The efficacy of cinacalcet in the treatment of hyperparathyroidism in Turkish hemodialysis patient population

WOS: 000393291900012OBJECTIVE: Cinacalcet reduces parathyroid hormone levels by increasing the sensitivity of the parathyroid gland to calcium. in this study, we firstly aimed to evaluate the efficacy of cinacalcet in Turkish hemodialysis patients. MATERIAL and METHODS: 4483 hemodialysis patients were screened and 469 patients who had used cinacalcet were included in the study. the patients were divided into 4 groups according to drug usage durations (Group 1: 3 months, Group 2: 6 months, Group 3: 9 months and Group 4: 12 months). the patients' Parathormone, Ca, P and CaxP levels at the 3rd, 6th, 9th and 12th months were compared to the start of treatment and previous months. RESULTS: the levels of Parathormone, Ca, P and CaxP significantly decreased compared to their initial levels in all groups (from 1412 pg/ml to 1222 pg/mL for Parathormone, p< 0,001) in the 3rd month. However, this reduction was not continued in the subsequent months (Parathormone: 1381 pg/ml for the 12th month). CONCLUSION: Cinacalcet may not provide adequate benefit in control of hyperparathyroidism in Turkish hemodialysis patient population

The Effect of Educational Intervention on Care Dependency and Symptom Management After Hematopoietic Stem Cell Transplantation: A Theory-Based Randomized Controlled Study

The objective of the research was to determine the effect of educational intervention based on Bandura’s Social Cognitive Learning Theory on care dependency and symptom management after hematopoietic stem cell transplantation. Methods. This randomized controlled trial was conducted between January 2019 and February 2020 at the Hematopoietic Stem Cell Transplantation Center. All the patients were randomly divided into two groups: 53 individuals in the intervention group and 53 individuals in the control group. The sociodemographic data collection form, the Edmonton Symptom Assessment Scale and the Care Dependency Scale were used for data collection. Data were collected from the patients one day after hematopoietic stem cell transplantation and 12 weeks later. Results. There were no statistically significant differences between the groups regarding the mean scores of the Edmonton Symptom Assessment Scale and the Care Dependency Scale at baseline. Twelve weeks after intervention, there were statistically significant differences between the groups regarding the mean scores of the Edmonton Symptom Assessment Scale and the Care Dependency Scale. Conclusions. Educational intervention along with telephone counseling based on Bandura’s theory was found to be an effective way to reduce symptom severity and care dependency in patients who underwent hematopoietic stem cell transplantation and is recommended for all patients after hematopoietic stem cell transplantation

Pedicled flap procedures for sensory restoration of the hand: long-term results

Amaç: Elde duyu ve yumuşak doku restorasyonu için pediküllü fleplerle onarım yapılan hastaların geç dönem sonuçları değerlendirildi. Çalışma planı: Çalışmaya 30 hasta (26 erkek, 4 kadın; ort. yaş 33; dağılım 16-62) alındı. Yirmi dört hastada başparmak, üçünde işaret parmağı, üçünde beşinci parmak ulnar taraf duyu restorasyonu yapıldı. Yirmi yedi hastada damarlı ve sinirli ada flebi, üç hastada duyulu çapraz parmak flebi kullanıldı. Onarımda damarlı ve sinirli ada flebi kullanılan hastaların 11’inde sinir ayırma ve tekrar birleştirme tekniği uygulandı. Duyu değerlendirmesi Semmes-Weinstein monofilaman testi ve iki nokta ayrım testiyle yapıldı. Ortalama izlem süresi 29.2 ay (dağılım 5-144 ay) idi. Sonuçlar: Hiçbir hastada flep kaybı gözlenmedi. Damarlı ve sinirli ada flebi uygulanan dört hastada (%14.8) donör parmaklarda kontraktür oluştu. Ayırma-tekrar birleştirme yöntemi uygulanan iki hastada (%18.2) tenar alanda nöroma oluşumu gözlendi. Statik ve hareketli iki nokta ayrım testleri, ayırma-tekrar birleştirme yapılan hastalarda sırasıyla ortalama 9.1 mm ve 7.4 mm, orijinal tekniğin uygulandığı hastalarda 8.3 mm ve 7 mm, duyulu çapraz parmak flebi uygulanan hastalarda ise 10.3 mm ve 8.6 mm olarak ölçüldü. Ayırma-tekrar birleştirme yapılan tüm hastalarda duyu lokalizasyonu alıcı sahada algılandı. Orijinal tekniğin uygulandığı 16 hastanın dokuzu (%56.3) duyuyu alıcı sahada lokalize ederken, üçü (%18.8) verici sahada algıladı. Dört hastada (%25) ise çapraz duyarlılık gözlendi. Çıkarımlar: Pediküllü flepler, parmaklarda hem yumuşak doku hem de duyu restorasyonu açısından oldukça güvenilir ve tatminkar seçeneklerdir. Ayırma-tekrar birleştirme işlemi çapraz duyarlılığı engellemek açısından oldukça başarılıdır.Objectives: We evaluated the long-term results of patients who underwent reconstruction with pedicled flaps for soft tissue and sensory restoration. Methods: The study included 30 patients (26 males, 4 females; mean age 33 years; range 16 to 62 years) who underwent sensory restorations of the thumb (n=24), the index finger (n=3), and the little finger (n=3). Twenty-seven patients received neurovascular island flaps and three patients received radial innervated cross-finger flaps. Disconnectionreconnection of the nerve was performed in 11 patients receiving a neurovascular island flap. Sensory evaluations were made with two-point discrimination and the Semmes- Weinstein monofilament test. The mean follow-up was 29.2 months (range 5 to 144 months). Results: There were no cases of flap loss. Contractures of donor digits were seen in four patients (14.8%) treated with neurovascular island flaps. Neuroma formation was noted in two patients (18.2%) in whom the disconnection-reconnection technique was used. Static and moving two-point discrimination test results were 9.1 mm and 7.4 mm with the disconnection- reconnection technique, 8.3 mm and 7 mm with the original technique, and 10.3 mm and 8.6 mm with radial innervated cross finger flaps, respectively. Sensation was at the recipient site in all the patients who underwent disconnection- reconnection. Of those in whom the original technique was employed, nine patients (56.3%) localized sensation at the recipient site, three patients (18.8%) at the donor site, while four patients (25%) showed double sensibility. Conclusion: Pedicled flaps are reliable and satisfactory alternatives for soft tissue and sensory restoration of hand injuries and disconnection-reconnection of the nerve is effective in preventing double sensibility

