Utilization of Guided Bone Regeneration Techniqes in Treatment of a Single Tooth Missing with Implant Supported Crown

Guided bone regeneration is developing very dynamically in dental surgery and in implantology. It relies on building up bone in places where it is lacking, utilizing a variety of grafting materials. Methods of guided bone regeneration utilize biological materials or synthetic specimens. The use of autogenous platelets rich plasma derived in the thromboforetic process (COBE spectra system) allows the employment of growth factors, which blood platelets contain in the formation of new bone tissues. Usage of BioOss together with platelet rich plasmas allows the creation of a resorbable carrier for growth factor (auto-xenogenic graft). The aim of the presentation is the analysis of clinical cases where usage of bone augmentation enabled the insertion of implants. Rebuilding the bone by means of guided bone regeneration facilitated the implant treatment and consequently the accomplishment of fixed prosthetics supported on implants

Decellularization and Delipidation Protocols of Bovine Bone and Pericardium for Bone Grafting and Guided Bone Regeneration Procedures

The combination of bone grafting materials with guided bone regeneration (GBR) membranes seems to provide promising results to restore bone defects in dental clinical practice. In the first part of this work, a novel protocol for decellularization and delipidation of bovine bone, based on multiple steps of thermal shock, washes with detergent and dehydration with alcohol, is described. This protocol is more effective in removal of cellular materials, and shows superior biocompatibility compared to other three methods tested in this study. Furthermore, histological and morphological analyses confirm the maintenance of an intact bone extracellular matrix (ECM). In vitro and in vivo experiments evidence osteoinductive and osteoconductive properties of the produced scaffold, respectively. In the second part of this study, two methods of bovine pericardium decellularization are compared. The osmotic shock-based protocol gives better results in terms of removal of cell components, biocompatibility, maintenance of native ECM structure, and host tissue reaction, in respect to the freeze/thaw method. Overall, the results of this study demonstrate the characterization of a novel protocol for the decellularization of bovine bone to be used as bone graft, and the acquisition of a method to produce a pericardium membrane suitable for GBR applications

How efficacious is the combination of substitute bone graft with autogenous bone graft in comparison with substitute bone graft alone in the horizontal bone gain? A systematic review and meta-analysis

A systematic review (SR) was conducted to answer the following focused question based on PICO strategy: In patients who were submitted to horizontal guided bone regeneration, ?how efficacious is the combination of substitute bone graft with autogenous bo

Effect of Membrane Exposure on Guided Bone Regeneration: A Systematic Review and Meta‐Analysis

Aims: This review aimed at investigating the effect of membrane exposure on guided bone regeneration (GBR) outcomes at peri-implant sites and edentulous ridges. Material and Methods: Electronic and manual literature searches were conducted by two independent reviewers using four databases, including MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials, for articles up to February 2017. Articles were included if they were human clinical trials or case series reporting outcomes of GBR procedures with and without membrane exposure. A random-effects meta-analysis was conducted, and the weighted mean difference (WMD) between the two groups and 95% confidence interval (CI) were reported. Results: Overall, eight articles were included in the quantitative analysis. The WMD of the horizontal bone gain at edentulous ridges was −76.24% (95% CI = −137.52% to −14.97%, p = .01) between sites with membrane exposure and without exposure. In addition, the WMD of the dehiscence reduction at peri- implant sites was −27.27% (95% CI of −45.87% to −8.68%, p = .004). Both analyses showed significantly favorable outcomes at the sites without membrane exposure. Conclusion: Based on the findings of this study, membrane exposure after GBR procedures has a significant detrimental influence on the outcome of bone augmentation. For the edentulous ridges, the sites without membrane exposure achieved 74% more horizontal bone gain than the sites with exposure. For peri-implant dehiscence defects, the sites without membrane exposure had 27% more defect reduction than the sites with exposure

Dental implants with versus without peri-implant bone defects treated with guided bone regeneration

Background: The guided bone regeneration (GBR) technique is highly successful for the treatment of peri-implant bone defects. The aim was to determine whether or not implants associated with GBR due to peri-implant defects show the same survival and success rates as implants placed in native bone without defects. Material and Methods: Patients with a minimum of two submerged dental implants: one suffering a dehiscence or fenestration defect during placement and undergoing simultaneous guided bone regeneration (test group), versus the other entirely surrounded by bone (control group) were treated and monitored annually for three years. Complications with the healing procedure, implant survival, implant success and peri-implant marginal bone loss were assessed. Statistical analysis was performed with non-parametric tests setting an alpha value of 0.05. Results: Seventy-two patients and 326 implants were included (142 test, 184 control). One hundred and twenty-five dehiscences (average height 1.92±1.11) and 18 fenestrations (average height 3.34±2.16) were treated. At 3 years post-loading, implant survival rates were 95.7% (test) and 97.3% (control) and implant success rates were 93.6% and 96.2%, respectively. Mean marginal bone loss was 0.54 (SD 0.26 mm) for the test group and 0.43 (SD 0.22 mm) for the control group. No statistically significant differences between both groups were found. Conclusions: Within the limits of this study, implants with peri-implant defects treated with guided bone regeneration exhibited similar survival and success rates and peri-implant marginal bone loss to implants without those defects. Large-scale randomized controlled studies with longer follow-ups involving the assessment of esthetic parameters and hard and soft peri-implant tissue stability are neede

Autologous graft in the anterior maxilla : a case report

Communication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.A 44-year-old male patient was referred to the Egas Moniz Dental Clinic, with a previous history of failed bone regeneration, resulting in a reduced buccal-palatal bone thickness and aesthetic compromise of the gingival margin of the anterior maxilla. Since the use of autologous bone is considered the “gold-standard” in guided bone regeneration, the treatment plan consisted of an autologous mental graft into the maxilla, with a simultaneous guided bone regeneration with a xenograft and absorbable membrane. This allowed a predictable volumetric bone regeneration with low patient morbidity and posterior fixed rehabilitation.info:eu-repo/semantics/publishedVersio

UJI BIODEGRADASI DEMINERALIZED FREEZE DRIED BOVINE CORTICAL BONE MEMBRANE (DFDBCBM) PASCA PENANAMAN SECARA SUBKUTAN Penelitian Experimental Laboratorik In Vivo Pada Tikus Strain Wistar

Guided bone regeneration is a type of treatment that allows the growth of bone in a space defined by the tissue barrier, but the relatively high prices become a constraint in clinical applications. Therefore development of freeze dried demineralized bovine cortical bone membrane (DFDBCBM) as an alternative collagen membrane that can be used as guided bone regeneration is important. To determine the effectiveness of 300 μm DFDBCBM as guided bone regeneration, a research on biodegradation rates of 300 μm DFDBCBM compared with bovine pericardium membrane (Jason®membrane, Botis Dental) were done, by implanted both membrane in subcutaneous dorsum region of Wistar rats. Study of degradation rate were observed using light microscope on specimen that stained with Hematoxilin Eosin on 7, 14, 21 and 28 days after implantation. The result of study showed that there were no significant difference on biodegradation rates between DFDBCBM compared to Jason®membrane after the implantation (p>0,05). We conclude that there were no difference on biodegradation rate between DFDBCBM and Jason® membrane. Keywords: guided bone regeneration, bioresorbable membrane, collagen membrane, biodegradatio