difference of Gaussian model, which is optimized to fit a two-dimensional intensity vessel segment. The performance of the method is evaluated against Brinchmann-Hansen's half height, Gregson's rectangular profile and Zhou's Gaussian model. Results from 100 sample profiles show that the presented algorithm is over 30% more precise than the compared techniques and is accurate to a third of a pixel