On the Use of a Magnetometer to Determine the Angular Motion of a Spinning Body in Regular Precession

Magnetometer for determination of angular motion of spinning body in regular precessio

X-ray observations of the galaxy cluster PKS 0745-191: To the virial radius, and beyond

We measure X-ray emission from the outskirts of the cluster of galaxies PKS 0745-191 with Suzaku, determining radial profiles of density, temperature, entropy, gas fraction, and mass. These measurements extend beyond the virial radius for the first time, providing new information about cluster assembly and the diffuse intracluster medium out to ~1.5 r_200, (r_200 ~ 1.7 Mpc ~ 15'). The temperature is found to decrease by roughly 70 per cent from 0.3-1 r_200. We also see a flattening of the entropy profile near the virial radius and consider the implications this has for the assumption of hydrostatic equilibrium when deriving mass estimates. We place these observations in the context of simulations and analytical models to develop a better understanding of non-gravitational physics in the outskirts of the cluster.Comment: 10 pages, 11 figures, accepted to MNRAS; expanded discussion of analysis and uncertainties, results qualitatively unchange

Emv2, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice

With the proliferation of sequence data, great challenges are posed in the correct annotation of endogenous retroviruses, which together comprise up to ten per cent of the genomes of many organisms. It is therefore essential that all sources of information are carefully considered before drawing conclusions concerning the phylogeny, distribution and biological properties of endogenous retroviruses. We suggest that such due diligence has not been applied in the description of an endogenous ecotropic retrovirus that recently appeared in Retrovirology

Decoupling Crossover in Asymmetric Broadside Coupled Split Ring Resonators at Terahertz Frequencies

We investigate the electromagnetic response of asymmetric broadside coupled split ring resonators (ABC-SRRs) as a function of the relative in-plane displacement between the two component SRRs. The asymmetry is defined as the difference in the capacitive gap widths (\Delta g) between the two resonators comprising a coupled unit. We characterize the response of ABC-SRRs both numerically and experimentally via terahertz time-domain spectroscopy. As with symmetric BC-SRRs (\Delta g=0 \mu m), a large redshift in the LC resonance is observed with increasing displacement, resulting from changes in the capacitive and inductive coupling. However, for ABC-SRRs, in-plane shifting between the two resonators by more than 0.375Lo (Lo=SRR sidelength) results in a transition to a response with two resonant modes, associated with decoupling in the ABC-SRRs. For increasing \Delta g, the decoupling transition begins at the same relative shift (0.375Lo), though with an increase in the oscillator strength of the new mode. This strongly contrasts with symmetric BC-SRRs which present only one resonance for shifts up to 0.75Lo. Since all BC-SRRs are effectively asymmetric when placed on a substrate, an understanding of ABC-SRR behavior is essential for a complete understanding of BC-SRR based metamaterials

Westward-propagating SST Anomalies and Baroclinic Eddies in the Sargasso Sea

Previous studies have documented the existence of a zonal band of strong, persistent, westward-propagating sea surface temperature (Ts) anomalies with zonal wavelengths of ≈800 km and periods of ≈200 days that are confined to the subtropical convergence zone (STCZ, roughly 26°–32°N). Two years of satellite-derived sea surface temperature (Ts) and sea surface elevation anomaly (η) maps of the Sargasso Sea (22.5°–33.5°N, 71.5°–59.5°W) are analyzed to determine how these anomalies are forced and why they an confined to the STCZ. A simple anomaly model forced by horizontal eddy currents and damped by a linear feedback mechanism explains many properties of the anomaly response. At wavelengths exceeding several hundred kilometers, forcing by horizontal eddy currents becomes less important relative to atmospheric forcing with increasing wavelength. The anomalies are confined to the STCZ partly because the large mean Ts gradient there enables the horizontal eddy currents to be relatively effective at forcing anomalies. Also, the eddies that force these anomalies, wavelike features with wavelengths of ∼800 km and periods of ∼200 days, are themselves confined to the STCZ. These wavelike eddies were not detecting during earlier experiments such as MODE because the domains within which they were conducted were too small. Within the STCZ, zonal dispersion properties of the eddy field are consistent with baroclinic Rossby wave variability. To the north and south of the STCZ, however, zonal dispersion properties differ substantially from the properties observed within the STCZ. The eddy dispersion properties change abruptly across transition zones 1–2 degree wide centered at 32.5° and 25.5°N. A simple linearized reduced-gravity model is used to demonstrate that interaction between eddies and zonal mean currents can qualitatively account for the change is dispersion properties south of the STCZ, but not to the north within the Gulf Stream recirculation region

Essentials of forensic accounting

https://egrove.olemiss.edu/aicpa_guides/2728/thumbnail.jp

Negative Selection by an Endogenous Retrovirus Promotes a Higher-Avidity CD4+ T Cell Response to Retroviral Infection

Effective T cell responses can decisively influence the outcome of retroviral infection. However, what constitutes protective T cell responses or determines the ability of the host to mount such responses is incompletely understood. Here we studied the requirements for development and induction of CD4+ T cells that were essential for immunity to Friend virus (FV) infection of mice, according to their TCR avidity for an FV-derived epitope. We showed that a self peptide, encoded by an endogenous retrovirus, negatively selected a significant fraction of polyclonal FV-specific CD4+ T cells and diminished the response to FV infection. Surprisingly, however, CD4+ T cell-mediated antiviral activity was fully preserved. Detailed repertoire analysis revealed that clones with low avidity for FV-derived peptides were more cross-reactive with self peptides and were consequently preferentially deleted. Negative selection of low-avidity FV-reactive CD4+ T cells was responsible for the dominance of high-avidity clones in the response to FV infection, suggesting that protection against the primary infecting virus was mediated exclusively by high-avidity CD4+ T cells. Thus, although negative selection reduced the size and cross-reactivity of the available FV-reactive naïve CD4+ T cell repertoire, it increased the overall avidity of the repertoire that responded to infection. These findings demonstrate that self proteins expressed by replication-defective endogenous retroviruses can heavily influence the formation of the TCR repertoire reactive with exogenous retroviruses and determine the avidity of the response to retroviral infection. Given the overabundance of endogenous retroviruses in the human genome, these findings also suggest that endogenous retroviral proteins, presented by products of highly polymorphic HLA alleles, may shape the human TCR repertoire that reacts with exogenous retroviruses or other infecting pathogens, leading to interindividual heterogeneity