Ray-tracing and physical-optics analysis of the aperture efficiency in a radio telescope

The performance of telescope systems working at microwave or visible/IR wavelengths is typically described in terms of different parameters according to the wavelength range. Most commercial ray tracing packages have been specifically designed for use with visible/IR systems and thus, though very flexible and sophisticated, do not provide the appropriate parameters to fully describe microwave antennas, and thus to compare with specifications. In this work we demonstrate that the Strehl ratio is equal to the phase efficiency when the apodization factor is taken into account. The phase efficiency is the most critical contribution to the aperture efficiency of an antenna, and the most difficult parameter to optimize during the telescope design. The equivalence between the Strehl ratio and the phase efficiency gives the designer/user of the telescope the opportunity to use the faster commercial ray-tracing software to optimize the design. We also discuss the results of several tests performed to check the validity of this relationship that we carried out using a ray-tracing software, ZEMAX and a full Physical Optics software, GRASP9.3, applied to three different telescope designs that span a factor of $\simeq 10 in terms of D/lambda. The maximum measured discrepancy between phase efficiency and Strehl ratio varies between$\simeq 0.4 and 1.9 up to an offset angle of >40 beams, depending on the optical configuration, but it is always less than 0.5 where the Strehl ratio is >0.95.Comment: 34 pages, 7 figure

Measuring growth of labour quality and the quality-adjusted unemployment rate in Switzerland

This paper presents results on human capital accumulation for the Swiss economy. We find that the index of labour quality has grown at a rate of 0.5% per year from 1991 to 2006. The main sources are the growth in average levels of education and the passing of the baby boom cohort through the age structure of the workforce. Projections over the period 2006-2050 suggest that labour quality growth will slow down with time. We also calculate a quality-adjusted unemployment rate and find that the unemployment rate is reduced by about 0.3 pp when human capital accumulation is taken into account.human capital, labour quality, unemployment rate

Dendritic-Cell (DC)-Based Immunotherapy: Tumor Endothelial Marker 8 (TEM8) Gene Expression of DC Vaccines Correlates with Clinical Outcome

ABSTRACT\ud Previous studies have shown that tumor-endothelial markers (TEMs) are upregulated in immunosuppressive, pro-angiogenic dendritic cells (DCs) found in tumor microenvironments. \ud We reported that pro-angiogenic monocyte-derived DCs (Mo-DCs), utilized for therapeutic vaccination of cancer patients upon maturation, markedly differ in their ability to up-regulate tumor-endothelial marker 8 (TEM8) gene\ud expression. A DC vaccination trial of 17 advanced cancer patients (13 melanoma and 4 renal cell carcinoma), carried out at the Cancer Institute of Romagna (I.R.S.T.) in Meldola, highlighted a significant correlation between delayed-type hypersensitivity test (DTH) and overall survival (OS). In the study, relative TEM8 mRNA and protein expression levels (mature (m) vs. immature (i) DCs), in DCs obtained for therapeutic vaccines were evaluated by quantitative real-time RT-PCR and cytofluorimetric analysis, respectively. mDCs from six healthy donors were included for comparison purposes. Eight non-progressing patients, all DTH-positive, had a mean fold increase\ud (mfi) of 1.97 in TEM8 expression. Similarly, a TEM8 mRNA mfi = 2.7 was found in healthy donor mDCs. Conversely, mDCs from nine progressing patients, all but one with negative DTH, had a TEM8 mRNA mfi of 12.88. Thus, mDC TEM8 expression levels would seem to identify (p = 0.0018) patients who could benefit from DC therapeutic vaccination

Social Bonds And Fear Of Crime Victimization Among Youth: An Analysis Using Ferraro’s Risk Assessment Framework

The impact of crime taking place in society can be fluid and may quickly gain the form of fear among individuals with both direct and no direct victimization experience. While youth are extensively more vulnerable and immature than adults (Krulichová & Podaná, 2019), they are more likely to have or learn the fear of crime victimization. Therefore, the distribution and etiology of youth fear of crime victimization should not be overlooked. Ferraro\u27s (1995) risk assessment framework suggests incorporating theoretical variables to predict the evolution of fear. With the inclusion of the perceived risk of victimization, Ferraro\u27s risk assessment framework provides a comprehensive understanding of how an individual\u27s response to crime transitions into fear of crime victimization. This research utilized the Ferraro risk assessment framework and employed Social Bond Theory to examine the impact of social bonds on youth\u27s perceived risk and fear of crime victimization. This quantitative research utilized secondary data to perform analysis. The data for this research came from the National Evaluation of the Teens, Crime, and Community and the Community Works (TCC/CW)program, a self-report study of adolescents from several locations across the United States (Esbensen, 2005). This research conducted a Mediation Analysis to understand the relationships between social bonds, such as parental attachment, school commitment, the belief of guilt for wrongdoings, and involvement in legitimate activities, perceived risk of victimization, and fear of crime victimization among youth in general and across various race/ethnic and gender backgrounds of the youth. Results from Mediation Analysis identified that perceived risk of victimization significantly mediated the relationship between parental attachment and fear of crime, and school commitment and fear of crime among all youth and girls. Further, the study results suggested a non-significant relationship between all the elements of the social bonds, perceived risk of victimization, and fear of crime victimization among young males irrespective of their race and ethnic origin. Overall, two elements of social bonds, parental attachment and school commitment, were found to be important in minimizing the perceived risk of victimization and fear of crime victimization among the youth in general and specifically among females. Keywords: social bonds, perceived risk of victimization, fear of crime victimization, Ferraro’s risk assessment framework, youth, gende

