39,041 research outputs found
A Deep Learning Framework for Unsupervised Affine and Deformable Image Registration
Image registration, the process of aligning two or more images, is the core
technique of many (semi-)automatic medical image analysis tasks. Recent studies
have shown that deep learning methods, notably convolutional neural networks
(ConvNets), can be used for image registration. Thus far training of ConvNets
for registration was supervised using predefined example registrations.
However, obtaining example registrations is not trivial. To circumvent the need
for predefined examples, and thereby to increase convenience of training
ConvNets for image registration, we propose the Deep Learning Image
Registration (DLIR) framework for \textit{unsupervised} affine and deformable
image registration. In the DLIR framework ConvNets are trained for image
registration by exploiting image similarity analogous to conventional
intensity-based image registration. After a ConvNet has been trained with the
DLIR framework, it can be used to register pairs of unseen images in one shot.
We propose flexible ConvNets designs for affine image registration and for
deformable image registration. By stacking multiple of these ConvNets into a
larger architecture, we are able to perform coarse-to-fine image registration.
We show for registration of cardiac cine MRI and registration of chest CT that
performance of the DLIR framework is comparable to conventional image
registration while being several orders of magnitude faster.Comment: Accepted: Medical Image Analysis - Elsevie
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Validating Dose Uncertainty Estimates Produced by AUTODIRECT: An Automated Program to Evaluate Deformable Image Registration Accuracy.
Deformable image registration is a powerful tool for mapping information, such as radiation therapy dose calculations, from one computed tomography image to another. However, deformable image registration is susceptible to mapping errors. Recently, an automated deformable image registration evaluation of confidence tool was proposed to predict voxel-specific deformable image registration dose mapping errors on a patient-by-patient basis. The purpose of this work is to conduct an extensive analysis of automated deformable image registration evaluation of confidence tool to show its effectiveness in estimating dose mapping errors. The proposed format of automated deformable image registration evaluation of confidence tool utilizes 4 simulated patient deformations (3 B-spline-based deformations and 1 rigid transformation) to predict the uncertainty in a deformable image registration algorithm's performance. This workflow is validated for 2 DIR algorithms (B-spline multipass from Velocity and Plastimatch) with 1 physical and 11 virtual phantoms, which have known ground-truth deformations, and with 3 pairs of real patient lung images, which have several hundred identified landmarks. The true dose mapping error distributions closely followed the Student t distributions predicted by automated deformable image registration evaluation of confidence tool for the validation tests: on average, the automated deformable image registration evaluation of confidence tool-produced confidence levels of 50%, 68%, and 95% contained 48.8%, 66.3%, and 93.8% and 50.1%, 67.6%, and 93.8% of the actual errors from Velocity and Plastimatch, respectively. Despite the sparsity of landmark points, the observed error distribution from the 3 lung patient data sets also followed the expected error distribution. The dose error distributions from automated deformable image registration evaluation of confidence tool also demonstrate good resemblance to the true dose error distributions. Automated deformable image registration evaluation of confidence tool was also found to produce accurate confidence intervals for the dose-volume histograms of the deformed dose
Computing Topology Preservation of RBF Transformations for Landmark-Based Image Registration
In image registration, a proper transformation should be topology preserving.
Especially for landmark-based image registration, if the displacement of one
landmark is larger enough than those of neighbourhood landmarks, topology
violation will be occurred. This paper aim to analyse the topology preservation
of some Radial Basis Functions (RBFs) which are used to model deformations in
image registration. Mat\'{e}rn functions are quite common in the statistic
literature (see, e.g. \cite{Matern86,Stein99}). In this paper, we use them to
solve the landmark-based image registration problem. We present the topology
preservation properties of RBFs in one landmark and four landmarks model
respectively. Numerical results of three kinds of Mat\'{e}rn transformations
are compared with results of Gaussian, Wendland's, and Wu's functions
Bivariate Gamma Distributions for Image Registration and Change Detection
This paper evaluates the potential interest of using bivariate gamma distributions for image registration and change detection. The first part of this paper studies estimators for the parameters of bivariate gamma distributions based on the maximum likelihood principle and the method of moments. The performance of both methods are compared in terms of estimated mean square errors and theoretical asymptotic variances. The mutual information is a classical similarity measure which can be used for image registration or change detection. The second part of the paper studies some properties of the mutual information for bivariate Gamma distributions. Image registration and change detection techniques based on bivariate gamma distributions are finally investigated. Simulation results conducted on synthetic and real data are very encouraging. Bivariate gamma distributions are good candidates allowing us to develop new image registration algorithms and new change detectors
Fast Predictive Image Registration
We present a method to predict image deformations based on patch-wise image
appearance. Specifically, we design a patch-based deep encoder-decoder network
which learns the pixel/voxel-wise mapping between image appearance and
registration parameters. Our approach can predict general deformation
parameterizations, however, we focus on the large deformation diffeomorphic
metric mapping (LDDMM) registration model. By predicting the LDDMM
momentum-parameterization we retain the desirable theoretical properties of
LDDMM, while reducing computation time by orders of magnitude: combined with
patch pruning, we achieve a 1500x/66x speed up compared to GPU-based
optimization for 2D/3D image registration. Our approach has better prediction
accuracy than predicting deformation or velocity fields and results in
diffeomorphic transformations. Additionally, we create a Bayesian probabilistic
version of our network, which allows evaluation of deformation field
uncertainty through Monte Carlo sampling using dropout at test time. We show
that deformation uncertainty highlights areas of ambiguous deformations. We
test our method on the OASIS brain image dataset in 2D and 3D
Learning Rigid Image Registration - Utilizing Convolutional Neural Networks for Medical Image Registration
Many traditional computer vision tasks, such as segmentation, have seen large step-changes in accuracy and/or speed with the application of Convolutional Neural Networks (CNNs). Image registration, the alignment of two or more images to a common space, is a fundamental step in many medical imaging workflows. In this paper we investigate whether these techniques can also bring tangible benefits to the registration task. We describe and evaluate the use of convolutional neural networks (CNNs) for both mono- and multi- modality registration and compare their performance to more traditional schemes, namely multi-scale, iterative registration. This paper also investigates incorporating inverse consistency of the learned spatial transformations to impose additional constraints on the network during training and investigate any benefit in accuracy during detection. The approaches are validated with a series of artificial mono-modal registration tasks utilizing T1-weighted MR brain i mages from the Open Access Series of Imaging Studies (OASIS) study and IXI brain development dataset and a series of real multi-modality registration tasks using T1-weighted and T2-weighted MR brain images from the 2015 Ischemia Stroke Lesion segmentation (ISLES) challenge. The results demonstrate that CNNs give excellent performance for both mono- and multi- modality head and neck registration compared to the baseline method with significantly fewer outliers and lower mean errors
Registration and Fusion of Multi-Spectral Images Using a Novel Edge Descriptor
In this paper we introduce a fully end-to-end approach for multi-spectral
image registration and fusion. Our method for fusion combines images from
different spectral channels into a single fused image by different approaches
for low and high frequency signals. A prerequisite of fusion is a stage of
geometric alignment between the spectral bands, commonly referred to as
registration. Unfortunately, common methods for image registration of a single
spectral channel do not yield reasonable results on images from different
modalities. For that end, we introduce a new algorithm for multi-spectral image
registration, based on a novel edge descriptor of feature points. Our method
achieves an accurate alignment of a level that allows us to further fuse the
images. As our experiments show, we produce a high quality of multi-spectral
image registration and fusion under many challenging scenarios
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