Landscape-Scale Disturbance: Insights into the Complexity of Catchment Hydrology in the Mountaintop Removal Mining Region of the Eastern United States

: Few land disturbances impact watersheds at the scale and extent of mountaintop removal mining (MTM). This practice removes forests, soils and bedrock to gain access to underground coal that results in likely permanent and wholesale changes that impact catchment hydrology, geochemistry and ecosystem health. MTM is the dominant driver of land cover changes in the central Appalachian Mountains region of the United States, converting forests to mine lands and burying headwater streams. Despite its dominance on the landscape, determining the hydrological impacts of MTM is complicated by underground coal mines that significantly alter groundwater hydrology. To provide insight into how coal mining impacts headwater catchments, we compared the hydrologic responses of an MTM and forested catchment using event rainfall-runoff analysis, modeling and isotopic approaches. Despite similar rainfall characteristics, hydrology in the two catchments differed in significant ways, but both catchments demonstrated threshold-mediated hydrologic behavior that was attributed to transient storage and the release of runoff from underground mines. Results suggest that underground mines are important controls for runoff generation in both obviously disturbed and seemingly undisturbed catchments and interact in uncertain ways with disturbance from MTM. This paper summarizes our results and demonstrates the complexity of catchment hydrology in the MTM region

What's the Risk? Older Women Report Fewer Symptoms for Suspected Acute Coronary Syndrome than Younger Women.

The purpose of the study was to determine whether older (≥65 years) and younger (<65 years) women presenting to the emergency department (ED) with symptoms suggestive of acute coronary syndrome (ACS) varied on risk factors, comorbid conditions, functional status, and symptoms that have implications for emergent cardiac care. Women admitted to five EDs were enrolled. The ACS Symptom Checklist was used to measure symptoms. Comorbid conditions and functional status were measured with the Charlson Comorbidity Index and Duke Activity Status Index. Logistic regression models were used to evaluate symptom differences in older and younger women adjusting for ACS diagnosis, functional status, body mass index (BMI), and comorbid conditions. Analyses were stratified by age, and interaction of symptom by age was tested. Four hundred women were enrolled. Mean age was 61.3 years (range 21-98). Older women (n = 163) were more likely to have hypertension, hypercholesterolemia, never smoked, lower BMI, more comorbid conditions, and lower functional status. Younger women (n = 237) were more likely to be members of minority groups, be college-educated, and have a non-ACS discharge diagnosis. Younger women had higher odds of experiencing chest discomfort, chest pain, chest pressure, shortness of breath, nausea, sweating, and palpitations. Lack of chest symptoms and shortness of breath (key symptoms triggering a decision to seek emergency care) may cause older women to delay seeking treatment, placing them at risk for poorer outcomes. Younger African American women may require more comprehensive risk reduction strategies and symptom management

Rua das Gaivotas 6 (projeto de empreendedorismo cultural): modelo de programação

Classificações JEL L31 – Instituições sem fins lucrativos; ONGsRua das Gaivotas 6 (Projeto de Empreendedorismo Cultural) – Modelo de Programação A cidade de Lisboa apresenta um aumento significativo de oferta e procura na área dos consumos culturais, sobretudo os que ultrapassam a moldura institucional, mas debate-se contudo com falta de espaços de criação e exibição. Neste projeto de tese apresenta-se um modelo de programação desenhado para o renovado espaço da Rua das Gaivotas, que pretende albergar projetos de índole criativa e cultural, com ênfase nas manifestações emergente da arte contemporânea portuguesa, jovens artistas que começam a dar os primeiros passos e que não encontram apoio nas estruturas culturais mais institucionalizadas. O espaço da Rua das Gaivotas (anteriormente designado pelo proprietário, a Câmara Municipal de Lisboa, como Escola das Gaivotas, inserida num edifício que estava degradado e devoluto) é um projeto com uma localização urbanística privilegiada e que foi objeto de um concurso público de atribuição do espaço para fins culturais ganho pela associação cultural Teatro Praga (do qual o autor deste projeto de tese é diretor artístico). Desde a sua atribuição a esta associação, e seguindo a tendência de aproveitamento de espaços devolutos para fins de reabilitação urbana com projetos culturais, o espaço tem sido sujeito a uma requalificação, um projeto do gabinete de arquitetura Artéria em estreita colaboração com a entidade responsável pela gestão do espaço. Este é um projeto que pretende ao mesmo tempo sustentabilidade financeira e impacto, tanto na reabilitação urbana e no desenvolvimento sociocultural das populações como no estímulo à criação e ao desenvolvimento de novas linguagens.Rua das Gaivotas 6 (Project of Cultural Entrepreneurship) – Model of Programming The city of Lisbon has a significant increase in supply and demand in the area of cultural consumption, especially in those beyond the institutional framework, but there is an ongoing debate about the lack of spaces for creation and presentation. This thesis presents a model of programming designed for the renovated space of Rua das Gaivotas, a space that aims to host projects of cultural and creative nature, with emphasis on emerging manifestations of Portuguese contemporary art, young artists beginning to take their first steps but that find no support in the more institutionalized cultural structures. The space of Rua das Gaivotas (previously designated by the owner, the Town Council, as Escola das Gaivotas) is set in a building that was run down and unoccupied on a prime urban location and that was the subject of a tender for its use for cultural purposes won by the cultural association Teatro Praga (of which the author of this thesis project is the artistic director). Since the space was assigned to this association, following the trend of using vacant buildings for urban renewal purposes with cultural projects, it has been the subject of a requalification, a project led by the architects Artéria in a strict cooperation with the entity responsible for the management of the space. This is a project that aims at the same time for financial sustainability and impact, both in urban regeneration and socio-cultural development of populations as in stimulating the creation and development of new artistic languages

O crime de recebimento indevido de vantagem : análise aos elementos objetivos

Desde sempre que a corrupção é entendida como um fenómeno complexo de elevada danosidade social que afeta, não só o Estado, como todos os cidadãos em geral. Assim, tem-se procurado combater tal fenómeno e os impactos que o mesmo possa vir a causar, através da criação de diversas medidas legislativas. É nesse contexto que surge, em 2010, o denominado crime de recebimento indevido de vantagem que pune as condutas de solicitação ou aceitação, dádiva ou promessa de vantagem indevida que ocorram no exercício das funções do funcionário ou por causa delas. Na presente dissertação é nosso objetivo analisar o crime previsto no artigo 372.º do Código Penal, em concreto, os seus elementos objetivos.Corruption has always been understood as a complex phenomenon of high social damage that affects not only the State, but all citizens in general. Thus, attempts have been made to fight this phenomenon and the impacts that it may cause, through the creation of various legislative measures. It is in this context that, in 2010, the crime of receiving undue advantage is created, which punishes the conduct of requesting or accepting, giving or promising an undue advantage that occurs in the exercise of the employee's duties or because of them. In the present dissertation, it is our objective to analyze the crime foreseen in article 372 of the Penal Code, specifically, its objective elements

Electrocardiographic diagnosis of ST segment elevation myocardial infarction: An evaluation of three automated interpretation algorithms

To assess the validity of three different computerized electrocardiogram (ECG) interpretation algorithms in correctly identifying STEMI patients in the prehospital environment who require emergent cardiac intervention

Using a data-driven approach to examine facility use definitions in campus recreation

Existing research in campus recreation establishes a relationship between facility use and academic outcomes, but published studies define users differently. In response to inconsistent definitions of participants in campus recreation, this study uses a data-driven approach to compare facility use definitions. Authors illustrate the implications of choosing different participant definitions for relationships between campus recreation and two undergraduate academic outcomes, first-year retention and first-year cumulative grade point average (GPA). This study uses data from a three-year timeframe, linking sources of data on students’ recreation facility use, academic outcomes, and student records. Authors provide a summary of previous definitions, results from original regression analyses, results for specific student subgroups, and recommendations for defining users

