Calcium Alginate Polysaccharide Dressing as an Accelerated Treatment for Burn Wound Healing

Patients with burn injuries suffer from pain and an inflammatory response; however, treatment methods are still not satisfactory and remain challenging. Due to the long stage of burn wound rehabilitation, which contributes to the long-term sensory problems, an effective treatment must begin at the outset of burn wound care. The functionalized wound dressing is expected to be a great treatment strategy over the commercialization wound dressing products and engineered skin substitutes nowadays. Some studies revealed the use of calcium alginate polysaccharide (CAPS) as an “active” dressing due to its calcium richness for wound healing and scar tissue formation. The outstanding outcome of CAPS dressing for severe burn injuries was indicated by natural wound healing and less scarring formation, minimum bacterial infection, cytokine enhancement regulation, and appropriate inflammatory response and pain regulation. These advantages affirmed the phyto-polysaccharide dressing as the next generation of wound dressing materials with highly desirable properties

Honey hydrogel dressing to treat burn wound in rats - a preliminary report

Various studies have shown that honey is effective in healing burns and wounds. In this study, Malaysian honey was incorporated into hydrogel dressing formulation using electron beam irradiation technique and introduced as Honey Hydrogel dressing. The wound healing efficacy of Honey Hydrogel dressing on deep partial thickness burns was monitored on the basis of gross appearances, rate of wound contraction and histopathological changes. Deep partial thickness burns were created by applying an aluminium template preheated to 85°C to the backs of rats for 5 s and randomly treated with Honey Hydrogel or hydrogel while control group received no treatment. Wound appearance was photographed and the rate of wound contraction was calculated at 7, 14, and 21 days post burn. Rats were euthanized after 21 days of treatment and skin samples were taken for histopathological examination. The wounds treated with Honey Hydrogel dressing showed better gross appearances and significantly (p<0.05) enhanced the rate of wound contraction as compared to the control group at 21 days post burn. Faster epithelialization was also seen in the Honey Hydrogel treated group as compared to the other groups, although this was not statistically significant. The results substantiate the potential efficacy of Honey Hydrogel in accelerating burn wound healing

Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing

A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy on deep partial thickness burn wounds in rats were assessed. Skin samples were taken at 7, 14, 21, and 28 days after burn for histopathological and molecular evaluations. Application of honey hydrogel dressings significantly enhanced (P < 0.05) wound closure and accelerated the rate of re-epithelialization as compared to control hydrogel and OpSite film dressing. A significant decrease in inflammatory response was observed in honey hydrogel treated wounds as early as 7 days after burn (P < 0.05). Semiquantitative analysis using RT-PCR revealed that treatment with honey hydrogel significantly (P < 0.05) suppressed the expression of proinflammatory cytokines (IL-1α, IL-1β, and IL-6). The present study substantiates the potential efficacy of honey hydrogel dressings in accelerating burn wound healing

Amniotic Membrane in the Treatment of Burns

Burn wound dressing represents an important aspect of burn care. The various inherent features of amniotic membrane proved to be useful as it contributes towards the attributes of an ideal dressing. This biological dressing is inexpensive, able to enhance re-epithelialization, readily available and stored, hence rendering it suitable for a wide range of burn wound treatment. The different preparations of amniotic membrane provide additional benefit whereby clinicians can have a range of product to choose from. Pain relief, good wound adherence and conformability further increase the importance of amnion as burn wound dressing. The versatility and efficacy of the amnion makes it an attractive option despite of the enormous range commercially available wound management products in the market. This chapter presents a review of the various aspects of amniotic membrane for burn wound treatment

Comparison of honey-ghee dressing with collagen dressing in the management of superficial burn wounds in children

Background: Options available for local management of burns include occlusive dressing and delayed skin grafting, open method and immediate excision followed by immediate skin grafting.Methods: A randomised controlled clinical trial was conducted in Mulago Hospital, Kampala to compare Honey-Ghee dressing and Collagen dressing in the management of superficial burn wounds. : A total of 52 children with superficial burn injury were studied to assess the efficacy and the safety of Collagen as a dressing in comparison with Honey-Ghee dressing.Results: The mean duration of wound healing of the 26 patients dressed with Collagen was 9.9 days while that for the 26 patients dressed with Honey-Ghee was 12.3 days. Collagen dressed wounds healed significantly faster than Honey-Ghee dressed wounds. Four (15.38%) patients of the 26 patients dressed with collagen developed wound infection while 5 (19.23%) of the 26 patients dressed with Honey Ghee dressing developed wound infection. There was no significant difference between the percentages. The organisms causing wound infections were Staphylococcus aurous (33.3%), Pseudomonas aeruginosa (33.3%), Citrobacter freundii (22.2%) and Escherichia coli (11.1%)

A COMPARISON OF SUPRATHEL BURN DRESSING VS STANDARD CARE ON LENGTH OF HOSPITALIZATION, PAIN SCORES, OPIOID USE, TREATMENTS, AND OUTCOMES.

