Electrical Steels and Their Evaluation for Automobile Motors

Achieving high efficiency and high torque is an important target in EV motors. This paper describes the effect of the magnetic properties of electrical steels used as core materials for synchronous motors with permanent magnets, which are commonly used as the EV traction motors. It was confirmed that electrical steels, which have high flux density and low iron loss properties can realize high motor efficiency and torque. When PWM excitation is considered, thinner electrical steels are advantageous to suppress increased loss due to higher harmonics. Based on these results, electrical steels having high flux densities and low iron losses at high frequencies were developed. Document type: Articl

Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21

The Helicobacter pylori CagA bacterial oncoprotein plays a critical role in gastric carcinogenesis. Upon delivery into epithelial cells, CagA causes loss of polarity and activates aberrant Erk signaling. We show that CagA-induced Erk activation results in senescence and mitogenesis in nonpolarized and polarized epithelial cells, respectively. In nonpolarized epithelial cells, Erk activation results in oncogenic stress, up-regulation of the p21Waf1/Cip1 cyclin-dependent kinase inhibitor, and induction of senescence. In polarized epithelial cells, CagA-driven Erk signals prevent p21Waf1/Cip1 expression by activating a guanine nucleotide exchange factor–H1–RhoA–RhoA-associated kinase–c-Myc pathway. The microRNAs miR-17 and miR-20a, induced by c-Myc, are needed to suppress p21Waf1/Cip1 expression. CagA also drives an epithelial-mesenchymal transition in polarized epithelial cells. These findings suggest that CagA exploits a polarity-signaling pathway to induce oncogenesis