Societal Perspectives on a Bio-Economy in Germany: An Explorative Study Using Q Methodology

Bio-economy describes an economy based on renewable instead of fossil resources. To ensure the success of this transformation it is necessary to involve society into the process. Q methodology was used to empirically assess people’s perspectives on bio-economy in Germany. Using a Q-type factor analysis three perspectives were identified. “Sufficiency and close affinity to nature” focuses on natural/ecological relations, while “Technological Progress” favours technologies to become less dependent on fossil resources. The third perspective “Not at any price” is rather concerned about economic trade-offs. An online survey is planned to investigate the representation of these perspectives in the wider population

Societal Perspectives on a Bio-economy in Germany: An Explorative Study Using Q Methodology

Bio-economy describes an economy based on renewable instead of fossil resources. To ensure the success of this transformation it is necessary to involve society into the process. Q methodology was used to empirically assess people’s perspectives on bio-economy in Germany. Using a Q-type factor analysis three perspectives were identified. “Sufficiency and close affinity to nature” focuses on natural/ecological relations, while “Technological Progress” favours technologies to become less dependent on fossil resources. The third perspective “Not at any price” is rather concerned about economic trade-offs. People’s viewpoints could be useful for politicians and stakeholders to improve communication and knowledge building on bio-economy in Germany

Three Essays on the Economics of Education: Equal Opportunities for All? Inequalities in the German Education System

The importance of tracking and educational reforms over the last decades in Germany, and their consequences in terms of inequalities, connects the three papers of this dissertation. In my first paper, I examine causal effects of relative school-starting age on children’s math, science, and reading competencies in primary school, as well as on teacher track recommendation at the end of grade four and actual track choice in grade five. I employ a fuzzy regression discontinuity design to account for the endogeneity of school-starting age. I find substantial positive effects on math, science, and reading competencies; my results also provide evidence that students who are the oldest in their cohort are more likely to receive a high-track teacher recommendation or attend a high-track school, compared to students who are among the youngest. I do not find differential effects depending on the student’s gender or socioeconomic background. In my second paper, I analyze the interacting influences of school type attended and school certificate earned on students’ transition chances to fully qualifying vocational training in Germany. More specifically, employing linear probability models, I explore whether those chances are different for intermediate (Realschule) certificate graduates depending on the type of school at which the certificate was obtained, and whether students attending the lowest-track Hauptschule who graduated with an intermediate certificate have better transition chances compared to their peers who earned lower school certificates. I find that intermediate certificate graduates who attended a Hauptschule have lower transition chances than intermediate certificate graduates who attended a Realschule or comprehensive school. I also find that students who attended a Hauptschule and graduated with an intermediate certificate have better transition chances compared to their Hauptschule peers who graduated with lower credentials. There is no evidence that students who earned an intermediate certificate enter vocational training positions of differing socioeconomic status or prestige depending on type of school attended. In my third paper, using school-fixed effects regression models, I investigate socioeconomic status gaps in students’ cognitive achievement in grade nine within different school types in Germany. I also explore the association between socioeconomic background and attainment of the intermediate secondary certificate and transition to upper secondary education in multi-track schools. My results provide suggestive evidence that socioeconomic status gaps in cognitive achievement exist within all school types. I also find that more privileged students are significantly more likely to earn an intermediate certificate or transition into upper secondary education. The decomposition of primary and secondary effects reveals that secondary effects are stronger at this transition in the German school syste

The Economic Value of Social and Emotional Learning

There is a growing body of research emphasizing the advantages of teaching students social and emotional (SE) skills in school. Here we examine the economic value of these skills within a benefit-cost analysis (BCA) framework. Our examination has three parts. First, we describe how the current method of BCA must be expanded to adequately evaluate SE skills, and we identify important decisions analysts must make. Second, we review the evidence on the benefits of SE skills, again noting key methodological issues with respect to shadow pricing. Finally, we perform BCA of four selected social and emotional learning (SEL) interventions: 4Rs; Second Step, Life Skills Training; and Responsive Classroom. These analyses illustrate both methodological and empirical challenges in estimating net present values for these interventions. Even with these challenges, we find that the benefits of these interventions substantially outweigh the costs. We highlight promising areas of research for improving the application of BCA to SEL

A Benefit-Cost Analysis of a Long-Term Intervention on Social and Emotional Learning in Compulsory School

There is growing evidence that social and emotional skills can be taught to students in school and teaching these skills can have a positive effect on later outcomes, such as better mental health and less drug use. This paper presents a benefit-cost analysis of a longitudinal social and emotional learning intervention in Sweden, using data for 663 students participating in the evaluation. Intervention costs are compared against treatment impact on self-reported drug use. Pre-test and post-test data are available. Since follow-up data for the participants´ drug use as adults is not available, informed projections have been made. Net present monetary values are calculated for the general public and society. The results show that students in the treatment group report decreasing use of drugs over the five year long intervention, the value of which easily outweighs the intervention costs