Uma biografia

Manoel do Espirito Santo Limpo (1755-1809) foi um importante escritor e lente1 português do século XVIII e inicio do século XIX. Este conciliava ambas as atividades e escrevia para os seus «discípulos», para que com as suas obras estes poupassem tempo a procurar as informações necessárias à sua formação. Enquanto lente, na Academia Real da Marinha e Companhia Real dos Guardas Marinhas, este teve um papel importantíssimo, nomeadamente no que toca à formação dos militares da Marinha de Guerra Portuguesa e da Marinha Mercante, tendo sido ele também o responsável por escrever, em língua portuguesa, os primeiros livros de Manobra de Navio e de Tática Naval. Para além do exposto anteriormente, foi também por nomeação da rainha D. Maria I, o primeiro diretor do Observatório Real da Marinha, aquando da sua criação em 1802. Aqui foi uma pessoa bastante combativa contra as condições em que este havia sido criado, e que limitavam em grande parte a atividade do observatório. Foi enquanto diretor do Observatório que, o nosso biografado preparou a transferência dos equipamentos do mesmo para o Brasil, como consequência das invasões francesas de 1807, contudo ir-se-á perceber que tal não aconteceu como planeado. Porém a sua vida foi repleta de contratempos, que culminaram na sua prisão pelo Santo Ofício em 1778. Nesta dissertação apresentamos, com base numa cópia do documento original Processo da Inquiziçaõ de Manoel do Espirito Santo Limpo, disponibilizado pelo Arquivo Nacional da Torre do Tombo, os aspetos que consideramos mais importantes aplicáveis à presente dissertação de mestrado. Dedicamos um capítulo, o terceiro e último capítulo da presente dissertação, à análise das obras e memórias escritas por Manoel do Espírito Santo Limpo. Essas abrangeram três áreas: Matemática, Navegação e Tática Naval, e acreditamos que estejam relacionadas entre si, tal como escrevemos no capítulo 3.1. Palavras-Chave: Inquisição; Navegação; Matemática; Tática Naval; Inquisição; Observatório Real da Marinha.This thesis is about Manoel do Espirito Santo Limpo (1755-1809). He was an important Portuguese writer and lecturer from the XVIII century to the beginning of XIX century. He conciliates both activities and also wrote textbooks for is disciples, sintetising the relevant for he courses. As a lecturer, at Academia Real da Marinha and Companhia Real dos Guardas Marinhas, had a major role, concerning the ruching of the war navy students. He was also responsible for writing the first books in Portuguese about ship manoeuvring and naval tactics. Queen Maria I appointed him the first director of the Observatório Real da Marinha, created in 1802. He opposed the existing registering of the Observatory which in his opinion. As the Observatory director he prepared the transfer of the observatory equipment to Brazil, because of the 1807 French invasion, yet it we will see their his did not. His life was filled with setbacks, which culminate his imprisonment by Santo Ofício in 1778. In this dissertation we will present, based on a copy of the Inquisition process of the Manoel do Espirito Santo Limpo, existing in the Nation Archive of Torre do Tombo, with we consider the most important aspects related to the present research. The chapter, the third one and also the last of the present dissertation will be on Manoel do Espirito Santo Limpo written memories. There are on three areas: Mathematics, Navigation and Naval tactics and we believe that they are interlinked, as described in 3.1 chapter. Keywords: Inquisition, Navigation, Mathematics, Naval tactics, Royal Navy Observator

Estágio no âmbito do projecto de execução de um viaduto de ligação entre a E.M. 575 e a E.M. 533-1 situado no Pinhal Novo

