15,935 research outputs found
The oblique S parameter in higgsless electroweak models
We present a one-loop calculation of the oblique S parameter within Higgsless
models of electroweak symmetry breaking. We have used a general effective
Lagrangian with at most two derivatives, implementing the chiral symmetry
breaking SU(2)_L x SU(2)_R -> SU(2)_{L+R} with Goldstones, gauge bosons and one
multiplet of vector and axial-vector resonances. The estimation is based on the
short-distance constraints and the dispersive approach proposed by Peskin and
Takeuchi.Comment: 5 pages, 2 figures. Talk given at QCD@work 2012, International
Workshop on Quantum Chromodynamics: Theory and Experiment, 18-21th June
(2012), Lecce (Italy
Monitoring fish populations in Lower Lough Erne, Northern Ireland: applicability of current methods and implications for future monitoring under the EC Water Framework Directive
The proposed EC Water Framework Directive (WFD) will require member states to monitor both biotic and abiotic components of lake environments. With adoption of the WFD some measurement of fish populations will also be required. This paper describes work carried out since 1971, and particularly since 1991, on the status of fish populations in Lower Lough Erne, Northern Ireland, with an emphasis on defining change over time due to human impacts on the lake. This offers a reasonable starting point from which to develop a monitoring programme suitable for the needs of the WFD in this lake. The implications for as yet unmonitored fish populations in lakes are also determined
Quantum loops in the Resonance Chiral Theory: improving the vector form factor
Quantum loops in the Resonance Chiral Theory are needed to improve the
implementation of non-perturbative QCD. Furthermore, the one-loop computations
can predict chiral low-energy couplings at next-to-leading order, a very
appealing task. We present a first calculation of the vector form factor of the
pion at subleading order in the 1/N_C expansion. From the analysis of the
result at large energies we justify the requirement of considering
short-distance constraints from form factors with resonances in the final
state. The long-distance limit of our results allows to get a next-to-leading
order estimate of \ell_6.Comment: Talk given at the International Workshop e+e- Collisions from phi to
J/psi, 27th February-2nd March (2006), Novosibirsk (Russia
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Electronic literacy with and attitudes towards the web as a resource for foreign language learning
About the book: This collection of papers aims at being the connecting link between their knowledge base and language as the main tool for achieving their aims and objectives. Internet in LSP and Foreign Language Teaching contains stimulating practical examples to achieve both academic and professional success, and it raises issues of concern in the field of English for Professional and Academic Purposes
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Online tutorial support in open distance learning through audio-graphic SCMC: tutor impressions
The adoption of audio-graphic conferencing brings with it changes to the learning experience for tutors and students alike. These need to be researched to gain an insight into the learning experience of those teaching and being taught through the medium. One of the conferencing tools that has been utilised for much of the documented research on audio-graphic conferencing is the Lyceum software, used at the UK Open University since 2002 to provide tutorial support for higher level language learners. The use of the software has been reported at different stages, from the pilot projects since 1997 (Hauck & Haezewindt, 1999, Shield 2000, Kötter 2001, Hewer and Shield 2001), to reports of the mainstream use (Hampel 2003, Hampel & Hauck 2004). It seems logical that the next step should be to research into the tutors’ experiences of the audio-graphic tool, which is a key element in the CALL research agenda (Warschauer, 1997; Debski & Levy, 1999). As the Open University prepares to phase out the software and replace it with a Moodle-based open-content audio-graphic synchronous conferencing tool, the insight into teaching with such tools becomes more valuable to other language learning professionals and institutions.
In this paper we will report on a study of data collected from 18 tutors after spending a year teaching a new beginners’ course online. We will examine their perceptions of the audio-graphic tool and challenge some of the results from the initial research into audio-graphic conferencing. Most tutors found the teaching experience very positive and liked using the tool; however some experienced technical problems and believe that these affect the learning experience. In addition we will report on the first and successful use of the environment for assessment purposes
Twitter: A Professional Development and Community of Practice Tool for Teachers
This article shows how a group of language teachers use Twitter as a tool for continuous professional development through the #MFLtwitterati hashtag. Based on data collected through a survey (n=116) and interviews (n=11), it describes how this collective of teachers use the hashtag and evaluates the impact of their Twitter network on their teaching practices. The results show that most users try the suggestions and ideas that they find on this network, which have a positive impact on their teaching. Finally, the article assesses whether the hashtag users can be described as a community of practice
Hot-spot analysis for drug discovery targeting protein-protein interactions
Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging. Hot-spot residues are seen as the best option to target such interactions, but their identification requires detailed structural and energetic characterization, which is only available for a tiny fraction of protein interactions.
Areas covered: In this review, the authors cover a variety of computational methods that have been reported for the energetic analysis of protein-protein interfaces in search of hot-spots, and the structural modeling of protein-protein complexes by docking. This can help to rationalize the discovery of small-molecule inhibitors of protein-protein interfaces of therapeutic interest. Computational analysis and docking can help to locate the interface, molecular dynamics can be used to find suitable cavities, and hot-spot predictions can focus the search for inhibitors of protein-protein interactions.
Expert opinion: A major difficulty for applying rational drug design methods to protein-protein interactions is that in the majority of cases the complex structure is not available. Fortunately, computational docking can complement experimental data. An interesting aspect to explore in the future is the integration of these strategies for targeting PPIs with large-scale mutational analysis.This work has been funded by grants BIO2016-79930-R and SEV-2015-0493 from the Spanish Ministry of Economy, Industry and Competitiveness, and grant EFA086/15 from EU Interreg V POCTEFA. M Rosell is supported by an FPI fellowship from the Severo Ochoa program. The authors are grateful for the support of the the Joint BSC-CRG-IRB Programme in Computational Biology.Peer ReviewedPostprint (author's final draft
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Design and user evaluation of a mobile app to teach Chinese characters.
This paper presents both the pedagogical design principles and the challenges faced during the development of a mobile app, Chinese Characters First Steps, to support recognising, learning and practising writing Chinese characters at beginners’ level, including the difficult balance between pedagogy and technical affordances. We also present the results of a research study which collected quantitative data from over 130 users of the app as well as qualitative data from interviews with four users.
The results offer a profile of language learning app users and very positive attitudes towards learning with apps. They also reveal users' reasons for learning Chinese, patterns of learning, expectations of the app, and evaluation of the different features for their own personal learning. Finally, the paper concludes that the chosen design principles for the app were appropriate for its purpose
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