A Dry EEG-System for Scientific Research and Brain–Computer Interfaces

Although it ranks among the oldest tools in neuroscientific research, electroencephalography (EEG) still forms the method of choice in a wide variety of clinical and research applications. In the context of brain–computer interfacing (BCI), EEG recently has become a tool to enhance human–machine interaction. EEG could be employed in a wider range of environments, especially for the use of BCI systems in a clinical context or at the homes of patients. However, the application of EEG in these contexts is impeded by the cumbersome preparation of the electrodes with conductive gel that is necessary to lower the impedance between electrodes and scalp. Dry electrodes could provide a solution to this barrier and allow for EEG applications outside the laboratory. In addition, dry electrodes may reduce the time needed for neurological exams in clinical practice. This study evaluates a prototype of a three-channel dry electrode EEG system, comparing it to state-of-the-art conventional EEG electrodes. Two experimental paradigms were used: first, event-related potentials (ERP) were investigated with a variant of the oddball paradigm. Second, features of the frequency domain were compared by a paradigm inducing occipital alpha. Furthermore, both paradigms were used to evaluate BCI classification accuracies of both EEG systems. Amplitude and temporal structure of ERPs as well as features in the frequency domain did not differ significantly between the EEG systems. BCI classification accuracies were equally high in both systems when the frequency domain was considered. With respect to the oddball classification accuracy, there were slight differences between the wet and dry electrode systems. We conclude that the tested dry electrodes were capable to detect EEG signals with good quality and that these signals can be used for research or BCI applications. Easy to handle electrodes may help to foster the use of EEG among a wider range of potential users

DNA polymerase zeta is required for proliferation of normal mammalian cells

Unique among translesion synthesis (TLS) DNA polymerases, pol ζ is essential during embryogenesis. To determine whether pol ζ is necessary for proliferation of normal cells, primary mouse fibroblasts were established in which Rev3L could be conditionally inactivated by Cre recombinase. Cells were grown in 2% O2 to prevent oxidative stress-induced senescence. Cells rapidly became senescent or apoptotic and ceased growth within 3–4 population doublings. Within one population doubling following Rev3L deletion, DNA double-strand breaks and chromatid aberrations were found in 30–50% of cells. These breaks were replication dependent, and found in G1 and G2 phase cells. Double-strand breaks were reduced when cells were treated with the reactive oxygen species scavenger N-acetyl-cysteine, but this did not rescue the cell proliferation defect, indicating that several classes of endogenously formed DNA lesions require Rev3L for tolerance or repair. T-antigen immortalization of cells allowed cell growth. In summary, even in the absence of external challenges to DNA, pol ζ is essential for preventing replication-dependent DNA breaks in every division of normal mammalian cells. Loss of pol ζ in slowly proliferating mouse cells in vivo may allow accumulation of chromosomal aberrations that could lead to tumorigenesis. Pol ζ is unique amongst TLS polymerases for its essential role in cell proliferation

Grundwasser - Altlasten - Boden aktuell

Neun Fachbeiträge dokumentieren Ergebnisse der aktuellen Projekt- und Forschungsarbeit des Landesamtes in den Themenbereichen Grundwasser, Altlasten und Boden. Die Inhalte reichen vom Interesse aus Namibia für diese Themenbereiche über verschiedene Auswertungen von Hintergrundwerten und Hochwasser 2013 bis hin zu Planungen im Bereich Bodendauerbeobachtung in Sachsen. Einzelerkenntnisse zu Wülknitz bzw. zum Tagebau Witznitz werden in dem Heft fortgeführt

Validation of MIPAS ClONO2 measurements

Altitude profiles of ClONO2 retrieved with the IMK (Institut fur Meteorologie und Klimaforschung) science-oriented data processor from MIPAS/Envisat (Michelson Interferometer for Passive Atmospheric Sounding on Envisat) mid-infrared limb emission measurements between July 2002 and March 2004 have been validated by comparison with balloon-borne (Mark IV, FIRS2, MIPAS-B), airborne (MIPAS-STR), ground-based (Spitsbergen, Thule, Kiruna, Harestua, Jungfraujoch, Izana, Wollongong, Lauder), and spaceborne (ACE-FTS) observations. With few exceptions we found very good agreement between these instruments and MIPAS with no evidence for any bias in most cases and altitude regions. For balloon-borne measurements typical absolute mean differences are below 0.05 ppbv over the whole altitude range from 10 to 39 km. In case of ACE-FTS observations mean differences are below 0.03 ppbv for observations below 26 km. Above this altitude the comparison with ACE-FTS is affected by the photochemically induced diurnal variation of ClONO2. Correction for this by use of a chemical transport model led to an overcompensation of the photochemical effect by up to 0.1 ppbv at altitudes of 30-35 km in case of MIPAS-ACE-FTS comparisons while for the balloon-borne observations no such inconsistency has been detected. The comparison of MIPAS derived total column amounts with ground-based observations revealed no significant bias in the MIPAS data. Mean differences between MIPAS and FTIR column abundances are 0.11 +/- 0.12 x 10(14) cm(-2) (1.0 +/- 1.1%) and -0.09 +/- 0.19 x 10(14) cm(-2) (-0.8 +/- 1.7%), depending on the coincidence criterion applied. chi(2) tests have been performed to assess the combined precision estimates of MIPAS and the related instruments. When no exact coincidences were available as in case of MIPAS-FTIR or MIPAS-ACE-FTS comparisons it has been necessary to take into consideration a coincidence error term to account for chi(2) deviations. From the resulting chi(2) profiles there is no evidence for a systematic over/underestimation of the MIPAS random error analysis.Peer reviewe

The German National Registry of Primary Immunodeficiencies (2012-2017)

Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment