Cigarette smoking is associated with amplified age-related volume loss in subcortical brain regions

BACKGROUND: Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. METHODS: Non-smokers (n=43) and smokers (n=40), 22-70 years of age, completed a 4T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. RESULTS: Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. CONCLUSIONS: Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei. Greater cigarette quantity/exposure was related to smaller volumes in regions that also showed greater age-related volume loss in smokers. Findings suggest smoking adversely affected the structural integrity of subcortical brain regions with increasing age and exposure. The greater age-related volume loss in smokers may have implications for cortical-subcortical structural and/or functional connectivity, and response to available smoking cessation interventions

Optimization Of Fuzzy Evapotranspiration Model Through Neural Training With Input–Output Examples

In a previous study, we demonstrated that fuzzy evapotranspiration (ET) models can achieve accurate estimation of daily ET comparable to the FAO Penman–Monteith equation, and showed the advantages of the fuzzy approach over other methods. The estimation accuracy of the fuzzy models, however, depended on the shape of the membership functions and the control rules built by trial–and–error methods. This paper shows how the trial and error drawback is eliminated with the application of a fuzzy–neural system, which combines the advantages of fuzzy logic (FL) and artificial neural networks (ANN). The strategy consisted of fusing the FL and ANN on a conceptual and structural basis. The neural component provided supervised learning capabilities for optimizing the membership functions and extracting fuzzy rules from a set of input–output examples selected to cover the data hyperspace of the sites evaluated. The model input parameters were solar irradiance, relative humidity, wind speed, and air temperature difference. The optimized model was applied to estimate reference ET using independent climatic data from the sites, and the estimates were compared with direct ET measurements from grass–covered lysimeters and estimations with the FAO Penman–Monteith equation. The model–estimated ET vs. lysimeter–measured ET gave a coefficient of determination (r2) value of 0.88 and a standard error of the estimate (Syx) of 0.48 mm d–1. For the same set of independent data, the FAO Penman–Monteith–estimated ET vs. lysimeter–measured ET gave an r2 value of 0.85 and an Syx value of 0.56 mm d–1. These results show that the optimized fuzzy–neural–model is reasonably accurate, and is comparable to the FAO Penman–Monteith equation. This approach can provide an easy and efficient means of tuning fuzzy ET models

Linear Self-Motion Cues Support the Spatial Distribution and Stability of Hippocampal Place Cells

The vestibular system provides a crucial component of place-cell and head-direction cell activity [1-7]. Otolith signals are necessary for head-direction signal stability and associated behavior [8, 9], and the head-direction signal's contribution to parahippocampal spatial representations [10-14] suggests that place cells may also require otolithic information. Here, we demonstrate that self-movement information from the otolith organs is necessary for the development of stable place fields within and across sessions. Place cells in otoconia-deficient tilted mice showed reduced spatial coherence and formed place fields that were located closer to environmental boundaries, relative to those of control mice. These differences reveal an important otolithic contribution to place-cell functioning and provide insight into the cognitive deficits associated with otolith dysfunction

Magic Numbers for the Photoelectron Anisotropy in Li-Doped Dimethyl Ether Clusters

Photoelectron velocity map imaging of Li(CH$_3$OCH$_3$)$_n$ clusters (1 $\leq$ n $\leq$ 175) is used to search for magic numbers related to the photoelectron anisotropy. Comparison with density functional calculations reveals magic numbers at n=4, 5, and 6, resulting from the symmetric charge distribution with high s-character of the highest occupied molecular orbital. Since each of these three cluster sizes correspond to the completion of a first coordination shell, they can be considered as 'isomeric motifs of the first coordination shell'. Differences in the photoelectron anisotropy, the vertical ionization energies and the enthalpies of vaporization between Li(CH$_3$OCH$_3$)$_n$ and Na(CH$_3$OCH$_3$)$_n$ can be rationalized in terms of differences in their solvation shells, atomic ionization energies, polarizabilities, metal-oxygen bonds, ligand-ligand interactions, and by cooperative effects

Report of the panel on earth structure and dynamics, section 6

The panel identified problems related to the dynamics of the core and mantle that should be addressed by NASA programs. They include investigating the geodynamo based on observations of the Earth's magnetic field, determining the rheology of the mantle from geodetic observations of post-glacial vertical motions and changes in the gravity field, and determining the coupling between plate motions and mantle flow from geodetic observations of plate deformation. Also emphasized is the importance of support for interdisciplinary research to combine various data sets with models which couple rheology, structure and dynamics