Purpose: The purpose of this evidenced-based practice Doctor of Nursing Practice (DNP) project was to determine the impact and efficacy of using Suprathel artificial wound and burn dressing on patients treated at a UC San Diego Health Regional Burn Center for second-degree burns. The primary goal of this project will be to evaluate the impact of using Suprathel on hospital length of stay; compare wound infection rates, pain score, and morphine equivalent use; and to identify the cost-effectiveness of the Suprathel artificial wound and burn dressing. Background: Burns are a global health concern causing significant morbidity and mortality, accounting for 180,000 deaths annually. Burn injuries are associated with a significant amount of pain and suffering, which has a substantial impact on the patient\u27s quality of life. The thermal insult on the skin can affect both the epidermal and dermal layers depending on its duration and intensity. Unsuccessful burn treatment leads to major economic and psychological impacts on long-term somatic sequelae, imposing additional costs to the healthcare system. Results: Suprathel artificial wound and burn dressing resulted in a reduction in patients\u27 length of stay and a lack of complications, as well as the elimination of the need for multiple painful dressing changes and expedited wound healing and improved patient outcomes. The average length of stay for patients treated with Suprathel was four days, whereas it was five days for those who did not receive this treatment. Furthermore, Suprathel patients did not experience any significant complications compared to those who did not receive Suprathel dressing. The results of the overall pain assessment indicate a mild difference in MME use per day among the Suprathel and non-Suprathel groups. The average MME use per day in the Suprathel and non-Suprathel patients are 22.19 and 22.2, respectively. Lastly, calculated cost shows a marked decrease in cost in the Suprathel population verses the non-suprathel. Evaluation: This intervention can ultimately eliminate the need and the burden associated with daily dressing changes for patients, caregivers, and staff. It also resulted in shorter hospitalization, reducing costs and allows them to return home which especially benefits pediatric patients. This results in better outcomes and less complications for those being treated for second degree burns. Keywords: Suprathel, Second Degree Burn Treatment, Cost Effectiveness, Patient Outcome

A functionalized nanobiopolymer as an alternative for burn wound dressing

[Excerpt] Introduction Burn wounds present higher risk of infection due to extensive damage suffered by the skin and can be dry or wet. Dry burn wounds require moisture environment while wet burn wounds produce exudate needing recurring wound dressing exchange. In both situations, the wound dressing replacement commonly causes excruciating pain.This research was funded by FEDER funds through the Operational Competitiveness Program–COMPETE, by National Funds through Fundação para a Ciência e Tecnologia (FCT), under the project UID/CTM/00264/2020. Talita Nicolau, Cátia Alves, Liliana Melro, Rui D. V. Fernandes, and Behnaz Mehravani acknowledge FCT, MCTES, FSE and UE PhD grants, 2022.15386.BD, 2022.10454.BD, 2020.04919.BD, SFRH/BD/145269/2019, 2022.13094.BD

Open versus closed sandwich wound dressing method in burn children

Background: Open method of dressing burn wounds has been the accepted mode of burn wound care in most of our hospitals. Closed dressing has been shunned because of the belief that it is costly and labour intensive.Methods: A retrospective study was conducted on 170 children under 12years admitted to the Pediatric surgical/female burn ward between the months of June 2006 to March 2007. A comparison was made between the open and closed sandwich method of burn wound dressing. The sandwich method entailed using 17 by 17cm square pieces of gauze with a layer of cotton in between. The dressing was left on for between 3 and 4 days. The open method was used on 92 patients (Group A) admitted between the months of June 2006 to October 2006, while the closed method was applied on 78 patients (Group B) admitted during the months of November 2006 to March 2007.The demographic data of the two groups were analyzed. The duration of hospital stay, fatalities and proportion of patients discharged were used as outcome indicators for the two groups. Results: The male to female ratio was found to be 1.4:1 for Group A and 1.5:1 for the Group B. The majority of burn wounds were caused by scalds with children under five being the most affected in both groups (81.5% and 85.9% respectively). Most of the burns in the two groups were less than 10% of the body. The results of outcome indicators showed no statistical differences between the two groups.Conclusion: Sandwich closed dressing changed every after three to four days does not adversely affect outcome of burn patients. This type of dressing is recommended for health facilities with limited resources since it reduces the burden on the nurse and also the cost of dressing materials while providing the benefits of closed dressing

The Guru-UKM Method: Synergistic Effect of Hydrogel, Hydrofibre and Dermal Conservation in Burn Wound Management

Initial wound care idioms were designed around a moist dressing in presumed better wound healing. As wound care advances, innovations of dressings were formed. In the Guru-UKM Method (GUM), we combined two well-established dressings producing a synergistic effect in burn wound management. Patients with deep partial thickness burns were selected for the GUM. From the time of admission, they receive 2 cycles of paraffin tulle dressings once every two days to allow demarcation, then are reassessed for suitability of the GUM technique. We discuss 7 different burn cases that presented to our Burn Unit from January 2014 – June 2015.All dressings should create a suitable moist environment for healing, yet should be a painless dressing to help the patient return to normal function as soon as possible. In burn wounds, a suitable dressing ideally also biochemically debrides fibrin and softens hardened eschar and slough, without necessitating the patient to undergo general anaesthesia and surgical debridement. The Guru-UKM Method is a combination dressing technique that facilitates optimal burn wound management

Microwaved bacterial cellulose-based hydrogel microparticles for the healing of partial thickness burn wounds

�� 2016, Controlled Release Society. Burn wound management is a complex process because the damage may extend as far as the dermis which has an acknowledged slow rate of regeneration. This study investigates the feasibility of using hydrogel microparticles composed of bacterial cellulose and polyacrylamide as a dressing material for coverage of partial-thickness burn wounds. The microparticulate carrier structure and surface morphology were investigated by Fourier transform infrared, X-ray diffraction, elemental analysis, and scanning electron microscopy. The cytotoxicity profile of the microparticles showed cytocompatibility with L929 cells. Dermal irritation test demonstrated that the hydrogel was non-irritant to the skin and had a significant effect on wound contraction compared to the untreated group. Moreover, histological examination of in vivo burn healing samples revealed that the hydrogel treatment enhanced epithelialization and accelerated fibroblast proliferation with wound repair and intact skin achieved by the end of the study. Both the in vitro and in vivo results proved the biocompatibility and efficacy of hydrogel microparticles as a wound dressing material.Published versio