Sirküler trakeal rekonstrüksiyonda farklı yöntemlerin karşılaştırılması: Deneysel çalışma

Amaç: Bu çalışmada sirküler trakeal rekonstrüksiyon için farklı prefabrike modellerin karşılaştırılması amaçlandı. Gereç ve Yöntem: Otuz adet erişkin dişi Yeni Zelanda tavşanı, farklı doku kombinasyonuyla sirküler trakeal rekonstrüksiyon için altı gruba ayrıldı. Prefabrike edilmiş trakealarda anastomoz yapılmadı. Vasküler kaynak olarak lateral torasik fasya veya pektoralis majör kası; iskeletsel çatı olarak polipropilen mesh, politetrafloroetilen (Gore-Tex) veya yüzük kartilajlar kullanıldı. İç yüzey tüysüz epitelyal deri greftinden sağlandı. Gruplar tüysüz epitel greftinin canlılığı, longitüdinal esneklik, dayanıklılık, flep duvar kalınlığı, iç çap ve flep canlılığı açısından karşılaştırıldı. Bulgular: Polipropilen mesh gruplarında tama yakın epitelyal deri grefti canlılığı görülürken (%95-%99), Gore-Tex gruplarında tama yakın nekroz gözlendi (%74-%71). Longitüdinal esneklik ve dayanıklılık Gore-Tex ve polipropilen mesh gruplarında normal trakeaya yakın ölçülerde bulundu. Kartilaj greftleri ile prefabrikasyon yapılan gruplar normalden fazla longitüdinal esneklik ve kolayca kollaps gösterdi. Sonuç: İskeletsel çatı olarak polipropilen mesh, vasküler kaynak olarak lateral torasik fasyanın kullanıldığı prefabrike model, sirküler trakea defektlerinin rekonstrüksiyonunda en iyi seçenek olarak görünmektedir.Objectives: This study was designed to compare different pr&eacute;fabrication models for circumferential tracheal reconstruction. Materials and Methods: Thirty adult female New Zealand rabbits were divided into six groups for circumferential tracheal reconstruction with a different tissue combination. Pr&eacute;fabrication of neotrachea was performed without anastomosis. Lateral thoracic fascia or pectoralis major muscle were used for vascular supply. Polypropylene mesh, polytetrafluoroethylene (Gore-Tex), or cartilage rings were used for skeletal framework. Hairless epithelial skin graft was used for inner lining. The groups were compared in terms of viability of hairless epithelial graft, longitudinal flexibility, rigidity, flap wall thickness, internal diameter, and flap viability. Results: Epithelial skin graft was almost totally viable (95%-99%) in the polypropylene mesh groups.. Gore-Tex groups exhibited almost total necrosis (74%-71%). Longitudinal flexibility and rigidity were similar to the native trachea in Gore-Tex and polypropylene mesh groups. Neotrachea prefabricated with cartilage grafts showed more than normal longitudinal flexibility and collapsed easily, Conclusion: The prefabricated model with the use of polypropylene mesh for skeletal framework and lateral thoracic fascia for vascular supply seems to be the best alternative in the reconstruction of circumferential tracheal defects