A Systematic Review of interventions to Promote Hpv Vaccination Globally

BACKGROUND: Despite the human papillomavirus (HPV) vaccine being a safe, effective cancer prevention method, its uptake is suboptimal in the United States (U.S.). Previous research has found a variety of intervention strategies (environmental and behavioral) to increase its uptake. The purpose of the study is to systematically review the literature on interventions that promote HPV vaccination from 2015 to 2020. METHODS: We updated a systematic review of interventions to promote HPV vaccine uptake globally. We ran keyword searches in six bibliographic databases. Target audience, design, level of intervention, components and outcomes were abstracted from the full-text articles in Excel databases. RESULTS: Of the 79 articles, most were conducted in the U.S. (72.2%) and in clinical (40.5%) or school settings (32.9%), and were directed at a single level (76.3%) of the socio-ecological model. Related to the intervention type, most were informational (n = 25, 31.6%) or patient-targeted decision support (n = 23, 29.1%). About 24% were multi-level interventions, with 16 (88.9%) combining two levels. Twenty-seven (33.8%) reported using theory in intervention development. Of those reporting HPV vaccine outcomes, post-intervention vaccine initiation ranged from 5% to 99.2%, while series completion ranged from 6.8% to 93.0%. Facilitators to implementation were the use of patient navigators and user-friendly resources, while barriers included costs, time to implement and difficulties of integrating interventions into the organizational workflow. CONCLUSIONS: There is a strong need to expand the implementation of HPV-vaccine promotion interventions beyond education alone and at a single level of intervention. Development and evaluation of effective strategies and multi-level interventions may increase the uptake of the HPV vaccine among adolescents and young adults

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

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An Interdisciplinary Approach to the Urban Streetscape of Budapest's Andrassy Ut

As Budapest's most prominent boulevard, Andrassy Ut (Andrassy Way) exhibits a variety of urban land uses designed to showcase Hungarian history and culture and provide modern housing and leisure amenities for the city's elite. Designed and constructed in the 1870s, it is anchored in by Erzsebet tor (Erzsebet Square) in the city center and extends 2.42 km (1.5 mi) northeast to Varosliget (City Park). This study, conducted in summer 2014 by students in UW-Eau Claire's interdisciplinary Central European Travel Seminar (CETS), examined the cultural streetscape of the boulevard through the lens of geography, history, and music. Teams of researchers were dispatched to designated stretches of Andrassy Ut to document the ways in which historically and musically significant buildings and institutions coincide with high-end residential and commercial land uses. Landscape analysis was then utilized to document concentrations of specific types of land uses. As the city embarks on a massive redevelopment project that will convert Andrassy Ut from mixed use corridor into the tourism-focused Andrassy Quarter, this study marks an important transition period in the boulevard's history

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Documents with no information that could identify a tribe or cooperativ