Animacy in early New Zealand english

The literature suggests that animacy effects in present-day spoken New Zealand English (NZE) differ from animacy effects in other varieties of English. We seek to determine if such differences have a history in earlier NZE writing or not. We revisit two grammatical phenomena — progressives and genitives — that are well known to be sensitive to animacy effects, and we study these phenomena in corpora sampling 19th- and early 20th-century written NZE; for reference purposes, we also study parallel samples of 19th- and early 20th-century British English and American English. We indeed find significant regional differences between early New Zealand writing and the other varieties in terms of the effect that animacy has on the frequency and probabilities of grammatical phenomena

The use of conversation mapping to frame key perceptual issues facing the general dental practice system in England

<b>Objective</b>: To demonstrate the use of a novel qualitative methodology namely conversation mapping, which can be used to capture differences in stakeholder perspectives and give a root definition of the problem in a complex policy area. The methodology is used in the context of the changes introduced in the English general dental practice system in April 2006, to investigate the key issues facing the system, as perceived by general dental practitioners (GDPs). <b>Basic research design</b>: From a broad trigger statement, three transformational statements were produced. Each participant recorded their contribution on a hard diagrammatic form as a ‘map’, with others responding with their own written comment, thus generating three conversation maps. Thematic analysis resulted in the generation of a preliminary model summarising key perceptual issues. <b>Results</b>: The five emergent themes identified were: financing, dentists’ wants/needs, the role of the public and patients, system goals and policy level decision making. Financing was identified as the core category to which all other categories were related. <b>Conclusions</b>: Conversation mapping, a methodology arising from a systems approach, can be used to develop a ‘rich picture’ of an oral health care system in order to define the core problem within this policy area. Findings suggest that GDPs identify the financing of the system as a fundamental source of problems within the general dental practice system. This appears to be at variance with the perception of policy makers, who report a more limited view, identifying the system of remuneration as the ‘heart of the problem’

Atomic secrets and governmental lies : nuclear science, politics and security in the Pontecorvo case

This paper focuses on the defection of nuclear physicist Bruno Pontecorvo from Britain to the USSR in 1950 in an attempt to understand how government and intelligence services assess threats deriving from the unwanted spread of secret scientific information. It questions whether contingent agendas play a role in these assessments, as new evidence suggests that this is exactly what happened in the Pontecorvo case. British diplomatic personnel involved in negotiations with their US counterparts considered playing down the case. Meanwhile, the press decided to play it up, claiming that Pontecorvo was an atom spy. Finally, the British secret services had evidence showing that this was a fabrication, but they did not disclose it. If all these manipulations served various purposes, then they certainly were not aimed at assessing if there was a threat and what this threat really was

For Slow Neutrons, Slow Pay: Enrico Fermi’s Patent and the US Atomic Energy Program, 1938-1953

This essay focuses on the history of one of the “atomic patents.” The patent, which described a process to slow down neutrons in nuclear reactions, was the result of experimental research conducted in the 1930s by Enrico Fermi and his group at the Institute of Physics, University of Rome. The value of the patented process became clear during World War II, as it was involved in most of the military and industrial applications of atomic energy. This ignited a controversy between Fermi and U.S. government representatives over royalties to be paid for use of the process during and after the war. The controversy sheds new light on the role that the management of patents played in the context of the Manhattan Project and in the postwar U.S. nuclear program, encompassing issues of power and economic influence in the relationship between scientists, the military, and public administrators

Discrimination of prostate cancer cells and non-malignant cells using secondary ion mass spectrometry

This communication utilises Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) combined with multivariate analysis to obtain spectra from the surfaces of three closely related cell lines allowing their discrimination based upon mass spectral ions

340 years of atmospheric circulation characteristics reconstructed from an eastern Antarctic Peninsula ice core

Copyright @ 2006 American Geophysical Union (AGU)Precipitation delivery mechanisms for Dolleman Island (DI), located off the east coast of the Antarctic Peninsula, are investigated using reanalysis and back trajectory data. The Southern Annular Mode (SAM) and ENSO are both shown to influence precipitation delivery and event size. Precipitation delivery variability is compared against the interannual variation of chemical data from two DI ice cores. Nitrate concentration in the cores is strongly linked with the ratio of easterly to westerly back trajectories arriving at DI, as described by a Cross-Peninsula Index (CPI) defined in this paper. This CPI is used subsequently to reconstruct the atmospheric circulation characteristics for the 340-year ice core record. The analysis highlights a period of increased easterlies during 1720–1780 and an increase in westerlies for 1950–1980, the latter concomitant with a positive SAM trend and western Peninsula warming. The reconstruction also reveals periods when polynyas may have been present in the Weddell Sea

Use of computer-aided detection (CAD) tools in screening mammography: a multidisciplinary investigation

We summarise a set of analyses and studies conducted to assess the effects of the use of a computer-aided detection (CAD) tool in breast screening. We have used an interdisciplinary approach that combines: (a) statistical analyses inspired by reliability modelling in engineering; (b) experimental studies of decisions of mammography experts using the tool, interpreted in the light of human factors psychology; and (c) ethnographic observations of the use of the tool both in trial conditions and in everyday screening practice. Our investigations have shown patterns of human behaviour and effects of computer-based advice that would not have been revealed by a standard clinical trial approach. For example, we found that the negligible measured effect of CAD could be explained by a range of effects on experts' decisions, beneficial in some cases and detrimental in others. There is some evidence of the latter effects being due to the experts using the computer tool differently from the intentions of the developers. We integrate insights from the different pieces of evidence and highlight their implications for the design, evaluation and deployment of this sort of computer tool

Local and global modes of drug action in biochemical networks

It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here present an integrative analysis of the interactions between drugs and metabolism based on the concept of drug scope. The drug scope represents the set of metabolic compounds and reactions that are potentially affected by a drug. We constructed and analyzed the scopes of all US approved drugs having metabolic targets. Our analysis shows that the distribution of drug scopes is highly uneven, and that drugs can be classified into several categories based on their scopes. Some of them have small scopes corresponding to localized action, while others have large scopes corresponding to potential large-scale systemic action. These groups are well conserved throughout different topologies of the underlying metabolic network. They can furthermore be associated to specific drug therapeutic properties

Symptomatic adrenal insufficiency during inhaled corticosteroid treatment

Symptomatic adrenal insufficiency, presenting as hypoglycaemia or poor weight gain, may occur on withdrawal of corticosteroid treatment but has not previously been reported during inhaled corticosteroid treatment. This case series illustrates the occurence of clinically significant adrenal insufficiency in asthmatic children while patients were on inhaled corticosteroid treatment and the unexpected modes of presentation. General practitioners and paediatricians need to be aware that this unusual but acute serious complication may occur in patients treated