Innovators in Urban China: Makerspaces and Marginality with Impact

In China, the emergence of makerspaces, hackerspaces, Fab Labs, and innovation labs reflects top-down and bottom-up dynamics. The grassroots movements and governmental efforts promoting innovation and creativity are part of the maker trend linked to the rise of the Internet and access to digital tools. The urban imaginary of the maker culture creates networks and events both globally and locally. The first makerspaces opened in Shanghai and Shenzhen in 2010 and attracted the attention of the government, which published an initiative in 2015 that influenced the typology of makerspaces in China. The ephemeral spaces for innovators, hackers, makers, and entrepreneurs shaped by this cultural context and local ecosystem are urban phenomena investigated with social anthropological and experimental methodologies to better understand the extension and platformisation of these autonomous and co-opted communities and narratives. This research fills the knowledge gap on makerspaces in China in recent years, showing the impact of governmental initiatives on a grassroots culture, the possible roles of makers, and the complexity and unlimitedness of the maker culture through international partnerships for projects such as Designed in Ethiopia and Kabakoo Academies

Modulation of ecdysal cyst and toxin dynamics of two Alexandrium (Dinophyceae) species under small-scale turbulence

Some dinoflagellate species have shown different physiological responses to certain turbulent conditions. Here we investigate how two levels of turbulent kinetic energy dissipation rates (epsilon = 0.4 and 27 cm(2) s(-3)) affect the PSP toxins and ecdysal cyst dynamics of two bloom forming species, Alexandrium minutum and A. catenella. The most striking responses were observed at the high epsilon generated by an orbital shaker. In the cultures of the two species shaken for more than 4 days, the cellular GTX(1+4) toxin contents were significantly lower than in the still control cultures. In A. minutum this trend was also observed in the C(1+2) toxin content. For the two species, inhibition of ecdysal cyst production occurred during the period of exposure of the cultures to stirring (4 or more days) at any time during their growth curve. Recovery of cyst abundances was always observed when turbulence stopped. When shaking persisted for more than 4 days, the net growth rate significantly decreased in A. minutum (from 0.25 +/- 0.01 day(-1) to 0.19 +/- 0.02 day(-1)) and the final cell numbers were lower (ca. 55.4%) than in the still control cultures. In A. catenella, the net growth rate was not markedly modified by turbulence although under long exposure to shaking, the cultures entered earlier in the stationary phase and the final cell numbers were significantly lower (ca. 23%) than in the control flasks. The described responses were not observed in the experiments performed at the low turbulence intensities with an orbital grid system, where the population development was favoured. In those conditions, cells appeared to escape from the zone of the influence of the grids and concentrated in calmer thin layers either at the top or at the bottom of the containers. This ecophysiological study provides new evidences about the sensitivity to high levels of small-scale turbulence by two life cycle related processes, toxin production and encystment, in dinoflagellates. This can contribute to the understanding of the dynamics of those organisms in nature

Contributors

Biographical information on contributors to volume 39, and a list of benefactors and donor

Table of Contents and Prologue

Editorial board, table of contents, and a prologue from the editor

Effects of vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure: a randomized placebo-controlled trial

Objectives: This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction. Background: Many patients with type 2 diabetes mellitus have heart failure and it is important to know about the safety of new treatments for diabetes in these individuals. Methods: Patients 18 to 85 years of age with type 2 diabetes and heart failure (New York Heart Association functional class I to III and left ventricular ejection fraction [LVEF] <0.40) were randomized to 52 weeks treatment with vildagliptin 50 mg twice daily (50 mg once daily if treated with a sulfonylurea) or matching placebo. The primary endpoint was between-treatment change from baseline in echocardiographic LVEF using a noninferiority margin of −3.5%. Results: A total of 254 patients were randomly assigned to vildagliptin (n = 128) or placebo (n = 126). Baseline LVEF was 30.6 ± 6.8% in the vildagliptin group and 29.6 ± 7.7% in the placebo group. The adjusted mean change in LVEF was 4.95 ± 1.25% in vildagliptin treated patients and 4.33 ± 1.23% in placebo treated patients, a difference of 0.62 (95% confidence interval [CI]: −2.21 to 3.44; p = 0.667). This difference met the predefined noninferiority margin of −3.5%. Left ventricular end-diastolic and end-systolic volumes increased more in the vildagliptin group by 17.1 ml (95% CI: 4.6 to 29.5 ml; p = 0.007) and 9.4 ml (95% CI: −0.49 to 19.4 ml; p = 0.062), respectively. Decrease in hemoglobin A1c from baseline to 16 weeks, the main secondary endpoint, was greater in the vildagliptin group: −0.62% (95% CI: −0.93 to −0.30%; p < 0.001; −6.8 mmol/mol; 95% CI: −10.2 to −3.3 mmol/mol). Conclusions: Compared with placebo, vildagliptin had no major effect on LVEF but did lead to an increase in left ventricular volumes, the cause and clinical significance of which is unknown. More evidence is needed regarding the safety of dipeptidyl peptidase-4 inhibitors in patients with heart failure and left ventricular systolic dysfunction. (Effect of Vildagliptin on Left Ventricular Function in Patients With Type 2 Diabetes and Congestive Heart Failure; NCT00894868