O presente relatório tem como objectivo descrever o trabalho desenvolvido ao longo de um estágio, realizado na empresa Professor Edgar Cardoso - Engenharia e Laboratório de Estruturas, durante o período de Fevereiro de 2009 a Maio de 2010. Durante este período, foi realizado um projecto de execução de um viaduto situado no Pinhal Novo. Este possui um comprimento total de 233,0 metros, suporta duas vias de trânsito em sentidos opostos e é constituído por 7 vãos com a seguinte distribuição: 20,0 m – 30,0 m – 35,0 m – 58,0 m – 40,0 m – 30,0 m – 20,0 m Além de compreender um vão central de 58,0 metros, existe ainda a particularidade de o viaduto atravessar um complexo feixe de linhas férreas e a sua directriz ser completamente curva. O tabuleiro é composto por betão armado, pré-esforçado na direcção longitudinal, encontra-se apoiado sobre os encontros e rigidamente ligado a 6 pilares de secção circular. A secção transversal do tabuleiro é constituída por uma nervura de secção trapezoidal, com 12 metros de largura, espessura variável e vazada no 2º, 4º e 6º vão. O dimensionamento respeitou os regulamentos nacionais em vigor, nomeadamente o Regulamento de Estruturas de Betão Armado e Pré-Esforçado (REBAP), o Regulamento de Segurança e Acções para Edifícios e Pontes (RSA) e o Eurocódigo 1, 2 e 8

In vitro cytocompatibility evaluation of poly(DL-lactic acid) scaffolds loaded with minocycline and voriconazole addressing osteomyelitis

Osteomyelitis or bone infection is an acute or chronic inflammatory process involving the bone and its structures, secondary to infection with pyogenic organisms, such as bacteria and fungi. Considering the associated high patient economic burden, morbidity, and mortality, it is essential to develop novel strategies for osteomyelitis management. Porous scaffolds based on biomaterials may locally deliver high concentrations of antibiotics, an effective strategy in eradicating bone infection. When incorporating bioactive bioglasses and bioresorbable polymers like poly(DL-lactic acid) (PDLLA), these structures exhibit biosafety, biodegradability, and the expected global structure to promote cell expansion and cell differentiation, being critical to consider and evaluate their biocompatibility compliance. As the encapsulation of more than one active pharmaceutical ingredient is an attractive approach, the present study focuses on the cytocompatibility evaluation of an innovative system based on the dual delivery of two antimicrobials, an antibiotic that enhances bone formation, minocycline (MH), and an antifungal agent with a broad spectrum of activity, voriconazole (VCZ), aiming bone infection therapeutics. Scaffolds were prepared by solvent casting/particulate leaching techniques and functionalized with bioglass. The scaffolds produced were adsorbed with 0.5 or 0.1 mg/mL of minocycline and also with 0.1 mg/mL of voriconazole. To test the bio-functionality and the biological safety of scaffolds, in vitro cell assays were achieved employing the MG-63 cell line (ATCC® CRL-1427TM human osteoblast cell line). The AlamarBlue® assay was used to measure cell proliferation in the scaffold. As osteoblast differentiation markers, the following were determined: alkaline phosphatase activity and mineralization using Alizarin red assay, an indicator of in vitro bone formation. All scaffolds sustained the proliferation of metabolically active cells, nonetheless, scaffolds adsorbed with the highest concentration of MH (0.5 mg/mL) presented a significant (p<0.05) cytotoxic effect. Matrix maturation assays supported early osteoblasts differentiation and the osteoinductive role of minocycline described in the literature was also highlighted. Matrix mineralization analysis showed the highest value associated with scaffolds with both antimicrobials adsorbed. Once the described scaffolds enhanced osteoblasts' differentiation, and matrix mineralization and evidenced no cytotoxic effects, they come to light as an auspicious alternative for local antimicrobial therapy addressing osteomyelitis prevention and therapeutics.info:eu-repo/semantics/publishedVersio

In vitro cytocompatibility evaluation of poly(DL-lactic acid) scaffolds loaded with minocycline and voriconazole addressing osteomyelitis

Purpose: In this work is proposed the cytocompatibility evaluation of an innovative system based on the dual delivery of minocycline (Min) and voriconazole (Vor), aiming for bone infection therapeutics.info:eu-repo/semantics/publishedVersio